ATE278798T1 - Verfahren zur herstellung von optisch aktiven 3- hydroxy-pyrrolidinderivaten durch enzymatische hydroxylierung - Google Patents

Verfahren zur herstellung von optisch aktiven 3- hydroxy-pyrrolidinderivaten durch enzymatische hydroxylierung

Info

Publication number: ATE278798T1
Authority: AT; Austria
Prior art keywords: optically active; hydroxy; producing optically; pyrrolidine derivatives; biocatalyst
Prior art date: 1998-11-17

Application number

AT99956030T

Other languages

English (en)

Inventor

Bernard Witholt

Zhi Li

Original Assignee

Eidgenoess Tech Hochschule

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-17

Filing date

1999-11-15

Publication date

2004-10-15

1999-11-15 Application filed by Eidgenoess Tech Hochschule filed Critical Eidgenoess Tech Hochschule

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE278798T1 publication Critical patent/ATE278798T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
JHHZLHWJQPUNKB-UHFFFAOYSA-N pyrrolidin-3-ol Chemical class OC1CCNC1 JHHZLHWJQPUNKB-UHFFFAOYSA-N 0.000 title abstract 2
230000002255 enzymatic effect Effects 0.000 title 1
230000033444 hydroxylation Effects 0.000 title 1
238000005805 hydroxylation reaction Methods 0.000 title 1
102000004190 Enzymes Human genes 0.000 abstract 3
108090000790 Enzymes Proteins 0.000 abstract 3
RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
239000011942 biocatalyst Substances 0.000 abstract 2
UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 abstract 1
241000235389 Absidia Species 0.000 abstract 1
241000228212 Aspergillus Species 0.000 abstract 1
241000193830 Bacillus <bacterium> Species 0.000 abstract 1
241000223679 Beauveria Species 0.000 abstract 1
241000190146 Botryosphaeria Species 0.000 abstract 1
241000222120 Candida <Saccharomycetales> Species 0.000 abstract 1
241000222199 Colletotrichum Species 0.000 abstract 1
241000186216 Corynebacterium Species 0.000 abstract 1
241000223208 Curvularia Species 0.000 abstract 1
102000005297 Cytochrome P-450 CYP4A Human genes 0.000 abstract 1
108010081498 Cytochrome P-450 CYP4A Proteins 0.000 abstract 1
241001508802 Diaporthe Species 0.000 abstract 1
241000223218 Fusarium Species 0.000 abstract 1
241001344107 Gnomonia Species 0.000 abstract 1
241000203751 Gordonia <actinomycete> Species 0.000 abstract 1
241000589345 Methylococcus Species 0.000 abstract 1
241000235575 Mortierella Species 0.000 abstract 1
241000235395 Mucor Species 0.000 abstract 1
241000186359 Mycobacterium Species 0.000 abstract 1
241000189150 Nigrospora Species 0.000 abstract 1
241000187654 Nocardia Species 0.000 abstract 1
241000190509 Ophiobolus Species 0.000 abstract 1
241000228143 Penicillium Species 0.000 abstract 1
241000235400 Phycomyces Species 0.000 abstract 1
241000589516 Pseudomonas Species 0.000 abstract 1
241000235527 Rhizopus Species 0.000 abstract 1
241000316848 Rhodococcus <scale insect> Species 0.000 abstract 1
241001330507 Sebekia Species 0.000 abstract 1
241000187747 Streptomyces Species 0.000 abstract 1
241000736854 Syncephalastrum Species 0.000 abstract 1
241000887187 Wojnowicia Species 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
UBCKGWBNUIFUST-YHYXMXQVSA-N tetrachlorvinphos Chemical compound COP(=O)(OC)O\C(=C/Cl)C1=CC(Cl)=C(Cl)C=C1Cl UBCKGWBNUIFUST-YHYXMXQVSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pyrrole Compounds (AREA)

AT99956030T 1998-11-17 1999-11-15 Verfahren zur herstellung von optisch aktiven 3- hydroxy-pyrrolidinderivaten durch enzymatische hydroxylierung ATE278798T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98203893A EP1002871A1 (de)	1998-11-17	1998-11-17	Verfahren zur Herstellung von optisch aktiven 3-hydroxy-pyrrolidinderivaten durch enzymatische Hydroxylierung
PCT/EP1999/009041 WO2000029606A1 (en)	1998-11-17	1999-11-15	Process for preparing optically active-3-hydroxy-pyrrolidine derivatives by enzymatic hydroxylation

Publications (1)

Publication Number	Publication Date
ATE278798T1 true ATE278798T1 (de)	2004-10-15

Family

ID=8234352

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99956030T ATE278798T1 (de)	1998-11-17	1999-11-15	Verfahren zur herstellung von optisch aktiven 3- hydroxy-pyrrolidinderivaten durch enzymatische hydroxylierung

Country Status (6)

Country	Link
US (2)	US20020106763A1 (de)
EP (2)	EP1002871A1 (de)
AT (1)	ATE278798T1 (de)
AU (1)	AU1273000A (de)
DE (1)	DE69920943T2 (de)
WO (1)	WO2000029606A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1130109A1 (de) *	2000-02-29	2001-09-05	Pfizer Products Inc.	Mikrobiologisches Verfahren zur Herstellung von optisch aktiven 3-Hydroxypyrrolidinderivaten
EP1188837A1 (de) *	2000-09-18	2002-03-20	Eidgenössische Technische Hochschule Zürich	Verfahren zur Herstellung von N-substituierten 4-Hydroxypiperidinen durch enzymatische Hydroxylierung
EP1197561A1 (de) *	2000-10-13	2002-04-17	Eidgenössische Technische Hochschule Zürich	Verfahren zur Herstellung optisch aktiver 4-Hydroxy-2-pyrrolidinone und N-substituierten 4-Hydroxy-2-pyrrolidinonen durch enzymatische hydroxylierung
FR2862647B1 (fr)	2003-11-25	2008-07-04	Aventis Pharma Sa	Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
WO2007024113A1 (en) *	2005-08-25	2007-03-01	Rstech Corporation	Process for the preparation of chiral 3-hydroxy pyrrolidine compound and derivatives thereof having high optical purity
JP5779100B2 (ja)	2008-11-24	2015-09-16	カウンシルオブサイエンティフィックアンドインダストリアルリサーチ	光学的に活性なｎ−ベンジル−３−ヒドロキシピロリジンの製造方法
CN113801821B (zh) *	2021-09-29	2023-09-05	浙江工业大学	新奥尔良分枝杆菌wcj及其在降解有机污染物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1140055A (en) *	1965-05-04	1969-01-15	Upjohn Co	Improvements in or relating to heterocyclic compounds and the manufacture thereof
JP3703928B2 (ja) *	1996-11-26	2005-10-05	株式会社カネカ	光学活性ｎ−ベンジル−３−ピロリジノールの製造方法

1998
- 1998-11-17 EP EP98203893A patent/EP1002871A1/de not_active Withdrawn
1999
- 1999-11-05 US US09/434,906 patent/US20020106763A1/en not_active Abandoned
- 1999-11-15 EP EP99956030A patent/EP1131460B1/de not_active Expired - Lifetime
- 1999-11-15 WO PCT/EP1999/009041 patent/WO2000029606A1/en not_active Ceased
- 1999-11-15 DE DE69920943T patent/DE69920943T2/de not_active Expired - Fee Related
- 1999-11-15 AU AU12730/00A patent/AU1273000A/en not_active Abandoned
- 1999-11-15 AT AT99956030T patent/ATE278798T1/de not_active IP Right Cessation
2003
- 2003-02-24 US US10/372,483 patent/US7141412B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1131460A1 (de)	2001-09-12
US20020106763A1 (en)	2002-08-08
AU1273000A (en)	2000-06-05
WO2000029606A1 (en)	2000-05-25
EP1002871A1 (de)	2000-05-24
DE69920943D1 (de)	2004-11-11
US20030219883A1 (en)	2003-11-27
EP1131460B1 (de)	2004-10-06
DE69920943T2 (de)	2005-10-13
US7141412B2 (en)	2006-11-28

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Legal Events

Date	Code	Title	Description
2005-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties