ATE267171T1 - Phenylsulphonylderivative als 5-ht rezeptorliganden - Google Patents
Phenylsulphonylderivative als 5-ht rezeptorligandenInfo
- Publication number
- ATE267171T1 ATE267171T1 AT00900723T AT00900723T ATE267171T1 AT E267171 T1 ATE267171 T1 AT E267171T1 AT 00900723 T AT00900723 T AT 00900723T AT 00900723 T AT00900723 T AT 00900723T AT E267171 T1 ATE267171 T1 AT E267171T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor ligands
- phenyl sulphonyl
- sulphonyl derivatives
- derivatives
- phenyl
- Prior art date
Links
- -1 PHENYL SULPHONYL Chemical class 0.000 title abstract 3
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title 1
- 102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical class C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 101000783617 Homo sapiens 5-hydroxytryptamine receptor 2A Proteins 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001539 azetidines Chemical class 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 125000003386 piperidinyl group Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Nutrition Science (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9901147.0A GB9901147D0 (en) | 1999-01-19 | 1999-01-19 | Therapeutic agents |
| PCT/GB2000/000153 WO2000043362A1 (en) | 1999-01-19 | 2000-01-11 | Phenylsulphonyl derivatives as 5-ht receptor ligands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267171T1 true ATE267171T1 (de) | 2004-06-15 |
Family
ID=10846135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00900723T ATE267171T1 (de) | 1999-01-19 | 2000-01-11 | Phenylsulphonylderivative als 5-ht rezeptorliganden |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6559166B1 (de) |
| EP (1) | EP1147084B1 (de) |
| JP (1) | JP2002535308A (de) |
| AT (1) | ATE267171T1 (de) |
| AU (1) | AU773296B2 (de) |
| CA (1) | CA2359983A1 (de) |
| DE (1) | DE60010855T2 (de) |
| ES (1) | ES2219296T3 (de) |
| GB (1) | GB9901147D0 (de) |
| WO (1) | WO2000043362A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10000739A1 (de) * | 2000-01-11 | 2001-07-12 | Merck Patent Gmbh | Piperidin- und Piperazinderivate |
| GB0007907D0 (en) * | 2000-03-31 | 2000-05-17 | Merck Sharp & Dohme | Therapeutic agents |
| GB0311349D0 (en) * | 2003-05-16 | 2003-06-25 | Merck Sharp & Dohme | Therapeutic agents, compositions, preparations and uses |
| GB0326221D0 (en) | 2003-11-10 | 2003-12-17 | Merck Sharp & Dohme | Therapeutic agents,compositions,preparations and uses |
| GB0419192D0 (en) * | 2004-08-27 | 2004-09-29 | Merck Sharp & Dohme | Therapeutic agents |
| GB0426313D0 (en) * | 2004-12-01 | 2005-01-05 | Merck Sharp & Dohme | Therapeutic agents |
| GB0504828D0 (en) * | 2005-03-09 | 2005-04-13 | Merck Sharp & Dohme | Therapeutic agents |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4128552A (en) | 1977-09-26 | 1978-12-05 | Warner-Lambert Company | 1-[4,4-Bis(4-fluorophenyl)butyl]-4-phenylthio-1,2,3,6-tetrahydropyridines and related sulfoxides and sulfones |
| US4218455A (en) | 1978-07-10 | 1980-08-19 | Warner-Lambert Company | 1-(4-Fluorophenyl)-4-[1,2,3,6-tetrahydro-4-(phenylthio)-1-pyridinyl]-butanones and related sulfoxides and sulfones |
| AU593194B2 (en) | 1986-09-26 | 1990-02-01 | Sumitomo Pharmaceuticals Company, Limited | Imide derivatives ,and their production and use |
| US5246946A (en) | 1987-08-24 | 1993-09-21 | Eisai Co., Ltd. | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same |
| PH25458A (en) | 1987-08-24 | 1991-07-01 | Eisai Co Ltd | Piperidine derivatives, therapeutic, preventive agents |
| US5162347A (en) | 1987-08-24 | 1992-11-10 | Eisai Co., Ltd. | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same |
| DK730588A (da) | 1988-02-03 | 1989-08-04 | Asta Pharma Ag | Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel |
| US5272160A (en) * | 1989-05-17 | 1993-12-21 | Pfizer Inc | 2-piperidino-1-alkanol derivatives as antiischemic agents |
| WO1991018602A1 (en) | 1990-06-01 | 1991-12-12 | Merrell Dow Pharmaceuticals Inc. | (+)-α-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL |
| US5418242A (en) | 1993-05-18 | 1995-05-23 | Laboratoires Upsa | Piperidinylthioindole derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as analgesics |
| US5753679A (en) * | 1995-05-10 | 1998-05-19 | Hoffmann-La Roche Inc. | Benzyl-piperidine derivatives |
| DE19601189A1 (de) | 1996-01-15 | 1997-07-17 | Degussa | Verfahren zur Herstellung von 1,2,4-Triazolin-3(2H)-onen |
| US6197791B1 (en) * | 1997-02-27 | 2001-03-06 | American Cyanamid Company | N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| JP2004530691A (ja) * | 2001-05-11 | 2004-10-07 | ファルマシア・コーポレーション | 芳香族スルホンヒドロキサメートおよびプロテアーゼ阻害剤としてのそれらの使用 |
-
1999
- 1999-01-19 GB GBGB9901147.0A patent/GB9901147D0/en not_active Ceased
-
2000
- 2000-01-11 EP EP00900723A patent/EP1147084B1/de not_active Expired - Lifetime
- 2000-01-11 AT AT00900723T patent/ATE267171T1/de not_active IP Right Cessation
- 2000-01-11 DE DE60010855T patent/DE60010855T2/de not_active Expired - Fee Related
- 2000-01-11 WO PCT/GB2000/000153 patent/WO2000043362A1/en not_active Ceased
- 2000-01-11 JP JP2000594778A patent/JP2002535308A/ja not_active Withdrawn
- 2000-01-11 AU AU30647/00A patent/AU773296B2/en not_active Ceased
- 2000-01-11 ES ES00900723T patent/ES2219296T3/es not_active Expired - Lifetime
- 2000-01-11 CA CA002359983A patent/CA2359983A1/en not_active Abandoned
- 2000-01-11 US US09/889,702 patent/US6559166B1/en not_active Expired - Fee Related
-
2003
- 2003-04-01 US US10/404,188 patent/US6777430B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60010855T2 (de) | 2005-06-16 |
| US20030203889A1 (en) | 2003-10-30 |
| WO2000043362A1 (en) | 2000-07-27 |
| GB9901147D0 (en) | 1999-03-10 |
| US6559166B1 (en) | 2003-05-06 |
| EP1147084B1 (de) | 2004-05-19 |
| AU3064700A (en) | 2000-08-07 |
| DE60010855D1 (de) | 2004-06-24 |
| AU773296B2 (en) | 2004-05-20 |
| ES2219296T3 (es) | 2004-12-01 |
| CA2359983A1 (en) | 2000-07-27 |
| US6777430B2 (en) | 2004-08-17 |
| EP1147084A1 (de) | 2001-10-24 |
| JP2002535308A (ja) | 2002-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |