ATE281462T1 - 4-cyklohexyl-1,3,2-oxazaborolidine als chirale hilfsmittel - Google Patents

4-cyklohexyl-1,3,2-oxazaborolidine als chirale hilfsmittel

Info

Publication number
ATE281462T1
ATE281462T1 AT01968760T AT01968760T ATE281462T1 AT E281462 T1 ATE281462 T1 AT E281462T1 AT 01968760 T AT01968760 T AT 01968760T AT 01968760 T AT01968760 T AT 01968760T AT E281462 T1 ATE281462 T1 AT E281462T1
Authority
AT
Austria
Prior art keywords
cyklohexyl
oxazaborolidine
chiral agents
unsubstituted
aryl
Prior art date
Application number
AT01968760T
Other languages
English (en)
Inventor
Richard W Draper
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE281462T1 publication Critical patent/ATE281462T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • B01J31/0252—Nitrogen containing compounds with a metal-nitrogen link, e.g. metal amides, metal guanidides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • B01J31/14—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron
    • B01J31/146—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides of aluminium or boron of boron
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/38—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/18—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/60—Reduction reactions, e.g. hydrogenation
    • B01J2231/64—Reductions in general of organic substrates, e.g. hydride reductions or hydrogenations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
AT01968760T 2000-09-11 2001-09-10 4-cyklohexyl-1,3,2-oxazaborolidine als chirale hilfsmittel ATE281462T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23163000P 2000-09-11 2000-09-11
PCT/US2001/028293 WO2002022623A1 (en) 2000-09-11 2001-09-10 4-cyclohexyl-1,3,2-oxazaborolidine chiral accessories

Publications (1)

Publication Number Publication Date
ATE281462T1 true ATE281462T1 (de) 2004-11-15

Family

ID=22870030

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01968760T ATE281462T1 (de) 2000-09-11 2001-09-10 4-cyklohexyl-1,3,2-oxazaborolidine als chirale hilfsmittel

Country Status (12)

Country Link
US (1) US6509472B2 (de)
EP (1) EP1317461B1 (de)
JP (1) JP2004509125A (de)
AT (1) ATE281462T1 (de)
AU (1) AU2001288984A1 (de)
CA (1) CA2421777A1 (de)
DE (1) DE60106956T2 (de)
DK (1) DK1317461T3 (de)
ES (1) ES2227264T3 (de)
MX (1) MXPA03002081A (de)
PT (1) PT1317461E (de)
WO (1) WO2002022623A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7109345B1 (en) 2003-02-07 2006-09-19 Margarita Ortiz-Marciales Efficient and convenient procedure for the synthesis of B-alkylated oxazaborolidines derived from ephedrine and norephedrine
PL2078723T3 (pl) * 2005-06-13 2011-05-31 Basf Se Sposób wytwarzania organo-oksazaborolidyn
US20080200672A1 (en) * 2005-08-30 2008-08-21 Margarita Ortiz-Marciales Highly enantioselective carbonyl reduction with borane catalyzed by chiral spiroborate esters derived from chiral beta-aminoalcohols
US20060223999A1 (en) * 2006-05-10 2006-10-05 Chemagis Ltd. Process for preparing montelukast and precursors thereof
FR2909671B1 (fr) * 2006-12-12 2009-03-06 Ppg Sipsy Soc Par Actions Simp Procede de preparation de composes 1,3,2-oxazaborolidines
CN117480174A (zh) * 2022-10-09 2024-01-30 成都化润药业有限公司 一种手性还原剂及合成手性尼古丁的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4943635A (en) * 1987-08-27 1990-07-24 President & Fellows Of Harvard College Enantioselective reduction of ketones
DE69306945T2 (de) 1992-05-14 1997-05-07 Pfizer Enantioselektive katalysatoren aus oxazaborolidin
JPH06329679A (ja) * 1993-01-20 1994-11-29 Nissan Chem Ind Ltd 光学活性β−アミノアルコキシボラン錯体
TW416958B (en) * 1993-05-14 2001-01-01 Pfizer Enantioselective oxazaborolidine catalysts

Also Published As

Publication number Publication date
DE60106956T2 (de) 2005-12-08
AU2001288984A1 (en) 2002-03-26
EP1317461A1 (de) 2003-06-11
MXPA03002081A (es) 2003-06-24
US20020038053A1 (en) 2002-03-28
US6509472B2 (en) 2003-01-21
JP2004509125A (ja) 2004-03-25
PT1317461E (pt) 2005-02-28
DK1317461T3 (da) 2005-02-07
WO2002022623A1 (en) 2002-03-21
CA2421777A1 (en) 2002-03-21
DE60106956D1 (de) 2004-12-09
EP1317461B1 (de) 2004-11-03
ES2227264T3 (es) 2005-04-01

Similar Documents

Publication Publication Date Title
DE60127845D1 (de) Benzylidenthiazolidindione und ihre verwendung als antimykotische mittel
EP0945764A3 (de) Fotoresistzusammensetzung
ES2177058T3 (es) Compuestos eter piperidinilaminometil trifluorometil ciclicos como antagonistas de la sustancia p.
UY24010A1 (es) Nuevos pirrolocarbazoles
DE60239170D1 (de) Bicyclische Verbindungen
DK1042319T3 (da) Dihydrobenzofuraner
EE200300008A (et) COMT-i inhibeeriva aktiivsusega kumariini derivaadid
DE60106956D1 (de) 4-cyklohexyl-1,3,2-oxazaborolidine als chirale hilfsmittel
BR0308483A (pt) Composto fenólico e material de gravação usando o mesmo
ATE337327T1 (de) Substituierte ferrocenyldiphosphinligande für homogene hydrogenieringskatalysatoren
ATE169921T1 (de) Optisch aktive beta-aminoalkoxyborankomplexe
TW200407325A (en) Novel interleukin-1β converting enzyme inhibitors
ATE420068T1 (de) Reverse hydroxamsäurederivate
SE0003186D0 (sv) New process
HUP0301258A2 (hu) Aminoizokinolincsoportot tartalmazó trombin inhibitorok és alkalmazásuk gyógyszerkészítmények előállítására
EP1403268A4 (de) Fluoreszente sonden für zink
ES2189162T3 (es) Colorantes disazoicos reactivos con las fibras.
MY103004A (en) Azole derivatives
DK0953564T3 (da) Fremgangsmåde til fremstilling af en 2-cyanobiphenylforbindelse
EP1300395A4 (de) 4-substituierte piperidinverbindung
EP1533312A4 (de) Heterobicyclische verbindungen
TW358098B (en) Cyclic phosphinic acid derivatives as stabilizers
EP1693421A4 (de) Benzimidazolonverbindung
TWI256383B (en) Anthraquinone compound
CO4370120A1 (es) Tintas reactivas diazo, procesos para su preparacion y usos .

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1317461

Country of ref document: EP

REN Ceased due to non-payment of the annual fee