ATE269701T1 - Gyrase-inhibitoren und ihre verwendung - Google Patents

Gyrase-inhibitoren und ihre verwendung

Info

Publication number: ATE269701T1
Authority: AT; Austria
Prior art keywords: gyrase inhibitors; gyrase; inhibitors
Prior art date: 2000-01-18

Application number

AT01903077T

Other languages

English (en)

Inventor

Paul Charifson

Dean Stamos

Michael Badia

Anne-Laure Grillot

Steven Ronkin

Martin Trudeau

Original Assignee

Vertex Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-18

Filing date

2001-01-16

Publication date

2004-07-15

2001-01-16 Application filed by Vertex Pharma filed Critical Vertex Pharma

2004-07-15 Application granted granted Critical

2004-07-15 Publication of ATE269701T1 publication Critical patent/ATE269701T1/de

Links

239000002271 gyrase inhibitor Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Rheumatology (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT01903077T 2000-01-18 2001-01-16 Gyrase-inhibitoren und ihre verwendung ATE269701T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17667100P	2000-01-18	2000-01-18
US25433100P	2000-12-08	2000-12-08
PCT/US2001/001374 WO2001052845A1 (en)	2000-01-18	2001-01-16	Gyrase inhibitors and uses thereof

Publications (1)

Publication Number	Publication Date
ATE269701T1 true ATE269701T1 (de)	2004-07-15

Family

ID=26872470

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01903077T ATE269701T1 (de)	2000-01-18	2001-01-16	Gyrase-inhibitoren und ihre verwendung

Country Status (23)

Country	Link
US (2)	US6608087B1 (de)
EP (1)	EP1251848B1 (de)
JP (1)	JP2003520233A (de)
CN (1)	CN1230166C (de)
AR (1)	AR027518A1 (de)
AT (1)	ATE269701T1 (de)
AU (1)	AU782883B2 (de)
BR (1)	BR0107713A (de)
CA (1)	CA2397686A1 (de)
CO (1)	CO5261612A1 (de)
DE (1)	DE60103974T2 (de)
DK (1)	DK1251848T3 (de)
EA (1)	EA005680B1 (de)
ES (1)	ES2222336T3 (de)
HK (1)	HK1053984B (de)
MX (1)	MXPA02007134A (de)
MY (1)	MY133572A (de)
NZ (1)	NZ520628A (de)
PT (1)	PT1251848E (de)
SI (1)	SI1251848T1 (de)
TR (1)	TR200401735T4 (de)
TW (1)	TWI287449B (de)
WO (1)	WO2001052845A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002256418A1 (en) *	2001-04-27	2002-11-11	Vertex Pharmaceuticals Incorporated	Inhibitors of bace
WO2003015776A1 (en) *	2001-08-13	2003-02-27	Janssen Pharmaceutica N.V.	2,4,5-trisubstituted thiazolyl derivatives and their antiinflammatory activity
US6984652B2 (en) *	2003-09-05	2006-01-10	Warner-Lambert Company Llc	Gyrase inhibitors
TW200526626A (en)	2003-09-13	2005-08-16	Astrazeneca Ab	Chemical compounds
FR2865733B1 (fr) *	2004-02-04	2007-10-12	Merck Sante Sas	Derives de thiazolylimidazole, leurs procedes de preparation, les compositions pharmaceutiques qui les contiennent et leurs applications en medecine
EP1819721A1 (de) *	2004-11-19	2007-08-22	Plant Bioscience Limited	Microcin-b17-analoga und verfahren zu ihrer herstellung und anwendung
NZ561613A (en)	2005-02-18	2010-12-24	Astrazeneca Ab	Antibacterial piperidine derivatives
CA2642264A1 (en) *	2006-02-13	2007-08-30	Trustees Of Boston University	Reca inhibitors with antibiotic activity, compositions and methods of use
WO2007149989A2 (en)	2006-06-21	2007-12-27	Cook Incorporated	Fistula grafts and related methods and systems useful for treating gastrointestinal fistulae
WO2008019292A2 (en) *	2006-08-04	2008-02-14	Trustees Of Boston University	Compositions and methods for potentiating antibiotic activity
TW200906412A (en) *	2007-06-12	2009-02-16	Astrazeneca Ab	Piperidine compounds and uses thereof
BRPI0817897A2 (pt) *	2007-11-02	2019-09-24	Methylgene Inc	composto, composição, e, métodos de inibição da atividade hdac, e de tratamento de uma doença responsiva a um inibidor de atividade hdac
US9029411B2 (en)	2008-01-25	2015-05-12	Millennium Pharmaceuticals, Inc.	Thiophenes and uses thereof
BRPI0908906A2 (pt) *	2008-03-21	2019-09-24	Novartis Ag	compostos heterocíclicos e usos dos mesmos
US8865732B2 (en) *	2008-03-21	2014-10-21	Novartis Ag	Heterocyclic compounds and uses thereof
JPWO2010007943A1 (ja) *	2008-07-17	2012-01-05	旭化成ファーマ株式会社	含窒素複素環化合物
BRPI0919004A2 (pt) *	2008-09-22	2019-09-24	Cayman Chem Co	composto de multiheteroarila como inibidores de h-pgds e sua utilização para o tratamento de doenças mediadas por prostaglandina d2
TW201026694A (en)	2008-12-12	2010-07-16	Astrazeneca Ab	Compound 468
TW201026695A (en)	2008-12-12	2010-07-16	Astrazeneca Ab	Piperidine compounds and uses thereof-596
US8796314B2 (en)	2009-01-30	2014-08-05	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
US9139589B2 (en)	2009-01-30	2015-09-22	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
US9090601B2 (en) *	2009-01-30	2015-07-28	Millennium Pharmaceuticals, Inc.	Thiazole derivatives
TW201102065A (en)	2009-05-29	2011-01-16	Astrazeneca Ab	Heterocyclic urea derivatives and methods of use thereof
UY32856A (es)	2009-08-26	2011-03-31	Astrazeneca Ab	Derivados heterocíclicos de urea y métodos de uso de los mismos
AU2010341229A1 (en)	2009-12-17	2012-08-02	Merck Patent Gmbh	Sphingosine kinase inhibitors
MA34797B1 (fr)	2010-08-11	2014-01-02	Millennium Pharm Inc	Hétéroaryles et leurs utilisations
EP2603216A4 (de)	2010-08-11	2013-12-18	Millennium Pharm Inc	Heteroaryle und verwendungen davon
WO2012021611A1 (en)	2010-08-11	2012-02-16	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
WO2012051410A2 (en)	2010-10-13	2012-04-19	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
CN102911173A (zh) *	2012-11-08	2013-02-06	苏州施亚生物科技有限公司	5,6,7,8-四氢-2H-吡啶并[4,3-c]哒嗪-3-酮的合成方法
US9242969B2 (en)	2013-03-14	2016-01-26	Novartis Ag	Biaryl amide compounds as kinase inhibitors
EP3102203A2 (de)	2014-02-03	2016-12-14	Spero Gyrase, Inc.	Antibakterielle kombinationen mit polymixin
UY36294A (es)	2014-09-12	2016-04-29	Novartis Ag	Compuestos y composiciones como inhibidores de quinasa
EP3515446B1 (de)	2016-09-19	2023-12-20	Novartis AG	Therapeutische kombinationen mit einem raf-hemmer und einem erk-hemmer
US20210070747A1 (en)	2017-03-24	2021-03-11	Taisho Pharmaceutical Co., Ltd.	2(1h)-quinolinone derivative
US11266653B2 (en)	2017-05-02	2022-03-08	Novartis Ag	Combination therapy
WO2018213185A1 (en)	2017-05-17	2018-11-22	Drexel University	Rela inhibitors for biofilm disruption
US12258342B2 (en)	2018-09-03	2025-03-25	Univerza V Ljubljani	Class of DNA gyrase and/or topoisomerase IV inhibitors with activity against gram-positive and gram-negative bacteria
ES3025633T3 (en)	2019-05-13	2025-06-09	Novartis Ag	New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
EP4263503A1 (de)	2020-12-17	2023-10-25	Univerza V Ljubljani	Neue n-phenylpyrrolamid-inhibitoren der dna-gyrase und topoisomerase iv mit antibakterieller wirkung
NL2033609B1 (en) *	2022-11-24	2024-05-30	Innes John Centre	DNA Gyrase Inhibitors
WO2024145662A1 (en) *	2022-12-30	2024-07-04	Altay Therapeutics, Inc.	2-substituted thiazole and benzothiazole compositions and methods as dux4 inhibitors
EP4663242A1 (de) *	2024-06-11	2025-12-17	Helmholtz-Zentrum für Infektionsforschung GmbH	Targeting des energiekopplungsfaktor (ecf)-transporters als neues antimikrobielles target

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5925659A (en) *	1996-05-07	1999-07-20	Merck & Co., Inc.	Antibacterial agents
AU711128C (en) *	1996-05-09	2002-11-07	Sankyo Company Limited	Anti-helicobacter pylori compositions containing 1-methylcarbapenem derivatives as the active ingredient

2001
- 2001-01-16 AU AU30940/01A patent/AU782883B2/en not_active Ceased
- 2001-01-16 EP EP01903077A patent/EP1251848B1/de not_active Expired - Lifetime
- 2001-01-16 HK HK03106328.7A patent/HK1053984B/zh not_active IP Right Cessation
- 2001-01-16 PT PT01903077T patent/PT1251848E/pt unknown
- 2001-01-16 NZ NZ520628A patent/NZ520628A/en not_active IP Right Cessation
- 2001-01-16 ES ES01903077T patent/ES2222336T3/es not_active Expired - Lifetime
- 2001-01-16 MX MXPA02007134A patent/MXPA02007134A/es active IP Right Grant
- 2001-01-16 WO PCT/US2001/001374 patent/WO2001052845A1/en not_active Ceased
- 2001-01-16 BR BR0107713-9A patent/BR0107713A/pt not_active IP Right Cessation
- 2001-01-16 CN CNB018050425A patent/CN1230166C/zh not_active Expired - Fee Related
- 2001-01-16 DK DK01903077T patent/DK1251848T3/da active
- 2001-01-16 SI SI200130127T patent/SI1251848T1/xx unknown
- 2001-01-16 DE DE60103974T patent/DE60103974T2/de not_active Expired - Lifetime
- 2001-01-16 CA CA002397686A patent/CA2397686A1/en not_active Abandoned
- 2001-01-16 TR TR2004/01735T patent/TR200401735T4/xx unknown
- 2001-01-16 JP JP2001552893A patent/JP2003520233A/ja active Pending
- 2001-01-16 AT AT01903077T patent/ATE269701T1/de not_active IP Right Cessation
- 2001-01-16 EA EA200200769A patent/EA005680B1/ru not_active IP Right Cessation
- 2001-01-17 MY MYPI20010220A patent/MY133572A/en unknown
- 2001-01-18 AR ARP010100229A patent/AR027518A1/es unknown
- 2001-01-18 CO CO01003497A patent/CO5261612A1/es unknown
- 2001-03-05 TW TW090101034A patent/TWI287449B/zh not_active IP Right Cessation
2002
- 2002-07-18 US US10/198,407 patent/US6608087B1/en not_active Expired - Fee Related
2003
- 2003-03-24 US US10/395,331 patent/US6930116B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HK1053984B (zh)	2006-07-28
JP2003520233A (ja)	2003-07-02
DE60103974D1 (de)	2004-07-29
MXPA02007134A (es)	2003-03-27
CN1230166C (zh)	2005-12-07
SI1251848T1 (en)	2004-12-31
TWI287449B (en)	2007-10-01
CA2397686A1 (en)	2001-07-26
PT1251848E (pt)	2004-10-29
DE60103974T2 (de)	2005-06-30
CN1400898A (zh)	2003-03-05
AU3094001A (en)	2001-07-31
ES2222336T3 (es)	2005-02-01
US20040024030A1 (en)	2004-02-05
EA005680B1 (ru)	2005-04-28
TR200401735T4 (tr)	2004-08-23
AR027518A1 (es)	2003-04-02
BR0107713A (pt)	2002-11-19
MY133572A (en)	2007-11-30
WO2001052845A1 (en)	2001-07-26
EP1251848B1 (de)	2004-06-23
CO5261612A1 (es)	2003-03-31
DK1251848T3 (da)	2004-10-18
US6930116B2 (en)	2005-08-16
HK1053984A1 (en)	2003-11-14
AU782883B2 (en)	2005-09-08
EP1251848A1 (de)	2002-10-30
EA200200769A1 (ru)	2002-12-26
US6608087B1 (en)	2003-08-19
NZ520628A (en)	2004-05-28

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2005-03-15

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Publication	Publication Date	Title
DE60103974D1 (de)	2004-07-29	Gyrase-inhibitoren und ihre verwendung
NO20032668D0 (no)	2003-06-12	Gyraseinhibitorer og anvendelser derav
DE60208661D1 (de)	2006-04-06	Diaminothiazole und ihre verwendung als cyclinabhängige kinase inhibitoren
IS6656A (is)	2002-12-17	Útskiptar kínasólínafleiður og notkun þeirra sem hemla
IS6934A (is)	2003-08-29	Nýjar spírótrísýklískar afleiður og notkun þeirrasem fosfódíesterasa-7-hindrar
DE60106423D1 (de)	2004-11-18	Entzündungshemmende verbindungen und ihre verwendung
NO20042147L (no)	2004-05-25	Heterocykliske forbindelser og fremgangsmater for anvendelse derav
NO20022656D0 (no)	2002-06-05	Caspaseinhibitorer og anvendelse derav
NO20040469L (no)	2004-04-30	Heterocykliske forbindelser samt fremstilling og anvendelse derav
DK1122244T3 (da)	2004-10-25	Uracilforbindelser og anvendelse deraf
NO20020343D0 (no)	2002-01-22	Kaspase-inhibitorer og anvendelse derav
EP1412378A4 (de)	2006-09-20	Aptamere und antiaptamere
EE200200550A (et)	2004-02-16	Karbamaatsed kaspaasi inhibiitorid ja nende kasutamine
DE60209486D1 (de)	2006-04-27	Pyranoindazole und ihre verwendung in der glaukombehandlung
ATE329906T1 (de)	2006-07-15	Substituierte 2-anilino-benzimidazole und ihre verwendung als nhe-inhibitoren
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