ATE267202T1 - 1,4-diazabicyclo(3.2.2)nonanbenzoxazol-, benzothiazol- und benzoimidazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung - Google Patents

1,4-diazabicyclo(3.2.2)nonanbenzoxazol-, benzothiazol- und benzoimidazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung

Info

Publication number: ATE267202T1
Authority: AT; Austria
Prior art keywords: nonanbenzoxazole; benzothiazole; diazabicyclo; production; therapeutic use
Prior art date: 2000-05-31

Application number

AT01938363T

Other languages

English (en)

Inventor

Frederic Galli

Alistair Lochead

Axelle Samson

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-31

Filing date

2001-05-29

Publication date

2004-06-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8850826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE267202(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-05-29 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2004-06-15 Application granted granted Critical

2004-06-15 Publication of ATE267202T1 publication Critical patent/ATE267202T1/de

Links

IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical compound C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 title 2
FTTATHOUSOIFOQ-UHFFFAOYSA-N 1,2,3,4,6,7,8,8a-octahydropyrrolo[1,2-a]pyrazine Chemical compound C1NCCN2CCCC21 FTTATHOUSOIFOQ-UHFFFAOYSA-N 0.000 title 1
HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Psychology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT01938363T 2000-05-31 2001-05-29 1,4-diazabicyclo(3.2.2)nonanbenzoxazol-, benzothiazol- und benzoimidazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung ATE267202T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0006975A FR2809730B1 (fr)	2000-05-31	2000-05-31	Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique
PCT/FR2001/001651 WO2001092261A1 (fr)	2000-05-31	2001-05-29	Derives de 1,4-diazabicyclo [3.2.2]nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique

Publications (1)

Publication Number	Publication Date
ATE267202T1 true ATE267202T1 (de)	2004-06-15

Family

ID=8850826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01938363T ATE267202T1 (de)	2000-05-31	2001-05-29	1,4-diazabicyclo(3.2.2)nonanbenzoxazol-, benzothiazol- und benzoimidazolderivate, verfahren zu ihrer herstellung und ihre therapeutische verwendung

Country Status (11)

Country	Link
US (1)	US7220740B2 (de)
EP (1)	EP1289988B1 (de)
JP (1)	JP4939721B2 (de)
AR (1)	AR028647A1 (de)
AT (1)	ATE267202T1 (de)
AU (1)	AU2001264044A1 (de)
DE (1)	DE60103395T2 (de)
FR (1)	FR2809730B1 (de)
HU (1)	HU229102B1 (de)
TW (1)	TW541307B (de)
WO (1)	WO2001092261A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0000540D0 (sv)	2000-02-18	2000-02-18	Astrazeneca Ab	New compounds
US20020086871A1 (en) *	2000-12-29	2002-07-04	O'neill Brian Thomas	Pharmaceutical composition for the treatment of CNS and other disorders
DK1406900T3 (da) *	2001-07-06	2007-01-29	Neurosearch As	Hidtil ukendte forbindelser, fremstilling og anvendelse deraf
FR2832714B1 (fr)	2001-11-23	2004-07-16	Sanofi Synthelabo	Derives de 4-(oxazolopyridin-2-yl)-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
SE0202465D0 (sv) *	2002-08-14	2002-08-14	Astrazeneca Ab	New compounds
US7456171B2 (en)	2002-10-08	2008-11-25	Sanofi-Aventis	1,4-Diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof
FR2845388B1 (fr) *	2002-10-08	2004-11-12	Sanofi Synthelabo	Derives de 1,4-diazabicyclo[3.2.2]nonanecarboxamides, leur preparation et leur application en therapeutique
WO2004043960A1 (en) *	2002-11-11	2004-05-27	Neurosearch A/S	1,4-diazabicyclo (3,2,2)nonane derivatives, preparation and therapeutical use thereof
US7223753B2 (en)	2002-11-11	2007-05-29	Neurosearch A/S	Diazabicyclic biaryl derivatives
JP2006519208A (ja) *	2003-02-27	2006-08-24	ニューロサーチ、アクティーゼルスカブ	新規ジアザビシクロアリール誘導体
FR2865208B1 (fr) *	2004-01-16	2009-01-16	Sanofi Synthelabo	Derives de 1,4-diazabicyclo[3.2.1]octanecarboxmique, leur preparation et leur application en therapeutique
JP2007520526A (ja)	2004-02-04	2007-07-26	ノイロサーチアクティーゼルスカブ	コリン作動性受容体モジュレーターとしてのジアザビシクロアリール誘導体
WO2006051410A1 (en) *	2004-11-15	2006-05-18	Pfizer Inc.	Azabenzoxazoles for the treatment of cns disorders
CA2587826A1 (en) *	2004-11-15	2006-05-18	Pfizer Products Inc.	Azabenzoxazoles for the treatment of cns disorders
WO2006051413A1 (en) *	2004-11-15	2006-05-18	Pfizer Inc.	Azabenoxazoles for the treatment of cns disorders
ATE495178T1 (de)	2005-02-16	2011-01-15	Neurosearch As	Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin- acetylcholin-rezeptoren
WO2007135121A1 (en)	2006-05-23	2007-11-29	Neurosearch A/S	Novel 8,10-diaza-bicyclo[4.3.1]decane derivatives and their medical use
CN104262348B (zh) *	2014-08-15	2017-12-15	北京师范大学	一种α7烟碱型乙酰胆碱受体配体及其制备方法
CN107188900B (zh) *	2017-05-27	2019-09-06	北京师范大学	α7烟碱型乙酰胆碱受体的配体化合物及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN166416B (de) *	1985-09-18	1990-05-05	Pfizer
NZ226000A (en) *	1987-09-10	1991-06-25	Merck Sharp & Dohme	Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
US5478939A (en) *	1994-07-20	1995-12-26	American Cyanamid Company	(R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786770B1 (fr)	1998-12-04	2001-01-19	Synthelabo	Derives de 1,4-diazabicyclo[3.2.2.]nonane, leur preparation et leur application en therapeutique
US20020086871A1 (en) *	2000-12-29	2002-07-04	O'neill Brian Thomas	Pharmaceutical composition for the treatment of CNS and other disorders

2000
- 2000-05-31 FR FR0006975A patent/FR2809730B1/fr not_active Expired - Fee Related
2001
- 2001-05-29 AT AT01938363T patent/ATE267202T1/de not_active IP Right Cessation
- 2001-05-29 DE DE60103395T patent/DE60103395T2/de not_active Expired - Lifetime
- 2001-05-29 US US10/276,646 patent/US7220740B2/en not_active Expired - Lifetime
- 2001-05-29 HU HU0302193A patent/HU229102B1/hu not_active IP Right Cessation
- 2001-05-29 WO PCT/FR2001/001651 patent/WO2001092261A1/fr not_active Ceased
- 2001-05-29 EP EP01938363A patent/EP1289988B1/de not_active Expired - Lifetime
- 2001-05-29 AU AU2001264044A patent/AU2001264044A1/en not_active Abandoned
- 2001-05-29 JP JP2002500874A patent/JP4939721B2/ja not_active Expired - Fee Related
- 2001-05-30 AR ARP010102574A patent/AR028647A1/es active IP Right Grant
- 2001-05-30 TW TW090113060A patent/TW541307B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2809730B1 (fr)	2002-07-19
EP1289988B1 (de)	2004-05-19
AR028647A1 (es)	2003-05-21
DE60103395D1 (de)	2004-06-24
DE60103395T2 (de)	2005-06-16
HUP0302193A3 (en)	2012-02-28
AU2001264044A1 (en)	2001-12-11
WO2001092261A1 (fr)	2001-12-06
JP4939721B2 (ja)	2012-05-30
US7220740B2 (en)	2007-05-22
HU229102B1 (en)	2013-07-29
FR2809730A1 (fr)	2001-12-07
US20030153574A1 (en)	2003-08-14
JP2003535091A (ja)	2003-11-25
TW541307B (en)	2003-07-11
HUP0302193A2 (hu)	2003-11-28
EP1289988A1 (de)	2003-03-12

Legal Events

Date	Code	Title	Description
2004-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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