ATE268328T1 - Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe - Google Patents

Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe

Info

Publication number: ATE268328T1
Authority: AT; Austria
Prior art keywords: alkyl; optionally substituted; serotonergic; actives; new
Prior art date: 1999-03-03

Application number

AT00910378T

Other languages

English (en)

Inventor

Annmarie Louise Sabb

Robert Lewis Vogel

Michael Gerard Kelly

Yvette Latko Palmer

Wayne Everett Childers

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-03

Filing date

2000-03-01

Publication date

2004-06-15

2000-03-01 Application filed by Wyeth Corp filed Critical Wyeth Corp

2004-06-15 Application granted granted Critical

2004-06-15 Publication of ATE268328T1 publication Critical patent/ATE268328T1/de

Links

WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
230000000862 serotonergic effect Effects 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
125000005330 8 membered heterocyclic group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
-1 phenoxy, thiophenoxy, phenyl Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
125000004001 thioalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

AT00910378T 1999-03-03 2000-03-01 Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe ATE268328T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US26134399A	1999-03-03	1999-03-03
PCT/US2000/005240 WO2000051999A1 (en)	1999-03-03	2000-03-01	New diazole derivatives as serotonergic agents

Publications (1)

Publication Number	Publication Date
ATE268328T1 true ATE268328T1 (de)	2004-06-15

Family

ID=22992878

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00910378T ATE268328T1 (de)	1999-03-03	2000-03-01	Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe

Country Status (11)

Country	Link
EP (1)	EP1161424B1 (de)
JP (1)	JP2002538152A (de)
CN (1)	CN1164580C (de)
AT (1)	ATE268328T1 (de)
AU (1)	AU3247800A (de)
CA (1)	CA2361179A1 (de)
DE (1)	DE60011241T2 (de)
DK (1)	DK1161424T3 (de)
ES (1)	ES2220422T3 (de)
PT (1)	PT1161424E (de)
WO (1)	WO2000051999A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR0015539A (pt) *	1999-11-12	2002-07-16	Wyeth Corp	Adamantil e noradamantil aril- e aralquilpiperazinas ramificadas com atividade 5-ht1a de serotonina
US6974818B2 (en) *	2002-03-01	2005-12-13	Euro-Celtique S.A.	1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
US7067518B2 (en)	2002-09-05	2006-06-27	Wyeth	Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
WO2004083235A2 (en) *	2003-03-19	2004-09-30	Exelixis Inc.	Tie-2 modulators and methods of use
MX2008002014A (es)	2005-08-15	2008-03-27	Hoffmann La Roche	Derivados de piperidina y piperazina como antagonistas de p2x3.
AU2012280420B2 (en) *	2011-07-01	2017-01-05	Remynd Nv	1, 2, 4 -thiadiazol- 5 -ylpiperazine derivatives useful in the treatment neurodegenerative diseases
AU2012326361B2 (en)	2011-10-17	2017-08-03	Biotheryx, Inc.	Substituted biaryl alkyl amides

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4539318A (en) *	1984-06-04	1985-09-03	Merck & Co., Inc.	Tertiary aminohydroxypropoxy substituted thiadiazoles, pharmaceutical compositions and use
IE911774A1 (en) *	1990-06-11	1991-12-18	Akzo Nv	Pyridinylpiperazine derivatives
DK60493D0 (da) *	1993-05-26	1993-05-26	Novo Nordisk As	Kemiske forbindelser, deres fremstilling og anvendelse
JP2000506871A (ja) *	1996-03-19	2000-06-06	ノボノルディスクアクティーゼルスカブ	複素環式化合物並びにその調製及び用途

2000
- 2000-03-01 CA CA002361179A patent/CA2361179A1/en not_active Abandoned
- 2000-03-01 AT AT00910378T patent/ATE268328T1/de not_active IP Right Cessation
- 2000-03-01 EP EP00910378A patent/EP1161424B1/de not_active Expired - Lifetime
- 2000-03-01 PT PT00910378T patent/PT1161424E/pt unknown
- 2000-03-01 AU AU32478/00A patent/AU3247800A/en not_active Abandoned
- 2000-03-01 CN CNB008069255A patent/CN1164580C/zh not_active Expired - Fee Related
- 2000-03-01 JP JP2000602226A patent/JP2002538152A/ja active Pending
- 2000-03-01 WO PCT/US2000/005240 patent/WO2000051999A1/en not_active Ceased
- 2000-03-01 DE DE60011241T patent/DE60011241T2/de not_active Expired - Fee Related
- 2000-03-01 ES ES00910378T patent/ES2220422T3/es not_active Expired - Lifetime
- 2000-03-01 DK DK00910378T patent/DK1161424T3/da active

Also Published As

Publication number	Publication date
DE60011241T2 (de)	2005-06-30
CN1349520A (zh)	2002-05-15
PT1161424E (pt)	2004-08-31
JP2002538152A (ja)	2002-11-12
EP1161424A1 (de)	2001-12-12
ES2220422T3 (es)	2004-12-16
CA2361179A1 (en)	2000-09-08
WO2000051999A1 (en)	2000-09-08
EP1161424B1 (de)	2004-06-02
AU3247800A (en)	2000-09-21
DE60011241D1 (de)	2004-07-08
DK1161424T3 (da)	2004-09-13
CN1164580C (zh)	2004-09-01

Legal Events

Date

Code

Title

Description

2004-12-15

UEP

Publication of translation of european patent specification

Ref document number: 1161424

Country of ref document: EP

2006-12-15

REN

Ceased due to non-payment of the annual fee

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ATE316961T1 (de)	2006-02-15	Heterozyclische derivate für die behandlung von herzversagen und andere erkrankungen
IL88122A0 (en)	1989-06-30	Heterocyclic derivatives and pharmaceutical compositions containing them
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SE9702799D0 (sv)	1997-07-25	New compounds
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NZ331613A (en)	2000-03-27	Piperazinyl or piperidinyl substituted 1,2,3,4-tetrahydronaphthalene derivatives
SE9703377D0 (sv)	1997-09-18	New compounds
DE69510033D1 (de)	1999-07-08	Aryl- und heteroaryl- pyrimidine als herbizide
ATE92486T1 (de)	1993-08-15	Dihydropyridine als antiallergische und entzuendungshemmende mittel.
ATE268328T1 (de)	2004-06-15	Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe
IS2194B (is)	2007-01-15	Efnasambönd sem innihalda píperasín sem eru gagnleg til meðhöndlunar á sársauka
FR2803593B1 (fr)	2002-02-15	Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
NO914226D0 (no)	1991-10-29	Fremgangsmaate og middel til farging av haar
ES454285A1 (es)	1977-11-16	Procedimiento para preparar derivados de 4-amina trans-deca-hidroquinolina.
MY104164A (en)	1994-02-28	Heterocyclic compounds.