ATE278418T1 - Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen - Google Patents

Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen

Info

Publication number: ATE278418T1
Authority: AT; Austria
Prior art keywords: haloacyl; polysaccharides; vaccines; protein; moiety
Prior art date: 1997-04-24

Application number

AT98918592T

Other languages

English (en)

Inventor

Andrew C Lees

Original Assignee

Jackson H M Found Military Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-24

Filing date

1998-04-23

Publication date

2004-10-15

1998-04-23 Application filed by Jackson H M Found Military Med filed Critical Jackson H M Found Military Med

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE278418T1 publication Critical patent/ATE278418T1/de

Links

229920001282 polysaccharide Polymers 0.000 title abstract 4
239000005017 polysaccharide Substances 0.000 title abstract 4
102000004169 proteins and genes Human genes 0.000 title abstract 3
108090000623 proteins and genes Proteins 0.000 title abstract 3
229960005486 vaccine Drugs 0.000 title abstract 3
150000004676 glycans Chemical class 0.000 title abstract 2
230000008878 coupling Effects 0.000 title 1
238000010168 coupling process Methods 0.000 title 1
238000005859 coupling reaction Methods 0.000 title 1
125000005252 haloacyl group Chemical group 0.000 abstract 5
239000003153 chemical reaction reagent Substances 0.000 abstract 3
VRDGQQTWSGDXCU-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate Chemical compound ICC(=O)ON1C(=O)CCC1=O VRDGQQTWSGDXCU-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000008064 anhydrides Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
-1 haloacyl chloride Chemical compound 0.000 abstract 1
230000028993 immune response Effects 0.000 abstract 1
230000001939 inductive effect Effects 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Mycology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

AT98918592T 1997-04-24 1998-04-23 Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen ATE278418T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4237997P	1997-04-24	1997-04-24
PCT/US1998/008138 WO1998047530A2 (en)	1997-04-24	1998-04-23	Coupling of unmodified proteins to haloacyl or dihaloacyl derivatized polysaccharides for the preparation of protein-polysaccharide vaccines

Publications (1)

Publication Number	Publication Date
ATE278418T1 true ATE278418T1 (de)	2004-10-15

Family

ID=21921604

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98918592T ATE278418T1 (de)	1997-04-24	1998-04-23	Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen

Country Status (9)

Country	Link
US (1)	US6087328A (de)
EP (1)	EP0977588B1 (de)
JP (1)	JP2002504096A (de)
AT (1)	ATE278418T1 (de)
AU (1)	AU740784B2 (de)
CA (1)	CA2288267A1 (de)
DE (1)	DE69826851T2 (de)
ES (1)	ES2230687T3 (de)
WO (1)	WO1998047530A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6248334B1 (en)	1997-01-08	2001-06-19	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
PT2332581E (pt)	2001-01-23	2015-10-16	Sanofi Pasteur Inc	Vacina meningocócica tri- ou tetravalente de conjugados de polissacárido e crm-197
GB0115176D0 (en) *	2001-06-20	2001-08-15	Chiron Spa	Capular polysaccharide solubilisation and combination vaccines
ES2461350T3 (es)	2003-01-30	2014-05-19	Novartis Ag	Vacunas inyectables contra múltiples serogrupos de meningococos
WO2005054493A2 (en) *	2003-06-12	2005-06-16	Mayo Foundation For Medical Education And Research	Altered activity of toll-like receptors
CA2556169C (en) *	2004-01-29	2011-11-22	Andrew Lees	Use of amino-oxy functional groups in the preparation of vaccines
ES2383209T3 (es)	2006-03-22	2012-06-19	Novartis Ag	Regímenes para la inmunización con conjugados meningococicos
US10828361B2 (en)	2006-03-22	2020-11-10	Glaxosmithkline Biologicals Sa	Regimens for immunisation with meningococcal conjugates
US8647621B2 (en)	2009-07-27	2014-02-11	Fina Biosolutions, Llc	Method of producing protein-carbohydrate vaccines reduced in free carbohydrate
CA2836140C (en)	2009-12-17	2016-06-21	Fina Biosolutions, Llc	Chemical reagents for the activation of polysaccharides in the preparation of conjugate vaccines
US8383783B2 (en)	2010-04-23	2013-02-26	Serum Institute Of India, Ltd.	Simple method for simultaneous removal of multiple impurities from culture supernatants to ultralow levels
CN108840912B (zh)	2011-05-11	2023-07-04	儿童医疗中心有限公司	修饰的生物素结合蛋白及其融合蛋白和应用
EP2755683B1 (de)	2011-09-14	2019-04-03	GlaxoSmithKline Biologicals SA	Verfahren zur herstellung von saccharidprotein-glykokonjugaten
CA2900008C (en)	2013-02-07	2025-10-07	Children's Medical Center Corporation	PROTEIN ANTIGENS THAT CONFER PROTECTION AGAINST COLONIZATION AND/OR PNEUMOCOCCAL DISEASE
US9815886B2 (en)	2014-10-28	2017-11-14	Adma Biologics, Inc.	Compositions and methods for the treatment of immunodeficiency
AU2016429272A1 (en)	2016-11-14	2019-05-02	Hangzhou Dac Biotech Co., Ltd.	Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers
US10259865B2 (en)	2017-03-15	2019-04-16	Adma Biologics, Inc.	Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
WO2018183475A1 (en)	2017-03-28	2018-10-04	Children's Medical Center Corporation	A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof
MX2019015524A (es)	2017-06-23	2020-09-10	Univ Maryland	Composiciones inmunogenicas.
US20210188895A1 (en) *	2017-10-13	2021-06-24	Bonac Corporation	Single-stranded nucleic acid molecule, and production method therefor
TWI852943B (zh)	2018-09-12	2024-08-21	美商兒童醫療中心公司	肺炎鏈球菌融合蛋白疫苗
IL281204B2 (en)	2018-09-12	2025-07-01	Affinivax Inc	Multivalent pneumococcal vaccines
AU2022342080A1 (en)	2021-09-09	2024-03-28	Affinivax, Inc.	Multivalent pneumococcal vaccines

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3278392A (en) *	1962-11-12	1966-10-11	Yeda Res & Dev	Water insoluble enzymes
US3816254A (en) *	1970-02-03	1974-06-11	Tanabe Seiyaku Co	Optical resolution of racemic amino acids
US4185090A (en) *	1972-02-02	1980-01-22	Abbott Laboratories	Chemically modified endotoxin immunizing agent
US4328311A (en) *	1978-02-10	1982-05-04	Syva Company	Enzyme-aminoglycoside conjugates
US4695624A (en) *	1984-05-10	1987-09-22	Merck & Co., Inc.	Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
NZ214503A (en) *	1984-12-20	1990-02-26	Merck & Co Inc	Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates
US5204098A (en) *	1988-02-16	1993-04-20	The United States Of America As Represented By The Department Of Health And Human Services	Polysaccharide-protein conjugates
US5445817A (en) *	1992-08-21	1995-08-29	The United States Of America As Represented By The Department Of Health And Human Services	Pertussis toxin used as a carrier protein with non-charged saccharides in conjugate vaccines
ES2210262T3 (es) *	1993-09-22	2004-07-01	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Procedimiento que permite activar un glucido soluble con la ayuda de nuevos reactivos cianilantes para producir estructuras inmunogenas.
US5565204A (en) *	1994-08-24	1996-10-15	American Cyanamid Company	Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
AU712981B2 (en) *	1995-03-22	1999-11-18	Henry M. Jackson Foundation For The Advancement Of Military Medicine	Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents

1998
- 1998-04-23 US US09/064,827 patent/US6087328A/en not_active Expired - Fee Related
- 1998-04-23 DE DE69826851T patent/DE69826851T2/de not_active Expired - Fee Related
- 1998-04-23 CA CA002288267A patent/CA2288267A1/en not_active Abandoned
- 1998-04-23 AU AU71491/98A patent/AU740784B2/en not_active Ceased
- 1998-04-23 AT AT98918592T patent/ATE278418T1/de not_active IP Right Cessation
- 1998-04-23 WO PCT/US1998/008138 patent/WO1998047530A2/en not_active Ceased
- 1998-04-23 ES ES98918592T patent/ES2230687T3/es not_active Expired - Lifetime
- 1998-04-23 EP EP98918592A patent/EP0977588B1/de not_active Expired - Lifetime
- 1998-04-23 JP JP54631698A patent/JP2002504096A/ja active Pending

Also Published As

Publication number	Publication date
WO1998047530A3 (en)	1999-01-28
AU7149198A (en)	1998-11-13
CA2288267A1 (en)	1998-10-29
ES2230687T3 (es)	2005-05-01
EP0977588B1 (de)	2004-10-06
US6087328A (en)	2000-07-11
AU740784B2 (en)	2001-11-15
DE69826851D1 (de)	2004-11-11
WO1998047530A2 (en)	1998-10-29
JP2002504096A (ja)	2002-02-05
EP0977588A2 (de)	2000-02-09
DE69826851T2 (de)	2005-02-10

Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69826851D1 (de)	2004-11-11	Kopplung unmodifizierter proteinen an haloacyl- oder dihaloacyl-derivatisierten polysacchariden zur herstellung von protein-polysaccharide impfstoffen
DK171951B1 (da)	1997-08-25	Fremgangsmaade til solubilisering af ikke-polyanioniske polysaccharider og fremgangsmaade til modificering af de solubiliserede neutrale polysaccharider
FI79024C (fi)	1989-11-10	Foerfarande foer framstaellning av haemophilus influenzae b-polysackaridexotoxoidkonjugatvaccin.
DE122009000058I1 (de)	2009-12-31	Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten
DK205585A (da)	1985-11-11	Polysaccharidproteinkonjugat, fremgangsmaade til fremstilling deraf ogpraeparat omfattende et polysaccharidproteinkonjugat
EP0598818A4 (de)	1995-04-05	Escherichia coli impfstoffe auf der basis von o-polysaccharid-protein konjugaten.
AU563356B2 (en)	1987-07-09	Conjugate of enzyme and antibody
Kubler-Kielb et al.	2005	A new method for conjugation of carbohydrates to proteins using an aminooxy-thiol heterobifunctional linker
EP0625910A1 (de)	1994-11-30	Dualer träger für immunogene konstrukte
JP4024849B2 (ja)	2007-12-19	インフルエンザウイルスのサブユニット複合体
WO1998030239A3 (en)	1999-02-11	Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this procedure
PT1204738E (pt)	2006-05-31	Processo para a diminuicao da formacao de espuma durante a cultura de um microrganismo
DK0450628T3 (da)	1996-01-02	Saccharidmidificerede, vandopløselæige proteiner
AU3313789A (en)	1989-10-26	Haemophilus influenza type B oxidized polysaccharide-outer membrane protein conjugate vaccine
WO1997035613A1 (en)	1997-10-02	Method of producing immunogenic products and vaccines
Mowat et al.	1995	Preparation of Immune Stimulating Complexes (ISCOM s) as Adjuvants
DE4122906A1 (de)	1992-02-13	Impfstoffe gegen virale antigene und verfahren zu ihrer herstellung
Schneerson et al.	1982	Bacterial capsular polysaccharide conjugates.
WO1991003494A1 (en)	1991-03-21	Cationized carriers for immunogen production
JP2000191693A (ja)	2000-07-11	抗原の可溶化法及び該方法により得られた可溶化抗原
NO157603B (no)	1988-01-11	Fremgangsmÿte for fremstilling av et vannopplelig kovale nt polysakkarid difteri/toksoid konjugat samt et hapten, i det vesentlige fritt for protein og nukleinsyre.