ATE272629T1 - Benzothiophene - Google Patents

Benzothiophene

Info

Publication number
ATE272629T1
ATE272629T1 AT98307627T AT98307627T ATE272629T1 AT E272629 T1 ATE272629 T1 AT E272629T1 AT 98307627 T AT98307627 T AT 98307627T AT 98307627 T AT98307627 T AT 98307627T AT E272629 T1 ATE272629 T1 AT E272629T1
Authority
AT
Austria
Prior art keywords
formula
compounds
benzothiophene
cervix
uterus
Prior art date
Application number
AT98307627T
Other languages
English (en)
Inventor
Jeffrey Alan Dodge
Mark Gregory Stocksdale
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE272629T1 publication Critical patent/ATE272629T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Bipolar Transistors (AREA)
  • Semiconductor Lasers (AREA)
AT98307627T 1997-09-23 1998-09-21 Benzothiophene ATE272629T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5962097P 1997-09-23 1997-09-23

Publications (1)

Publication Number Publication Date
ATE272629T1 true ATE272629T1 (de) 2004-08-15

Family

ID=22024136

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98307627T ATE272629T1 (de) 1997-09-23 1998-09-21 Benzothiophene

Country Status (8)

Country Link
EP (1) EP0905132B1 (de)
JP (1) JP2001517664A (de)
AT (1) ATE272629T1 (de)
AU (1) AU9493698A (de)
CA (1) CA2304138A1 (de)
DE (1) DE69825381T2 (de)
ES (1) ES2226072T3 (de)
WO (1) WO1999015521A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462647B2 (en) 2003-06-10 2008-12-09 Eli Lilly And Company Pentalfluoroalkanesulfinyl naphthalenes and related estrogen receptor modulators
ES2774935T3 (es) * 2012-10-24 2020-07-23 Univ Illinois Composiciones y métodos para tratar trastornos médicos relacionados con estrógeno
ES2857196T3 (es) 2012-10-24 2021-09-28 The Board Of Trustees Of The Univ Of Illionis Composiciones y métodos para tratar trastornos médicos relacionados con estrógenos
GB201311888D0 (en) * 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
WO2018053354A1 (en) 2016-09-15 2018-03-22 Arvinas, Inc. Indole derivatives as estrogen receptor degraders
IL266842B (en) 2016-12-01 2022-09-01 Arvinas Operations Inc History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists
WO2018140809A1 (en) * 2017-01-26 2018-08-02 Arvinas, Inc. Modulators of estrogen receptor proteolysis and associated methods of use
BR112019015484A2 (pt) 2017-01-31 2020-04-28 Arvinas Operations Inc ligantes de cereblon e compostos bifuncionais compreendendo os mesmos
JP2021512153A (ja) 2018-01-26 2021-05-13 イエール ユニバーシティ タンパク質分解のイミド系モジュレーターおよび使用方法
CA3152401A1 (en) 2019-08-26 2021-03-04 Arvinas Operations, Inc. Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders
CR20220353A (es) 2019-12-19 2022-10-20 Arvinas Operations Inc Compuestos y métodos para la degradación dirigida del receptor de andrógenos
CN116390916A (zh) 2020-09-14 2023-07-04 阿尔维纳斯运营股份有限公司 用于靶向降解雌激素受体的化合物的结晶形式
CN116813603B (zh) * 2023-06-02 2024-10-22 成都市第三人民医院 一种选择性雌激素受体α降解化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5589482A (en) * 1994-12-14 1996-12-31 Pfizer Inc. Benzo-thiophene estrogen agonists to treat prostatic hyperplasia
DE69600709T2 (de) * 1995-06-07 1999-03-18 Eli Lilly And Co., Indianapolis, Ind. Verbindungen mit N-Acyliertem Piperidin in der Seitenkette und Zusammensetzungen
US6444688B1 (en) * 1995-06-07 2002-09-03 Eli Lilly And Company Compounds and compositions with nitrogen-containing non-basic side chains
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
PT791591E (pt) * 1996-02-22 2001-12-28 Lilly Co Eli Benzotiofenos, formulacoes que os contem e metodos

Also Published As

Publication number Publication date
AU9493698A (en) 1999-04-12
JP2001517664A (ja) 2001-10-09
DE69825381D1 (de) 2004-09-09
EP0905132B1 (de) 2004-08-04
EP0905132A1 (de) 1999-03-31
WO1999015521A1 (en) 1999-04-01
DE69825381T2 (de) 2005-07-21
CA2304138A1 (en) 1999-04-01
ES2226072T3 (es) 2005-03-16

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties