ATE273952T1 - Verfahren und zwischenprodukte zur trennung von piperidylacetamid-stereoisomeren - Google Patents

Verfahren und zwischenprodukte zur trennung von piperidylacetamid-stereoisomeren

Info

Publication number
ATE273952T1
ATE273952T1 AT98922398T AT98922398T ATE273952T1 AT E273952 T1 ATE273952 T1 AT E273952T1 AT 98922398 T AT98922398 T AT 98922398T AT 98922398 T AT98922398 T AT 98922398T AT E273952 T1 ATE273952 T1 AT E273952T1
Authority
AT
Austria
Prior art keywords
stereoisomers
piperidylacetamide
separating
intermediate products
threo
Prior art date
Application number
AT98922398T
Other languages
English (en)
Inventor
Vikram Khetani
Yalin Luo
Sowmianarayanan Ramaswamy
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Application granted granted Critical
Publication of ATE273952T1 publication Critical patent/ATE273952T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
AT98922398T 1997-05-22 1998-05-18 Verfahren und zwischenprodukte zur trennung von piperidylacetamid-stereoisomeren ATE273952T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/861,988 US5936091A (en) 1997-05-22 1997-05-22 Processes and intermediates for resolving piperidyl acetamide stereoisomers
PCT/US1998/010131 WO1998052921A1 (en) 1997-05-22 1998-05-18 Processes and intermediates for resolving piperidyl acetamide stereoisomers

Publications (1)

Publication Number Publication Date
ATE273952T1 true ATE273952T1 (de) 2004-09-15

Family

ID=25337317

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04076158T ATE546429T1 (de) 1997-05-22 1998-05-18 Verfahren zur trennung von piperidylacetamid- stereoisomeren
AT98922398T ATE273952T1 (de) 1997-05-22 1998-05-18 Verfahren und zwischenprodukte zur trennung von piperidylacetamid-stereoisomeren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT04076158T ATE546429T1 (de) 1997-05-22 1998-05-18 Verfahren zur trennung von piperidylacetamid- stereoisomeren

Country Status (12)

Country Link
US (1) US5936091A (de)
EP (2) EP1506961B1 (de)
JP (1) JP4439595B2 (de)
AT (2) ATE546429T1 (de)
AU (1) AU735353B2 (de)
CA (1) CA2291170C (de)
CY (1) CY1113023T1 (de)
DE (1) DE69825746T2 (de)
DK (2) DK1506961T3 (de)
ES (2) ES2381361T3 (de)
PT (2) PT983238E (de)
WO (1) WO1998052921A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
US6486177B2 (en) * 1995-12-04 2002-11-26 Celgene Corporation Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate
US5922736A (en) * 1995-12-04 1999-07-13 Celegene Corporation Chronic, bolus administration of D-threo methylphenidate
US6962997B1 (en) * 1997-05-22 2005-11-08 Celgene Corporation Process and intermediates for resolving piperidyl acetamide steroisomers
US6127385A (en) * 1999-03-04 2000-10-03 Pharmaquest Limited Method of treating depression using l-threo-methylphenidate
US6395752B1 (en) * 1999-03-04 2002-05-28 Pharmaquest Limited Method of treating depression using 1-threo-methylphenidate
US20020187192A1 (en) * 2001-04-30 2002-12-12 Yatindra Joshi Pharmaceutical composition which reduces or eliminates drug abuse potential
US6638533B2 (en) 2002-01-03 2003-10-28 George Krsek Pulse dosage formulations of methylphenidate and method to prepare same
CH712083B1 (de) * 2003-02-05 2017-07-31 Siegfried Ag Verfahren zur Herstellung von d-threo-2-Phenyl-2-piperidin-2-yl-essigsäureestern.
US20050239830A1 (en) * 2004-04-26 2005-10-27 Vikram Khetani Methods of diminishing co-abuse potential
US20060127421A1 (en) * 2004-12-09 2006-06-15 Celgene Corporation Treatment using D-threo methylphenidate
CN101786982A (zh) * 2010-03-30 2010-07-28 华东师范大学 一种合成2-吡啶基苯乙腈的方法
KR20150029769A (ko) 2010-12-17 2015-03-18 로드스 테크놀로지즈 메틸페니데이트 염산염의 저온합성
US9233924B2 (en) 2014-03-11 2016-01-12 Ampac Fine Chemicals Llc Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof
US11440882B2 (en) 2016-07-18 2022-09-13 Harman Finochem Limited Process for the preparation of dexmethyl phenidate hydrochloride
CN115322141B (zh) * 2022-09-01 2024-04-16 凯特立斯（深圳）科技有限公司 一种不对称氢化制备手性哌甲酯类化合物的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2507631A (en) * 1944-01-19 1950-05-16 Ciba Pharm Prod Inc Pyridine and piperidine compounds and process of making same
US2957880A (en) * 1953-12-23 1960-10-25 Ciba Pharm Prod Inc Process for the conversion of stereoisomers

Also Published As

Publication number Publication date
JP4439595B2 (ja) 2010-03-24
EP1506961B1 (de) 2012-02-22
CA2291170C (en) 2008-09-16
AU7495598A (en) 1998-12-11
ES2381361T3 (es) 2012-05-25
AU735353B2 (en) 2001-07-05
CY1113023T1 (el) 2016-04-13
DK0983238T3 (da) 2004-11-29
PT983238E (pt) 2004-10-29
ES2226131T3 (es) 2005-03-16
EP0983238A4 (de) 2001-08-08
EP1506961A3 (de) 2007-01-03
HK1071895A1 (en) 2005-08-05
CA2291170A1 (en) 1998-11-26
DK1506961T3 (da) 2012-05-21
ATE546429T1 (de) 2012-03-15
JP2002515066A (ja) 2002-05-21
PT1506961E (pt) 2012-05-07
DE69825746D1 (de) 2004-09-23
EP0983238B1 (de) 2004-08-18
DE69825746T2 (de) 2005-08-18
EP1506961A2 (de) 2005-02-16
WO1998052921A1 (en) 1998-11-26
US5936091A (en) 1999-08-10
EP0983238A1 (de) 2000-03-08

Similar Documents

Publication Publication Date Title
ATE273952T1 (de) Verfahren und zwischenprodukte zur trennung von piperidylacetamid-stereoisomeren
ATE145891T1 (de) Verfahren zur herstellung von alkoxyiminoacetamid-derivaten und ein zwischenproduckt dafür
ATE162529T1 (de) Verfahren zur herstellung von verbrückten, chiralen metallocenkatalysatoren des types bisindenyl
DE69527429D1 (de) Verfahren zur herstellung von wasserfreien und hydrat-formen von antihistaminischen piperinderivaten, polymerphe und pseudomorphe davon
DE69513458D1 (de) Verfahren zur Herstellung von hochmolekularen Milchsäure-Copolyestern
ATE277999T1 (de) Verfahren zur herstellung von amin- umsetzungsprodukt-teilchen
ATE304531T1 (de) Verfahren und zwischenprodukte zur herstellung 2- substituierter piperidin-stereoisomere
ATE70064T1 (de) Verfahren zur herstellung von penemen.
DE69100196D1 (de) Verfahren zur herstellung von benzylaminen.
ATE125254T1 (de) Verfahren zur racematspaltung von 5-alkoxy- substituierten (+/-)-1,3- dimethyloxindolylethylaminen.
ATE156484T1 (de) Verfahren für die racemattrennung von zwischenprodukten, die bei der herstellung von 1,5-benzothiazepinen verwendbar sind
ATE200276T1 (de) Verfahren zur herstellung von diacylimiden
ATE233267T1 (de) Verfahren zur herstellung von 3- vinylcephalosporinen
DE69502145D1 (de) Verbessertes Verfahren zur Herstellung von Iodoniumsalzen
ATE167668T1 (de) Verfahren zur herstellung von guaniden
ATE171933T1 (de) Verfahren zur gleichzeitigen herstellung von dicarbonsäuren und diaminen aus polyamiden
ATE237583T1 (de) Verfahren zur herstellung von depsipeptiden und zwischenprodukten davon
ATE311382T1 (de) Verfahren zur herstellung von 2-carbamoyl- pyridinen
DE69330130D1 (de) Verfahren zur herstellung von optisch aktiven 1,4-dihydropyridinen
ATE146785T1 (de) Verfahren zur herstellung von diltiazem
ATE154022T1 (de) Verfahren zur herstellung von epibatidin
ATE139999T1 (de) Verfahren zur herstellung von fluormethyl- substituierter piperidin-carbodithioaten
ATE299498T1 (de) Verfahren zur herstellung von imidazolderivaten
DE69016380D1 (de) Verfahren zur Herstellung von molluskiziden 2,4,5-Tribrompyrrol-3-Carbonitrilen.
ATE126508T1 (de) Verfahren zur herstellung von 2,3- pyridindicarbonsäuren aus 3-(2-imidazolin-2- yl)picolinsäuren.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0983238

Country of ref document: EP