ATE277011T1 - Flouride von 4-substituierten piperidin-derivaten - Google Patents
Flouride von 4-substituierten piperidin-derivatenInfo
- Publication number
- ATE277011T1 ATE277011T1 AT00906631T AT00906631T ATE277011T1 AT E277011 T1 ATE277011 T1 AT E277011T1 AT 00906631 T AT00906631 T AT 00906631T AT 00906631 T AT00906631 T AT 00906631T AT E277011 T1 ATE277011 T1 AT E277011T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted piperidine
- flouride
- piperidine derivatives
- hydrates
- pharmaceutically acceptable
- Prior art date
Links
- -1 4-SUBSTITUTED PIPERIDINE Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000012440 Acetylcholinesterase Human genes 0.000 abstract 1
- 108010022752 Acetylcholinesterase Proteins 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- 229940022698 acetylcholinesterase Drugs 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5575599 | 1999-03-03 | ||
| PCT/JP2000/001232 WO2000051985A1 (en) | 1999-03-03 | 2000-03-02 | Fluorides of 4-substituted piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277011T1 true ATE277011T1 (de) | 2004-10-15 |
Family
ID=13007671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00906631T ATE277011T1 (de) | 1999-03-03 | 2000-03-02 | Flouride von 4-substituierten piperidin-derivaten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6677330B1 (de) |
| EP (1) | EP1157989B1 (de) |
| KR (1) | KR100694682B1 (de) |
| AT (1) | ATE277011T1 (de) |
| AU (1) | AU2825600A (de) |
| DE (1) | DE60014043T2 (de) |
| WO (1) | WO2000051985A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016105A1 (en) * | 1999-09-01 | 2001-03-08 | Eisai Co., Ltd. | 4-substituted piperidine derivatives |
| US6906083B2 (en) * | 2000-06-21 | 2005-06-14 | Eisai Co., Ltd. | 4-substituted piperidine compound |
| WO2002002526A1 (fr) * | 2000-07-03 | 2002-01-10 | Eisai Co., Ltd. | Compositions pharmaceutiques servant a stabiliser la tension intraoculaire |
| KR100659679B1 (ko) * | 2000-09-01 | 2006-12-21 | 에자이 가부시키가이샤 | 1-벤질-4-[(5,6-디메톡시-2-플루오로-1-인다논)-2-일]메틸피페리딘 |
| EP1466625A4 (de) * | 2001-12-28 | 2007-07-18 | Takeda Pharmaceutical | Vorbeugungs-/heilmittel für blasenstörungen |
| US20050107432A1 (en) * | 2002-01-22 | 2005-05-19 | Yoichi Iimura | Sigma receptor binder containing indanone derivative |
| AU2007333586A1 (en) * | 2006-12-11 | 2008-06-19 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using indanone based cholinesterase inhibitors |
| KR101454362B1 (ko) * | 2008-03-24 | 2014-10-23 | 아이큐어 주식회사 | 도네페질을 유효성분으로 함유하는 치매 치료용경피흡수제제 |
| EP3034079B1 (de) | 2010-11-15 | 2018-01-10 | Agenebio, Inc. | Pyridazinderivate, zusammensetzungen und verfahren zur behandlung von kognitiven störungen |
| US9249098B2 (en) * | 2012-07-10 | 2016-02-02 | Xueheng Cheng | Derivatives of donepezil |
| CN103787954B (zh) * | 2012-10-26 | 2016-01-20 | 中国科学院上海药物研究所 | 一类氟取代的环状胺类化合物及其制备方法、药物组合物和用途 |
| NZ760341A (en) | 2013-12-20 | 2021-12-24 | Agenebio Inc | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| MX392119B (es) | 2015-06-19 | 2025-03-11 | Agenebio Inc | Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo |
| KR101714575B1 (ko) * | 2015-10-15 | 2017-03-09 | 국방과학연구소 | 피리디니움 옥심 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 약학적 조성물 |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CN112601749B (zh) | 2018-06-19 | 2024-03-26 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法 |
| CN120584115A (zh) | 2022-08-19 | 2025-09-02 | 艾吉因生物股份有限公司 | 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK623586A (da) * | 1985-12-27 | 1987-06-28 | Eisai Co Ltd | Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne |
| FI95572C (fi) * | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| JP3075566B2 (ja) * | 1990-05-15 | 2000-08-14 | エーザイ株式会社 | 光学活性インダノン誘導体 |
| TW197435B (de) * | 1990-11-22 | 1993-01-01 | Takeda Pharm Industry Co Ltd | |
| EP0535496A1 (de) | 1991-09-25 | 1993-04-07 | Hoechst-Roussel Pharmaceuticals Incorporated | (1-Indanon-2-yl)Methylpiperidine, Zwischenprodukte und Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JPH07133274A (ja) | 1993-11-09 | 1995-05-23 | Sankyo Co Ltd | ピロール誘導体 |
| WO1997046526A1 (en) * | 1996-06-07 | 1997-12-11 | Eisai Co., Ltd. | Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production |
| US6277866B1 (en) * | 1999-03-03 | 2001-08-21 | Eisai Co., Ltd. | 1-benzyl-4[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine |
| DE10104415A1 (de) | 2001-02-01 | 2002-08-29 | Heidelberger Druckmasch Ag | Verfahren und Vorrichtung zur Handhabung einer zu belichtenden Belichtungsfläche, insbesondere einer Druckplatte |
| US6696802B1 (en) | 2002-08-22 | 2004-02-24 | Fusion Uv Systems Inc. | Radio frequency driven ultra-violet lamp |
| US7154919B2 (en) | 2003-06-02 | 2006-12-26 | Fujikura Ltd. | Optical fiber laser and laser light emitting method |
-
2000
- 2000-03-02 US US09/914,581 patent/US6677330B1/en not_active Expired - Fee Related
- 2000-03-02 AT AT00906631T patent/ATE277011T1/de not_active IP Right Cessation
- 2000-03-02 WO PCT/JP2000/001232 patent/WO2000051985A1/ja not_active Ceased
- 2000-03-02 AU AU28256/00A patent/AU2825600A/en not_active Abandoned
- 2000-03-02 KR KR1020017011037A patent/KR100694682B1/ko not_active Expired - Fee Related
- 2000-03-02 DE DE60014043T patent/DE60014043T2/de not_active Expired - Lifetime
- 2000-03-02 EP EP00906631A patent/EP1157989B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1157989A1 (de) | 2001-11-28 |
| KR20010102440A (ko) | 2001-11-15 |
| US6677330B1 (en) | 2004-01-13 |
| WO2000051985A1 (en) | 2000-09-08 |
| EP1157989A4 (de) | 2002-05-29 |
| AU2825600A (en) | 2000-09-21 |
| EP1157989B1 (de) | 2004-09-22 |
| KR100694682B1 (ko) | 2007-03-13 |
| DE60014043D1 (de) | 2004-10-28 |
| DE60014043T2 (de) | 2005-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |