ATE278418T1 - Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen - Google Patents

Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen

Info

Publication number: ATE278418T1
Authority: AT; Austria
Prior art keywords: haloacyl; polysaccharides; vaccines; protein; moiety
Prior art date: 1997-04-24

Application number

AT98918592T

Other languages

English (en)

Inventor

Andrew C Lees

Original Assignee

Jackson H M Found Military Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-24

Filing date

1998-04-23

Publication date

2004-10-15

1998-04-23 Application filed by Jackson H M Found Military Med filed Critical Jackson H M Found Military Med

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE278418T1 publication Critical patent/ATE278418T1/de

Links

229920001282 polysaccharide Polymers 0.000 title abstract 4
239000005017 polysaccharide Substances 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 title abstract 3
229960005486 vaccine Drugs 0.000 title abstract 3
150000004676 glycans Chemical class 0.000 title abstract 2
230000008878 coupling Effects 0.000 title 1
238000010168 coupling process Methods 0.000 title 1
238000005859 coupling reaction Methods 0.000 title 1
125000005252 haloacyl group Chemical group 0.000 abstract 5
239000003153 chemical reaction reagent Substances 0.000 abstract 3
VRDGQQTWSGDXCU-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate Chemical compound ICC(=O)ON1C(=O)CCC1=O VRDGQQTWSGDXCU-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
-1 haloacyl chloride Chemical compound 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Immunology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT98918592T 1997-04-24 1998-04-23 Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen ATE278418T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4237997P	1997-04-24	1997-04-24
PCT/US1998/008138 WO1998047530A2 (en)	1997-04-24	1998-04-23	Coupling of unmodified proteins to haloacyl or dihaloacyl derivatized polysaccharides for the preparation of protein-polysaccharide vaccines

Publications (1)

Publication Number	Publication Date
ATE278418T1 true ATE278418T1 (de)	2004-10-15

Family

ID=21921604

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98918592T ATE278418T1 (de)	1997-04-24	1998-04-23	Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen

Country Status (9)

Country	Link
US (1)	US6087328A (de)
EP (1)	EP0977588B1 (de)
JP (1)	JP2002504096A (de)
AT (1)	ATE278418T1 (de)
AU (1)	AU740784B2 (de)
CA (1)	CA2288267A1 (de)
DE (1)	DE69826851T2 (de)
ES (1)	ES2230687T3 (de)
WO (1)	WO1998047530A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6248334B1 (en) *	1997-01-08	2001-06-19	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
SI21352A (sl)	2001-01-23	2004-06-30	Aventis Pasteur	Multivalentno meningokokno cepivo iz konjugata polisaharida-proteina
GB0115176D0 (en) *	2001-06-20	2001-08-15	Chiron Spa	Capular polysaccharide solubilisation and combination vaccines
EP2172213B1 (de)	2003-01-30	2013-04-03	Novartis AG	Injizierbarer Impfstoff gegen multiple Meningokokken-Serogruppen
WO2005054493A2 (en) *	2003-06-12	2005-06-16	Mayo Foundation For Medical Education And Research	Altered activity of toll-like receptors
CA2556169C (en) *	2004-01-29	2011-11-22	Andrew Lees	Use of amino-oxy functional groups in the preparation of vaccines
US10828361B2 (en)	2006-03-22	2020-11-10	Glaxosmithkline Biologicals Sa	Regimens for immunisation with meningococcal conjugates
PL2004225T3 (pl)	2006-03-22	2012-09-28	Novartis Ag	Schematy immunizacji koniugatami meningokokowymi
WO2011017101A2 (en)	2009-07-27	2011-02-10	Fina Biosolutions, Llc	Method for producing protein-carbohydrate vaccines reduced in free carbohydrate
CA2836153C (en)	2009-12-17	2016-06-21	Fina Biosolutions, Llc	Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines
EP2560738B8 (de)	2010-04-23	2019-09-25	Serum Institute of India Private Limited	Einfaches verfahren zur simultanen beseitigung mehrerer unreinheiten aus kulturüberständen auf extrem geringe konzentrationen
CN103648489A (zh) *	2011-05-11	2014-03-19	儿童医疗中心有限公司	多抗原提呈免疫原性组合物及其方法和用途
US9358284B2 (en)	2011-09-14	2016-06-07	Glaxosmithkline Biologicals Sa	Methods for making saccharide-protein glycoconjugates
US11576958B2 (en)	2013-02-07	2023-02-14	Children's Medical Center Corporation	Protein antigens that provide protection against pneumococcal colonization and/or disease
US9107906B1 (en)	2014-10-28	2015-08-18	Adma Biologics, Inc.	Compositions and methods for the treatment of immunodeficiency
KR20220150408A (ko)	2016-11-14	2022-11-10	항저우 디에이씨 바이오테크 씨오, 엘티디	결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
US10259865B2 (en)	2017-03-15	2019-04-16	Adma Biologics, Inc.	Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
AU2018243910B2 (en)	2017-03-28	2025-04-10	The Children's Medical Center Corporation	A multiple antigen presenting system (MAPS)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof
MX2019015524A (es)	2017-06-23	2020-09-10	Univ Maryland	Composiciones inmunogenicas.
US20210188895A1 (en) *	2017-10-13	2021-06-24	Bonac Corporation	Single-stranded nucleic acid molecule, and production method therefor
SG11202101973YA (en)	2018-09-12	2021-03-30	Childrens Medical Ct Corp	Pneumococcal fusion protein vaccines
CN112969474A (zh)	2018-09-12	2021-06-15	艾芬尼维克斯公司	多价肺炎球菌疫苗
MX2024002779A (es)	2021-09-09	2024-06-11	Affinivax Inc	Vacunas neumocócicas multivalentes.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3278392A (en) *	1962-11-12	1966-10-11	Yeda Res & Dev	Water insoluble enzymes
US3816254A (en) *	1970-02-03	1974-06-11	Tanabe Seiyaku Co	Optical resolution of racemic amino acids
US4185090A (en) *	1972-02-02	1980-01-22	Abbott Laboratories	Chemically modified endotoxin immunizing agent
US4328311A (en) *	1978-02-10	1982-05-04	Syva Company	Enzyme-aminoglycoside conjugates
US4695624A (en) *	1984-05-10	1987-09-22	Merck & Co., Inc.	Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
NZ214503A (en) *	1984-12-20	1990-02-26	Merck & Co Inc	Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
US5204098A (en) *	1988-02-16	1993-04-20	The United States Of America As Represented By The Department Of Health And Human Services	Polysaccharide-protein conjugates
US5445817A (en) *	1992-08-21	1995-08-29	The United States Of America As Represented By The Department Of Health And Human Services	Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines
WO1995008348A1 (en) *	1993-09-22	1995-03-30	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs
US5565204A (en) *	1994-08-24	1996-10-15	American Cyanamid Company	Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
NZ304715A (en) *	1995-03-22	1999-07-29	Jackson H M Found Military Med	Production of immunogenic constructs using organic cyanylating reagents to activate carbohydrates and then coupling the carbohydrate to a protein, peptide or hapten

1998
- 1998-04-23 EP EP98918592A patent/EP0977588B1/de not_active Expired - Lifetime
- 1998-04-23 US US09/064,827 patent/US6087328A/en not_active Expired - Fee Related
- 1998-04-23 DE DE69826851T patent/DE69826851T2/de not_active Expired - Fee Related
- 1998-04-23 AU AU71491/98A patent/AU740784B2/en not_active Ceased
- 1998-04-23 AT AT98918592T patent/ATE278418T1/de not_active IP Right Cessation
- 1998-04-23 WO PCT/US1998/008138 patent/WO1998047530A2/en not_active Ceased
- 1998-04-23 JP JP54631698A patent/JP2002504096A/ja active Pending
- 1998-04-23 ES ES98918592T patent/ES2230687T3/es not_active Expired - Lifetime
- 1998-04-23 CA CA002288267A patent/CA2288267A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1998047530A2 (en)	1998-10-29
DE69826851T2 (de)	2005-02-10
WO1998047530A3 (en)	1999-01-28
CA2288267A1 (en)	1998-10-29
AU740784B2 (en)	2001-11-15
US6087328A (en)	2000-07-11
ES2230687T3 (es)	2005-05-01
EP0977588B1 (de)	2004-10-06
EP0977588A2 (de)	2000-02-09
DE69826851D1 (de)	2004-11-11
JP2002504096A (ja)	2002-02-05
AU7149198A (en)	1998-11-13

Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE278418T1 (de)	2004-10-15	Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen
DK171951B1 (da)	1997-08-25	Fremgangsmaade til solubilisering af ikke-polyanioniske polysaccharider og fremgangsmaade til modificering af de solubiliserede neutrale polysaccharider
FI79024C (fi)	1989-11-10	Foerfarande foer framstaellning av haemophilus influenzae b-polysackaridexotoxoidkonjugatvaccin.
DE122009000058I1 (de)	2009-12-31	Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten
DK205585A (da)	1985-11-11	Polysaccharidproteinkonjugat, fremgangsmaade til fremstilling deraf ogpraeparat omfattende et polysaccharidproteinkonjugat
EP0598818A4 (de)	1995-04-05	Escherichia coli impfstoffe auf der basis von o-polysaccharid-protein konjugaten.
Kubler-Kielb et al.	2005	A new method for conjugation of carbohydrates to proteins using an aminooxy-thiol heterobifunctional linker
EP0625910A1 (de)	1994-11-30	Dualer träger für immunogene konstrukte
AU1250483A (en)	1983-09-22	Conjugate of enzyme and antibody
JP4024849B2 (ja)	2007-12-19	インフルエンザウイルスのサブユニット複合体
WO1998030239A3 (en)	1999-02-11	Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this procedure
PT1204738E (pt)	2006-05-31	Processo para a diminuicao da formacao de espuma durante a cultura de um microrganismo
DK0450628T3 (da)	1996-01-02	Saccharidmidificerede, vandopløselæige proteiner
Lambden et al.	1982	Synthesis of immunogenic oligosaccharide-protein conjugates from the lipopolyasaccharide of Neisseria Gonorrhoeae P9
DE68915046D1 (de)	1994-06-09	Haemophilus influenzae Typ B Polysaccharid-Aussermembranprotein-Konjugat als Impfstoff.
EP0894008A1 (de)	1999-02-03	Verfahren zur herstellung von immunoaktiven mittel und impfstoffe
Mowat et al.	1995	Preparation of Immune Stimulating Complexes (ISCOM s) as Adjuvants
DE4122906A1 (de)	1992-02-13	Impfstoffe gegen virale antigene und verfahren zu ihrer herstellung
Schneerson et al.	1982	Bacterial capsular polysaccharide conjugates.
WO1991003494A1 (en)	1991-03-21	Cationized carriers for immunogen production
JP2000191693A (ja)	2000-07-11	抗原の可溶化法及び該方法により得られた可溶化抗原
NO157603B (no)	1988-01-11	Fremgangsmÿte for fremstilling av et vannopplelig kovale nt polysakkarid difteri/toksoid konjugat samt et hapten, i det vesentlige fritt for protein og nukleinsyre.