ATE268178T1 - Stabile medizinische zusammenstellungen die 4,5- epoxymorphinanderivate enthalten - Google Patents
Stabile medizinische zusammenstellungen die 4,5- epoxymorphinanderivate enthaltenInfo
- Publication number
- ATE268178T1 ATE268178T1 AT98931040T AT98931040T ATE268178T1 AT E268178 T1 ATE268178 T1 AT E268178T1 AT 98931040 T AT98931040 T AT 98931040T AT 98931040 T AT98931040 T AT 98931040T AT E268178 T1 ATE268178 T1 AT E268178T1
- Authority
- AT
- Austria
- Prior art keywords
- derivatives
- epoxymorphine
- compositions containing
- medical compositions
- stable medical
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- RKCNPNLELJQQCQ-WTXDQKIBSA-N C1=CC(O)C23C=4[C@@]56C(O2)([C@@H](O)C=C[C@H]5[C@@H](CC1=4)N(C)CC6)O3 Chemical class C1=CC(O)C23C=4[C@@]56C(O2)([C@@H](O)C=C[C@H]5[C@@H](CC1=4)N(C)CC6)O3 RKCNPNLELJQQCQ-WTXDQKIBSA-N 0.000 title 1
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- QONGLMDHKNFCDX-KBHMWOLSSA-N (4r,4ar,12bs)-1,2,3,4,4a,5,6,7,7a,13-decahydro-4,12-methanobenzofuro[3,2-e]isoquinoline Chemical class O1C2CCC[C@H]3[C@]4([H])NCC[C@]23C2=C1C=CC=C2C4 QONGLMDHKNFCDX-KBHMWOLSSA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Epoxy Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP18695097 | 1997-07-11 | ||
| PCT/JP1998/003096 WO1999002158A1 (fr) | 1997-07-11 | 1998-07-10 | Compositions medicinales stables, contenant des derives de 4,5-epoxymorphinane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE268178T1 true ATE268178T1 (de) | 2004-06-15 |
Family
ID=16197570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98931040T ATE268178T1 (de) | 1997-07-11 | 1998-07-10 | Stabile medizinische zusammenstellungen die 4,5- epoxymorphinanderivate enthalten |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6372755B2 (de) |
| EP (1) | EP0948965B1 (de) |
| JP (3) | JP3617055B2 (de) |
| KR (1) | KR100514963B1 (de) |
| CN (1) | CN100379419C (de) |
| AT (1) | ATE268178T1 (de) |
| AU (1) | AU740404B2 (de) |
| CA (1) | CA2265767C (de) |
| DE (1) | DE69824277T2 (de) |
| DK (1) | DK0948965T3 (de) |
| ES (1) | ES2217563T3 (de) |
| NO (1) | NO318831B1 (de) |
| PT (1) | PT948965E (de) |
| TW (1) | TWI285644B (de) |
| WO (1) | WO1999002158A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ899400A0 (en) * | 2000-07-26 | 2000-08-17 | Csl Limited | A method of stabilisation and compositions for use therein |
| SG90259A1 (en) * | 2000-08-17 | 2002-07-23 | Control Ox Oy | Plant-derived and synthetic phenolic compounds and plant extracts, effective in the treatment and prevention of chlamydial infections |
| JP4880813B2 (ja) * | 2000-10-26 | 2012-02-22 | 第一三共株式会社 | 外用消炎鎮痛剤組成物 |
| US20140271788A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| DE10161110A1 (de) * | 2001-12-12 | 2003-06-26 | Ursapharm Arzneimittel Gmbh | Pharmazeutische Zusammensetzung zur ophthalmologischen und rhinologischen Anwendung |
| DE10161149B4 (de) * | 2001-12-12 | 2007-03-08 | Ursapharm Arzneimittel Gmbh & Co. Kg | Verwendung von Heparin-haltigem Ophthalmikum |
| ZA200409537B (en) | 2003-01-31 | 2006-10-25 | Yamanouchi Pharma Co Ltd | Stable solid medicinal composition for oral administration |
| GB0308734D0 (en) * | 2003-04-15 | 2003-05-21 | Axcess Ltd | Uptake of macromolecules |
| EP1735004A4 (de) * | 2004-04-07 | 2011-11-09 | Resveratrol Partners Llc | Nahrungsergänzung und verfahren zu ihrer verarbeitung |
| JP2007536277A (ja) * | 2004-05-07 | 2007-12-13 | エスケイ ファーマシューティカルズ インコーポレイテッド | 安定化されたヒアルロナン調製物及びその方法 |
| US8288362B2 (en) | 2004-05-07 | 2012-10-16 | S.K. Pharmaceuticals, Inc. | Stabilized glycosaminoglycan preparations and related methods |
| US20060078616A1 (en) * | 2004-08-30 | 2006-04-13 | Georgewill Dawaye A | Thermoreversible pharmaceutical formulation for anti-microbial agents comprising poloxamer polymers and hydroxy fatty acid ester of polyethylene glycol |
| WO2006067605A1 (en) * | 2004-12-23 | 2006-06-29 | Ranbaxy Laboratories Limited | Stable pharmaceutical compositions of tiagabine and processes for their preparation |
| CN101150955B (zh) * | 2005-01-27 | 2013-04-17 | 埃里莫斯医药品有限公司 | 递送包括ndga化合物的儿茶酚丁烷的口服制剂 |
| JP5069130B2 (ja) * | 2005-01-27 | 2012-11-07 | エリモス・ファーマスーティカルズ・エルエルシー | Ｎｄｇａ化合物を包含するカテコールブタンの送達のための経口用製剤 |
| TWI286941B (en) * | 2005-07-27 | 2007-09-21 | Anagen Therapeutics Inc | Stabilized pharmaceutical and cosmetic composition of catechins or derivatives thereof |
| ATE550023T1 (de) | 2007-04-26 | 2012-04-15 | Toray Industries | Stabile feste zubereitung mit 4,5- epoxymorphinanderivat |
| WO2008143240A1 (ja) * | 2007-05-21 | 2008-11-27 | Toray Industries, Inc. | 特定の有機酸を含有する経口製剤並びに経口製剤の溶出性及び化学的安定性の改善方法 |
| CN101658489B (zh) * | 2008-08-27 | 2011-11-23 | 海南四环心脑血管药物研究院有限公司 | 一种盐酸纳美芬注射液及其制备方法 |
| DK2356989T3 (en) | 2008-10-24 | 2018-05-07 | Toray Industries | Stable tablet containing 4,5-epoxymorphinane derivative |
| TWI455733B (zh) | 2009-03-30 | 2014-10-11 | Toray Industries | 口腔內崩壞性被覆錠劑 |
| CN102802668A (zh) | 2009-06-04 | 2012-11-28 | Alk股份公司 | 包含至少一种肾上腺素能化合物的稳定化组合物 |
| PL2616064T3 (pl) | 2010-10-21 | 2020-02-28 | Rtu Pharmaceuticals Llc | Gotowe do zastosowania formulacje ketorolaku |
| JP5750278B2 (ja) * | 2011-02-28 | 2015-07-15 | 東洋カプセル株式会社 | カンデサルタンシレキセチルのカプセル充填用組成物 |
| WO2013070656A1 (en) * | 2011-11-07 | 2013-05-16 | Navinta Llc | Sustained release suspension preparation for dextromethorphan |
| WO2013074948A1 (en) | 2011-11-16 | 2013-05-23 | Resveratrol Partners, Llc | Compositions containing resveratrol and nucleotides |
| JP6064252B2 (ja) * | 2012-01-19 | 2017-01-25 | 三笠製薬株式会社 | そう痒症改善経皮吸収貼付剤 |
| JP6247118B2 (ja) * | 2014-03-05 | 2017-12-13 | 東海カプセル株式会社 | カプセル充填組成物 |
| CN107427483B (zh) | 2015-03-19 | 2021-06-29 | 第一三共株式会社 | 含有着色剂的固体制剂 |
| CA2980096C (en) * | 2015-03-19 | 2019-12-17 | Daiichi Sankyo Company, Limited | Solid preparations of [(1r,5s,6s)-6-(aminomethyl)-3-ethylbicyclo[3.2.0]hept-3-en-6-yl]acetic acid monobenzenesulfonate stabilized by containing a specific antioxidant, and methodsfor preparing the same |
| JP5918894B1 (ja) * | 2015-05-21 | 2016-05-18 | 富士カプセル株式会社 | ナルフラフィン塩酸塩含有カプセル製剤 |
| TW201707703A (zh) * | 2015-06-04 | 2017-03-01 | Tokai Capsule Co Ltd | 軟膠囊劑 |
| US11185509B2 (en) | 2016-07-29 | 2021-11-30 | Toray Industries, Inc. | Solid preparation having improved light stability |
| JP6131379B1 (ja) * | 2016-12-28 | 2017-05-17 | 森下仁丹株式会社 | ４，５−エポキシモルヒナン誘導体含有製剤 |
| ES2902123T3 (es) | 2017-03-31 | 2022-03-25 | Toray Industries | Composición medicinal en tabletas que comprende nalfurafina |
| HUE069820T2 (hu) | 2018-03-08 | 2025-04-28 | Victoria Link Ltd | Nalfurafin alkalmazása demielinizációs betegségek kezelésére |
| US12083226B2 (en) | 2018-07-30 | 2024-09-10 | Daiichi Sankyo Company, Limited | Stabilizer-containing solid drug formulation |
| US11198831B2 (en) | 2019-01-31 | 2021-12-14 | Kvi Llc | Lubricant for a device |
| US11214577B2 (en) | 2019-03-29 | 2022-01-04 | Humanwell Pharmaceutical US | Morphinans useful for treating medical disorders |
| EP4062973A4 (de) * | 2019-11-20 | 2023-11-29 | Shionogi & Co., Ltd | 6,7-ungesättigtes-7-carbamoyl-morphinanderivat enthaltende feste formulierung |
| JP7728367B2 (ja) | 2021-06-14 | 2025-08-22 | スコーピオン・セラピューティクス・インコーポレイテッド | がんを処置するために使用され得る尿素誘導体 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2765694B2 (ja) * | 1988-01-29 | 1998-06-18 | 日清バーディシェ株式会社 | 酸化感受性化合物の安定な組成物 |
| GB8820327D0 (en) | 1988-08-26 | 1988-09-28 | May & Baker Ltd | New compositions of matter |
| ES2121988T3 (es) * | 1992-01-23 | 1998-12-16 | Toray Industries | Derivado de morfinano y uso medicinal. |
| AU686203B2 (en) * | 1993-07-23 | 1998-02-05 | Toray Industries, Inc. | Morphinan derivative and medicinal use |
| US5948389A (en) * | 1995-06-07 | 1999-09-07 | El Khoury & Stein, Ltd. | Method of enhancing the analgesic efficacy of locally and topically administered opioids and other local anesthetics |
| DE29719704U1 (de) | 1997-02-14 | 1998-01-22 | Gödecke AG, 10587 Berlin | Stabile Zubereitungen von Naloxonhydrochlorid |
-
1998
- 1998-07-10 AT AT98931040T patent/ATE268178T1/de active
- 1998-07-10 WO PCT/JP1998/003096 patent/WO1999002158A1/ja not_active Ceased
- 1998-07-10 TW TW087111243A patent/TWI285644B/zh not_active IP Right Cessation
- 1998-07-10 KR KR10-1999-7001987A patent/KR100514963B1/ko not_active Expired - Lifetime
- 1998-07-10 PT PT98931040T patent/PT948965E/pt unknown
- 1998-07-10 JP JP50845399A patent/JP3617055B2/ja not_active Expired - Lifetime
- 1998-07-10 EP EP98931040A patent/EP0948965B1/de not_active Expired - Lifetime
- 1998-07-10 ES ES98931040T patent/ES2217563T3/es not_active Expired - Lifetime
- 1998-07-10 US US09/254,650 patent/US6372755B2/en not_active Expired - Lifetime
- 1998-07-10 DK DK98931040T patent/DK0948965T3/da active
- 1998-07-10 AU AU81282/98A patent/AU740404B2/en not_active Expired
- 1998-07-10 DE DE69824277T patent/DE69824277T2/de not_active Expired - Lifetime
- 1998-07-10 CN CNB98801274XA patent/CN100379419C/zh not_active Expired - Lifetime
- 1998-07-10 CA CA002265767A patent/CA2265767C/en not_active Expired - Lifetime
-
1999
- 1999-03-10 NO NO19991152A patent/NO318831B1/no not_active IP Right Cessation
-
2004
- 2004-07-16 JP JP2004210133A patent/JP3743449B2/ja not_active Expired - Lifetime
-
2005
- 2005-04-22 JP JP2005124736A patent/JP4311369B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2265767A1 (en) | 1999-01-21 |
| NO991152L (no) | 1999-05-10 |
| CN1237106A (zh) | 1999-12-01 |
| PT948965E (pt) | 2004-08-31 |
| EP0948965B1 (de) | 2004-06-02 |
| NO318831B1 (no) | 2005-05-09 |
| TWI285644B (en) | 2007-08-21 |
| US20010004637A1 (en) | 2001-06-21 |
| JP3743449B2 (ja) | 2006-02-08 |
| JP2005002123A (ja) | 2005-01-06 |
| US6372755B2 (en) | 2002-04-16 |
| JP4311369B2 (ja) | 2009-08-12 |
| DE69824277D1 (de) | 2004-07-08 |
| AU740404B2 (en) | 2001-11-01 |
| KR100514963B1 (ko) | 2005-09-15 |
| NO991152D0 (no) | 1999-03-10 |
| AU8128298A (en) | 1999-02-08 |
| EP0948965A1 (de) | 1999-10-13 |
| EP0948965A4 (de) | 2002-10-16 |
| JP2005247866A (ja) | 2005-09-15 |
| CN100379419C (zh) | 2008-04-09 |
| DK0948965T3 (da) | 2004-07-05 |
| DE69824277T2 (de) | 2004-09-23 |
| CA2265767C (en) | 2007-12-04 |
| ES2217563T3 (es) | 2004-11-01 |
| JP3617055B2 (ja) | 2005-02-02 |
| WO1999002158A1 (fr) | 1999-01-21 |
| KR20000068528A (ko) | 2000-11-25 |
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