ATE268330T1 - Azaidole mit serotonin rezeptor affinität - Google Patents

Azaidole mit serotonin rezeptor affinität

Info

Publication number
ATE268330T1
ATE268330T1 AT00949846T AT00949846T ATE268330T1 AT E268330 T1 ATE268330 T1 AT E268330T1 AT 00949846 T AT00949846 T AT 00949846T AT 00949846 T AT00949846 T AT 00949846T AT E268330 T1 ATE268330 T1 AT E268330T1
Authority
AT
Austria
Prior art keywords
group
formula
azaidole
double bond
serotonin receptor
Prior art date
Application number
AT00949846T
Other languages
English (en)
Inventor
Louise Edwards
Abdelmalik Slassi
Ashok Tehim
Tao Xin
Original Assignee
Nps Allelix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Allelix Corp filed Critical Nps Allelix Corp
Application granted granted Critical
Publication of ATE268330T1 publication Critical patent/ATE268330T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
AT00949846T 1999-08-12 2000-08-14 Azaidole mit serotonin rezeptor affinität ATE268330T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14834399P 1999-08-12 1999-08-12
PCT/IB2000/001122 WO2001012629A1 (en) 1999-08-12 2000-08-14 Azaindoles having serotonin receptor affinity

Publications (1)

Publication Number Publication Date
ATE268330T1 true ATE268330T1 (de) 2004-06-15

Family

ID=22525363

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00949846T ATE268330T1 (de) 1999-08-12 2000-08-14 Azaidole mit serotonin rezeptor affinität

Country Status (10)

Country Link
EP (1) EP1204662B1 (de)
JP (1) JP4969004B2 (de)
AT (1) ATE268330T1 (de)
AU (1) AU779832B2 (de)
CA (1) CA2382247C (de)
DE (1) DE60011269T2 (de)
DK (1) DK1204662T3 (de)
ES (1) ES2222219T3 (de)
MX (1) MXPA02001473A (de)
WO (1) WO2001012629A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10030037A1 (de) 2000-06-17 2001-12-20 Mann & Hummel Filter Zylindrische Filterpatrone mit Stützrohr
ITRM20010356A1 (it) * 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
TW200301251A (en) 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
ATE335477T1 (de) * 2001-12-20 2006-09-15 Wyeth Corp Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
WO2003080608A2 (en) * 2002-03-27 2003-10-02 Glaxo Group Limited Quinoline and aza-indole derivatives and their use as 5-ht6 ligands
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
EP1897881A3 (de) 2002-06-20 2009-03-18 Biovitrum AB (publ) Zur Behandlung von Obesitas, Typ II-Diabetes und ZNS-Erkrankungen geeignete Verbindungen
TW200403243A (en) 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
CA2514656A1 (en) * 2003-01-31 2004-08-12 Pfizer Products Inc. 5ht7 antagonists and inverse agonists
WO2004074286A1 (en) * 2003-02-14 2004-09-02 Wyeth Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
WO2005009996A1 (en) * 2003-07-23 2005-02-03 Wyeth Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands
ES2222828B1 (es) 2003-07-30 2006-04-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.
EP1984351A1 (de) 2006-02-17 2008-10-29 Memory Pharmaceuticals Corporation Verbindungen mit 5-ht6-rezeptor-affinität
CA2655694C (en) * 2006-07-03 2014-12-16 Biovitrum Ab (Publ) 1,4-substituted indoles useful for modulation of the 5-ht6 receptor
JP2014515368A (ja) * 2011-05-26 2014-06-30 第一三共株式会社 プロテインキナーゼ阻害剤としての複素環化合物
EP3083588B1 (de) 2013-12-20 2020-12-09 Sunshine Lake Pharma Co., Ltd. Aromatische heterocyclische verbindungen und deren anwendung in pharmazeutika
EP3166924B1 (de) 2014-07-08 2019-02-20 Sunshine Lake Pharma Co., Ltd. Aromatische heterocyclische derivate und pharmazeutische anwendungen davon

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9406128A (pt) * 1993-03-01 1996-02-27 Merck Sharp & Dohme Uso de um composto processo para o tratamento e/ou prevençao de distúrbios psicóticos composto composiçao farmacêutica processos para a preparaçao de um composto e de uma composiçao farmacêutica
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
EP0875513A1 (de) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituierte heteroaromatische 5-HT1F Agoniste
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6562809B1 (en) * 1998-09-18 2003-05-13 Nps Allelix Corp. 3-bicycloindole compounds

Also Published As

Publication number Publication date
ES2222219T3 (es) 2005-02-01
JP2003507380A (ja) 2003-02-25
JP4969004B2 (ja) 2012-07-04
MXPA02001473A (es) 2003-07-21
EP1204662B1 (de) 2004-06-02
WO2001012629A1 (en) 2001-02-22
AU779832B2 (en) 2005-02-10
EP1204662A1 (de) 2002-05-15
CA2382247A1 (en) 2001-02-22
AU6310300A (en) 2001-03-13
DE60011269T2 (de) 2005-06-23
DK1204662T3 (da) 2004-10-04
CA2382247C (en) 2010-09-28
DE60011269D1 (de) 2004-07-08

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