ATE26839T1 - Aminonaphtacen derivate und ihre herstellung. - Google Patents

Aminonaphtacen derivate und ihre herstellung.

Info

Publication number: ATE26839T1
Authority: AT; Austria
Prior art keywords: group; hydrogen atom; hydroxy; aminophtacene; derivatives
Prior art date: 1982-10-22

Application number

AT83306384T

Other languages

English (en)

Inventor

Kikuo Ishizumi

Naohito Ohashi

Norihiko Tanno

Hiromi Sato

Masaru Fukui

Shinya Morisada

Original Assignee

Sumitomo Chemical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-10-22

Filing date

1983-10-20

Publication date

1987-05-15

1983-10-20 Application filed by Sumitomo Chemical Co filed Critical Sumitomo Chemical Co

1987-05-15 Application granted granted Critical

1987-05-15 Publication of ATE26839T1 publication Critical patent/ATE26839T1/de

Links

125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000004066 1-hydroxyethyl group Chemical group [H]OC([H])([*])C([H])([H])[H] 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000001093 anti-cancer Effects 0.000 abstract 1
239000013043 chemical agent Substances 0.000 abstract 1
230000007794 irritation Effects 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
FUIJBTPGTRUBJJ-UHFFFAOYSA-N tetracen-2-amine Chemical class C1=CC=CC2=CC3=CC4=CC(N)=CC=C4C=C3C=C21 FUIJBTPGTRUBJJ-UHFFFAOYSA-N 0.000 abstract 1
-1 tetrahydropyranyloxy group Chemical group 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT83306384T 1982-10-22 1983-10-20 Aminonaphtacen derivate und ihre herstellung. ATE26839T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP57186514A JPS5976099A (ja)	1982-10-22	1982-10-22	アミノナフタセン誘導体とその製造方法
EP83306384A EP0107486B1 (de)	1982-10-22	1983-10-20	Aminonaphtacen Derivate und ihre Herstellung

Publications (1)

Publication Number	Publication Date
ATE26839T1 true ATE26839T1 (de)	1987-05-15

Family

ID=16189827

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83306384T ATE26839T1 (de)	1982-10-22	1983-10-20	Aminonaphtacen derivate und ihre herstellung.

Country Status (7)

Country	Link
US (1)	US4673668A (de)
EP (1)	EP0107486B1 (de)
JP (1)	JPS5976099A (de)
AT (1)	ATE26839T1 (de)
CA (1)	CA1245642A (de)
DE (1)	DE3371205D1 (de)
ES (2)	ES526641A0 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2603480B2 (ja) *	1987-08-05	1997-04-23	住友製薬株式会社	安定化されたアンスラサイクリン系製剤
US6376469B1 (en)	1997-11-28	2002-04-23	Sumitomo Pharmaceuticals Company, Limited	Crystalline amrubicin hydrochloride
EP1364652B1 (de) *	2001-01-30	2014-04-09	Dainippon Sumitomo Pharma Co., Ltd.	Heilmittel gegen lungenkrebs
US7091188B2 (en) *	2001-10-23	2006-08-15	Sumitomo Chemical Company, Limited	Stabilization of amrubicin hydrochloride
CA2509449C (en)	2002-11-29	2012-01-31	Sumitomo Pharmaceuticals Co., Ltd.	Lyophilized preparation of stabilized anthracycline compounds
US8173621B2 (en)	2008-06-11	2012-05-08	Gilead Pharmasset Llc	Nucleoside cyclicphosphates
EP2376515A1 (de)	2008-12-23	2011-10-19	Pharmasset, Inc.	Synthese von purinnukleosiden
CA2748057C (en)	2008-12-23	2018-07-03	Pharmasset, Inc.	Nucleoside phosphoramidates
US8551973B2 (en)	2008-12-23	2013-10-08	Gilead Pharmasset Llc	Nucleoside analogs
ES2524700T3 (es)	2009-05-27	2014-12-11	Sumitomo Dainippon Pharma Co., Ltd.	Formulación estabilizada y liofilizada de compuestos de antraciclina
CL2011000718A1 (es)	2010-03-31	2012-04-09	Gilead Pharmasset Llc	Proceso para la preparacion de compuestos fosforados enantiomericos.
CN103421059B (zh) *	2012-05-22	2016-04-06	重庆圣华曦药业股份有限公司	一种氨柔比星的合成方法
CN105367418A (zh) *	2014-08-14	2016-03-02	上海科胜药物研发有限公司	一种四氢萘类化合物及其合成方法
US10668166B2 (en)	2016-05-30	2020-06-02	Toxinvent Ou	Antibody-drug-conjugates comprising novel anthracycline-derivatives for cancer treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2314726A1 (fr) *	1975-06-16	1977-01-14	Rhone Poulenc Ind	Nouveaux derives du naphtagene, leur preparation et les compositions qui les contiennent
IT1098211B (it) *	1978-05-09	1985-09-07	Farmaceutici Italia	Deossiantracicline antitumorali
US4540695A (en)	1981-08-12	1985-09-10	Sumitomo Chemical Co., Ltd.	Aminonaphthacene derivatives and their use

1982
- 1982-10-22 JP JP57186514A patent/JPS5976099A/ja active Pending
1983
- 1983-10-17 CA CA000439091A patent/CA1245642A/en not_active Expired
- 1983-10-20 AT AT83306384T patent/ATE26839T1/de not_active IP Right Cessation
- 1983-10-20 DE DE8383306384T patent/DE3371205D1/de not_active Expired
- 1983-10-20 EP EP83306384A patent/EP0107486B1/de not_active Expired
- 1983-10-21 ES ES526641A patent/ES526641A0/es active Granted
1985
- 1985-04-10 US US06/721,606 patent/US4673668A/en not_active Expired - Lifetime
- 1985-05-30 ES ES543672A patent/ES543672A0/es active Granted

Also Published As

Publication number	Publication date
DE3371205D1 (en)	1987-06-04
US4673668A (en)	1987-06-16
CA1245642A (en)	1988-11-29
ES8602836A1 (es)	1985-11-01
EP0107486A1 (de)	1984-05-02
JPS5976099A (ja)	1984-04-28
ES526641A0 (es)	1985-11-01
EP0107486B1 (de)	1987-04-29
ES8603858A1 (es)	1986-01-01
ES543672A0 (es)	1986-01-01

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Legal Events

Date	Code	Title	Description
1987-09-15	UEP	Publication of translation of european patent specification
2004-01-15	EELA	Cancelled due to lapse of time