ATE270663T1 - Trizyklische 1-benzylpyrazol-3- carbonsäurederivate als cannabinoidrezeptorantagonisten - Google Patents

Trizyklische 1-benzylpyrazol-3- carbonsäurederivate als cannabinoidrezeptorantagonisten

Info

Publication number: ATE270663T1
Authority: AT; Austria
Prior art keywords: benzylpyrazole; carboxylic acid; trizyclic; acid derivatives; receptor antagonists
Prior art date: 1999-11-03

Application number

AT00974627T

Other languages

English (en)

Inventor

Francis Barth

Joseph Millan

Didier Oustric

Murielle Rinaldi

Martine Vernhet

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-11-03

Filing date

2000-11-02

Publication date

2004-07-15

2000-11-02 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2004-07-15 Application granted granted Critical

2004-07-15 Publication of ATE270663T1 publication Critical patent/ATE270663T1/de

Links

CZPRLVUTBZKCJG-UHFFFAOYSA-N 1-benzylpyrazole-3-carboxylic acid Chemical class N1=C(C(=O)O)C=CN1CC1=CC=CC=C1 CZPRLVUTBZKCJG-UHFFFAOYSA-N 0.000 title abstract 2
229940122820 Cannabinoid receptor antagonist Drugs 0.000 title 1
239000003536 cannabinoid receptor antagonist Substances 0.000 title 1
239000005557 antagonist Substances 0.000 abstract 1
229930003827 cannabinoid Natural products 0.000 abstract 1
239000003557 cannabinoid Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Diabetes (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Cardiology (AREA)
AIDS & HIV (AREA)
Dermatology (AREA)

AT00974627T 1999-11-03 2000-11-02 Trizyklische 1-benzylpyrazol-3- carbonsäurederivate als cannabinoidrezeptorantagonisten ATE270663T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9913847A FR2800372B1 (fr)	1999-11-03	1999-11-03	Derives tricycliques d'acide 1-benzylpyrazole-3- carboxylique, leur preparation, les medicaments en contenant
PCT/FR2000/003047 WO2001032629A1 (fr)	1999-11-03	2000-11-02	Derives trycycliques d'acides 1-benzylpyrazole-3-carboxylique comme antagonistes des recepteurs de cannabinoides

Publications (1)

Publication Number	Publication Date
ATE270663T1 true ATE270663T1 (de)	2004-07-15

Family

ID=9551736

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00974627T ATE270663T1 (de)	1999-11-03	2000-11-02	Trizyklische 1-benzylpyrazol-3- carbonsäurederivate als cannabinoidrezeptorantagonisten

Country Status (9)

Country	Link
US (1)	US6916838B1 (de)
EP (1)	EP1230222B1 (de)
JP (1)	JP4944329B2 (de)
AT (1)	ATE270663T1 (de)
AU (1)	AU1285801A (de)
DE (1)	DE60012040T2 (de)
FR (1)	FR2800372B1 (de)
HU (1)	HU225156B1 (de)
WO (1)	WO2001032629A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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FR2800375B1 (fr) *	1999-11-03	2004-07-23	Sanofi Synthelabo	Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
CA2468794A1 (en) *	2001-12-07	2003-06-19	Virginia Commonwealth University	Treatment of neoplasia
NZ535349A (en)	2002-03-08	2007-01-26	Signal Pharm Inc	JNK inhibitors with chemotherapeutic agents in a combination therapy for treating or preventing cancer and other proliferative disorders in refractory patients in particular
US6825209B2 (en)	2002-04-15	2004-11-30	Research Triangle Institute	Compounds having unique CB1 receptor binding selectivity and methods for their production and use
US7129239B2 (en)	2002-10-28	2006-10-31	Pfizer Inc.	Purine compounds and uses thereof
US7247628B2 (en)	2002-12-12	2007-07-24	Pfizer, Inc.	Cannabinoid receptor ligands and uses thereof
US7329658B2 (en)	2003-02-06	2008-02-12	Pfizer Inc	Cannabinoid receptor ligands and uses thereof
US7176210B2 (en)	2003-02-10	2007-02-13	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
US7141669B2 (en)	2003-04-23	2006-11-28	Pfizer Inc.	Cannabiniod receptor ligands and uses thereof
US7268133B2 (en)	2003-04-23	2007-09-11	Pfizer, Inc. Patent Department	Cannabinoid receptor ligands and uses thereof
US7145012B2 (en)	2003-04-23	2006-12-05	Pfizer Inc.	Cannabinoid receptor ligands and uses thereof
US7232823B2 (en)	2003-06-09	2007-06-19	Pfizer, Inc.	Cannabinoid receptor ligands and uses thereof
ITMI20041033A1 (it) *	2004-05-24	2004-08-24	Neuroscienze S C A R L	Composti farmaceutici
ITMI20041032A1 (it)	2004-05-24	2004-08-24	Neuroscienze S C A R L	Compositi farmaceutici
CA2586011C (en)	2004-07-12	2011-07-19	Cadila Healthcare Limited	Tricyclic pyrazole derivatives as cannabinoid receptor modulators
US20060025448A1 (en)	2004-07-22	2006-02-02	Cadila Healthcare Limited	Hair growth stimulators
RU2420518C2 (ru) *	2005-06-02	2011-06-10	Гленмарк Фармасеутикалс С.А.	Новые лиганды каннабиоидных рецепторов, содержащие их фармацевтические композиции и способ их получения
US7923465B2 (en)	2005-06-02	2011-04-12	Glenmark Pharmaceuticals S.A.	Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
CA2613678A1 (en) *	2005-06-02	2006-12-07	Glenmark Pharmaceuticals S.A.	Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
US20070060638A1 (en) *	2005-08-26	2007-03-15	Olmstead Mary C	Methods and therapies for potentiating therapeutic activities of a cannabinoid receptor agonist via administration of a cannabinoid receptor antagonist
US8378096B2 (en)	2005-09-23	2013-02-19	Janssen Pharmaceutica N.V.	Hexahydro-cycloheptapyrazole cannabinoid modulators
ES2375213T3 (es) *	2005-09-23	2012-02-27	Janssen Pharmaceutica Nv	Moduladores de cannabinoides de hexadhidro-cicloheptapirazol.
US8378117B2 (en)	2005-09-23	2013-02-19	Janssen Pharmaceutica N.V.	Hexahydro-cycloheptapyrazole cannabinoid modulators
CA2623525A1 (en) *	2005-09-23	2007-04-05	Janssen Pharmaceutica N.V.	Tetrahydro-indazolyl cannabinoid modulators
UA93389C2 (en)	2005-09-23	2011-02-10	Янссен Фармацевтика H.B.	Hexahydro cyclooctyl pyrazole cannabinoid modulators
US7825151B2 (en)	2005-09-23	2010-11-02	Janssen Pharmaceutica Nv	Hexahydro-cyclooctyl pyrazole cannabinoid modulators
EP1985295A1 (de)	2007-04-04	2008-10-29	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Selektive Inhibitoren der CB2-Rezeptorexpression und/oder Aktivität zur Behandlung von Adipositas und Krankheiten im Zusammenhang mit Adipositas
FR2916758B1 (fr) *	2007-06-04	2009-10-09	Sanofi Aventis Sa	Derives de 1-benzylpyrazole, leur preparation et leur application en therapeutique
IT1395724B1 (it)	2009-02-25	2012-10-19	Neuroscienze Pharmaness S C A R L	Composti farmaceutici
IT1394400B1 (it)	2009-02-25	2012-06-15	Neuroscienze Pharmaness S C Ar L	Composizioni farmaceutiche
EP2789619A1 (de)	2013-04-12	2014-10-15	Kemotech S.r.l.	Pharmazeutische Verbindungen mit angiogenesehemmender Wirkung

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GB1382773A (en) *	1972-04-07	1975-02-05	Searle & Co	Esters and amides of 4,5-dihydrobenz-g-indazole-3-carboxylic acids and related compounds
FR2665898B1 (fr) *	1990-08-20	1994-03-11	Sanofi	Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2692575B1 (fr)	1992-06-23	1995-06-30	Sanofi Elf	Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) *	1993-12-02	1996-03-01	Sanofi Sa	N-pipéridino-3-pyrazolecarboxamide substitué.
US5547975A (en) *	1994-09-20	1996-08-20	Talley; John J.	Benzopyranopyrazolyl derivatives for the treatment of inflammation
US5696143A (en) *	1994-09-20	1997-12-09	Talley; John J.	Benz G! indazolyl derivatives for the treatment of inflammation
IT1271266B (it) *	1994-12-14	1997-05-27	Valle Francesco Della	Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi
FR2742148B1 (fr) *	1995-12-08	1999-10-22	Sanofi Sa	Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
EP0979228A4 (de) *	1997-03-18	2000-05-03	Smithkline Beecham Corp	Cannabinoid-rezeptor agonisten

1999
- 1999-11-03 FR FR9913847A patent/FR2800372B1/fr not_active Expired - Fee Related
2000
- 2000-11-02 HU HU0204143A patent/HU225156B1/hu not_active IP Right Cessation
- 2000-11-02 JP JP2001534780A patent/JP4944329B2/ja not_active Expired - Fee Related
- 2000-11-02 AT AT00974627T patent/ATE270663T1/de not_active IP Right Cessation
- 2000-11-02 DE DE60012040T patent/DE60012040T2/de not_active Expired - Lifetime
- 2000-11-02 WO PCT/FR2000/003047 patent/WO2001032629A1/fr not_active Ceased
- 2000-11-02 EP EP00974627A patent/EP1230222B1/de not_active Expired - Lifetime
- 2000-11-02 US US10/111,916 patent/US6916838B1/en not_active Expired - Lifetime
- 2000-11-02 AU AU12858/01A patent/AU1285801A/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1230222B1 (de)	2004-07-07
DE60012040D1 (de)	2004-08-12
EP1230222A1 (de)	2002-08-14
HUP0204143A2 (en)	2003-05-28
JP4944329B2 (ja)	2012-05-30
WO2001032629A1 (fr)	2001-05-10
US6916838B1 (en)	2005-07-12
DE60012040T2 (de)	2005-03-31
AU1285801A (en)	2001-05-14
HU225156B1 (en)	2006-07-28
JP2003513077A (ja)	2003-04-08
HUP0204143A3 (en)	2003-07-28
FR2800372B1 (fr)	2001-12-07
FR2800372A1 (fr)	2001-05-04

Legal Events

Date	Code	Title	Description
2005-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE60012040D1 (de)	2004-08-12	Trizyklische 1-benzylpyrazol-3-carbonsäurederivate als cannabinoidrezeptorantagonisten
DE69532162D1 (de)	2003-12-24	Cannabinoid-rezeptor-antagonisten
FR2800375B1 (fr)	2004-07-23	Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
DE60021282D1 (de)	2005-08-18	Carbamat-derivate als muscarin-rezeptor antonisten
EP0903349A3 (de)	2000-05-24	CCR-3-Rezeptor-Antagonisten
FR2838439B1 (fr)	2005-05-20	Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
ATE461196T1 (de)	2010-04-15	Benzodiazepin-cgrp-rezeptor-antagonisten
YU19903A (sh)	2006-05-25	Novi receptor nukleinskih kiselina i polipeptida
ATE300533T1 (de)	2005-08-15	1,2,3,4-tetrahydroisochinolin-derivate als urotensin ii rezeptor-antagonisten
MXPA05010859A (es)	2005-12-14	Antagonistas mchr1 heterociclicos.
BG101806A (bg)	1998-04-30	Индолови производни като антагонисти на 5-нт рецептори
EA200101177A1 (ru)	2002-04-25	Производные индола в качестве антагонистов прогестерона
BR0015963A (pt)	2002-08-06	Compostos de uréia antagonistas receptor muscarìnico, composições farmacêuticas compreendendo tais compostos e método de preparação destes compostos
IL140622A0 (en)	2002-02-10	Biphenyl sufonamide derivatives, pharmaceutical compositions containing the same and methods for the preparation thereof
DE60023167T2 (de)	2006-06-14	Pyrazol-derivate als cannabinoidrezeptor-antagonisten
TR200101155T2 (tr)	2001-09-21	4-Aroil Piperidin CCR-3 Reseptör Antagonistleri III
ATE293448T1 (de)	2005-05-15	Benzo(d)azepin-derivative als 5-ht6-rezeptor- antagonisten
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