ATE278418T1 - Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen - Google Patents
Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffenInfo
- Publication number
- ATE278418T1 ATE278418T1 AT98918592T AT98918592T ATE278418T1 AT E278418 T1 ATE278418 T1 AT E278418T1 AT 98918592 T AT98918592 T AT 98918592T AT 98918592 T AT98918592 T AT 98918592T AT E278418 T1 ATE278418 T1 AT E278418T1
- Authority
- AT
- Austria
- Prior art keywords
- haloacyl
- polysaccharides
- vaccines
- protein
- moiety
- Prior art date
Links
- 229920001282 polysaccharide Polymers 0.000 title abstract 4
- 239000005017 polysaccharide Substances 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 229960005486 vaccine Drugs 0.000 title abstract 3
- 150000004676 glycans Chemical class 0.000 title abstract 2
- 230000008878 coupling Effects 0.000 title 1
- 238000010168 coupling process Methods 0.000 title 1
- 238000005859 coupling reaction Methods 0.000 title 1
- 125000005252 haloacyl group Chemical group 0.000 abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract 3
- VRDGQQTWSGDXCU-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate Chemical compound ICC(=O)ON1C(=O)CCC1=O VRDGQQTWSGDXCU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- -1 haloacyl chloride Chemical compound 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4237997P | 1997-04-24 | 1997-04-24 | |
| PCT/US1998/008138 WO1998047530A2 (en) | 1997-04-24 | 1998-04-23 | Coupling of unmodified proteins to haloacyl or dihaloacyl derivatized polysaccharides for the preparation of protein-polysaccharide vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE278418T1 true ATE278418T1 (de) | 2004-10-15 |
Family
ID=21921604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98918592T ATE278418T1 (de) | 1997-04-24 | 1998-04-23 | Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6087328A (de) |
| EP (1) | EP0977588B1 (de) |
| JP (1) | JP2002504096A (de) |
| AT (1) | ATE278418T1 (de) |
| AU (1) | AU740784B2 (de) |
| CA (1) | CA2288267A1 (de) |
| DE (1) | DE69826851T2 (de) |
| ES (1) | ES2230687T3 (de) |
| WO (1) | WO1998047530A2 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248334B1 (en) | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
| EP2957300B1 (de) | 2001-01-23 | 2021-07-14 | Sanofi Pasteur Inc. | Mehrwertiger meningokokkus-polysaccharid-proteinkonjugat-impfstoff |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| DK1587537T3 (da) | 2003-01-30 | 2012-07-16 | Novartis Ag | Injicerbare vacciner mod multiple meningococ-serogrupper |
| WO2005054493A2 (en) * | 2003-06-12 | 2005-06-16 | Mayo Foundation For Medical Education And Research | Altered activity of toll-like receptors |
| EP1713508A2 (de) * | 2004-01-29 | 2006-10-25 | Biosynexus Incorporated | Verwendung von aminoox-funktionalen gruppen bei der herstellung von vakzine-konjugaten |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| AU2007229449A1 (en) | 2006-03-22 | 2007-10-04 | Novartis Ag | Regimens for immunisation with meningococcal conjugates |
| US8647621B2 (en) | 2009-07-27 | 2014-02-11 | Fina Biosolutions, Llc | Method of producing protein-carbohydrate vaccines reduced in free carbohydrate |
| US9044517B2 (en) | 2009-12-17 | 2015-06-02 | Fina Biosolutions, Llc | Activation of polysaccharides via the cyanylating agent, 1-cyano-4-pyrrolidinopyridinium tetrafluoroborate (CPPT), in the preparation of polysaccharide/protein conjugate vaccines |
| WO2011133191A1 (en) | 2010-04-23 | 2011-10-27 | Serum Institute Of India, Ltd. | Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels |
| AU2012253359B2 (en) * | 2011-05-11 | 2017-06-08 | Children's Medical Center Corporation | Multiple antigen presenting immunogenic composition, and methods and uses thereof |
| CN103917245B (zh) * | 2011-09-14 | 2017-06-06 | 葛兰素史密丝克莱恩生物有限公司 | 用于制备糖‑蛋白质糖缀合物的方法 |
| CA2900008C (en) | 2013-02-07 | 2025-10-07 | Children's Medical Center Corporation | PROTEIN ANTIGENS THAT CONFER PROTECTION AGAINST COLONIZATION AND/OR PNEUMOCOCCAL DISEASE |
| US9815886B2 (en) | 2014-10-28 | 2017-11-14 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| CN116143678A (zh) | 2016-11-14 | 2023-05-23 | 杭州多禧生物科技有限公司 | 偶联连接体，含有此连接体的细胞结合分子-药物偶联物及其制备和应用 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| EP3600400A4 (de) | 2017-03-28 | 2021-01-13 | The Children's Medical Center Corporation | Auf system mit mehreren antigenen (maps) basierter staphylococcus-aureus-impfstoff, immunogene zusammensetzung und verwendungen davon |
| CN111065417B (zh) | 2017-06-23 | 2024-04-19 | 美商艾芬尼维克斯公司 | 免疫原性组合物 |
| JPWO2019074110A1 (ja) * | 2017-10-13 | 2020-12-24 | 株式会社ボナック | 一本鎖核酸分子およびその製造方法 |
| TW202019470A (zh) | 2018-09-12 | 2020-06-01 | 美商艾芬尼維克斯公司 | 多價肺炎球菌疫苗 |
| KR102922338B1 (ko) | 2018-09-12 | 2026-02-05 | 더 칠드런스 메디칼 센터 코포레이션 | 폐렴구균 융합 단백질 백신 |
| WO2023039223A1 (en) | 2021-09-09 | 2023-03-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278392A (en) * | 1962-11-12 | 1966-10-11 | Yeda Res & Dev | Water insoluble enzymes |
| US3816254A (en) * | 1970-02-03 | 1974-06-11 | Tanabe Seiyaku Co | Optical resolution of racemic amino acids |
| US4185090A (en) * | 1972-02-02 | 1980-01-22 | Abbott Laboratories | Chemically modified endotoxin immunizing agent |
| US4328311A (en) * | 1978-02-10 | 1982-05-04 | Syva Company | Enzyme-aminoglycoside conjugates |
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| NZ214503A (en) * | 1984-12-20 | 1990-02-26 | Merck & Co Inc | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates |
| US5204098A (en) * | 1988-02-16 | 1993-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-protein conjugates |
| US5445817A (en) * | 1992-08-21 | 1995-08-29 | The United States Of America As Represented By The Department Of Health And Human Services | Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines |
| DE69433341T2 (de) * | 1993-09-22 | 2004-04-15 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten |
| US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
| ATE241384T1 (de) * | 1995-03-22 | 2003-06-15 | Jackson H M Found Military Med | Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden |
-
1998
- 1998-04-23 EP EP98918592A patent/EP0977588B1/de not_active Expired - Lifetime
- 1998-04-23 US US09/064,827 patent/US6087328A/en not_active Expired - Fee Related
- 1998-04-23 JP JP54631698A patent/JP2002504096A/ja active Pending
- 1998-04-23 WO PCT/US1998/008138 patent/WO1998047530A2/en not_active Ceased
- 1998-04-23 DE DE69826851T patent/DE69826851T2/de not_active Expired - Fee Related
- 1998-04-23 AT AT98918592T patent/ATE278418T1/de not_active IP Right Cessation
- 1998-04-23 ES ES98918592T patent/ES2230687T3/es not_active Expired - Lifetime
- 1998-04-23 CA CA002288267A patent/CA2288267A1/en not_active Abandoned
- 1998-04-23 AU AU71491/98A patent/AU740784B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2230687T3 (es) | 2005-05-01 |
| JP2002504096A (ja) | 2002-02-05 |
| AU740784B2 (en) | 2001-11-15 |
| EP0977588B1 (de) | 2004-10-06 |
| DE69826851T2 (de) | 2005-02-10 |
| WO1998047530A3 (en) | 1999-01-28 |
| CA2288267A1 (en) | 1998-10-29 |
| US6087328A (en) | 2000-07-11 |
| DE69826851D1 (de) | 2004-11-11 |
| EP0977588A2 (de) | 2000-02-09 |
| AU7149198A (en) | 1998-11-13 |
| WO1998047530A2 (en) | 1998-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |