ATE266029T1 - Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung - Google Patents

Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung

Info

Publication number: ATE266029T1
Authority: AT; Austria
Prior art keywords: pyrrolobenzimidazole; inflammatory; derivatives; substituted; synthesis
Prior art date: 1998-02-26

Application number

AT99908456T

Other languages

English (en)

Inventor

John H Dodd

James A Henry

Kenneth C Rupert

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-02-26

Filing date

1999-02-25

Publication date

2004-05-15

1999-02-25 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE266029T1 publication Critical patent/ATE266029T1/de

Links

230000003110 anti-inflammatory effect Effects 0.000 title 1
BKOVMXWXILSWCU-UHFFFAOYSA-N pyrrolo[3,2-e]benzimidazole Chemical class C1=CC2=NC=CC2=C2N=CN=C21 BKOVMXWXILSWCU-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99908456T 1998-02-26 1999-02-25 Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung ATE266029T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US7606398P	1998-02-26	1998-02-26
PCT/US1999/004085 WO1999043680A1 (en)	1998-02-26	1999-02-25	Substituted pyrrolobenzimidazoles for treating inflammatory diseases

Publications (1)

Publication Number	Publication Date
ATE266029T1 true ATE266029T1 (de)	2004-05-15

Family

ID=22129714

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99908456T ATE266029T1 (de)	1998-02-26	1999-02-25	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung

Country Status (8)

Country	Link
US (2)	US6147096A (de)
EP (1)	EP1060181B1 (de)
JP (1)	JP4570777B2 (de)
AT (1)	ATE266029T1 (de)
AU (1)	AU759297B2 (de)
CA (1)	CA2321559A1 (de)
DE (1)	DE69917005T2 (de)
WO (1)	WO1999043680A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10121215A1 (de) *	2001-04-30	2002-10-31	Merck Patent Gmbh	Dihydro-imidazo[4,5-e]indol- und 7H-Pyrrolo[3,2-f]chinoxalin Derivate als nikotinische Acetylcholinrezeptor Liganden und/oder serotonerge Liganden
US6908899B2 (en) *	2001-08-17	2005-06-21	U.S. Dept. Of Veterans Affairs	Pro-inflammatory fibrinopeptide
ES2278170T3 (es)	2002-07-09	2007-08-01	BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG	Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias.
JP2006527197A (ja) *	2003-06-06	2006-11-30	ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア	ｐ３８キナーゼ阻害剤組成物及びその使用方法
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
EP1676574A3 (de)	2004-12-30	2006-07-26	Johnson & Johnson Vision Care, Inc.	Verfahren zur Förderung des Überlebens von Zell- und Gewebe-Transplantaten
US7737279B2 (en)	2005-05-10	2010-06-15	Bristol-Myers Squibb Company	1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same
EP1992344A1 (de)	2007-05-18	2008-11-19	Institut Curie	P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
EA039897B1 (ru)	2014-05-16	2022-03-24	Атрива Терепьютикс Гмбх	Применение ингибитора мек для лечения коинфекции, включающей бактериальную инфекцию и инфекцию, вызванную вирусом гриппа
TW202214632A (zh) *	2020-07-27	2022-04-16	大陸商江蘇恆瑞醫藥股份有限公司	吲哚稠環類衍生物、其製備方法及其在醫藥上的應用
WO2023280911A1 (en)	2021-07-06	2023-01-12	Westfälische Wilhelms-Universität Münster	P38-inhibitors for the treatment of coronavirus infections and/or covid-19 cytokine storm

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL104369A0 (en) *	1992-01-13	1993-05-13	Smithkline Beecham Corp	Novel compounds and compositions

1999
- 1999-02-25 WO PCT/US1999/004085 patent/WO1999043680A1/en not_active Ceased
- 1999-02-25 EP EP99908456A patent/EP1060181B1/de not_active Expired - Lifetime
- 1999-02-25 US US09/257,121 patent/US6147096A/en not_active Expired - Lifetime
- 1999-02-25 AT AT99908456T patent/ATE266029T1/de not_active IP Right Cessation
- 1999-02-25 JP JP2000533434A patent/JP4570777B2/ja not_active Expired - Lifetime
- 1999-02-25 DE DE69917005T patent/DE69917005T2/de not_active Expired - Lifetime
- 1999-02-25 AU AU27888/99A patent/AU759297B2/en not_active Expired
- 1999-02-25 CA CA002321559A patent/CA2321559A1/en not_active Abandoned
2000
- 2000-09-25 US US09/669,002 patent/US6469174B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2321559A1 (en)	1999-09-02
JP4570777B2 (ja)	2010-10-27
AU2788899A (en)	1999-09-15
EP1060181A1 (de)	2000-12-20
AU759297B2 (en)	2003-04-10
DE69917005T2 (de)	2005-03-24
DE69917005D1 (de)	2004-06-09
US6469174B1 (en)	2002-10-22
WO1999043680A1 (en)	1999-09-02
JP2002504555A (ja)	2002-02-12
EP1060181B1 (de)	2004-05-06
US6147096A (en)	2000-11-14

Legal Events

Date	Code	Title	Description
2004-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
EA199900373A2 (ru)	1999-12-29	Фармацевтические композиции
BR0109703A (pt)	2003-02-04	Derivados de piperazina
CY1108522T1 (el)	2014-04-09	Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της
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JO2372B1 (en)	2006-12-12	Source drugs of 4-phenylpyridine derivatives
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ATE357438T1 (de)	2007-04-15	1,2,4-triaminobenzolderivate zur behandlung von erkrankungen des zentralnervensystems
ATE238981T1 (de)	2003-05-15	Antitumorwirkstoffe
TR200100895T2 (tr)	2001-12-21	Heterosiklik ikameli propanolamin türevleri, üretimi, ilaçları,kullanımı
ATE266029T1 (de)	2004-05-15	Substituierte pyrrolobenzimidazolderivate zur entzündungshemmung
WO2001081316A3 (en)	2002-05-23	Substituted phenyl farnesyltransferase inhibitors
MY138826A (en)	2009-07-31	2,7-substituted indoles
SE9801494D0 (sv)	1998-04-28	Novel use
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NO20014241D0 (no)	2001-08-31	C16-umettede FP-selektive prostaglandinanaloger
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DK1109560T3 (da)	2003-11-03	Som AICARFT-inhibitorer anvendelige forbindelser