ATE277624T1 - Kovalent gebundenes n,o-carboxymethylchitosan und seine verwendungen - Google Patents

Kovalent gebundenes n,o-carboxymethylchitosan und seine verwendungen

Info

Publication number
ATE277624T1
ATE277624T1 AT98922090T AT98922090T ATE277624T1 AT E277624 T1 ATE277624 T1 AT E277624T1 AT 98922090 T AT98922090 T AT 98922090T AT 98922090 T AT98922090 T AT 98922090T AT E277624 T1 ATE277624 T1 AT E277624T1
Authority
AT
Austria
Prior art keywords
nocc
carboxymethyl
chitosane
compositions
covalently bonded
Prior art date
Application number
AT98922090T
Other languages
English (en)
Inventor
Clive M Elson
Original Assignee
Chitogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chitogenics Inc filed Critical Chitogenics Inc
Application granted granted Critical
Publication of ATE277624T1 publication Critical patent/ATE277624T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
    • C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
AT98922090T 1997-05-06 1998-05-04 Kovalent gebundenes n,o-carboxymethylchitosan und seine verwendungen ATE277624T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/852,005 US5888988A (en) 1995-05-08 1997-05-06 Covalently linked N,O-carboxymethylchitosan and uses thereof
PCT/US1998/009001 WO1998050050A1 (en) 1997-05-06 1998-05-04 Covalently linked n,o-carboxymethylchitosan and uses thereof

Publications (1)

Publication Number Publication Date
ATE277624T1 true ATE277624T1 (de) 2004-10-15

Family

ID=25312270

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98922090T ATE277624T1 (de) 1997-05-06 1998-05-04 Kovalent gebundenes n,o-carboxymethylchitosan und seine verwendungen

Country Status (8)

Country Link
US (1) US5888988A (de)
EP (1) EP1003526B1 (de)
JP (1) JP2001524156A (de)
AT (1) ATE277624T1 (de)
CA (1) CA2288983C (de)
DE (1) DE69826684T2 (de)
ES (1) ES2230692T3 (de)
WO (1) WO1998050050A1 (de)

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US6645947B1 (en) * 1999-05-20 2003-11-11 Chitogenics, Inc. Adhesive N, O-carboxymethylchitosan coatings which inhibit attachment of substrate-dependent cells and proteins
WO2001024840A1 (en) 1999-10-07 2001-04-12 Coloplast A/S Wound care device
KR20010107068A (ko) * 2000-05-25 2001-12-07 김정식 유착방지제
WO2003082163A1 (en) * 2002-03-28 2003-10-09 Chitogenics, Inc. Adherent n,o-carboxymethylchitosan drug delivery devices for moist tissue and methods of their use
US7456267B2 (en) * 2004-03-25 2008-11-25 Kytogenics Pharmaceuticals, Inc. N-acylated chitinous polymers and methods of use thereof
JP5060131B2 (ja) * 2004-09-07 2012-10-31 中外製薬株式会社 水溶性ヒアルロン酸修飾物の製造方法
CA2481491A1 (en) * 2004-09-14 2006-03-14 Le Groupe Lysac Inc. Amidinated or guanidinated polysaccharides, their use as absorbents and a process for producing same
TW200643033A (en) * 2005-03-08 2006-12-16 Chugai Pharmaceutical Co Ltd Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue
US9119901B2 (en) 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
US20070031467A1 (en) * 2005-08-04 2007-02-08 Abrahams John M Composition and method for vascular embolization
US20080075657A1 (en) * 2006-04-18 2008-03-27 Abrahams John M Biopolymer system for tissue sealing
US20070243130A1 (en) * 2006-04-18 2007-10-18 Weiliam Chen Biopolymer system for tissue sealing
US20090010982A1 (en) * 2006-04-18 2009-01-08 Endomedix, Inc. Biocompatible adherent sheet for tissue sealing
US7854923B2 (en) 2006-04-18 2010-12-21 Endomedix, Inc. Biopolymer system for tissue sealing
NZ583819A (en) 2007-08-28 2012-08-31 Medtronic Xomed Inc Polymer comprising a dicarboxy-derivatised chitosan polymer cross-linked to an aldehyde-derivatised dextran polymer useful for preventing tissue adhesion and for promoting wound healing
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
TWI399385B (zh) * 2009-12-29 2013-06-21 Univ Vanung Chitosan Derivatives and Their Preparation
EP2737902A1 (de) * 2012-11-28 2014-06-04 Zarzatech, Inc. Zusammensetzungen mit Cimetindin und n,o-Carboxymethylchitosan zur Prävention und Therapie von Pathologien der Haut und der Mukosemembranen und im Feld der Zahnheilkunde
CN106046397A (zh) * 2016-06-28 2016-10-26 深圳市阳光之路生物材料科技有限公司 一种关节润滑材料及其制备方法
US10590257B2 (en) 2016-09-26 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Biomimetic, moldable, self-assembled cellulose silica-based trimeric hydrogels and their use as viscosity modifying carriers in industrial applications
US11975123B2 (en) 2018-04-02 2024-05-07 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
US11969526B2 (en) 2017-04-03 2024-04-30 The Board Of Trustees Of The Leland Stanford Junior University Adhesion prevention with shear-thinning polymeric hydrogels
WO2020072495A1 (en) 2018-10-01 2020-04-09 The Board Of Trustees Of The Leland Stanford Junior University Injectable hydrogels for controlled release of immunomodulatory compounds
US10517988B1 (en) 2018-11-19 2019-12-31 Endomedix, Inc. Methods and compositions for achieving hemostasis and stable blood clot formation
EP3883615B1 (de) 2018-11-19 2024-06-12 Endomedix, Inc. Verfahren und zusammensetzungen zur erzielung von hämostase und stabiler blutgerinnselbildung
CN115054734B (zh) * 2022-07-05 2024-01-05 诺一迈尔(山东)医学科技有限公司 一种可塑性复合骨修复支架及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4424346A (en) * 1981-06-04 1984-01-03 Canadian Patents And Development Ltd. Derivatives of chitins, chitosans and other polysaccharides
SE456346B (sv) * 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4619995A (en) * 1984-12-24 1986-10-28 Nova Chem Limited N,O-carboxymethyl chitosan and preparative method therefor
US4819617A (en) * 1986-09-04 1989-04-11 University Of Florida Viscoelastic material for ophthalmic surgery
US5080893A (en) * 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
US5023090A (en) * 1989-08-16 1991-06-11 Levin Robert H Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE
US5140016A (en) * 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5093319A (en) * 1989-10-31 1992-03-03 Pfizer Hospital Products Group, Inc. Use of derivatives of chitin soluble in aqueous solutions for preventing adhesions
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5412084A (en) * 1991-10-09 1995-05-02 Nova Chem Limited N-O-carboxymethylchitosonium carboxylate salts
JPH0826081B2 (ja) * 1991-12-20 1996-03-13 ハウメディカ・インコーポレーテッド キトサンのｎ−カルボキシアルキル誘導体を不溶化する方法
US5411988A (en) * 1993-10-27 1995-05-02 Bockow; Barry I. Compositions and methods for inhibiting inflammation and adhesion formation
EP0665022A1 (de) * 1994-01-28 1995-08-02 Prodex, Inc. Viskoelastische Lösung aus N,O-Carboxymethylchitosan zur opthalmischen Verwendung
GB9421969D0 (en) * 1994-10-28 1994-12-21 Innovative Tech Ltd Wound treatment composition
US5679658A (en) * 1995-05-08 1997-10-21 Chitogenics, Inc. N,O-carbonxymethylchitosan for prevention of surgical adhesions
JPH11507697A (ja) * 1995-06-09 1999-07-06 エヌ． ドロハン，ウィリアム キチンヒドロゲル、それらの製造方法及び利用
CA2192725C (en) * 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives

Also Published As

Publication number Publication date
EP1003526B1 (de) 2004-09-29
CA2288983C (en) 2010-07-20
WO1998050050A1 (en) 1998-11-12
US5888988A (en) 1999-03-30
DE69826684D1 (de) 2004-11-04
CA2288983A1 (en) 1998-11-12
DE69826684T2 (de) 2005-10-06
JP2001524156A (ja) 2001-11-27
EP1003526A1 (de) 2000-05-31
EP1003526A4 (de) 2000-05-31
ES2230692T3 (es) 2005-05-01

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Legal Events

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