ATE278032T1 - Verfahren zur fermentativen herstellung von deacylierten cephalosporinen - Google Patents

Verfahren zur fermentativen herstellung von deacylierten cephalosporinen

Info

Publication number
ATE278032T1
ATE278032T1 AT98924209T AT98924209T ATE278032T1 AT E278032 T1 ATE278032 T1 AT E278032T1 AT 98924209 T AT98924209 T AT 98924209T AT 98924209 T AT98924209 T AT 98924209T AT E278032 T1 ATE278032 T1 AT E278032T1
Authority
AT
Austria
Prior art keywords
fermentative production
deacylated
cephalosporins
deacylated cephalosporins
production
Prior art date
Application number
AT98924209T
Other languages
English (en)
Inventor
Maarten Nieboer
Vroom Erik De
Johannis Lugtenburg
Dirk Schipper
Andrianus Wilhelmus Vollebregt
Roelof Ary Lans Bovenberg
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE278032T1 publication Critical patent/ATE278032T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT98924209T 1997-04-22 1998-04-22 Verfahren zur fermentativen herstellung von deacylierten cephalosporinen ATE278032T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97201196 1997-04-22
PCT/EP1998/002460 WO1998048034A1 (en) 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins

Publications (1)

Publication Number Publication Date
ATE278032T1 true ATE278032T1 (de) 2004-10-15

Family

ID=8228236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98924209T ATE278032T1 (de) 1997-04-22 1998-04-22 Verfahren zur fermentativen herstellung von deacylierten cephalosporinen

Country Status (14)

Country Link
US (1) US6518039B2 (de)
EP (1) EP0912754B1 (de)
JP (1) JP2000512511A (de)
KR (1) KR20000022108A (de)
CN (2) CN1224468A (de)
AT (1) ATE278032T1 (de)
AU (1) AU7648898A (de)
BR (1) BR9804857A (de)
DE (1) DE69826604D1 (de)
PL (1) PL330759A1 (de)
RU (1) RU2208644C2 (de)
TW (1) TW565613B (de)
WO (1) WO1998048034A1 (de)
ZA (1) ZA983394B (de)

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US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7148054B2 (en) 1997-01-17 2006-12-12 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US7390619B1 (en) 1998-02-11 2008-06-24 Maxygen, Inc. Optimization of immunomodulatory properties of genetic vaccines
JP2002522072A (ja) 1998-08-12 2002-07-23 マキシジェン， インコーポレイテッド 工業用化学薬品の製造のためのモノオキシゲナーゼ遺伝子のｄｎａシャッフリング。
JP2002526107A (ja) 1998-10-07 2002-08-20 マキシジェン， インコーポレイテッド マイコトキシンの解毒のための核酸を生成するためのｄｎａシャッフリング
WO2000028018A1 (en) 1998-11-10 2000-05-18 Maxygen, Inc. Modified adp-glucose pyrophosphorylase for improvement and optimization of plant phenotypes
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
ES2341217T3 (es) 1999-01-19 2010-06-17 Maxygen, Inc. Recombinacion de acidos nucleicos mediada por oligonucleotidos.
US7024312B1 (en) 1999-01-19 2006-04-04 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
JP2003524394A (ja) 1999-02-11 2003-08-19 マキシジェン， インコーポレイテッド ハイスループット質量分析法
US6531316B1 (en) 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
US7430477B2 (en) 1999-10-12 2008-09-30 Maxygen, Inc. Methods of populating data structures for use in evolutionary simulations
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
US7115712B1 (en) 1999-12-02 2006-10-03 Maxygen, Inc. Cytokine polypeptides
IL150291A0 (en) 2000-01-11 2002-12-01 Maxygen Inc Integrated systems and methods for diversity generation and screening
WO2002000897A2 (en) 2000-06-23 2002-01-03 Maxygen, Inc. Novel chimeric promoters
EP1360290A2 (de) 2000-06-23 2003-11-12 Maxygen, Inc. Costimulierende moleküle
US6858422B2 (en) 2000-07-13 2005-02-22 Codexis, Inc. Lipase genes
CN101555463B (zh) * 2008-04-08 2012-05-30 中国科学院上海生命科学研究院湖州工业生物技术中心 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法
EP2123772A1 (de) 2008-04-29 2009-11-25 DSM IP Assets B.V. Beta-Lactamantibiotikum produzierende Stämme
EP2310487A2 (de) 2008-08-05 2011-04-20 DSM IP Assets B.V. Adipoyl-7-adca produzierende stämme
EP2310488B1 (de) 2008-08-05 2012-09-19 DSM Sinochem Pharmaceuticals Netherlands B.V. Adipoyl-7-adca produzierende stämme
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
WO2011161004A1 (en) 2010-06-22 2011-12-29 Dsm Ip Assets B.V. Air bubble fermentation process
WO2012117038A1 (en) 2011-03-03 2012-09-07 Dsm Sinochem Pharmaceuticals Netherlands B.V. Degradation of penicillin compounds
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
US10208755B2 (en) * 2014-08-08 2019-02-19 Baker Hughes, A Ge Company, Llc Magnetic coupling for motor drive shaft of electrical submersible pump

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5671092A (en) * 1979-11-14 1981-06-13 Kyowa Hakko Kogyo Co Ltd Optical active cephalosporin analogous derivative
EP0045717B1 (de) * 1980-08-01 1985-09-25 BIOCHEMIE Gesellschaft m.b.H. Cephalosporinderivate, ihre Herstellung und Anwendung
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
PT97116B (pt) 1990-03-23 1998-10-30 Gist Brocades Nv Processo para modular a producao de metabolitos secundarios nomeadamente derivados de beta-lactama
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
ES2194873T3 (es) 1993-07-30 2003-12-01 Dsm Ip Assets Bv Procedimiento para la produccion eficaz de 7-adca a traves de 3-(carboxietil)propionil-7-adca.
BR9407108A (pt) * 1993-07-30 1996-08-27 Gist Brocades Nv Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido

Also Published As

Publication number Publication date
WO1998048034A1 (en) 1998-10-29
EP0912754B1 (de) 2004-09-29
CN1224468A (zh) 1999-07-28
JP2000512511A (ja) 2000-09-26
RU2208644C2 (ru) 2003-07-20
AU7648898A (en) 1998-11-13
DE69826604D1 (de) 2004-11-04
BR9804857A (pt) 1999-08-24
US20020037547A1 (en) 2002-03-28
KR20000022108A (ko) 2000-04-25
ZA983394B (en) 1998-10-30
EP0912754A1 (de) 1999-05-06
US6518039B2 (en) 2003-02-11
PL330759A1 (en) 1999-05-24
CN1706963A (zh) 2005-12-14
TW565613B (en) 2003-12-11

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