ATE269103T1 - Stabilisierte wässerige glukagonlösungen enthaltend detergenzien - Google Patents

Stabilisierte wässerige glukagonlösungen enthaltend detergenzien

Info

Publication number: ATE269103T1
Authority: AT; Austria
Prior art keywords: solutions containing; stabilized aqueous; containing detergents; glucagon solutions; aqueous glucagon
Prior art date: 1998-03-13

Application number

AT99906095T

Other languages

English (en)

Inventor

Niels C Kaarsholm

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-13

Filing date

1999-03-08

Publication date

2004-07-15

1999-03-08 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1999-03-08 Priority claimed from PCT/DK1999/000115 external-priority patent/WO1999047160A1/en

2004-07-15 Application granted granted Critical

2004-07-15 Publication of ATE269103T1 publication Critical patent/ATE269103T1/de

Links

239000003599 detergent Substances 0.000 title abstract 3
102000051325 Glucagon Human genes 0.000 title abstract 2
108060003199 Glucagon Proteins 0.000 title abstract 2
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
229960004666 glucagon Drugs 0.000 title abstract 2
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
102100040918 Pro-glucagon Human genes 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
230000003381 solubilizing effect Effects 0.000 abstract 1
230000000087 stabilizing effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Immunology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Organic Chemistry (AREA)
Biophysics (AREA)
Hematology (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Detergent Compositions (AREA)
Cosmetics (AREA)

AT99906095T 1998-03-13 1999-03-08 Stabilisierte wässerige glukagonlösungen enthaltend detergenzien ATE269103T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98610006		1998-03-13
PCT/DK1999/000115 WO1999047160A1 (en)	1998-03-13	1999-03-08	Stabilized aqueous peptide solutions

Publications (1)

Publication Number	Publication Date
ATE269103T1 true ATE269103T1 (de)	2004-07-15

Family

ID=32524325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99906095T ATE269103T1 (de)	1998-03-13	1999-03-08	Stabilisierte wässerige glukagonlösungen enthaltend detergenzien

Country Status (3)

Country	Link
US (1)	US6384016B1 (de)
AT (1)	ATE269103T1 (de)
DE (1)	DE69918070T2 (de)

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BR0107837A (pt)	2000-01-27	2003-01-14	Lilly Co Eli	Processo para solubilização de compostos peptìdeo 1 semelhantes a glucagon
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MXPA04012497A (es)	2002-07-04	2005-07-14	Zealand Pharma As	Glp-1 y metodos para tratar la diabetes.
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BRPI0410972C1 (pt) *	2003-06-03	2021-05-25	Novo Nordisk As	método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia
DK3300721T4 (da) *	2003-11-20	2025-03-03	Novo Nordisk As	Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
PL1789434T3 (pl) *	2004-08-31	2014-07-31	Novo Nordisk As	Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek
CN106137952B (zh) *	2004-11-12	2020-11-17	诺和诺德公司	促胰岛素肽的稳定制剂
EP1898931B1 (de) *	2005-07-07	2014-12-31	Postech Foundation	Glucose-aufnahmemodulator und verfahren zur behandlung von diabetes oder diabetischen komplikationen
EP3228320B1 (de)	2008-10-17	2019-12-18	Sanofi-Aventis Deutschland GmbH	Kombination von einem insulin und einem glp-1-agonisten
EP3202394A1 (de)	2009-07-06	2017-08-09	Sanofi-Aventis Deutschland GmbH	Wässrige insulinzubereitungen enthaltend methionin
US9610329B2 (en) *	2009-10-22	2017-04-04	Albireo Pharma, Inc.	Stabilized glucagon solutions
US20110097386A1 (en) *	2009-10-22	2011-04-28	Biodel, Inc.	Stabilized glucagon solutions
PT2554183T (pt)	2009-11-13	2018-07-09	Sanofi Aventis Deutschland	Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
PE20121316A1 (es)	2009-11-13	2012-10-05	Sanofi Aventis Deutschland	Composicion farmaceutica que comprende un agonista de glp-1 y metionina
WO2011123943A1 (en)	2010-04-09	2011-10-13	Mount Sinai Hospital	Methods for treating disorders of the gastrointestinal tract using a glp-1 agonist
SG184988A1 (en)	2010-04-27	2012-11-29	Zealand Pharma As	Peptide conjugates of glp-1 receptor agonists and gastrin and their use
WO2011138802A1 (en) *	2010-05-07	2011-11-10	Sun Pharma Advanced Research Company Ltd.,	Injection solution
US20140148384A1 (en)	2010-08-30	2014-05-29	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (zh)	2011-08-29	2018-05-29	赛诺菲-安万特德国有限公司	用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CA2853884A1 (en)	2011-11-03	2013-05-10	Zealand Pharma A/S	Glp-1 receptor agonist peptide gastrin conjugates
CN107583039A (zh)	2012-01-09	2018-01-16	阿道恰公司	Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液
MY170671A (en)	2012-07-23	2019-08-26	Zealand Pharma As	Glucagon analogues
US20150314003A2 (en)	2012-08-09	2015-11-05	Adocia	Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
TWI608013B (zh)	2012-09-17	2017-12-11	西蘭製藥公司	升糖素類似物
TWI641381B (zh)	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
SI3057984T1 (sl)	2013-10-17	2018-10-30	Zealand Pharma A/S	Acilirani glukagonski analogi
US9988429B2 (en)	2013-10-17	2018-06-05	Zealand Pharma A/S	Glucagon analogues
US10093713B2 (en)	2013-11-06	2018-10-09	Zealand Pharma A/S	GIP-GLP-1 dual agonist compounds and methods
EA035688B1 (ru)	2013-11-06	2020-07-27	Зилэнд Фарма А/С	Соединения, которые представляют собой тройные агонисты глюкагона, glp-1 и gip
RU2016132340A (ru)	2014-01-09	2018-02-14	Санофи	Стабилизированные фармацевтические составы на основе инсулина аспарта
KR20160104724A (ko)	2014-01-09	2016-09-05	사노피	인슐린 유사체 및/또는 인슐린 유도체의 안정화된 약제학적 제형
CN105899191B (zh)	2014-01-09	2020-06-16	赛诺菲	胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
EP3189072B1 (de)	2014-09-05	2018-07-18	University of Copenhagen	Gip-peptidanalogen
TWI705973B (zh)	2014-10-29	2020-10-01	丹麥商西蘭製藥公司	Ｇｉｐ促效劑化合物及方法
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
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MA52253A (fr)	2015-02-17	2021-02-17	Lilly Co Eli	Formulation de poudre nasale pour le traitement de l'hypoglycémie
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
TWI707867B (zh)	2015-04-16	2020-10-21	丹麥商西蘭製藥公司	醯化之昇糖素類似物
BR112018075250A2 (pt)	2016-06-07	2019-03-12	Adocia	composição na forma de uma solução aquosa injetável, cujo ph é de 6,0 a 8,0
WO2018104561A1 (en)	2016-12-09	2018-06-14	Zealand Pharma A/S	Acylated glp-1/glp-2 dual agonists
BR112019025195A8 (pt)	2017-05-31	2020-07-07	Univ Copenhagen	análogos do peptídeo gip de ação prolongada
TWI847306B (zh)	2017-08-24	2024-07-01	丹麥商諾佛儂迪克股份有限公司	Ｇｌｐ-１組成物及其用途
WO2019110838A1 (fr)	2017-12-07	2019-06-13	Adocia	Compositions sous forme d'une solution aqueuse injectable comprenant du glucagon humain et un co-polyaminoacide
AU2018380993A1 (en)	2017-12-07	2020-06-11	Adocia	Compositions in the form of an injectable aqueous solution comprising human glucagon and a copolyamino acid
EP3731858A1 (de)	2017-12-07	2020-11-04	Adocia	Zusammensetzungen in form einer injizierbaren wässrigen lösung mit menschlichem glucagon und einer copolyaminosäure
KR20240171195A (ko)	2017-12-07	2024-12-06	아도시아	인간 글루카곤 및 코-폴리아미노산을 포함하는 주사용 수용액 형태의 조성물
FR3083087A1 (fr)	2018-06-29	2020-01-03	Adocia	Compositions sous forme d'une solution aqueuse injectable comprenant du glucagon humain et un co-polyaminoacide
FR3067247A1 (fr)	2018-06-07	2018-12-14	Adocia	Compositions sous forme d'une solution aqueuse injectable comprenant du glucagon humain et un co-polyaminoacide
US12297250B2 (en)	2018-12-03	2025-05-13	Antag Therapeutics Aps	Modified GIP peptide analogues
BR112022013795A2 (pt)	2020-02-18	2022-09-13	Novo Nordisk As	Composição farmacêutica líquida, e, kit

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US5120712A (en)	1986-05-05	1992-06-09	The General Hospital Corporation	Insulinotropic hormone
NZ250844A (en)	1993-04-07	1996-03-26	Pfizer	Treatment of non-insulin dependant diabetes with peptides; composition
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1999
- 1999-03-08 AT AT99906095T patent/ATE269103T1/de not_active IP Right Cessation
- 1999-03-08 DE DE69918070T patent/DE69918070T2/de not_active Expired - Fee Related
- 1999-03-08 US US09/265,141 patent/US6384016B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6384016B1 (en)	2002-05-07
DE69918070T2 (de)	2005-08-25
DE69918070D1 (de)	2004-07-22

Legal Events

Date	Code	Title	Description
2004-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE269103T1 (de)	2004-07-15	Stabilisierte wässerige glukagonlösungen enthaltend detergenzien
RU97118224A (ru)	1999-07-27	Соединения и композиции для доставки активных агентов
HUP9904596A1 (hu)	2000-06-28	Mellékpajzsmirigy-hormon analógok
FI956310L (fi)	1995-12-28	Stabiloidut farmaseuttiset peptidikoostumukset
NO995568D0 (no)	1999-11-12	Paratyroidhormon peptidanaloger
MY126897A (en)	2006-10-31	Anticonvulsant derivatives useful for preventing the development of type ii diabetes mellitus and syndrome x
ES2052488T1 (es)	1994-07-16	Peptidos antagonistas de la hormona liberadora de hormona luteinizante.
DE69823320D1 (de)	2004-05-27	Entwicklernachfüllgerät
DK0440885T3 (da)	1994-08-08	Blandinger af forbindelser isoleret fra Curcuma Spp. som antiinflammatoriske midler
DE69911993D1 (de)	2003-11-13	Polyol/öl-suspensionen zur verzörgerten freisetzung von proteinen
JO2034B1 (en)	1999-05-15	Isotopes of the hormone peptide its uses and the chemical compounds it contains
IT9019421A0 (it)	1990-02-20	Formulazioni acquose stabilizzate di piccoli peptidi.
DE59911563D1 (de)	2005-03-10	Flüssige reinigungs- oder waschmittelzusammensetzung
DE69331721D1 (de)	2002-04-25	Neue carbamazepin hapten Analoge
PH31076A (en)	1998-02-05	Surfactant blends for detergent compositions.
FI973380L (fi)	1997-08-20	Bentsotiatsiinidioksidit endoteliiniantagonisteina
ES2079138T3 (es)	1996-01-01	Composiciones de limpieza auto-espesantes.
FI956050A7 (fi)	1995-12-15	Biologisesti aktiiviset vasopressiinianalogit
HRP20010238B1 (en)	2006-05-31	2-methyl-thieno-benzodiazepine formulation
BR9816029A (pt)	2001-05-29	Composições detergente
ATE248904T1 (de)	2003-09-15	Amphotere reinigungslösung von niedrigem ph
AR023006A1 (es)	2002-09-04	Composicion de champu
DK1235579T3 (da)	2003-10-20	Farmaceutiske præparater med indhold af trimegeston
DE69208492D1 (de)	1996-04-04	Stabilisierte Polyacetalzusammensetzungen
EP0616800A3 (de)	1995-02-15	Rieckstoffmittel mit verlängerter Diffusion.