ATE270429T1 - Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionen - Google Patents

Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionen

Info

Publication number
ATE270429T1
ATE270429T1 AT99904525T AT99904525T ATE270429T1 AT E270429 T1 ATE270429 T1 AT E270429T1 AT 99904525 T AT99904525 T AT 99904525T AT 99904525 T AT99904525 T AT 99904525T AT E270429 T1 ATE270429 T1 AT E270429T1
Authority
AT
Austria
Prior art keywords
binding reactions
molecule binding
signal
detecting molecule
molecular binding
Prior art date
Application number
AT99904525T
Other languages
English (en)
Inventor
John Hefti
Original Assignee
Mds Sciex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mds Sciex filed Critical Mds Sciex
Application granted granted Critical
Publication of ATE270429T1 publication Critical patent/ATE270429T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites
    • GPHYSICS
    • G11INFORMATION STORAGE
    • G11CSTATIC STORES
    • G11C13/00Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00
    • G11C13/0002Digital stores characterised by the use of storage elements not covered by groups G11C11/00, G11C23/00, or G11C25/00 using resistive RAM [RRAM] elements
    • G11C13/0009RRAM elements whose operation depends upon chemical change
    • G11C13/0014RRAM elements whose operation depends upon chemical change comprising cells based on organic memory material
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/806Electrical property or magnetic property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Materials Engineering (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Seal Device For Vehicle (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT99904525T 1998-02-02 1999-02-01 Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionen ATE270429T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7344598P 1998-02-02 1998-02-02
PCT/US1999/002147 WO1999039190A1 (en) 1998-02-02 1999-02-01 Method and apparatus for detecting molecular binding events

Publications (1)

Publication Number Publication Date
ATE270429T1 true ATE270429T1 (de) 2004-07-15

Family

ID=22113726

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99904525T ATE270429T1 (de) 1998-02-02 1999-02-01 Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionen

Country Status (13)

Country Link
US (1) US6368795B1 (de)
EP (1) EP0991938B1 (de)
JP (2) JP2002502028A (de)
KR (1) KR20010040559A (de)
CN (1) CN1292087A (de)
AT (1) ATE270429T1 (de)
AU (1) AU745416B2 (de)
CA (1) CA2318191C (de)
DE (1) DE69918389T2 (de)
GB (1) GB2342176B (de)
IL (1) IL137260A0 (de)
NO (1) NO20003911L (de)
WO (1) WO1999039190A1 (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287874B1 (en) * 1998-02-02 2001-09-11 Signature Bioscience, Inc. Methods for analyzing protein binding events
US6287776B1 (en) 1998-02-02 2001-09-11 Signature Bioscience, Inc. Method for detecting and classifying nucleic acid hybridization
AU769226B2 (en) * 1998-02-02 2004-01-22 Signature Bioscience Inc. Test systems and sensors for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events
US6485905B2 (en) * 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
WO1999039190A1 (en) 1998-02-02 1999-08-05 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US20020177175A1 (en) * 1998-02-02 2002-11-28 Hefti John J. Coplanar waveguide biosensor for detecting molecular or cellular events
CN1301168A (zh) * 1998-05-22 2001-06-27 印斯拜尔药品股份有限公司 治疗性二核苷酸和衍生物
WO2000045160A1 (en) * 1999-02-01 2000-08-03 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
WO2001027610A2 (en) * 1999-10-13 2001-04-19 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample
DE10002597A1 (de) * 2000-01-21 2001-08-02 Infineon Technologies Ag Verfahren und Vorrichtung zur Identifikation von in einer Trägerflüssigkeit vorhandenen Molekülen
US7049579B2 (en) 2000-07-26 2006-05-23 The Regents Of The University Of California Manipulation of live cells and inorganic objects with optical micro beam arrays
CN100394171C (zh) 2000-08-02 2008-06-11 卡钳技术有限公司 基于分离的高处理量分析系统
JP4860841B2 (ja) * 2000-08-25 2012-01-25 シスメックス株式会社 分析データ提供方法、分析データ提供装置及び分析データ提供プログラム
US6586946B2 (en) 2000-11-13 2003-07-01 Signature Bioscience, Inc. System and method for detecting and identifying molecular events in a test sample using a resonant test structure
US8900811B2 (en) 2000-11-16 2014-12-02 Caliper Life Sciences, Inc. Method and apparatus for generating thermal melting curves in a microfluidic device
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US20020168659A1 (en) * 2001-02-12 2002-11-14 Signature Bioscience Inc. System and method for characterizing the permittivity of molecular events
WO2002077605A2 (en) * 2001-03-21 2002-10-03 Signature Bioscience, Inc. Reentrant cavity bioassay for detecting molecular or cellular events
US6627461B2 (en) * 2001-04-18 2003-09-30 Signature Bioscience, Inc. Method and apparatus for detection of molecular events using temperature control of detection environment
US20030059807A1 (en) * 2001-06-07 2003-03-27 Proligo Llc Microcalorimetric detection of analytes and binding events
US20040166593A1 (en) * 2001-06-22 2004-08-26 Nolte David D. Adaptive interferometric multi-analyte high-speed biosensor
US20030032000A1 (en) * 2001-08-13 2003-02-13 Signature Bioscience Inc. Method for analyzing cellular events
AU2002359263A1 (en) * 2001-10-12 2003-04-22 Wisconsin Alumni Research Foundation Microwave dielectric spectroscopy method and apparatus for assays of proteins and other biological molecules
US7160423B2 (en) 2002-03-05 2007-01-09 Caliper Life Sciences, Inc. Mixed mode microfluidic systems
AU2003228395B2 (en) 2002-04-02 2006-12-21 Caliper Life Sciences, Inc. Methods and apparatus for separation and isolation of components from a biological sample
US7560269B2 (en) * 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
CA2493101C (en) * 2002-07-20 2012-05-08 Acea Biosciences, Inc. Impedance based apparatuses and methods for analyzing cells and particles
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7732127B2 (en) * 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US7192752B2 (en) 2002-12-20 2007-03-20 Acea Biosciences Real time electronic cell sensing systems and applications for cell-based assays
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US7745221B2 (en) 2003-08-28 2010-06-29 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
EP1671125A1 (de) * 2003-09-29 2006-06-21 Koninklijke Philips Electronics N.V. Markierungsfreier nachweis von biomolekülen
US7514938B2 (en) * 2004-05-11 2009-04-07 Board Of Regents Of The University And College System Of Nevada, On Behalf Of The University Of Nevada, Reno Dielectric relaxation spectroscopy apparatus and methods of use
JP4546326B2 (ja) 2004-07-30 2010-09-15 キヤノン株式会社 センシング装置
KR100667305B1 (ko) * 2005-01-03 2007-01-12 삼성전자주식회사 생분자결합 검출장치 및 그 방법
US20070023643A1 (en) * 2005-02-01 2007-02-01 Nolte David D Differentially encoded biological analyzer planar array apparatus and methods
US7910356B2 (en) * 2005-02-01 2011-03-22 Purdue Research Foundation Multiplexed biological analyzer planar array apparatus and methods
US7405831B2 (en) * 2005-02-01 2008-07-29 Purdue Research Foundation Laser scanning interferometric surface metrology
WO2007131103A2 (en) * 2006-05-03 2007-11-15 Quadraspec, Inc. Direct printing of patterned hydrophobic wells
US8041515B2 (en) * 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
US7522282B2 (en) * 2006-11-30 2009-04-21 Purdue Research Foundation Molecular interferometric imaging process and apparatus
US20080144899A1 (en) * 2006-11-30 2008-06-19 Manoj Varma Process for extracting periodic features from images by template matching
US20080230605A1 (en) * 2006-11-30 2008-09-25 Brian Weichel Process and apparatus for maintaining data integrity
JP4928249B2 (ja) * 2006-12-20 2012-05-09 キヤノン株式会社 検出装置
WO2008089495A2 (en) 2007-01-19 2008-07-24 Purdue Research Foundation System with extended range of molecular sensing through integrated multi-modal data acquisition
US7787126B2 (en) * 2007-03-26 2010-08-31 Purdue Research Foundation Method and apparatus for conjugate quadrature interferometric detection of an immunoassay
WO2009039298A2 (en) 2007-09-18 2009-03-26 University Of Florida Research Foundation, Inc. Sensors using aigan/gan high electron mobility transistors
WO2009137440A1 (en) 2008-05-05 2009-11-12 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US8836351B2 (en) * 2008-06-10 2014-09-16 University Of Florida Research Foundation, Inc. Chloride detection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
WO2011146531A1 (en) 2010-05-18 2011-11-24 Acea Biosciences, Inc Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments
US9949679B2 (en) * 2012-12-07 2018-04-24 Ascilion Ab Microfabricated sensor and a method of sensing the level of a component in bodily fluid
EP3071965A1 (de) 2013-11-21 2016-09-28 Avails Medical, Inc. Elektrischer biosensor zum nachweis einer substanz in einer körperflüssigkeit sowie verfahren und system dafür
US10782285B2 (en) 2014-10-03 2020-09-22 Rite Taste, LLC Device and method for chemical analysis
US9702847B2 (en) * 2014-12-30 2017-07-11 Avails Medical, Inc. Systems and methods for detecting a substance in bodily fluid
EP3341464B1 (de) 2015-08-25 2024-05-08 Avails Medical, Inc. Vorrichtungen, systeme und verfahren zum nachweis lebensfähiger mikroorganismen in einer fluidprobe
AT517604B1 (de) * 2015-10-06 2017-03-15 Siemens Ag Oesterreich Messfühler
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
EP3356511B1 (de) 2016-01-25 2022-04-27 Avails Medical, Inc. Verfahren zum nachweis lebensfähiger infektionserreger in einer probenflüssigkeit mithilfe eines elektrolytisolatorhalbleitersensors
WO2017209839A1 (en) 2016-05-31 2017-12-07 Avails Medical, Inc. Detecting viable infectious agents in a fluid sample and susceptibility of infectious agents to anti-infectives
WO2018111234A1 (en) 2016-12-13 2018-06-21 Avails Medical, Inc. DEVICES, SYSTEMS AND METHODS TO DETECT THE PRESENCE OF ß-LACTAM ANTIBIOTIC HYDROLYZING BACTERIA IN A SAMPLE
CN108241056A (zh) * 2016-12-23 2018-07-03 财团法人金属工业研究发展中心 生物检测装置
EP4549553A3 (de) 2017-03-03 2025-07-16 Agilent Technologies, Inc. Verfahren und systeme zur funktionellen reifung von kardiomyozyten aus ipsc und esc
WO2019005296A1 (en) 2017-06-27 2019-01-03 Avails Medical, Inc. APPARATUS, SYSTEMS AND METHODS FOR DETERMINING THE SENSITIVITY OF MICROORGANISMS TO ANTI-INFECTIOUS
GB201711543D0 (en) 2017-07-18 2017-08-30 Univ Oxford Innovation Ltd Sensor, sensing system and sensing method
US10775422B2 (en) * 2017-09-05 2020-09-15 Texas Instruments Incorporated Molecular spectroscopy cell with resonant cavity
CA3077052A1 (en) 2017-10-03 2019-04-11 Avails Medical, Inc. Apparatus, systems, and methods for determining the concentration of microorganisms and the susceptibility of microorganisms to anti-infectives based on redox reactions
WO2019113226A1 (en) 2017-12-05 2019-06-13 Avails Medical, Inc. Preparing an output sample comprising a defined concentration of an infectious agent for downstream testing
US12055543B2 (en) 2018-05-24 2024-08-06 Graphene-Dx, Inc. Methods and devices for detection of THC
WO2020117650A1 (en) 2018-12-03 2020-06-11 Avails Medical, Inc. Apparatus, systems, and methods for quantifying infectious agents
EP3952724A1 (de) * 2019-04-10 2022-02-16 Graphene-Dx, Inc. Verfahren und vorrichtung für den nachweis von thc
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
CN113218968B (zh) * 2021-05-26 2022-07-15 江南大学 酵母菌测试用高灵敏度微波生物传感器及其应用
CN118874567B (zh) * 2024-07-16 2025-10-03 山东大学 一种集成化的微波-微流体芯片及其制备方法和检测方法

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288229A (en) 1980-03-07 1981-09-08 Envirotech Corporation Determination of total organic carbon in a plurality of aqueous samples containing halide ion
US4407290A (en) 1981-04-01 1983-10-04 Biox Technology, Inc. Blood constituent measuring device and method
US4767717A (en) 1985-05-02 1988-08-30 Baisden C Robert Method of detecting and quantitating cell malignancy in biological tissue
EP0213825A3 (de) 1985-08-22 1989-04-26 Molecular Devices Corporation Chemisch-modulierte Mehrfachkapazitanz
US4765179A (en) 1985-09-09 1988-08-23 Solid State Farms, Inc. Radio frequency spectroscopy apparatus and method using multiple frequency waveforms
US4679426A (en) 1985-09-09 1987-07-14 Fuller Milton E Wave shape chemical analysis apparatus and method
US4822566A (en) * 1985-11-19 1989-04-18 The Johns Hopkins University Optimized capacitive sensor for chemical analysis and measurement
GB8612221D0 (en) 1986-05-20 1986-06-25 Amersham Int Plc Assaying species in sample
GB8801807D0 (en) 1988-01-27 1988-02-24 Amersham Int Plc Biological sensors
EP0341927B1 (de) 1988-05-10 1993-07-14 AMERSHAM INTERNATIONAL plc Biosensoren
GB8811919D0 (en) 1988-05-20 1988-06-22 Amersham Int Plc Biological sensors
US5120648A (en) 1988-05-26 1992-06-09 Lim Technology Laboratories, Inc. Chemical analyzer using rf radiation attenuation measurements
GB8813307D0 (en) 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
US5478755A (en) * 1988-07-25 1995-12-26 Ares Serono Research & Development Ltd. Long range surface plasma resonance immunoassay
WO1990002327A1 (en) * 1988-08-18 1990-03-08 AUSTRALIAN MEMBRANE AND BIOTECHNOLOGY RESEARCH INSTITUTE LTD., Commonwealth Scientific and Industrial Research Organization Improvements in sensitivity and selectivity of ion channel membrane biosensors
US5156810A (en) * 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5025222A (en) 1989-07-07 1991-06-18 Phase Dynamics, Inc. System and method for monitoring substances and reactions
US5434084A (en) 1989-09-06 1995-07-18 The Washington Research Foundation Flow optrode having separate reaction and detection chambers
US5082629A (en) 1989-12-29 1992-01-21 The Board Of The University Of Washington Thin-film spectroscopic sensor
US5082630A (en) * 1990-04-30 1992-01-21 The United States Of America As Represented By The United States Department Of Energy Fiber optic detector for immuno-testing
DE69114247T2 (de) 1990-06-04 1996-03-21 Behring Diagnostics Inc Analytischer test.
GB9019123D0 (en) 1990-09-01 1990-10-17 Fisons Plc Analytical device
US5212099A (en) 1991-01-18 1993-05-18 Eastman Kodak Company Method and apparatus for optically measuring concentration of an analyte
US5233306A (en) 1991-02-13 1993-08-03 The Board Of Regents Of The University Of Wisconsin System Method and apparatus for measuring the permittivity of materials
GB9111912D0 (en) 1991-06-04 1991-07-24 Fisons Plc Analytical methods
US5340715A (en) * 1991-06-07 1994-08-23 Ciba Corning Diagnostics Corp. Multiple surface evanescent wave sensor with a reference
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
EP0517930B1 (de) * 1991-06-08 1995-05-24 Hewlett-Packard GmbH Verfahren und Gerät zur Feststellung und/oder Konzentrationsbestimmung von Biomolekülen
US5218814A (en) * 1991-06-14 1993-06-15 Deere & Company Engine and transaxle module
WO1993008464A1 (en) 1991-10-21 1993-04-29 Holm Kennedy James W Method and device for biochemical sensing
IL103674A0 (en) 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
US5478748A (en) 1992-04-01 1995-12-26 Thomas Jefferson University Protein assay using microwave energy
US5403747A (en) 1992-04-01 1995-04-04 Thomas Jefferson University Protein assay using microwave energy
GB9212416D0 (en) * 1992-06-11 1992-07-22 Medical Res Council Reversible binding substances
US5504366A (en) 1992-07-17 1996-04-02 Biotechnology Research And Development Corp. System for analyzing surfaces of samples
US5397896A (en) 1992-07-17 1995-03-14 Penn State Research Foundation And Biotechnology Research And Development Corporation Multiple source and detection frequencies in detecting threshold phenomena associated with and/or atomic or molecular spectra
US5268573A (en) 1992-07-17 1993-12-07 The Penn State Research Foundation System for detecting threshold phenomena associated with and/or atomic or molecular spectra of a substance
US5348003A (en) 1992-09-03 1994-09-20 Sirraya, Inc. Method and apparatus for chemical analysis
US5543329A (en) 1992-11-03 1996-08-06 Intelligent Monitoring Systems And Advanced Global Technologies Sensor for antigen-antibody reactions
US5359681A (en) * 1993-01-11 1994-10-25 University Of Washington Fiber optic sensor and methods and apparatus relating thereto
US5327225A (en) * 1993-01-28 1994-07-05 The Center For Innovative Technology Surface plasmon resonance sensor
US5363052A (en) 1993-02-16 1994-11-08 Solid State Farms, Inc. Permittivity spectroscopy apparatus and method
US5919712A (en) * 1993-05-18 1999-07-06 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5512492A (en) * 1993-05-18 1996-04-30 University Of Utah Research Foundation Waveguide immunosensor with coating chemistry providing enhanced sensitivity
WO1994028417A1 (en) 1993-06-01 1994-12-08 E.I. Du Pont De Nemours And Company Analyte-responsive ktp composition and method
AU7552194A (en) * 1993-07-26 1995-02-20 Phase Dynamics, Inc. System and method for monitoring substances and reactions
US5508203A (en) 1993-08-06 1996-04-16 Fuller; Milton E. Apparatus and method for radio frequency spectroscopy using spectral analysis
US5792668A (en) 1993-08-06 1998-08-11 Solid State Farms, Inc. Radio frequency spectral analysis for in-vitro or in-vivo environments
JPH0763760A (ja) * 1993-08-31 1995-03-10 Daikin Ind Ltd 光学的免疫測定方法およびその装置
US5432096A (en) 1993-12-20 1995-07-11 Cetac Technologies Inc. Simultaneous multiple, single wavelength electromagnetic wave energy absorbtion detection and quantifying spectrophotometric system, and method of use
GB9401170D0 (en) * 1994-01-21 1994-03-16 Lynxvale Limited . Optical sensor
EP0690306A1 (de) 1994-06-28 1996-01-03 Mochida Pharmaceutical Co., Ltd. Methode und Vorrichtung für eine Bestimmung durch spezifische Bindung
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5656428A (en) 1994-09-08 1997-08-12 Biode, Inc. Homogeneous bioassay using acoustic emission spectroscopy
GB9418981D0 (en) 1994-09-21 1994-11-09 Univ Glasgow Apparatus and method for carrying out analysis of samples
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US6035246A (en) 1994-11-04 2000-03-07 Sandia Corporation Method for identifying known materials within a mixture of unknowns
US5814565A (en) * 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5629213A (en) * 1995-03-03 1997-05-13 Kornguth; Steven E. Analytical biosensor
EP0871871B1 (de) 1995-05-17 2004-05-06 Ambri Limited Verbesserung eines ionenreservoirs durch die verwendung eines elektrischen potentials
GB9518429D0 (en) * 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
WO1997015819A1 (en) * 1995-10-25 1997-05-01 University Of Washington Surface plasmon resonance light pipe sensor
AU7526496A (en) * 1995-10-25 1997-05-15 University Of Washington Surface plasmon resonance electrode as chemical sensor
US5661301A (en) 1996-02-07 1997-08-26 The Penn State Research Foundation Spectroscopy and mapping of atoms, molecules and surface features via difference frequency generation with a scanning tunneling microscope or related instruments
US5671303A (en) 1996-04-17 1997-09-23 Motorola, Inc. Molecular detection apparatus and method using optical waveguide detection
IL126581A (en) * 1996-04-25 2004-03-28 Pence Inc Biosensor for detecting a binding event between a ligand and ligand-binding receptor
US5827482A (en) 1996-08-20 1998-10-27 Motorola Corporation Transistor-based apparatus and method for molecular detection and field enhancement
US5832165A (en) * 1996-08-28 1998-11-03 University Of Utah Research Foundation Composite waveguide for solid phase binding assays
US5858666A (en) 1996-08-29 1999-01-12 Biotechnology Research And Development Corporation Apparatus and method of detection employing an AC frequency sensor array
US5846843A (en) 1996-11-18 1998-12-08 The University Of Toledo Sensor using long range surface plasmon resonance with diffraction double-grating
US6306584B1 (en) 1997-01-21 2001-10-23 President And Fellows Of Harvard College Electronic-property probing of biological molecules at surfaces
US6048692A (en) 1997-10-07 2000-04-11 Motorola, Inc. Sensors for electrically sensing binding events for supported molecular receptors
WO1999039190A1 (en) 1998-02-02 1999-08-05 Signature Bioscience Inc. Method and apparatus for detecting molecular binding events
US6395480B1 (en) 1999-02-01 2002-05-28 Signature Bioscience, Inc. Computer program and database structure for detecting molecular binding events

Also Published As

Publication number Publication date
JP2005308761A (ja) 2005-11-04
NO20003911D0 (no) 2000-08-01
GB9923039D0 (en) 1999-12-01
AU745416B2 (en) 2002-03-21
AU2490699A (en) 1999-08-16
WO1999039190A1 (en) 1999-08-05
DE69918389T2 (de) 2005-10-06
GB2342176A (en) 2000-04-05
CA2318191C (en) 2009-05-05
CA2318191A1 (en) 1999-08-05
DE69918389D1 (de) 2004-08-05
JP2002502028A (ja) 2002-01-22
US6368795B1 (en) 2002-04-09
KR20010040559A (ko) 2001-05-15
GB2342176B (en) 2001-05-02
IL137260A0 (en) 2001-07-24
EP0991938B1 (de) 2004-06-30
NO20003911L (no) 2000-09-29
EP0991938A1 (de) 2000-04-12
CN1292087A (zh) 2001-04-18

Similar Documents

Publication Publication Date Title
ATE270429T1 (de) Verfahren und vorrichtung zur erkennung von molekül-bindungsreaktionen
ATE373822T1 (de) Verfahren zur detektion von markierstoffen in kohlenwasserstoffen und kohlenwasserstoffgemischen
DE69728017D1 (de) Vorrichtungen und Verfahren zur Erkennung von mehreren Analyten in Proben
DE69915926D1 (de) Verfahren und Echographiegerät zur Erfassung von Elastizitätsveränderungen
DE69706315D1 (de) Verfahren, reagentiensätze und zusammensetzungen zur unterdrückung der bindung von detektierbaren sonden an nicht-zielsequenzen in hybridisierungstests
DE69829072D1 (de) Verfahren und vorrichtung zur bildung, prüfung und modifizierung von geologischen unterirdischen modellen
DE69717027D1 (de) Testvorrichtung für Strassenbelagproben
DE69636183D1 (de) Vorrichtung zur Prüfung von Halbleitersubstraten
DE69938900D1 (de) Gerät und verfahren zur erfassung von batterieeigenschaften aus komplexer impedanz/admittanz
DE69624880D1 (de) Anordnung und Verfahren zur Widerstandsmessung von unterirdischen Formationen
DE19983231T1 (de) System und Verfahren zur Sekundärförderung von Kohlenwasserstoff
DE69033130D1 (de) Verfahren und Gerät zur Prüfung von Substraten
DE69815085D1 (de) System und verfahren zur klassifizierrung von zellproben
EP1216218A4 (de) Verfahren zur anreicherung von kohlenwasserstoffen
DE69938766D1 (de) Verfahren zur Rückgewinnung von Substratscheiben
DE60018626D1 (de) Vorrichtung und Verfahren zur Eingabe von Steuerungsdateien für Musikvorträge
DE69008055D1 (de) Verfahren und Einrichtung zur Ablagerung von Mineralfasern.
DE69408615D1 (de) Verfahren und Vorrichtung zur Erfassung von seismischen Signalen
DE69700087D1 (de) Gerät und Verfahren zur Signalanalyse
DE59912933D1 (de) Verfahren und vorrichtung zur detektion von fehlern in flachglas
DE69918123D1 (de) Verfahren und reagentiensatz zur erkennung von protein-protein wechselwirkungen
DE69937858D1 (de) Verfahren und Vorrichtung zur Messung von Vibrationswellen
BR9609742A (pt) Sistema de separação e concentração baseados em domínios de ligação de oligossarídeo solúvel
DE69824850D1 (de) Benzol-umwandlung in einem verbesserten verfahren zur ausreichung von kohlenwasserstoffen
DE60132729D1 (de) Verfahren und Vorrichtung zur Erfassung von Azimutinformation

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties