ATE271394T1 - Hybride zusammensetzungen für intrazellulaire verabreichung - Google Patents
Hybride zusammensetzungen für intrazellulaire verabreichungInfo
- Publication number
- ATE271394T1 ATE271394T1 AT97947833T AT97947833T ATE271394T1 AT E271394 T1 ATE271394 T1 AT E271394T1 AT 97947833 T AT97947833 T AT 97947833T AT 97947833 T AT97947833 T AT 97947833T AT E271394 T1 ATE271394 T1 AT E271394T1
- Authority
- AT
- Austria
- Prior art keywords
- domain
- hybrid compositions
- intracellular administration
- sub
- hybrid compounds
- Prior art date
Links
- 230000003834 intracellular effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010017898 Shiga Toxins Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3166896P | 1996-11-22 | 1996-11-22 | |
| US6105097P | 1997-10-03 | 1997-10-03 | |
| US6104497P | 1997-10-04 | 1997-10-04 | |
| PCT/IB1997/001620 WO1998022140A2 (en) | 1996-11-22 | 1997-11-22 | Hybrid compositions for intracellular targeting |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE271394T1 true ATE271394T1 (de) | 2004-08-15 |
Family
ID=27363932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97947833T ATE271394T1 (de) | 1996-11-22 | 1997-11-22 | Hybride zusammensetzungen für intrazellulaire verabreichung |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6482586B1 (de) |
| EP (1) | EP0959904B1 (de) |
| JP (1) | JP2001504480A (de) |
| AT (1) | ATE271394T1 (de) |
| CA (1) | CA2272747A1 (de) |
| DE (1) | DE69729959T2 (de) |
| ES (1) | ES2225996T3 (de) |
| WO (1) | WO1998022140A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482586B1 (en) * | 1996-11-22 | 2002-11-19 | Hospital For Sick Children Research And Development Limited Partnership | Hybrid compositions for intracellular targeting |
| FR2766193B1 (fr) * | 1997-07-18 | 2001-09-14 | Inst Curie | Polypeptide chimerique comprenant le fragment b de la toxine shiga et des peptides d'interet therapeutique |
| US20040185039A1 (en) * | 2002-08-30 | 2004-09-23 | Heinz Kohler | Therapeutic applications of noncovalent dimerizing antibodies |
| US20050033033A1 (en) * | 1998-05-04 | 2005-02-10 | Heinz Kohler | Trans-membrane-antibody induced inhibition of apoptosis |
| US7569674B2 (en) * | 1998-05-04 | 2009-08-04 | Innexus Biotechnology International Limited | Autophilic antibodies |
| GB9721901D0 (en) * | 1997-10-16 | 1997-12-17 | Univ Manchester | Particles |
| US20090208418A1 (en) * | 2005-04-29 | 2009-08-20 | Innexus Biotechnology Internaltional Ltd. | Superantibody synthesis and use in detection, prevention and treatment of disease |
| CA2333921C (en) | 1998-05-15 | 2014-04-22 | Allan M. Green | Verotoxin b subunit for immunization |
| US6903077B1 (en) | 1999-01-04 | 2005-06-07 | University Of Vermont And State Agricultural College | Methods and products for delivering nucleic acids |
| US20030104622A1 (en) * | 1999-09-01 | 2003-06-05 | Robbins Paul D. | Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses |
| WO2009131435A1 (en) * | 2008-04-23 | 2009-10-29 | Erasmus University Medical Center Rotterdam | Linker containing bungarotoxin and a binding peptide |
| WO2010043927A1 (en) * | 2008-10-13 | 2010-04-22 | Xeptagen Spa | Method for the preparation of immunoconjugates and use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2547731A1 (fr) | 1983-06-27 | 1984-12-28 | Centre Nat Rech Scient | Immunotoxine antitumorale, preparations pharmaceutiques la contenant et son utilisation in vitro |
| US5166320A (en) | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| CA2071969A1 (en) | 1989-12-22 | 1991-06-23 | John R. Murphy | Hybrid molecules having translocation region and cell-binding region |
| WO1993015766A1 (en) | 1992-02-10 | 1993-08-19 | Seragen, Inc. | Desensitization to specific allergens |
| CA2218601A1 (en) * | 1995-03-24 | 1996-10-03 | Ophidian Pharmaceuticals, Inc. | Treatment for verotoxin-producing escherichia coli |
| EP0739984A1 (de) | 1995-04-26 | 1996-10-30 | San Tumorforschungs-Gmbh | Bivalente Polypeptiden die mindestens zwei Bereichen enthalten |
| US6482586B1 (en) * | 1996-11-22 | 2002-11-19 | Hospital For Sick Children Research And Development Limited Partnership | Hybrid compositions for intracellular targeting |
| US6017735A (en) * | 1997-01-23 | 2000-01-25 | Marie Curie Cancer Care | Materials and methods for intracellular transport and their uses |
-
1997
- 1997-11-21 US US08/975,953 patent/US6482586B1/en not_active Expired - Fee Related
- 1997-11-22 DE DE69729959T patent/DE69729959T2/de not_active Expired - Fee Related
- 1997-11-22 ES ES97947833T patent/ES2225996T3/es not_active Expired - Lifetime
- 1997-11-22 WO PCT/IB1997/001620 patent/WO1998022140A2/en not_active Ceased
- 1997-11-22 CA CA002272747A patent/CA2272747A1/en not_active Abandoned
- 1997-11-22 JP JP52340998A patent/JP2001504480A/ja not_active Ceased
- 1997-11-22 AT AT97947833T patent/ATE271394T1/de not_active IP Right Cessation
- 1997-11-22 EP EP97947833A patent/EP0959904B1/de not_active Expired - Lifetime
-
2002
- 2002-11-18 US US10/298,408 patent/US7335750B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7335750B2 (en) | 2008-02-26 |
| ES2225996T3 (es) | 2005-03-16 |
| WO1998022140A3 (en) | 1998-08-27 |
| US6482586B1 (en) | 2002-11-19 |
| DE69729959T2 (de) | 2005-07-28 |
| EP0959904A2 (de) | 1999-12-01 |
| CA2272747A1 (en) | 1998-05-28 |
| EP0959904B1 (de) | 2004-07-21 |
| US20030068323A1 (en) | 2003-04-10 |
| DE69729959D1 (de) | 2004-08-26 |
| WO1998022140A2 (en) | 1998-05-28 |
| JP2001504480A (ja) | 2001-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |