ATE273715T1 - Alkyldextran-polyalcohol arzneimittel-komplexe - Google Patents
Alkyldextran-polyalcohol arzneimittel-komplexeInfo
- Publication number
- ATE273715T1 ATE273715T1 AT97924325T AT97924325T ATE273715T1 AT E273715 T1 ATE273715 T1 AT E273715T1 AT 97924325 T AT97924325 T AT 97924325T AT 97924325 T AT97924325 T AT 97924325T AT E273715 T1 ATE273715 T1 AT E273715T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyldextrane
- polyalcohol
- medicinal
- complexes
- spacer
- Prior art date
Links
- 150000005846 sugar alcohols Polymers 0.000 title abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 125000006850 spacer group Chemical group 0.000 abstract 2
- 229920002307 Dextran Polymers 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14442196 | 1996-06-06 | ||
| PCT/JP1997/001914 WO1997046260A1 (fr) | 1996-06-06 | 1997-06-05 | Complexes medicamenteux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273715T1 true ATE273715T1 (de) | 2004-09-15 |
Family
ID=15361795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97924325T ATE273715T1 (de) | 1996-06-06 | 1997-06-05 | Alkyldextran-polyalcohol arzneimittel-komplexe |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6436912B1 (de) |
| EP (1) | EP0916348B1 (de) |
| JP (1) | JP4137183B2 (de) |
| KR (1) | KR20000016558A (de) |
| CN (1) | CN1227499A (de) |
| AT (1) | ATE273715T1 (de) |
| AU (1) | AU723392B2 (de) |
| CA (1) | CA2257245A1 (de) |
| DE (1) | DE69730332T2 (de) |
| DK (1) | DK0916348T3 (de) |
| EA (1) | EA001550B1 (de) |
| ES (1) | ES2229354T3 (de) |
| ID (1) | ID18298A (de) |
| NO (1) | NO985666L (de) |
| PT (1) | PT916348E (de) |
| TW (1) | TW527183B (de) |
| WO (1) | WO1997046260A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH071238U (ja) * | 1993-06-11 | 1995-01-10 | 株式会社大井製作所 | ドアロック操作用のロッド連結装置 |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| EA003398B1 (ru) * | 1998-05-22 | 2003-04-24 | Дайити Фармасьютикал Ко., Лтд. | Лекарственный комплекс c полимерным носителем |
| CN1191093C (zh) | 1998-10-30 | 2005-03-02 | 第一制药株式会社 | Dds化合物及其测定方法 |
| US6677456B2 (en) | 1999-10-15 | 2004-01-13 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic taxan compound |
| MXPA02003797A (es) * | 1999-10-15 | 2002-12-13 | Daiichi Seiyaku Co | Compuestos de taxano pentaciclico. |
| US20030166513A1 (en) * | 2000-06-29 | 2003-09-04 | Akihiro Imura | Dds compound and process for the preparation thereof |
| AU2001271037A1 (en) * | 2000-07-13 | 2002-01-30 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing dds compounds |
| US20030092608A1 (en) * | 2001-08-21 | 2003-05-15 | Takayuki Kawaguchi | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| CA2508831C (en) * | 2002-12-13 | 2012-05-01 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| EP2478912B1 (de) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Konjugate von Auristatin mit gegen HER2- oder CD22-gerichtete Antikörper und deren therapeutische Verwendung |
| EP2382996B1 (de) * | 2005-02-18 | 2015-01-14 | The University of Tokushima | Lipidfilmstruktur enthaltend ein Polyoxyalkylenkettenhaltiges Lipidderivat |
| CN100516067C (zh) * | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
| WO2011150022A2 (en) | 2010-05-25 | 2011-12-01 | Syndevrx, Inc. | Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| ES2773710T3 (es) | 2012-10-11 | 2020-07-14 | Daiichi Sankyo Co Ltd | Enlazadores para conjugados de anticuerpo - fármaco |
| WO2014061277A1 (ja) | 2012-10-19 | 2014-04-24 | 第一三共株式会社 | 親水性構造を含むリンカーで結合させた抗体－薬物コンジュゲート |
| CA2908993C (en) | 2013-04-10 | 2023-05-23 | Syndevrx, Inc. | Metap2 inhibitors and methods of treating obesity |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| AU2014371934B2 (en) | 2013-12-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Anti-TROP2 antibody-drug conjugate |
| IL310627B2 (en) | 2014-01-31 | 2026-04-01 | Daiichi Sankyo Co Ltd | Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof |
| EP3130608B1 (de) * | 2014-04-10 | 2019-09-04 | Daiichi Sankyo Co., Ltd. | (anti-her2-antikörper)-arzneimittelkonjugat |
| KR102445502B1 (ko) * | 2014-04-10 | 2022-09-21 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
| CN116059395A (zh) | 2015-06-29 | 2023-05-05 | 第一三共株式会社 | 用于选择性制造抗体-药物缀合物的方法 |
| ES2893749T3 (es) | 2015-12-10 | 2022-02-10 | Syndevrx Inc | Derivados de fumagilol y polimorfos de los mismos |
| CA3239447A1 (en) | 2016-01-11 | 2017-07-20 | Syndevrx, Inc. | Treatment for tumors driven by metabolic dysfunction |
| KR20190066026A (ko) | 2016-10-07 | 2019-06-12 | 다이이찌 산쿄 가부시키가이샤 | 항 her2 항체-약물 콘주게이트 투여에 의한 내성암의 치료 |
| US11273155B2 (en) | 2016-12-12 | 2022-03-15 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and immune checkpoint inhibitor |
| JP6679762B2 (ja) | 2017-01-17 | 2020-04-15 | 第一三共株式会社 | 抗ｇｐｒ２０抗体及び抗ｇｐｒ２０抗体−薬物コンジュゲート |
| TW202532104A (zh) | 2017-05-15 | 2025-08-16 | 日商第一三共股份有限公司 | 抗體－藥物結合物及其用途 |
| IL324591A (en) | 2017-08-31 | 2026-01-01 | Daiichi Sankyo Co Ltd | Improved antibody-drug conjugate production methods |
| CA3074208C (en) | 2017-08-31 | 2023-10-03 | Daiichi Sankyo Company, Limited | Novel method for producing antibody-drug conjugate |
| SG11202010496WA (en) | 2018-05-18 | 2020-12-30 | Daiichi Sankyo Co Ltd | Anti-muc1 antibody-drug conjugate |
| WO2020022475A1 (ja) | 2018-07-27 | 2020-01-30 | 第一三共株式会社 | 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質 |
| CA3108044A1 (en) | 2018-07-31 | 2020-02-06 | Daiichi Sankyo Company, Limited | Treatment of metastatic brain tumor by administration of antibody-drug conjugate |
| JP2022512826A (ja) | 2018-10-26 | 2022-02-07 | シンデブルックス，インコーポレイティド | ＭｅｔＡＰ２阻害剤のバイオマーカーとその応用 |
| US11555019B2 (en) | 2019-07-10 | 2023-01-17 | Cybrexa 3, Inc. | Peptide conjugates of microtubule-targeting agents as therapeutics |
| MX2022000449A (es) | 2019-07-10 | 2022-04-25 | Cybrexa 2 Inc | Conjugados peptídicos de citotoxinas como terapéuticos. |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| TW202320858A (zh) | 2021-07-19 | 2023-06-01 | 美商薩諾管理公司 | 免疫接合物及方法 |
| EP4538276A1 (de) | 2022-07-11 | 2025-04-16 | Pinotbio, Inc. | Ddx5-proteinbindende camptothecinderivate und prodrugs davon |
| WO2025185559A1 (zh) * | 2024-03-04 | 2025-09-12 | 杭州中美华东制药有限公司 | 抗FGFR2b抗体、其抗体药物偶联物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59220197A (ja) | 1983-05-30 | 1984-12-11 | Snow Brand Milk Prod Co Ltd | 新規な含窒素多糖体およびその製造方法 |
| JP2604930B2 (ja) * | 1990-12-14 | 1997-04-30 | 株式会社ディ・ディ・エス研究所 | ヒアルロン酸およびコンドロイチン誘導体 |
| JPH0784481B2 (ja) | 1991-02-21 | 1995-09-13 | 株式会社デイ・デイ・エス研究所 | カルボキシメチルマンノグルカン及びその誘導体 |
| JP3359955B2 (ja) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
| ES2149867T3 (es) | 1993-02-26 | 2000-11-16 | Drug Delivery System Inst Ltd | Derivados de polisacaridos y soportes para farmacos. |
| JPH0784481A (ja) | 1993-06-26 | 1995-03-31 | Ricoh Co Ltd | 画像形成装置 |
| US5811510A (en) * | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| SG50747A1 (en) | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| EA003398B1 (ru) | 1998-05-22 | 2003-04-24 | Дайити Фармасьютикал Ко., Лтд. | Лекарственный комплекс c полимерным носителем |
| CN1191093C (zh) | 1998-10-30 | 2005-03-02 | 第一制药株式会社 | Dds化合物及其测定方法 |
-
1997
- 1997-05-31 TW TW086107455A patent/TW527183B/zh not_active IP Right Cessation
- 1997-06-05 KR KR1019980710148A patent/KR20000016558A/ko not_active Abandoned
- 1997-06-05 US US09/147,342 patent/US6436912B1/en not_active Expired - Fee Related
- 1997-06-05 DE DE69730332T patent/DE69730332T2/de not_active Expired - Lifetime
- 1997-06-05 WO PCT/JP1997/001914 patent/WO1997046260A1/ja not_active Ceased
- 1997-06-05 AU AU29787/97A patent/AU723392B2/en not_active Ceased
- 1997-06-05 EP EP97924325A patent/EP0916348B1/de not_active Expired - Lifetime
- 1997-06-05 ID IDP971928A patent/ID18298A/id unknown
- 1997-06-05 PT PT97924325T patent/PT916348E/pt unknown
- 1997-06-05 CA CA002257245A patent/CA2257245A1/en not_active Abandoned
- 1997-06-05 CN CN97197008A patent/CN1227499A/zh active Pending
- 1997-06-05 JP JP50042198A patent/JP4137183B2/ja not_active Expired - Fee Related
- 1997-06-05 DK DK97924325T patent/DK0916348T3/da active
- 1997-06-05 AT AT97924325T patent/ATE273715T1/de not_active IP Right Cessation
- 1997-06-05 ES ES97924325T patent/ES2229354T3/es not_active Expired - Lifetime
- 1997-06-05 EA EA199900004A patent/EA001550B1/ru not_active IP Right Cessation
-
1998
- 1998-12-04 NO NO985666A patent/NO985666L/no not_active Application Discontinuation
-
2002
- 2002-05-28 US US10/155,170 patent/US6838450B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU723392B2 (en) | 2000-08-24 |
| ES2229354T3 (es) | 2005-04-16 |
| EP0916348A1 (de) | 1999-05-19 |
| PT916348E (pt) | 2004-10-29 |
| NO985666L (no) | 1999-02-04 |
| DK0916348T3 (da) | 2004-12-06 |
| ID18298A (id) | 1998-03-26 |
| EA001550B1 (ru) | 2001-04-23 |
| TW527183B (en) | 2003-04-11 |
| EP0916348B1 (de) | 2004-08-18 |
| DE69730332T2 (de) | 2005-09-22 |
| US6838450B2 (en) | 2005-01-04 |
| CN1227499A (zh) | 1999-09-01 |
| NO985666D0 (no) | 1998-12-04 |
| US6436912B1 (en) | 2002-08-20 |
| JP4137183B2 (ja) | 2008-08-20 |
| AU2978797A (en) | 1998-01-05 |
| KR20000016558A (ko) | 2000-03-25 |
| DE69730332D1 (de) | 2004-09-23 |
| CA2257245A1 (en) | 1997-12-11 |
| EP0916348A4 (de) | 2000-11-29 |
| WO1997046260A1 (fr) | 1997-12-11 |
| EA199900004A1 (ru) | 1999-06-24 |
| US20030171262A1 (en) | 2003-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE273715T1 (de) | Alkyldextran-polyalcohol arzneimittel-komplexe | |
| NO301829B1 (no) | 2-pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og farmasöytiske preparater basert på disse | |
| CA2203694A1 (en) | Cancer inhibitory peptides | |
| ATE386808T1 (de) | Arzneimittelzubereitungen für die behandlung von alpha-galactosidase a-mangel | |
| IL96549A0 (en) | Production of a biologically active protein | |
| CA2192944A1 (en) | Stimulation of Hair Growth by Peptide-Copper Complexes | |
| RU94040170A (ru) | Изохинолины | |
| JPH02500276A (ja) | 創傷において生物学的複覆を誘導する方法 | |
| CA2144312A1 (en) | Unsaturated aliphatic dicarboxylic acids | |
| DE69124705D1 (de) | Hexapeptide als liganden des anaphylatoxin-rezeptors | |
| FI940375A0 (fi) | Peptidit, joilla on elimiä suojaavaa vaikutusta, menetelmä niiden valmistamiseksi ja niiden käyttö terapiassa | |
| RU95105977A (ru) | Комплексы включения солей нимезулида с циклодекстринами, способ их получения, фармацевтические композиции на их основе и способ лечения | |
| CA2052713A1 (en) | Delivery of agents | |
| AU1064988A (en) | Polymer complexes of metals useful as pharmaceutical agents | |
| CA2163197A1 (en) | Tri(platinum) complexes | |
| ATE363214T1 (de) | Löslicher natamycin-proteinkomplex | |
| DE69001334D1 (de) | Uebergangsmetall-tris-dithiolen und verwandte komplexe als vorprodukte fuer aktive katalysatoren. | |
| HU912010D0 (en) | Utilization of macroring amino-phosphonic acid complexes as transformation agents | |
| DE69513324D1 (de) | L-Lysyl-Glycyl-L-Histidin und entsprechende pharmazeutische Zusammensetzungen zur Wundheilung | |
| IT8868117A0 (it) | Solfonammidi di benzilidene canfora derivanti da amminoacidi e loro impiego in cosmesi particolarmente come filtri solari | |
| ATE25708T1 (de) | Biologisch aktive konjugate, ihre herstellung und ihre anwendung. | |
| FI933507A7 (fi) | Bisyklopolyatsamakrosyklofosfonihappoja, niiden komplekseja ja konjuga atteja käytettäväksi varjoaineina ja menetelmä niiden valmistamiseksi | |
| ATE137487T1 (de) | Komplexe, enthaltend s(+)-phenyl-alkansäuren und alpha-hydroxy-alkansäuren | |
| FI933506A7 (fi) | Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaat teja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina | |
| RU95101840A (ru) | Сложные эфиры циклогексанола и содержащий их фармацевтический препарат |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0916348 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |