ATE275559T1 - Aromatische amin-derivate verwendbar als pharmazeutische mittel - Google Patents
Aromatische amin-derivate verwendbar als pharmazeutische mittelInfo
- Publication number
- ATE275559T1 ATE275559T1 AT99925183T AT99925183T ATE275559T1 AT E275559 T1 ATE275559 T1 AT E275559T1 AT 99925183 T AT99925183 T AT 99925183T AT 99925183 T AT99925183 T AT 99925183T AT E275559 T1 ATE275559 T1 AT E275559T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- aromatic amine
- pharmaceutical agents
- amine derivatives
- derivatives usable
- Prior art date
Links
- 150000004982 aromatic amines Chemical class 0.000 title abstract 2
- 239000008177 pharmaceutical agent Substances 0.000 title 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9811969.6A GB9811969D0 (en) | 1998-06-03 | 1998-06-03 | Chemical compounds |
| PCT/GB1999/001741 WO1999062901A1 (en) | 1998-06-03 | 1999-06-03 | Aromatic amine derivatives as pharmaceutical agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE275559T1 true ATE275559T1 (de) | 2004-09-15 |
Family
ID=10833164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99925183T ATE275559T1 (de) | 1998-06-03 | 1999-06-03 | Aromatische amin-derivate verwendbar als pharmazeutische mittel |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6110945A (de) |
| EP (1) | EP1084119B1 (de) |
| JP (1) | JP2002517391A (de) |
| AT (1) | ATE275559T1 (de) |
| AU (1) | AU765979B2 (de) |
| CA (1) | CA2331791A1 (de) |
| DE (1) | DE69920010T2 (de) |
| ES (1) | ES2228050T3 (de) |
| GB (1) | GB9811969D0 (de) |
| WO (1) | WO1999062901A1 (de) |
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| GB0327761D0 (en) * | 2003-11-29 | 2003-12-31 | Astrazeneca Ab | Compounds |
| GB0328178D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Compounds |
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| GB0423044D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
| KR20070085371A (ko) | 2004-10-16 | 2007-08-27 | 아스트라제네카 아베 | 페녹시 벤즈아미드 화합물의 제조 방법 |
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| KR101346902B1 (ko) * | 2005-07-09 | 2014-01-02 | 아스트라제네카 아베 | 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체 |
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| US9202182B2 (en) * | 2005-08-11 | 2015-12-01 | International Business Machines Corporation | Method and system for analyzing business architecture |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
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| TW200825063A (en) * | 2006-10-23 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
| TW200825060A (en) * | 2006-10-26 | 2008-06-16 | Astrazeneca Ab | Chemical compounds |
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| KR20170052526A (ko) | 2014-03-13 | 2017-05-12 | 프로테나 바이오사이언시즈 리미티드 | 다발성 경화증에 대한 병용 치료 |
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| EP3873605B1 (de) | 2018-10-30 | 2024-10-23 | Gilead Sciences, Inc. | Verbindungen zur inhibierung von alpha4-beta7-integrin |
| JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ， インコーポレイテッド | アルファ４ベータ７インテグリンの阻害のための化合物 |
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| AR016133A1 (es) * | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
| IL133639A0 (en) * | 1997-07-31 | 2001-04-30 | Elan Pharm Inc | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by vla-4 |
| AU8678698A (en) * | 1997-07-31 | 1999-02-22 | American Home Products Corporation | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
| JP2001512137A (ja) * | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Ｖｌａ−４により媒介される白血球の付着を阻害するジペプチド化合物 |
| KR20010022411A (ko) * | 1997-07-31 | 2001-03-15 | 진 엠. 듀발 | Ｖｌａ-4에 의해 매개되는 백혈구 부착을 억제하는 치환된페닐알라닌계의 화합물 |
| PL338457A1 (en) * | 1997-07-31 | 2000-11-06 | Elan Pharm Inc | Sulphonylated dipeptidic compounds capable to inhibit adhesion of leucocytes through the mediation of vla-4 |
| CN1276785A (zh) * | 1997-08-22 | 2000-12-13 | 霍夫曼-拉罗奇有限公司 | N－烷酰基苯丙氨酸衍生物 |
| EP1005445B1 (de) * | 1997-08-22 | 2004-05-26 | F. Hoffmann-La Roche Ag | N-alkanoylphenylalaninderivate |
| WO1999020272A1 (en) * | 1997-10-21 | 1999-04-29 | Merck & Co., Inc. | Azapeptide acids as cell adhesion inhibitors |
| CA2315370A1 (en) | 1997-12-17 | 1999-06-24 | Merck & Co., Inc. | Integrin receptor antagonists |
| US6197794B1 (en) * | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| US6329372B1 (en) * | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
| DE69919334T2 (de) * | 1998-02-26 | 2005-08-04 | Celltech Therapeutics Ltd., Slough | Phenylalaninderivate als inhibitoren von alpha4 integrinen |
| US6521626B1 (en) * | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
| GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9821406D0 (en) | 1998-10-01 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
| GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
| CN1334797A (zh) | 1998-12-14 | 2002-02-06 | 美国家用产品公司 | 抑制经vla－4介导的白细胞粘附的3,4－二氨基－3－环丁烯－1,2－二酮衍生物 |
| US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
-
1998
- 1998-06-03 GB GBGB9811969.6A patent/GB9811969D0/en not_active Ceased
-
1999
- 1999-06-02 US US09/323,966 patent/US6110945A/en not_active Expired - Fee Related
- 1999-06-03 AU AU41566/99A patent/AU765979B2/en not_active Ceased
- 1999-06-03 EP EP99925183A patent/EP1084119B1/de not_active Expired - Lifetime
- 1999-06-03 ES ES99925183T patent/ES2228050T3/es not_active Expired - Lifetime
- 1999-06-03 WO PCT/GB1999/001741 patent/WO1999062901A1/en not_active Ceased
- 1999-06-03 DE DE69920010T patent/DE69920010T2/de not_active Expired - Fee Related
- 1999-06-03 CA CA002331791A patent/CA2331791A1/en not_active Abandoned
- 1999-06-03 AT AT99925183T patent/ATE275559T1/de not_active IP Right Cessation
- 1999-06-03 JP JP2000552112A patent/JP2002517391A/ja active Pending
-
2000
- 2000-03-30 US US09/538,918 patent/US6369229B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2331791A1 (en) | 1999-12-09 |
| AU4156699A (en) | 1999-12-20 |
| EP1084119A1 (de) | 2001-03-21 |
| DE69920010T2 (de) | 2005-09-15 |
| US6110945A (en) | 2000-08-29 |
| ES2228050T3 (es) | 2005-04-01 |
| JP2002517391A (ja) | 2002-06-18 |
| GB9811969D0 (en) | 1998-07-29 |
| US6369229B1 (en) | 2002-04-09 |
| DE69920010D1 (de) | 2004-10-14 |
| AU765979B2 (en) | 2003-10-09 |
| EP1084119B1 (de) | 2004-09-08 |
| WO1999062901A1 (en) | 1999-12-09 |
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| Date | Code | Title | Description |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |