ATE269349T1 - Derivativen von monosacchariden als zelladhäsionshemmer - Google Patents

Derivativen von monosacchariden als zelladhäsionshemmer

Info

Publication number
ATE269349T1
ATE269349T1 AT00900087T AT00900087T ATE269349T1 AT E269349 T1 ATE269349 T1 AT E269349T1 AT 00900087 T AT00900087 T AT 00900087T AT 00900087 T AT00900087 T AT 00900087T AT E269349 T1 ATE269349 T1 AT E269349T1
Authority
AT
Austria
Prior art keywords
monosaccharides
derivatives
cell adhesion
adhesion inhibitors
inhibitors
Prior art date
Application number
AT00900087T
Other languages
English (en)
Inventor
Sudershan K Arora
Madan P Tanwar
Jang Bahadur Gupta
Geeta Sharma
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Application granted granted Critical
Publication of ATE269349T1 publication Critical patent/ATE269349T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00900087T 1999-01-12 2000-01-10 Derivativen von monosacchariden als zelladhäsionshemmer ATE269349T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22915599A 1999-01-12 1999-01-12
US09/411,357 US6329344B1 (en) 1998-10-22 1999-10-01 Derivatives of monosaccharides as cell adhesion inhibitors
PCT/IB2000/000021 WO2000042053A1 (en) 1999-01-12 2000-01-10 Derivatives of monosaccharides as cell adhesion inhibitors

Publications (1)

Publication Number Publication Date
ATE269349T1 true ATE269349T1 (de) 2004-07-15

Family

ID=26922990

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900087T ATE269349T1 (de) 1999-01-12 2000-01-10 Derivativen von monosacchariden als zelladhäsionshemmer

Country Status (29)

Country Link
US (1) US6329344B1 (de)
EP (1) EP1144425B1 (de)
JP (1) JP2002534529A (de)
CN (1) CN1254478C (de)
AR (1) AR033939A1 (de)
AT (1) ATE269349T1 (de)
AU (1) AU767948B2 (de)
BG (1) BG105795A (de)
BR (1) BR0007489A (de)
CA (1) CA2359980A1 (de)
CO (1) CO5170511A1 (de)
CZ (1) CZ20012541A3 (de)
DE (1) DE60011568T2 (de)
DK (1) DK1144425T3 (de)
ES (1) ES2223447T3 (de)
HK (1) HK1041006B (de)
HR (1) HRP20010527B1 (de)
HU (1) HUP0200097A3 (de)
ID (1) ID30259A (de)
IL (2) IL144274A0 (de)
MA (1) MA25679A1 (de)
MY (1) MY122723A (de)
NZ (2) NZ512851A (de)
PA (1) PA8489601A1 (de)
PT (1) PT1144425E (de)
SK (1) SK284568B6 (de)
TR (1) TR200102031T2 (de)
WO (1) WO2000042053A1 (de)
YU (1) YU50101A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152397A (en) * 2002-10-21 2009-02-11 Hadasit Med Res Service Compositions and compounds for the treatment of hyperglycemia
AU2003202767A1 (en) * 2003-02-12 2004-09-06 Ranbaxy Laboratories Limited Preparation of monosaccharide derivatives
WO2004099229A1 (en) * 2003-05-06 2004-11-18 Ranbaxy Laboratories Limited Process for the synthesis of base addition salts of 2,3-0-isopropylidene-1-0-substituted-5,6-dideoxy-5-n- (4-(2-hydroxy-2-oxoethyl)-phenylaminocarbonyl) amino-l-gulofuranosides
CN1812983A (zh) 2003-05-30 2006-08-02 兰贝克赛实验室有限公司 取代的吡咯衍生物及其作为hmg－co抑制剂的用途
WO2005030735A1 (en) * 2003-09-25 2005-04-07 Ranbaxy Laboratories Limited Triazines derivatives as cell adhesion inhibitors
WO2005092908A1 (en) * 2004-03-18 2005-10-06 Ranbaxy Laboratories Limited Base addition salts of monosaccharides derivatives as inhibitors of airway hyper reactivity and airway inflammation
WO2005092907A2 (en) * 2004-03-26 2005-10-06 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
WO2005100373A2 (en) * 2004-04-13 2005-10-27 Ranbaxy Laboratories Limited Monosaccharide derivatives as anti-cancer and anti-inflammatory agents
US20090221515A1 (en) * 2004-09-02 2009-09-03 Viswajanani Jitendra Sattigeri Monosaccharide derivatives
JP2008525421A (ja) * 2004-12-22 2008-07-17 ランバクシー ラボラトリーズ リミテッド モノサッカリド誘導体
EP1915160A2 (de) * 2005-07-22 2008-04-30 Ranbaxy Laboratories Limited Derivate von monosacchariden zur behandlung von copd und der allergischen rhinitis
SG166829A1 (en) 2005-11-08 2010-12-29 Ranbaxy Lab Ltd Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US20080114031A1 (en) * 2006-03-29 2008-05-15 Sattigeri Viswajanani J Monosaccharide derivatives
EP1864992A2 (de) * 2006-05-30 2007-12-12 Ranbaxy Laboratories, Ltd. Monosaccharidderivate
EP1953170A1 (de) * 2006-10-03 2008-08-06 Ranbaxy Laboratories Limited Monosaccharidderivate als entzündungshemmende Agentien
CN105367612A (zh) * 2014-08-13 2016-03-02 中国药科大学 龙脷叶由来天然产物丁基2-脱氧-3，6-脱水-β-D-阿拉伯糖呋喃糖苷的全合成方法
US20220356150A1 (en) * 2021-04-30 2022-11-10 Evoco Limited Biobased diisocyanates, and process for preparation of same
JPWO2024135721A1 (de) * 2022-12-21 2024-06-27

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2715121A (en) 1950-09-09 1955-08-09 American Home Prod Alkyl sugar derivatives and their preparation
US4056322A (en) 1973-12-14 1977-11-01 Strategic Medical Research Corporation Preparation of ethers of monosaccharides
DE2936240A1 (de) * 1979-09-07 1981-03-26 Bayer Ag, 51373 Leverkusen Verfahren zur herstellung bekannter und neuer 6-amino-6-desoxy-2,3-0-isopropyliden-(alpha)-l-sorbofuranose-derivate sowie neue zwischenprodukte des verfahrens
US4735934A (en) 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4996195A (en) 1989-01-09 1991-02-26 Greenwich Pharmaceuticals Inc. Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5298494A (en) 1989-01-09 1994-03-29 Greenwich Pharmaceuticals Incorporated Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
US5010058A (en) 1989-06-22 1991-04-23 501 Greenwich Pharmaceuticals Incorporated 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives
US5192746A (en) 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
IL100833A0 (en) 1991-02-20 1992-09-06 Greenwich Pharma Method for synthesis of ethereally substituted blocked monosaccharides
US5360792A (en) 1991-12-20 1994-11-01 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
US5360794A (en) 1992-08-03 1994-11-01 Medicarb Inc. Disubstituted and deoxy disubstituted derivatives of α-D-mannofuranosides and β-L-gulofuranosides having anti-inflammatory and anti-proliferative activity
US5367062A (en) 1992-08-21 1994-11-22 Medicarb Inc. Disubstituted and deoxydisubstituted derivatives of α-d-lyxofuranosides having anti-inflammatory and anti-proliferative activity
US5508387A (en) * 1993-08-04 1996-04-16 Glycomed Incorporated Selectin binding glycopeptides
CA2173990A1 (en) * 1993-10-12 1995-04-20 Narasinga Rao A library of glyco-peptides useful for identification of cell adhesion inhibitors
US5637570A (en) 1995-05-09 1997-06-10 Chemora Pharmochem Disubstituted and trisubstituted derivatives of 2,3:4,6-di-O-isopropylidene-α-L-xylo-2-hexulofuranosonic acid having anti-cancer, anti-inflammatory and anti-proliferative activity
WO1997015585A1 (en) * 1995-10-26 1997-05-01 Kanebo, Ltd. Fucose derivatives, drugs containing the same as active ingredient, and intermediates for producing the same
US5824657A (en) 1997-03-18 1998-10-20 Cubist Pharmaceuticals, Inc. Aminoacyl sulfamides for the treatment of hyperproliferative disorders

Also Published As

Publication number Publication date
ID30259A (id) 2001-11-15
HRP20010527B1 (en) 2005-06-30
HK1041006B (en) 2005-02-04
HRP20010527A2 (en) 2002-08-31
HUP0200097A3 (en) 2003-03-28
HK1041006A1 (en) 2002-06-28
CO5170511A1 (es) 2002-06-27
IL144274A0 (en) 2002-05-23
AR033939A1 (es) 2004-01-21
AU767948B2 (en) 2003-11-27
IL144274A (en) 2007-05-15
MY122723A (en) 2006-04-29
PT1144425E (pt) 2004-10-29
PA8489601A1 (es) 2000-09-29
TR200102031T2 (tr) 2001-12-21
BR0007489A (pt) 2002-01-02
CZ20012541A3 (cs) 2002-02-13
AU1886000A (en) 2000-08-01
US6329344B1 (en) 2001-12-11
JP2002534529A (ja) 2002-10-15
CA2359980A1 (en) 2000-07-20
CN1343212A (zh) 2002-04-03
ES2223447T3 (es) 2005-03-01
SK284568B6 (sk) 2005-06-02
WO2000042053A1 (en) 2000-07-20
NZ527482A (en) 2005-02-25
BG105795A (en) 2002-05-31
CN1254478C (zh) 2006-05-03
DE60011568T2 (de) 2005-08-18
DE60011568D1 (de) 2004-07-22
MA25679A1 (fr) 2003-04-01
NZ512851A (en) 2004-02-27
YU50101A (sh) 2005-07-19
DK1144425T3 (da) 2004-10-18
HUP0200097A2 (hu) 2002-05-29
EP1144425A1 (de) 2001-10-17
SK9962001A3 (en) 2002-02-05
EP1144425B1 (de) 2004-06-16

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