ATE267586T1 - An phosphocholin gebundene prodrug-derivate - Google Patents
An phosphocholin gebundene prodrug-derivateInfo
- Publication number
- ATE267586T1 ATE267586T1 AT00908713T AT00908713T ATE267586T1 AT E267586 T1 ATE267586 T1 AT E267586T1 AT 00908713 T AT00908713 T AT 00908713T AT 00908713 T AT00908713 T AT 00908713T AT E267586 T1 ATE267586 T1 AT E267586T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- unsubstituted
- compounds
- phosphocholine
- substituent
- Prior art date
Links
- 239000000651 prodrug Substances 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title abstract 2
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical group C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 229940124597 therapeutic agent Drugs 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12048399P | 1999-02-18 | 1999-02-18 | |
| PCT/US2000/004140 WO2000048572A1 (en) | 1999-02-18 | 2000-02-16 | Phosphocholine linked prodrug derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE267586T1 true ATE267586T1 (de) | 2004-06-15 |
Family
ID=22390592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00908713T ATE267586T1 (de) | 1999-02-18 | 2000-02-16 | An phosphocholin gebundene prodrug-derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7060290B1 (de) |
| EP (1) | EP1161226B1 (de) |
| JP (1) | JP2002537243A (de) |
| AT (1) | ATE267586T1 (de) |
| AU (1) | AU3000800A (de) |
| DE (1) | DE60011053T2 (de) |
| WO (1) | WO2000048572A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1430017A2 (de) | 2001-09-26 | 2004-06-23 | Theravance, Inc. | Substituierter phenolverbindungen zur anästhesie und sedierung |
| US20050203068A1 (en) * | 2002-04-08 | 2005-09-15 | Peggy Wingard | Pharmaceutical compositions containing water-soluble prodrugs of propofol and methods of administering same |
| US7732432B2 (en) | 2003-01-21 | 2010-06-08 | Merck Sharp & Dohme Corp. | 17-carbamoyloxy cortisol derivatives as selective glucocorticoid receptor modulators |
| ZA200504940B (en) * | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| WO2005023204A2 (en) | 2003-09-09 | 2005-03-17 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
| WO2005105153A1 (en) * | 2004-04-30 | 2005-11-10 | Kopran Research Laboratories Limited | Hydroxyalkyl derivatives of biologically active compounds |
| PT1781596E (pt) | 2004-07-12 | 2009-01-12 | Xenoport Inc | Pró-fármacos de propofol derivados de aminoácidos, composições e utilizações dos mesmos |
| WO2006017351A1 (en) | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
| JP2008525501A (ja) | 2004-12-23 | 2008-07-17 | ゼノポート，インコーポレイティド | セリンアミノ酸誘導のプロポフォールのプロドラッグ、その使用及び結晶体 |
| WO2006091790A1 (en) | 2005-02-23 | 2006-08-31 | Xenoport, Inc. | Platinum-containing compounds exhibiting cytostatic activity, synthesis and methods of use |
| BRPI0620040A2 (pt) * | 2005-12-19 | 2011-10-25 | Methylgene Inc | inibidores de histona desacetilase para realçar a atividade de agentes antifúngicos |
| MX2009006542A (es) | 2006-12-19 | 2009-06-30 | Methylgene Inc | Inhibidores de histona desacetilasa y sus profarmacos. |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| CA2685813A1 (en) | 2007-05-09 | 2008-11-20 | Pharmacofore, Inc. | Therapeutic compounds |
| EP2810927A1 (de) | 2007-05-09 | 2014-12-10 | Sowood Healthcare LLC | Therapeutische Verbindungen |
| CA2739936C (en) | 2008-10-17 | 2017-12-12 | Pharmacofore, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| US9493477B2 (en) * | 2009-09-08 | 2016-11-15 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
| WO2011133348A1 (en) | 2010-04-21 | 2011-10-27 | Pharmacofore, Inc. | Compositions comprising enzyme-cleavable amphetamine prodrugs and inhibitors thereof |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| CN101885735B (zh) | 2010-06-23 | 2012-09-12 | 四川大学华西医院 | 取代苯酚羟基酸酯的磷酸酯化合物、制备方法及在药物中的应用 |
| CN101906039B (zh) * | 2010-06-23 | 2013-05-08 | 四川大学华西医院 | 取代苯酚的羟基酸酯化合物、制备方法及在药物中的应用 |
| WO2012096887A2 (en) | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| US8497237B2 (en) | 2011-01-11 | 2013-07-30 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| AU2012225337B2 (en) | 2011-03-09 | 2016-04-28 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| WO2013009701A2 (en) | 2011-07-08 | 2013-01-17 | The University Of North Carolina At Chapel Hill | Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders |
| JP6547755B2 (ja) * | 2014-10-15 | 2019-07-24 | 日油株式会社 | ホスホリルコリン基含有化合物およびホスホリルコリン複合体 |
| SI3750545T1 (sl) * | 2014-11-17 | 2024-06-28 | Cellectar Biosciences, Inc. | Analogi fosfolipidnega etra kot nosilci zdravil, ki ciljajo na raka |
| US10335406B2 (en) | 2015-10-01 | 2019-07-02 | Elysium Therapeutics, Inc. | Opioid compositions resistant to overdose and abuse |
| GB2556817B (en) | 2015-10-01 | 2019-11-06 | Elysium Therapeutics Inc | Polysubunit opioid prodrugs resistant to overdose and abuse |
| US11246877B2 (en) * | 2016-05-20 | 2022-02-15 | The University Of Chicago | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
| AU2018234911B2 (en) | 2017-03-17 | 2024-04-18 | Elysium Therapeutics, Inc. | Polysubunit opioid prodrugs resistant to overdose and abuse |
| WO2019028250A1 (en) | 2017-08-02 | 2019-02-07 | The University Of Chicago | NOMOGENEOUS ORGANOMETALLIC ORGANOMETRIC ORGANOMETRIC LAYERS FOR X-RAY INDUCED PHOTODYNAMIC THERAPY, RADIOTHERAPY, RODIODYNAMIC THERAPY, CHEMOTHERAPY, IMMUNOTHERAPY, AND ANY COMBINATION THEREOF |
| US11547714B2 (en) | 2020-02-05 | 2023-01-10 | Epalex Corporation | Fospropofol salts, methods and compositions |
| US11439653B1 (en) | 2021-03-30 | 2022-09-13 | Epalex Corporation | Fospropofol formulations |
| US11478490B1 (en) | 2021-03-30 | 2022-10-25 | Epalex Corporation | Fospropofol formulations |
| US11628178B2 (en) | 2019-03-26 | 2023-04-18 | Epalex Corporation | Fospropofol methods and compositions |
| EP4293032A4 (de) * | 2021-02-10 | 2024-10-23 | Shanghai Senhui Medicine Co., Ltd. | Benzazepinverbindungen, herstellungsverfahren dafür und pharmazeutische verwendung davon |
| MX2023010506A (es) | 2021-03-09 | 2023-09-20 | Ensysce Biosciences Inc | Composiciones que comprenden profarmacos de escision enzimatica y nafamostat de liberacion controlada y metodos de uso de estos. |
| CA3230025A1 (en) | 2021-09-29 | 2023-04-06 | Lynn Kirkpatrick | Enzyme-cleavable methadone prodrugs and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5534499A (en) * | 1994-05-19 | 1996-07-09 | The University Of British Columbia | Lipophilic drug derivatives for use in liposomes |
| WO1996016680A1 (en) | 1994-11-30 | 1996-06-06 | Amur Research Corp. | Phosphocholine drug derivatives |
| JP2002514183A (ja) * | 1996-09-17 | 2002-05-14 | スーパージェン・インコーポレーテッド | リン脂質薬剤誘導体 |
| US5830432A (en) * | 1997-03-31 | 1998-11-03 | Amur Pharmacuticals, Inc. | Phospholipid drug derivatives |
| US5776915A (en) * | 1997-08-12 | 1998-07-07 | Clarion Pharmaceuticals Inc. | Phosphocholines of retinoids |
| WO2000045822A1 (en) * | 1999-02-03 | 2000-08-10 | Supergen, Inc. | Phosphocholine surfactants and their use |
-
2000
- 2000-02-16 AT AT00908713T patent/ATE267586T1/de not_active IP Right Cessation
- 2000-02-16 JP JP2000599364A patent/JP2002537243A/ja active Pending
- 2000-02-16 DE DE60011053T patent/DE60011053T2/de not_active Expired - Fee Related
- 2000-02-16 US US09/890,006 patent/US7060290B1/en not_active Expired - Fee Related
- 2000-02-16 AU AU30008/00A patent/AU3000800A/en not_active Abandoned
- 2000-02-16 WO PCT/US2000/004140 patent/WO2000048572A1/en not_active Ceased
- 2000-02-16 EP EP00908713A patent/EP1161226B1/de not_active Expired - Lifetime
-
2006
- 2006-03-21 US US11/386,991 patent/US20060166903A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1161226A4 (de) | 2002-04-10 |
| AU3000800A (en) | 2000-09-04 |
| US7060290B1 (en) | 2006-06-13 |
| EP1161226A1 (de) | 2001-12-12 |
| WO2000048572A1 (en) | 2000-08-24 |
| JP2002537243A (ja) | 2002-11-05 |
| EP1161226B1 (de) | 2004-05-26 |
| DE60011053D1 (de) | 2004-07-01 |
| US20060166903A1 (en) | 2006-07-27 |
| DE60011053T2 (de) | 2005-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |