ATE276748T1 - Verfahren zur herstellung einer stabilen pharmazeutischen zusammensetzung enthaltend mikronisiertes formoterol - Google Patents

Verfahren zur herstellung einer stabilen pharmazeutischen zusammensetzung enthaltend mikronisiertes formoterol

Info

Publication number: ATE276748T1
Authority: AT; Austria
Prior art keywords: pharmaceutical composition; producing; stable pharmaceutical; composition containing; containing micronized
Prior art date: 2000-05-19

Application number

AT01932484T

Other languages

English (en)

Inventor

Eva Trofast

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-05-19

Filing date

2001-05-17

Publication date

2004-10-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9892016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE276748(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-05-17 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE276748T1 publication Critical patent/ATE276748T1/de

Links

BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title abstract 2
229960002848 formoterol Drugs 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000008101 lactose Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1
206010039083 rhinitis Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Otolaryngology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Saccharide Compounds (AREA)
Separation By Low-Temperature Treatments (AREA)

AT01932484T 2000-05-19 2001-05-17 Verfahren zur herstellung einer stabilen pharmazeutischen zusammensetzung enthaltend mikronisiertes formoterol ATE276748T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0012261.4A GB0012261D0 (en)	2000-05-19	2000-05-19	Novel process
PCT/SE2001/001117 WO2001089491A1 (en)	2000-05-19	2001-05-17	Novel process

Publications (1)

Publication Number	Publication Date
ATE276748T1 true ATE276748T1 (de)	2004-10-15

Family

ID=9892016

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01932484T ATE276748T1 (de)	2000-05-19	2001-05-17	Verfahren zur herstellung einer stabilen pharmazeutischen zusammensetzung enthaltend mikronisiertes formoterol

Country Status (19)

Country	Link
US (3)	US7179489B2 (de)
EP (1)	EP1289505B1 (de)
JP (3)	JP5739597B2 (de)
KR (1)	KR100799452B1 (de)
CN (1)	CN1245962C (de)
AT (1)	ATE276748T1 (de)
AU (2)	AU5900601A (de)
BR (1)	BRPI0110947B8 (de)
CA (1)	CA2409660C (de)
DE (1)	DE60105807T2 (de)
ES (1)	ES2227190T3 (de)
GB (1)	GB0012261D0 (de)
IL (2)	IL152532A0 (de)
MX (1)	MXPA02011310A (de)
NO (1)	NO20025220D0 (de)
NZ (1)	NZ522419A (de)
PT (1)	PT1289505E (de)
WO (1)	WO2001089491A1 (de)
ZA (1)	ZA200208710B (de)

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ES2165768B1 (es)	1999-07-14	2003-04-01	Almirall Prodesfarma Sa	Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US20030055026A1 (en)	2001-04-17	2003-03-20	Dey L.P.	Formoterol/steroid bronchodilating compositions and methods of use thereof
GB0219511D0 (en)	2002-08-21	2002-10-02	Norton Healthcare Ltd	Method of preparing dry powder inhalation compositions
NZ538965A (en)	2002-08-21	2006-11-30	Norton Healthcare Ltd	Dry powder inhalation compositions
US20040105821A1 (en) *	2002-09-30	2004-06-03	Howard Bernstein	Sustained release pharmaceutical formulation for inhalation
US7879833B2 (en)	2002-12-12	2011-02-01	Nycomed Gmbh	Combination medicament
US6962006B2 (en) *	2002-12-19	2005-11-08	Acusphere, Inc.	Methods and apparatus for making particles using spray dryer and in-line jet mill
US20040121003A1 (en) *	2002-12-19	2004-06-24	Acusphere, Inc.	Methods for making pharmaceutical formulations comprising deagglomerated microparticles
GB0312148D0 (en)	2003-05-28	2003-07-02	Aventis Pharma Ltd	Stabilized pharmaceutical products
GB0315889D0 (en)	2003-07-08	2003-08-13	Aventis Pharma Ltd	Stable pharmaceutical products
TWI359675B (en)	2003-07-10	2012-03-11	Dey L P	Bronchodilating β-agonist compositions
ES2284025T3 (es) *	2003-07-29	2007-11-01	Boehringer Ingelheim International Gmbh	Medicamentos para inhalar que comprenden betamimeticos y un anticolinergico.
PT1670482E (pt)	2003-09-16	2014-03-12	Takeda Gmbh	Utilização de ciclesonida para o tratamento de doenças respiratórias
GB0323684D0 (en)	2003-10-09	2003-11-12	Jagotec Ag	Improvements in or relating to organic compounds
WO2005123072A1 (en) *	2004-06-14	2005-12-29	Sepracor Inc.	Methods and compositions for the treatment of pulmonary diseases
MX2007009656A (es)	2005-02-10	2007-11-07	Glaxo Group Ltd	Proceso para elaborar lactosa utilizando tecnicas de clasificacion previa y formulaciones farmaceuticas formadas de la misma.
EP1978933A2 (de) *	2005-12-15	2008-10-15	Acusphere, Inc.	Verfahren zur herstellung von pharmazeutischen formulierungen auf teilchenbasis zur oralen verabreichung
US7913223B2 (en) *	2005-12-16	2011-03-22	Dialogic Corporation	Method and system for development and use of a user-interface for operations, administration, maintenance and provisioning of a telecommunications system
CN101342155B (zh) *	2007-07-11	2012-01-04	天津帝士力投资控股集团有限公司	一种(r,r)-福莫特罗吸入粉雾剂及其制备方法
EP2100599A1 (de)	2008-03-13	2009-09-16	Laboratorios Almirall, S.A.	Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
EP2100598A1 (de)	2008-03-13	2009-09-16	Laboratorios Almirall, S.A.	Inhalationszusammensetzung enthaltend Aclidinium zur Behandlung von Asthma sowie chronisch-obstruktiver Lungenerkrankung
WO2010144043A1 (en) *	2009-06-12	2010-12-16	Astrazeneca Ab	A novel 4-methylbenzenesulphonate salt and a process for preparing a pharmaceutical composition comprising the salt
GB0918149D0 (en)	2009-10-16	2009-12-02	Jagotec Ag	Improved medicinal aerosol formulation
EP2538922B1 (de) *	2010-02-25	2016-04-06	Andi-Ventis Limited	Formulierung von zusammensetzungen zur behandlung von entzündungserkrankungen
TR201007250A2 (tr) *	2010-09-01	2012-03-21	Bi̇lgi̇ç Mahmut	Selobioz içeren formülasyon.
EP2510928A1 (de)	2011-04-15	2012-10-17	Almirall, S.A.	Aclidinium zur Verbesserung der Schlafqualität bei atemwegserkrankten Patienten
WO2013109215A1 (en) *	2012-01-16	2013-07-25	Mahmut Bilgic	Preparation of dry powder formulations comprising formoterol
EP2804583A1 (de) *	2012-01-16	2014-11-26	Mahmut Bilgic	Trockenpulverformulierungen mit r-formoterol als wirkstoff
NZ629438A (en) *	2012-02-28	2016-10-28	Iceutica Holdings Inc	Inhalable pharmaceutical compositions
CA3150240A1 (en)	2019-09-24	2021-04-01	Tomaso GUIDI	Dry powder formulation for a dry powder inhaler, with a combination of spheronised particles and coarse particles, and a dry powder inhaler comprising the formulation

Family Cites Families (18)

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JP2514078B2 (ja) *	1988-08-22	1996-07-10	エスエス製薬株式会社	圧縮成型製剤
US5795564A (en) *	1991-04-05	1998-08-18	Sepracor, Inc.	Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US5874063A (en) *	1991-04-11	1999-02-23	Astra Aktiebolag	Pharmaceutical formulation
SE9302777D0 (sv) *	1993-08-27	1993-08-27	Astra Ab	Process for conditioning substances
EP0525388B1 (de) *	1991-07-01	1995-09-20	Gerhard Dr. Gergely	Lutsch- oder Kautablette
JPH0558911A (ja) *	1991-08-27	1993-03-09	N D Shinyaku Kaihatsu Kenkyusho:Kk	鎮咳去痰剤
DK0613371T3 (da)	1991-12-18	2002-05-13	Astrazeneca Ab	Ny kombination af formoterol og budesonid
SE9404080L (sv) *	1993-12-28	1995-06-29	Ciba Geigy Ag	Förfarande för framställning av en optiskt ren enantiomer av formoterol
SE9700136D0 (sv) *	1997-01-20	1997-01-20	Astra Ab	New formulation
SE9700134D0 (sv) *	1997-01-20	1997-01-20	Astra Ab	New formulation
SE9700133D0 (sv) *	1997-01-20	1997-01-20	Astra Ab	New formulation
SE9700135D0 (sv)	1997-01-20	1997-01-20	Astra Ab	New formulation
SE9703407D0 (sv)	1997-09-19	1997-09-19	Astra Ab	New use
SE9802073D0 (sv) *	1998-06-11	1998-06-11	Astra Ab	New use
PL200941B1 (pl)	1998-11-13	2009-02-27	Jagotec Ag	Suchy proszkowy preparat inhalacyjny
US6034604A (en) *	1999-01-14	2000-03-07	Kaltner; George	Deactivation prevention for electronic article surveillance systems
PE20011227A1 (es)	2000-04-17	2002-01-07	Chiesi Farma Spa	Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
GB0012260D0 (en) *	2000-05-19	2000-07-12	Astrazeneca Ab	Novel composition

2000
- 2000-05-19 GB GBGB0012261.4A patent/GB0012261D0/en not_active Ceased
2001
- 2001-05-17 CA CA2409660A patent/CA2409660C/en not_active Expired - Lifetime
- 2001-05-17 AT AT01932484T patent/ATE276748T1/de active
- 2001-05-17 BR BRPI0110947A patent/BRPI0110947B8/pt not_active IP Right Cessation
- 2001-05-17 CN CNB018097227A patent/CN1245962C/zh not_active Expired - Lifetime
- 2001-05-17 JP JP2001585736A patent/JP5739597B2/ja not_active Expired - Lifetime
- 2001-05-17 ES ES01932484T patent/ES2227190T3/es not_active Expired - Lifetime
- 2001-05-17 MX MXPA02011310A patent/MXPA02011310A/es active IP Right Grant
- 2001-05-17 IL IL15253201A patent/IL152532A0/xx active IP Right Grant
- 2001-05-17 WO PCT/SE2001/001117 patent/WO2001089491A1/en not_active Ceased
- 2001-05-17 DE DE60105807T patent/DE60105807T2/de not_active Expired - Lifetime
- 2001-05-17 AU AU5900601A patent/AU5900601A/xx active Pending
- 2001-05-17 PT PT01932484T patent/PT1289505E/pt unknown
- 2001-05-17 KR KR1020027015533A patent/KR100799452B1/ko not_active Expired - Lifetime
- 2001-05-17 NZ NZ522419A patent/NZ522419A/en not_active IP Right Cessation
- 2001-05-17 US US10/276,458 patent/US7179489B2/en not_active Expired - Lifetime
- 2001-05-17 AU AU2001259006A patent/AU2001259006B2/en not_active Expired
- 2001-05-17 EP EP01932484A patent/EP1289505B1/de not_active Revoked
2002
- 2002-10-28 ZA ZA200208710A patent/ZA200208710B/xx unknown
- 2002-10-31 NO NO20025220A patent/NO20025220D0/no not_active Application Discontinuation
2007
- 2007-01-25 US US11/627,051 patent/US7670625B2/en not_active Expired - Fee Related
2010
- 2010-01-14 US US12/687,691 patent/US20100183729A1/en not_active Abandoned
2012
- 2012-05-14 IL IL219785A patent/IL219785A/en active IP Right Grant
- 2012-11-27 JP JP2012258478A patent/JP2013040214A/ja active Pending
2014
- 2014-12-04 JP JP2014246231A patent/JP2015042693A/ja active Pending

Also Published As

Publication number	Publication date
US20030129245A1 (en)	2003-07-10
JP5739597B2 (ja)	2015-06-24
US7179489B2 (en)	2007-02-20
DE60105807T2 (de)	2005-11-24
KR20030001514A (ko)	2003-01-06
PT1289505E (pt)	2005-01-31
US20070259048A1 (en)	2007-11-08
WO2001089491A1 (en)	2001-11-29
AU5900601A (en)	2001-12-03
BR0110947A (pt)	2003-04-29
NZ522419A (en)	2003-08-29
IL219785A (en)	2015-10-29
MXPA02011310A (es)	2003-04-25
ZA200208710B (en)	2004-02-10
IL152532A0 (en)	2003-06-24
CA2409660A1 (en)	2001-11-29
AU2001259006B2 (en)	2005-03-24
BRPI0110947B8 (pt)	2021-05-25
ES2227190T3 (es)	2005-04-01
CN1245962C (zh)	2006-03-22
CN1429103A (zh)	2003-07-09
DE60105807D1 (de)	2004-10-28
KR100799452B1 (ko)	2008-01-30
EP1289505A1 (de)	2003-03-12
JP2015042693A (ja)	2015-03-05
JP2013040214A (ja)	2013-02-28
US20100183729A1 (en)	2010-07-22
NO20025220L (no)	2002-10-31
US7670625B2 (en)	2010-03-02
NO20025220D0 (no)	2002-10-31
EP1289505B1 (de)	2004-09-22
GB0012261D0 (en)	2000-07-12
JP2003534272A (ja)	2003-11-18
CA2409660C (en)	2011-02-08
BRPI0110947B1 (pt)	2016-12-27
IL219785A0 (en)	2012-06-28

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2005-04-15

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Publication	Publication Date	Title
ATE276748T1 (de)	2004-10-15	Verfahren zur herstellung einer stabilen pharmazeutischen zusammensetzung enthaltend mikronisiertes formoterol
IL152470A0 (en)	2003-06-24	Pharmaceutical composition comprising micronised formoterol and micronised glucocorticosteroid
AU2001295760A1 (en)	2002-04-29	Pharmaceutical composition comprising resveratrol for treating inflammatory respiratory disorders
NO20024708D0 (no)	2002-10-01	Behandling av respiratoriske sykdommer
MY145166A (en)	2011-12-30	Novel tiotropium salts, process for the preparation and pharmaceutical compositions thereof
MY143364A (en)	2011-04-29	Method for producing tiotropium salts
SE9900834D0 (sv)	1999-03-09	Novel combination
MXPA04007294A (es)	2004-10-29	Composicion para inhalacion.
WO2005011615A3 (en)	2007-04-19	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
DE60321551D1 (de)	2008-07-24	Verfahren zur herstellung einer pharmazeutischen zusammensetzung aus mycobakterium w bei der behandlung von asthma (obstruktiver lungenerkrankung)
WO2002095008A3 (en)	2003-11-06	Methods of modulating surfactant phospholipid production
WO2002078618A3 (en)	2003-12-18	Methods of modulating surfactant production