ATE279924T1 - 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5- dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose - Google Patents
3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5- dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler skleroseInfo
- Publication number
- ATE279924T1 ATE279924T1 AT00910736T AT00910736T ATE279924T1 AT E279924 T1 ATE279924 T1 AT E279924T1 AT 00910736 T AT00910736 T AT 00910736T AT 00910736 T AT00910736 T AT 00910736T AT E279924 T1 ATE279924 T1 AT E279924T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclopropylmethoxy
- difluoromethoxy
- benzamide
- treatment
- multiple sclerosis
- Prior art date
Links
- 201000006417 multiple sclerosis Diseases 0.000 title abstract 2
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99104793 | 1999-03-10 | ||
| PCT/EP2000/001703 WO2000053182A2 (en) | 1999-03-10 | 2000-03-01 | 3-cyclopropylmethoxy-4-difluoromethoxy-n-(3,5-dichloropyrid-4-yl)benzamide in the treatment of multiple sclerosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE279924T1 true ATE279924T1 (de) | 2004-11-15 |
Family
ID=8237737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00910736T ATE279924T1 (de) | 1999-03-10 | 2000-03-01 | 3-cyclopropylmethoxy-4-difluormethoxy-n-(3,5- dichlor-pyrid-4-yl)-benzamid zur behandlung von multipler sklerose |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6531493B1 (de) |
| EP (1) | EP1161239B1 (de) |
| JP (1) | JP2002538207A (de) |
| AT (1) | ATE279924T1 (de) |
| AU (1) | AU3284000A (de) |
| CA (1) | CA2364258C (de) |
| DE (1) | DE60015098T2 (de) |
| DK (1) | DK1161239T3 (de) |
| ES (1) | ES2231162T3 (de) |
| PT (1) | PT1161239E (de) |
| SI (1) | SI1161239T1 (de) |
| WO (1) | WO2000053182A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1188438A1 (de) * | 2000-09-15 | 2002-03-20 | Warner-Lambert Company | Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen |
| EP1199074A1 (de) * | 2000-09-15 | 2002-04-24 | Warner-Lambert Company | Pharmazeutische Zusammensetzungen zur Vorbeugung oder Behandlung von mit IL-12 Überproduktion assozierten Erkrankungen |
| WO2002088079A2 (en) * | 2001-05-01 | 2002-11-07 | Bristol-Myers Squibb Company | Dual inhibitors of pde 7 and pde 4 |
| US20030092706A1 (en) * | 2001-11-09 | 2003-05-15 | Johannes Barsig | Combination |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| TR201815573T4 (tr) | 2002-05-28 | 2018-11-21 | Astrazeneca Ab | Topikal olarak uygulanabilir farmasötik preparasyon. |
| US6822114B1 (en) | 2002-10-08 | 2004-11-23 | Albemarle Corporation | Process for production of fluoroalkoxy-substituted benzamides and their intermediates |
| DK1606261T3 (da) | 2003-03-10 | 2010-01-18 | Nycomed Gmbh | Hidtil ukendt fremgangsmåde til fremstilling af roflumilast |
| DE102004046235A1 (de) | 2004-09-22 | 2006-03-30 | Altana Pharma Ag | Arzneimittelzubereitung |
| AU2006224619B2 (en) * | 2005-03-16 | 2012-06-07 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2227519T3 (es) * | 1992-07-28 | 2005-04-01 | Aventis Pharma Limited | Inhibidores de c-amp-fosfodiesterasa. |
| DE59410119D1 (de) * | 1993-07-02 | 2002-06-20 | Byk Gulden Lomberg Chem Fab | Fluoralkoxy substituierte benzamide und ihre verwendung als zyklisch-nukleotid phosphodiesterase-inhibitoren |
| WO1995028926A1 (en) * | 1994-04-21 | 1995-11-02 | Schering Aktiengesellschaft | Pde iv inhibitors for treating multiple sclerosis |
-
2000
- 2000-03-01 EP EP00910736A patent/EP1161239B1/de not_active Expired - Lifetime
- 2000-03-01 CA CA002364258A patent/CA2364258C/en not_active Expired - Fee Related
- 2000-03-01 AU AU32840/00A patent/AU3284000A/en not_active Abandoned
- 2000-03-01 SI SI200030586T patent/SI1161239T1/xx unknown
- 2000-03-01 AT AT00910736T patent/ATE279924T1/de active
- 2000-03-01 PT PT00910736T patent/PT1161239E/pt unknown
- 2000-03-01 DK DK00910736T patent/DK1161239T3/da active
- 2000-03-01 US US09/914,763 patent/US6531493B1/en not_active Expired - Lifetime
- 2000-03-01 DE DE60015098T patent/DE60015098T2/de not_active Expired - Lifetime
- 2000-03-01 JP JP2000603671A patent/JP2002538207A/ja active Pending
- 2000-03-01 WO PCT/EP2000/001703 patent/WO2000053182A2/en not_active Ceased
- 2000-03-01 ES ES00910736T patent/ES2231162T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK1161239T3 (da) | 2005-02-14 |
| ES2231162T3 (es) | 2005-05-16 |
| WO2000053182A2 (en) | 2000-09-14 |
| WO2000053182A3 (en) | 2001-04-12 |
| CA2364258A1 (en) | 2000-09-14 |
| DE60015098D1 (de) | 2004-11-25 |
| EP1161239B1 (de) | 2004-10-20 |
| EP1161239A2 (de) | 2001-12-12 |
| JP2002538207A (ja) | 2002-11-12 |
| US6531493B1 (en) | 2003-03-11 |
| DE60015098T2 (de) | 2006-02-02 |
| AU3284000A (en) | 2000-09-28 |
| CA2364258C (en) | 2008-12-30 |
| SI1161239T1 (en) | 2005-06-30 |
| PT1161239E (pt) | 2005-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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