ATE266624T1 - Verfahren zur herstellung von l-valinbenzylester- p-toluolsufonaten - Google Patents
Verfahren zur herstellung von l-valinbenzylester- p-toluolsufonatenInfo
- Publication number
- ATE266624T1 ATE266624T1 AT99909211T AT99909211T ATE266624T1 AT E266624 T1 ATE266624 T1 AT E266624T1 AT 99909211 T AT99909211 T AT 99909211T AT 99909211 T AT99909211 T AT 99909211T AT E266624 T1 ATE266624 T1 AT E266624T1
- Authority
- AT
- Austria
- Prior art keywords
- toluenesulfonate
- valine
- toluene
- benzyl ester
- valinebenzylester
- Prior art date
Links
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 abstract 3
- QWUQVUDPBXFOKF-MERQFXBCSA-N benzyl (2s)-2-amino-3-methylbutanoate;4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.CC(C)[C@H](N)C(=O)OCC1=CC=CC=C1 QWUQVUDPBXFOKF-MERQFXBCSA-N 0.000 abstract 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 1
- 229940030600 antihypertensive agent Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 239000003849 aromatic solvent Substances 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960004295 valine Drugs 0.000 abstract 1
- 239000008096 xylene Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP06672598A JP3892963B2 (ja) | 1998-03-17 | 1998-03-17 | Ｌ−バリンベンジルエステルｐ−トルエンスルホン酸塩の製造方法 |
| PCT/JP1999/001334 WO1999047488A1 (en) | 1998-03-17 | 1999-03-17 | Process for producing l-valine benzyl ester p-toluenesulfonate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE266624T1 true ATE266624T1 (de) | 2004-05-15 |
Family
ID=13324172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99909211T ATE266624T1 (de) | 1998-03-17 | 1999-03-17 | Verfahren zur herstellung von l-valinbenzylester- p-toluolsufonaten |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0985658B1 (de) |
| JP (1) | JP3892963B2 (de) |
| AT (1) | ATE266624T1 (de) |
| DE (1) | DE69917163T2 (de) |
| ES (1) | ES2220050T3 (de) |
| PT (1) | PT985658E (de) |
| WO (1) | WO1999047488A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4929938B2 (ja) * | 2006-09-12 | 2012-05-09 | 住友化学株式会社 | 光学活性なα−アミノ酸ベンジルエステル類の製造方法 |
| CN103554047A (zh) * | 2013-10-11 | 2014-02-05 | 镇江市高等专科学校 | 制备缬沙坦的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4199499A (en) * | 1978-08-24 | 1980-04-22 | Eli Lilly And Company | Pharmacologically active peptides |
| FR2620700B1 (fr) * | 1987-09-17 | 1990-06-01 | Adir | Procede de synthese d'alpha amino acides n alkyles et leurs esters. application a la synthese de carboxyalkyl dipeptides |
| US5362912A (en) * | 1989-05-23 | 1994-11-08 | Abbott Laboratories | Process for the preparation of a substituted diaminodiol |
| EP0528762B1 (de) * | 1991-08-15 | 1997-05-07 | Novartis AG | N-Acyl-N-Heterocyclyl- oder Naphthylalkyl-Aminosäuren als Angiotensin II Antagonisten |
-
1998
- 1998-03-17 JP JP06672598A patent/JP3892963B2/ja not_active Expired - Fee Related
-
1999
- 1999-03-17 WO PCT/JP1999/001334 patent/WO1999047488A1/ja not_active Ceased
- 1999-03-17 AT AT99909211T patent/ATE266624T1/de active
- 1999-03-17 EP EP99909211A patent/EP0985658B1/de not_active Expired - Lifetime
- 1999-03-17 DE DE69917163T patent/DE69917163T2/de not_active Expired - Lifetime
- 1999-03-17 ES ES99909211T patent/ES2220050T3/es not_active Expired - Lifetime
- 1999-03-17 PT PT99909211T patent/PT985658E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11263757A (ja) | 1999-09-28 |
| EP0985658B1 (de) | 2004-05-12 |
| ES2220050T3 (es) | 2004-12-01 |
| EP0985658A1 (de) | 2000-03-15 |
| DE69917163D1 (de) | 2004-06-17 |
| PT985658E (pt) | 2004-08-31 |
| EP0985658A4 (de) | 2002-10-23 |
| JP3892963B2 (ja) | 2007-03-14 |
| WO1999047488A1 (en) | 1999-09-23 |
| DE69917163T2 (de) | 2005-07-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0985658 Country of ref document: EP |
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| EEIH | Change in the person of patent owner |