ATE280770T1 - Antibakterielle nitroimidazolverbindungen und verfahren zu deren verwendung - Google Patents

Antibakterielle nitroimidazolverbindungen und verfahren zu deren verwendung

Info

Publication number
ATE280770T1
ATE280770T1 AT96923447T AT96923447T ATE280770T1 AT E280770 T1 ATE280770 T1 AT E280770T1 AT 96923447 T AT96923447 T AT 96923447T AT 96923447 T AT96923447 T AT 96923447T AT E280770 T1 ATE280770 T1 AT E280770T1
Authority
AT
Austria
Prior art keywords
compounds
loweralkyl
hydrogen
heterocycle
aryl
Prior art date
Application number
AT96923447T
Other languages
English (en)
Inventor
William R Baker
Cai Shaopei
Eric L Keeler
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of ATE280770T1 publication Critical patent/ATE280770T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT96923447T 1995-06-26 1996-06-25 Antibakterielle nitroimidazolverbindungen und verfahren zu deren verwendung ATE280770T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/496,850 US5668127A (en) 1995-06-26 1995-06-26 Nitroimidazole antibacterial compounds and methods of use thereof
PCT/US1996/010904 WO1997001562A1 (en) 1995-06-26 1996-06-25 Nitroimidazole antibacterial compounds and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE280770T1 true ATE280770T1 (de) 2004-11-15

Family

ID=23974441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96923447T ATE280770T1 (de) 1995-06-26 1996-06-25 Antibakterielle nitroimidazolverbindungen und verfahren zu deren verwendung

Country Status (10)

Country Link
US (1) US5668127A (de)
EP (1) EP0866793B1 (de)
JP (1) JP4621819B2 (de)
AT (1) ATE280770T1 (de)
AU (1) AU706448B2 (de)
CA (1) CA2225822C (de)
DE (1) DE69633734T2 (de)
ES (1) ES2235190T3 (de)
PT (1) PT866793E (de)
WO (1) WO1997001562A1 (de)

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US6087358A (en) * 1995-06-26 2000-07-11 Pathogenesis Corporation Nitro-[2,1-b]imidazopyran compounds and antibacterial uses thereof
EP0962424A1 (de) 1998-06-05 1999-12-08 SOLVAY (Société Anonyme) Umhüllte Natriumpercarbonatpartikel, Verfahren zu deren Herstellung, deren Verwendung in Waschmittelzusammensetzungen und Waschmittelzusammensetzungen die diese enthalten
WO2004007407A2 (en) 2002-07-11 2004-01-22 Fluorous Technologies Incorporated Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
AR041198A1 (es) * 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
CA2494710C (en) 2002-10-15 2011-05-03 Otsuka Pharmaceutical Co., Ltd. 1-substituted-4-nitroimidazole compound and method for preparing the same
PT1678185E (pt) * 2003-10-31 2009-01-13 Otsuka Pharma Co Ltd Compostos 2,3-di-hidro-6-nitroimidazo[2,1-b]oxazole para o tratamento da tuberculose
JP4761756B2 (ja) * 2003-10-31 2011-08-31 大塚製薬株式会社 ２，３−ジヒドロイミダゾ［２，１−ｂ］オキサゾ−ル化合物
TWI300409B (en) 2004-02-18 2008-09-01 Otsuka Pharma Co Ltd Method for producing 4-nitroimidazole compound
JP4787529B2 (ja) * 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
JP4789966B2 (ja) * 2004-04-09 2011-10-12 大塚製薬株式会社 医薬組成物
EP3153159A1 (de) 2004-07-09 2017-04-12 Robert Sabin Zusammensetzungen mit einer kupferverbindung zur behandlung von erkrankungen bei säugetieren
US7115736B2 (en) 2004-09-17 2006-10-03 Daiso Co., Ltd. Process for preparing imidazopyran derivatives
US20080275035A1 (en) * 2005-12-23 2008-11-06 Jan Jiricek Nitroimidazole Compounds
WO2009033165A1 (en) * 2007-09-06 2009-03-12 Threshold Pharmaceuticals, Inc. Hypoxia activated prodrugs of bis-alkylating agents
JP5613656B2 (ja) * 2008-03-26 2014-10-29 グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール
EP2270133B1 (de) 2008-04-22 2015-06-24 Corporación Alimentaria Peñasanta (Capsa) Verfahren zur gewinnung eines neuen strangs aus bifidobacterium bifidum mit wirkung gegen infektionen durch helicobacter pylori
CA2769359C (en) 2009-07-31 2017-03-07 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
BR112012002214B1 (pt) 2009-07-31 2022-01-25 Global Alliance For Tb Drug Development Análogos de nitroimidazooxazina e nitroimidazooxazol, seus usos e composição farmacêutica
US9198913B2 (en) 2009-07-31 2015-12-01 Global Alliance For Tb Drug Development Nitroimidazooxazines and their uses in anti-tubercular therapy
US9216979B2 (en) 2009-10-16 2015-12-22 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
WO2011047320A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
TW201726630A (zh) * 2009-10-16 2017-08-01 梅林塔療法公司 抗微生物性化合物及其製造與使用方法
JP5770096B2 (ja) 2009-10-26 2015-08-26 富士フイルムＲｉファーマ株式会社 感染症診断薬
CN102234287B (zh) 2010-04-26 2015-08-05 上海阳帆医药科技有限公司 硝基咪唑类化合物、其制备方法和用途
WO2012018867A1 (en) * 2010-08-02 2012-02-09 University Of Medicine And Dentistry Of New Jersey Gas-based treatment for infective disease
US9051333B2 (en) 2011-04-15 2015-06-09 Otsuka Pharmaceutical Co., Ltd. 6,7-dihydroimidazo [2,1-b] [1,3]oxazine bactericides
WO2013072903A1 (en) 2011-11-17 2013-05-23 Ithemba Pharmaceuticals (Proprietary) Limited Nitroimidazoxadiazocine compounds
CN103450220B (zh) * 2012-06-05 2017-02-08 上海阳帆医药科技有限公司 一种硝基咪唑类化合物及其在药学中的用途
CN104059082B (zh) * 2013-03-21 2016-08-03 苏州迈泰生物技术有限公司 硝基咪唑杂环类化合物及其在制备治疗结核病药物中的应用
KR20160070066A (ko) 2013-09-09 2016-06-17 멜린타 테라퓨틱스, 인크. 항균 화합물, 및 이의 제조 방법 및 이용 방법
EP3038623A4 (de) 2013-09-09 2017-04-19 Melinta Therapeutics, Inc. Antimikrobielle verbindungen und verfahren zur herstellung und verwendung davon
CN104177372A (zh) * 2014-07-31 2014-12-03 中国人民解放军第四军医大学 抗结核候选药物pa-824的合成方法
TWI687409B (zh) 2014-08-28 2020-03-11 日商大塚製藥股份有限公司 稠合雜環化合物
KR101682356B1 (ko) * 2014-11-04 2016-12-06 한국화학연구원 이미다조 옥사진 유도체, 이의 약학적으로 허용 가능한 염 또는 이의 광학이성질체 및 이를 유효성분으로 함유하는 약제학적 조성물
CN105732659B (zh) * 2014-12-12 2019-07-16 上海阳帆医药科技有限公司 硝基咪唑类化合物及其制备方法和在制药中的用途
WO2016119706A1 (zh) 2015-01-29 2016-08-04 南京明德新药研发股份有限公司 抗肺结核病的硝基咪唑衍生物
CA2979342A1 (en) 2015-03-11 2016-09-15 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
EP3421454B9 (de) 2016-02-26 2023-08-09 Otsuka Pharmaceutical Co., Ltd. Piperidinderivate
WO2017193016A1 (en) 2016-05-06 2017-11-09 Melinta Therapeutics, Inc. Antimicrobials and methods of making and using same
EP4271679A4 (de) * 2021-02-01 2024-09-11 The Global Alliance for TB Drug Development, Inc. Amorphe form von pretomaniden

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GB826838A (en) * 1957-04-29 1960-01-20 Monsanto Canada Ltd Arylsulfonyl derivatives of bicyclic guanidines
GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US4918074A (en) * 1984-03-12 1990-04-17 Yoshitomi Pharmaceutical Industries, Ltd. Polyazaheterocycle compounds
JPH05503919A (ja) * 1989-06-13 1993-06-24 スミスクライン・ビーチャム・コーポレイション 単球および／またはマクロファージによるインターロイキン―１または腫瘍壊死因子生成の抑制
JPH0717971A (ja) * 1993-07-02 1995-01-20 Takeda Chem Ind Ltd イミダゾール誘導体、その製造法及び用途

Also Published As

Publication number Publication date
AU706448B2 (en) 1999-06-17
DE69633734T2 (de) 2005-09-15
JPH11508270A (ja) 1999-07-21
CA2225822C (en) 2010-02-16
US5668127A (en) 1997-09-16
JP4621819B2 (ja) 2011-01-26
ES2235190T3 (es) 2005-07-01
CA2225822A1 (en) 1997-01-16
WO1997001562A1 (en) 1997-01-16
EP0866793B1 (de) 2004-10-27
EP0866793A4 (de) 1998-10-07
EP0866793A1 (de) 1998-09-30
AU6395496A (en) 1997-01-30
PT866793E (pt) 2005-04-29
DE69633734D1 (de) 2004-12-02

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