ATE270T1 - NEW N1-BENZOYL-N2-PHENYL-1,3-DIAMINOPROPAN-2-OLS AND THEIR SALTS; PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS. - Google Patents

NEW N1-BENZOYL-N2-PHENYL-1,3-DIAMINOPROPAN-2-OLS AND THEIR SALTS; PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS.

Info

Publication number
ATE270T1
ATE270T1 AT79101634T AT79101634T ATE270T1 AT E270 T1 ATE270 T1 AT E270T1 AT 79101634 T AT79101634 T AT 79101634T AT 79101634 T AT79101634 T AT 79101634T AT E270 T1 ATE270 T1 AT E270T1
Authority
AT
Austria
Prior art keywords
diaminopropan
ols
benzoyl
phenyl
compounds
Prior art date
Application number
AT79101634T
Other languages
German (de)
Inventor
Hans Dipl.-Chem. Dr.Rer.Na Liepmann
Rolf Dipl.-Chem. Dr.Rer.Na Hueschens
Wolfgang Dipl.-Chem. Dr. Milkowski
Horst Dipl.-Chem. Dr.Rer.Na Zeugner
Henning Dipl.-Chem. Dr.Re Heinemann
Klaus-Ullrich Dr.Vet. Wolf
Insa Dr.Vet. Hell
Reinhard Dr.Med. Hempel
Original Assignee
Kali-Chemie Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kali-Chemie Pharma Gmbh filed Critical Kali-Chemie Pharma Gmbh
Application granted granted Critical
Publication of ATE270T1 publication Critical patent/ATE270T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

N1-benzoyl-N2-phenyl-1,3-diaminopropan-2-ols are disclosed which exhibit a stabilizing effect on the gastric mucosa and enhance the stability and resistance of the gastic mucosa against harmful effects caused by, e.g., excessive alcohol consumption or drugs. The compounds are useful in the prophylaxis and treatment of gastritis. Further disclosed are pharmaceutical compositions which are effective in stabilizing the gastric mucosa and in the treatment and proplylaxis of gastritis and which comprise as a pharmacologically active ingredient N1-benzoyl-N2-phenyl-1,3-diaminopropan-2-ols, or a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutically acceptable diluent. Further disclosed are processes for the preparation of the N1-benzoyl-N2-phenyl-1,3-diaminopropan-2-ols.
AT79101634T 1978-06-24 1979-05-29 NEW N1-BENZOYL-N2-PHENYL-1,3-DIAMINOPROPAN-2-OLS AND THEIR SALTS; PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS. ATE270T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782827801 DE2827801A1 (en) 1978-06-24 1978-06-24 NEW N LOW 1 -BENZOYL-N LOW 2 -PHENYL-1,3-DIAMINOPROPAN-2-OLE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS
EP79101634A EP0006458B1 (en) 1978-06-24 1979-05-29 N1-benzoyl-n2-phenyl-1,3-diaminopropane-2-ols and their salts, process for their preparation and medicaments containing them

Publications (1)

Publication Number Publication Date
ATE270T1 true ATE270T1 (en) 1981-10-15

Family

ID=6042666

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101634T ATE270T1 (en) 1978-06-24 1979-05-29 NEW N1-BENZOYL-N2-PHENYL-1,3-DIAMINOPROPAN-2-OLS AND THEIR SALTS; PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICALS CONTAINING THESE COMPOUNDS.

Country Status (13)

Country Link
US (1) US4271193A (en)
EP (1) EP0006458B1 (en)
JP (1) JPS554397A (en)
AT (1) ATE270T1 (en)
AU (1) AU4831279A (en)
DE (2) DE2827801A1 (en)
DK (1) DK263579A (en)
ES (1) ES481792A1 (en)
FI (1) FI791976A7 (en)
HU (1) HU179996B (en)
IL (1) IL57513A0 (en)
NO (1) NO792105L (en)
PT (1) PT69808A (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198352A (en) 1978-11-29 1980-04-15 Shell Oil Company Internal olefin hydroformylation process
US4313955A (en) * 1980-10-14 1982-02-02 Ciba-Geigy Corporation 1,5-Bis(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols
FR2726267B1 (en) * 1994-10-26 1998-01-02 Smithkline Beecham Lab NOVEL ARRHYTHMIC AGENTS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR PREPARING THEM
JP4775259B2 (en) * 2004-03-31 2011-09-21 味の素株式会社 Aniline derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2265371C3 (en) * 1972-05-03 1980-12-11 Kali-Chemie Ag, 3000 Hannover N- (3-Benzoylaminopropyl) anilines
GB1374366A (en) * 1972-07-21 1974-11-20 Science Union & Cie Propanol derivatives and a process for their preparation
DE2720908A1 (en) * 1977-05-10 1978-11-23 Kali Chemie Pharma Gmbh MEDICINE WITH ULKUS THERAPEUTIC EFFECT
DE2720968C2 (en) * 1977-05-10 1986-05-07 Kali-Chemie Pharma Gmbh, 3000 Hannover N? 1? -Acyl-2-hydroxy-1,3-diaminopropanes and drugs

Also Published As

Publication number Publication date
ES481792A1 (en) 1980-07-01
AU4831279A (en) 1980-01-03
IL57513A0 (en) 1979-10-31
DK263579A (en) 1979-12-25
NO792105L (en) 1979-12-28
HU179996B (en) 1983-01-28
JPS6245858B2 (en) 1987-09-29
EP0006458A1 (en) 1980-01-09
JPS554397A (en) 1980-01-12
PT69808A (en) 1979-07-01
EP0006458B1 (en) 1981-10-07
FI791976A7 (en) 1979-12-25
US4271193A (en) 1981-06-02
DE2960927D1 (en) 1981-12-17
DE2827801A1 (en) 1980-01-10

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