ATE271919T1 - Mikrodosier- und probennahmevorrichtung sowie mikrochip mit dieser vorrichtung - Google Patents

Mikrodosier- und probennahmevorrichtung sowie mikrochip mit dieser vorrichtung

Info

Publication number
ATE271919T1
ATE271919T1 AT02022888T AT02022888T ATE271919T1 AT E271919 T1 ATE271919 T1 AT E271919T1 AT 02022888 T AT02022888 T AT 02022888T AT 02022888 T AT02022888 T AT 02022888T AT E271919 T1 ATE271919 T1 AT E271919T1
Authority
AT
Austria
Prior art keywords
channel
wall
open
microchip
liquid
Prior art date
Application number
AT02022888T
Other languages
English (en)
Inventor
Minoru Seki
Masumi Yamada
Hisashi Hagiwara
Original Assignee
Aida Eng Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aida Eng Ltd filed Critical Aida Eng Ltd
Application granted granted Critical
Publication of ATE271919T1 publication Critical patent/ATE271919T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/7172—Feed mechanisms characterised by the means for feeding the components to the mixer using capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/30—Injector mixers
    • B01F25/31—Injector mixers in conduits or tubes through which the main component flows
    • B01F25/314—Injector mixers in conduits or tubes through which the main component flows wherein additional components are introduced at the circumference of the conduit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/714—Feed mechanisms for feeding predetermined amounts
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71805—Feed mechanisms characterised by the means for feeding the components to the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/75—Discharge mechanisms
    • B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
    • B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/80—Forming a predetermined ratio of the substances to be mixed
    • B01F35/81—Forming mixtures with changing ratios or gradients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165—Specific details about hydrophobic, oleophobic surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
AT02022888T 2001-10-18 2002-10-14 Mikrodosier- und probennahmevorrichtung sowie mikrochip mit dieser vorrichtung ATE271919T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001320592 2001-10-18
JP2002278924 2002-09-25

Publications (1)

Publication Number Publication Date
ATE271919T1 true ATE271919T1 (de) 2004-08-15

Family

ID=26623967

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02022888T ATE271919T1 (de) 2001-10-18 2002-10-14 Mikrodosier- und probennahmevorrichtung sowie mikrochip mit dieser vorrichtung

Country Status (5)

Country Link
US (1) US20030077204A1 (de)
EP (1) EP1304167B1 (de)
AT (1) ATE271919T1 (de)
CA (1) CA2408692C (de)
DE (1) DE60200822T2 (de)

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US6875403B2 (en) * 2001-02-09 2005-04-05 Microchem Solutions Method and apparatus for reproducible sample injection on microfabricated devices
DE20317944U1 (de) * 2003-11-18 2004-03-11 Heiser, Volker, Dr. Probenträger für Moleküle
JP4646809B2 (ja) * 2003-12-26 2011-03-09 パナソニック株式会社 生体サンプル判別装置、生体サンプル判別方法、及び生体サンプル判別用プレート
US7592185B2 (en) 2004-02-17 2009-09-22 Molecular Bioproducts, Inc. Metering doses of sample liquids
WO2006062149A1 (ja) * 2004-12-08 2006-06-15 Matsushita Electric Industrial Co., Ltd. 生体サンプル分析用プレート
WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
US7731907B2 (en) * 2005-04-09 2010-06-08 Boehringer Ingelheim Microparts Gmbh Device and process for testing a sample liquid
EP1717585B1 (de) * 2005-04-28 2013-01-16 FUJIFILM Corporation Mikrochip und Analyseverfahren unter Verwendung desselben
CN101400432B (zh) * 2006-03-09 2012-02-15 积水化学工业株式会社 微量流体设备及微量液体稀释方法
EP2101917A1 (de) 2007-01-10 2009-09-23 Scandinavian Micro Biodevices A/S Mikrofluidische vorrichtung und mikrofluidisches system und verfahren zur testdurchführung
JP5052996B2 (ja) * 2007-08-22 2012-10-17 アイダエンジニアリング株式会社 電気泳動用マイクロ流路チップ及び電気泳動方法
WO2011028764A2 (en) 2009-09-02 2011-03-10 President And Fellows Of Harvard College Multiple emulsions created using jetting and other techniques
BR112013029729A2 (pt) * 2011-05-23 2017-01-24 Basf Se controle de emulsões, incluindo emulsões múltiplas
CN103764265A (zh) 2011-07-06 2014-04-30 哈佛学院院长等 多重乳剂和用于配制多重乳剂的技术
WO2013029159A1 (en) 2011-08-30 2013-03-07 The Royal Institution For The Advancement Of Learning / Mcgill University Method and system for pre-programmed self-power microfluidic circuits
CN103717553B (zh) * 2012-06-08 2015-08-19 积水化学工业株式会社 气体发生材料及微型泵
EP2902784B1 (de) 2012-09-28 2018-10-24 National Institute of Advanced Industrial Science and Technology Assayvorrichtung mit einem porösen medium
EP3132019A1 (de) * 2014-04-16 2017-02-22 The Charles Stark Draper Laboratory, Inc. Mikrofluidisches gewebemodell
US10309976B2 (en) 2014-06-30 2019-06-04 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
US10520521B2 (en) 2014-06-30 2019-12-31 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and program for sample analysis system
US10539582B2 (en) 2014-06-30 2020-01-21 Phc Holdings Corporation Substrate for sample analysis, sample analysis device, sample analysis system, and method for removing liquid from liquid that contains magnetic particles
JP6548645B2 (ja) 2014-06-30 2019-07-24 Ｐｈｃホールディングス株式会社 試料分析用基板および試料分析装置
WO2016093332A1 (ja) 2014-12-12 2016-06-16 パナソニックヘルスケアホールディングス株式会社 試料分析用基板、試料分析装置、試料分析システムおよび試料分析システム用プログラム
JP6924556B2 (ja) * 2016-04-12 2021-08-25 株式会社日立プラントサービス マイクロリアクタ、化成品製造システム及びマイクロリアクタの製造方法
US11185830B2 (en) 2017-09-06 2021-11-30 Waters Technologies Corporation Fluid mixer
JP7245242B2 (ja) 2019-04-22 2023-03-23 積水化学工業株式会社 チップ及び流体の合流方法
CN112108192B (zh) * 2019-06-19 2022-03-22 中国科学院大连化学物理研究所 一种微流控芯片及其应用
CN114207433B (zh) 2019-08-12 2025-01-14 沃特世科技公司 用于色谱系统的混合器
US11898999B2 (en) 2020-07-07 2024-02-13 Waters Technologies Corporation Mixer for liquid chromatography
WO2022010666A1 (en) 2020-07-07 2022-01-13 Waters Technologies Corporation Combination mixer arrangement for noise reduction in fluid chromatography
EP4217729B1 (de) 2020-09-22 2025-08-13 Waters Technologies Corporation Durchlaufmischer
US12399158B2 (en) 2021-05-20 2025-08-26 Waters Technologies Corporation Equal dispersion split-flow mixer
US12551858B2 (en) 2021-06-23 2026-02-17 Waters Technologies Corporation Passive solvent mixer for liquid chromatography
CN116651520A (zh) * 2023-05-08 2023-08-29 复旦大学 微流控芯片及微流控装置

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CN1173776C (zh) * 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US6143248A (en) * 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US6117396A (en) * 1998-02-18 2000-09-12 Orchid Biocomputer, Inc. Device for delivering defined volumes
EP1062042B1 (de) * 1998-03-11 2003-05-28 Steag MicroParts GmbH Probenträger
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US6875403B2 (en) * 2001-02-09 2005-04-05 Microchem Solutions Method and apparatus for reproducible sample injection on microfabricated devices

Also Published As

Publication number Publication date
DE60200822T2 (de) 2005-09-15
EP1304167B1 (de) 2004-07-28
EP1304167A1 (de) 2003-04-23
CA2408692C (en) 2007-01-30
DE60200822D1 (de) 2004-09-02
US20030077204A1 (en) 2003-04-24
CA2408692A1 (en) 2003-04-18

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