ATE281648T1 - Verfahren zum assay von troponin i und t und komplexen von troponin i und t und auswahl von antikörpern zur verwendung in immunoassays - Google Patents
Verfahren zum assay von troponin i und t und komplexen von troponin i und t und auswahl von antikörpern zur verwendung in immunoassaysInfo
- Publication number
- ATE281648T1 ATE281648T1 AT96913812T AT96913812T ATE281648T1 AT E281648 T1 ATE281648 T1 AT E281648T1 AT 96913812 T AT96913812 T AT 96913812T AT 96913812 T AT96913812 T AT 96913812T AT E281648 T1 ATE281648 T1 AT E281648T1
- Authority
- AT
- Austria
- Prior art keywords
- troponin
- disclosed
- antibodies
- complexes
- forms
- Prior art date
Links
- 238000003018 immunoassay Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 102000013394 Troponin I Human genes 0.000 abstract 10
- 108010065729 Troponin I Proteins 0.000 abstract 10
- 102000004903 Troponin Human genes 0.000 abstract 6
- 108090001027 Troponin Proteins 0.000 abstract 6
- 102000004987 Troponin T Human genes 0.000 abstract 4
- 108090001108 Troponin T Proteins 0.000 abstract 4
- 210000004369 blood Anatomy 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 108090000362 Lymphotoxin-beta Proteins 0.000 abstract 1
- 102000013534 Troponin C Human genes 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 150000001945 cysteines Chemical class 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2474/00—Immunochemical assays or immunoassays characterised by detection mode or means of detection
- G01N2474/20—Immunohistochemistry assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/961—Chemistry: molecular biology and microbiology including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/971—Capture of complex after antigen-antibody reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/423,582 US5795725A (en) | 1995-04-18 | 1995-04-18 | Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays |
| US08/633,248 US6174686B1 (en) | 1995-04-18 | 1996-04-18 | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
| PCT/US1996/005476 WO1996033415A1 (en) | 1995-04-18 | 1996-04-18 | Novel methods for the assay of troponin i and t and complexes of troponin i and t and selection of antibodies for use in immunoassays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE281648T1 true ATE281648T1 (de) | 2004-11-15 |
Family
ID=27026061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96913812T ATE281648T1 (de) | 1995-04-18 | 1996-04-18 | Verfahren zum assay von troponin i und t und komplexen von troponin i und t und auswahl von antikörpern zur verwendung in immunoassays |
Country Status (3)
| Country | Link |
|---|---|
| US (3) | US6174686B1 (de) |
| AT (1) | ATE281648T1 (de) |
| DE (1) | DE69633780T3 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6991907B1 (en) * | 1995-04-18 | 2006-01-31 | Biosite, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
| US6627404B1 (en) * | 1995-04-18 | 2003-09-30 | Biosite, Inc. | Methods for improving the recovery of troponin I and T in membranes, filters and vessels |
| US7285418B2 (en) * | 1996-06-25 | 2007-10-23 | Hytest Ltd. | Method and kit for the diagnosis of troponin I |
| WO2002063302A1 (en) * | 2001-02-07 | 2002-08-15 | Immunomatrix Inc. | A method for reducing heparin interference in diagnostic tests for cardiac troponin |
| US7632647B2 (en) * | 2001-04-13 | 2009-12-15 | Biosite Incorporated | Use of B-type natriuretic peptide as a prognostic indicator in acute coronary syndromes |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US7524635B2 (en) * | 2003-04-17 | 2009-04-28 | Biosite Incorporated | Methods and compositions for measuring natriuretic peptides and uses thereof |
| US20030199000A1 (en) * | 2001-08-20 | 2003-10-23 | Valkirs Gunars E. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US20040253637A1 (en) * | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US20040176914A1 (en) * | 2001-04-13 | 2004-09-09 | Biosite Incorporated | Methods and compositions for measuring biologically active natriuretic peptides and for improving their therapeutic potential |
| GB0109925D0 (en) * | 2001-04-23 | 2001-06-13 | Axis Shield Asa | Method |
| US20040209307A1 (en) * | 2001-08-20 | 2004-10-21 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US20040219509A1 (en) * | 2001-08-20 | 2004-11-04 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US7608406B2 (en) * | 2001-08-20 | 2009-10-27 | Biosite, Inc. | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| US6461828B1 (en) | 2001-09-04 | 2002-10-08 | Syn X Pharma | Conjunctive analysis of biological marker expression for diagnosing organ failure |
| JP2005510696A (ja) * | 2001-11-27 | 2005-04-21 | ダイアジェニクス インターナショナル コーポレーション | 患者サンプル中の生化学的標識の迅速同時検出のための免疫分析法および免疫分析キット |
| CA2500739A1 (en) * | 2002-10-09 | 2004-04-22 | Dmi Biosciences, Inc. | Diagnosis and monitoring of inflammation, ischemia and appendicitis |
| US7473548B2 (en) | 2003-04-25 | 2009-01-06 | Medtronic, Inc. | Optical detector for enzyme activation |
| US20050096516A1 (en) * | 2003-10-30 | 2005-05-05 | Orhan Soykan | Optical detector of organic analyte |
| US20050164409A1 (en) * | 2003-12-10 | 2005-07-28 | Kiernan Urban A. | Method and apparatus for mass spectrometric immunoassay analysis of specific biological fluid proteins |
| US20050266503A1 (en) * | 2004-05-24 | 2005-12-01 | Esoterix, Inc. | Simultaneous assay of target and target-drug binding |
| US8129352B2 (en) * | 2004-09-16 | 2012-03-06 | Avi Biopharma, Inc. | Antisense antiviral compound and method for treating ssRNA viral infection |
| US20080318340A1 (en) * | 2004-11-01 | 2008-12-25 | Tokyo Metropolitan Organization For Medical Resear | Method of Detecting Target Substances |
| US20060199280A1 (en) * | 2005-03-03 | 2006-09-07 | David Bar-Or | Quantification of proteins |
| EP2005168A4 (de) * | 2006-03-09 | 2009-05-20 | Biosite Inc | Verfahren und zusammensetzung zur diagnose von krankheiten der aorta |
| EP1835284B1 (de) * | 2006-03-13 | 2010-09-29 | Siemens Healthcare Diagnostics Inc. | Reduktion von Blutplättcheninterferenzen bei Plasmatestproben |
| US20080118924A1 (en) * | 2006-05-26 | 2008-05-22 | Buechler Kenneth F | Use of natriuretic peptides as diagnostic and prognostic indicators in vascular diseases |
| US20080081354A1 (en) * | 2006-10-02 | 2008-04-03 | Cardiac Pacemakers, Inc. | Devices, vectors and methods for inducible ischemia cardioprotection |
| US9285362B2 (en) | 2006-10-18 | 2016-03-15 | Axela, Inc. | Measuring multiple analytes over a broad range of concentrations using optical diffraction |
| EP2097750A2 (de) * | 2006-10-26 | 2009-09-09 | Abbott Laboratories | Immunoassay aus analyten in proben mit endogenen antikörpern gegen analyte |
| US7776605B2 (en) * | 2006-10-26 | 2010-08-17 | Abbott Laboratories | Assay for cardiac troponin autoantibodies |
| US20080305512A1 (en) * | 2006-10-26 | 2008-12-11 | Mattingly Phillip G | Assay for cardiac troponin autoantibodies |
| WO2008060607A2 (en) * | 2006-11-14 | 2008-05-22 | Biosite Incorporated | Methods and compositions for monitoring and risk prediction in cardiorenal syndrome |
| WO2008061149A2 (en) * | 2006-11-14 | 2008-05-22 | Biosite Incorporated | Methods and compositions for diagnosis and prognosis of renal artery stenosis |
| JP2010517023A (ja) * | 2007-01-25 | 2010-05-20 | エフ.ホフマン−ラ ロシュ アーゲー | 心不全の評価におけるigfbp−7の使用 |
| CN101627306B (zh) * | 2007-03-08 | 2014-02-05 | 霍夫曼-拉罗奇有限公司 | Slim-1在心力衰竭评估中的用途 |
| EP2265950B1 (de) * | 2008-03-05 | 2019-01-23 | Axela Inc. | Nachweis von biomarkern und biomarker-komplexen |
| EP2274622B1 (de) * | 2008-04-30 | 2014-10-08 | The Governing Council of the University of Toronto | Verwendung von sfrp-3 bei der beurteilung von herzversagen |
| JP5618831B2 (ja) * | 2008-08-27 | 2014-11-05 | 株式会社Lsiメディエンス | 修飾抗ヘパリン/pf4複合体抗体及びhit抗体標準品 |
| JP5528461B2 (ja) * | 2008-10-17 | 2014-06-25 | エフ.ホフマン−ラ ロシュ アーゲー | 心不全の評価におけるビグリカンの使用 |
| EP2454371B1 (de) | 2009-07-13 | 2021-01-20 | Somagenics, Inc. | Chemische modifikation kleiner haarnadel-rnas zur genexpressionshemmung |
| CN105548563B (zh) | 2009-07-27 | 2017-09-22 | 霍夫曼-拉罗奇有限公司 | mimecan在评价心力衰竭中的用途 |
| US20110306148A1 (en) | 2010-06-14 | 2011-12-15 | Siemens Healthcare Diagnostics Inc. | Composition for use as an assay reagent |
| JP5864530B2 (ja) | 2011-02-25 | 2016-02-17 | 株式会社Lsiメディエンス | 心筋トロポニンの測定法 |
| DE102012223378A1 (de) * | 2012-12-17 | 2014-06-18 | Charité - Universitätsmedizin Berlin | In-vitro Verfahren und Kit zur Diagnose von akutem Koronarsyndrom |
| WO2014121252A1 (en) * | 2013-02-04 | 2014-08-07 | The General Hospital Corporation | Biomarkers for stroke diagnosis |
| CA2961340C (en) | 2014-09-26 | 2023-10-17 | Somalogic, Inc. | Cardiovascular risk event prediction and uses thereof |
| CN111735965B (zh) * | 2020-07-02 | 2023-07-25 | 北京美联泰科生物技术有限公司 | 心肌肌钙蛋白i检测试剂和制备方法以及心肌肌钙蛋白i检测试剂盒 |
| WO2025036431A1 (zh) * | 2023-08-14 | 2025-02-20 | 深圳迈瑞生物医疗电子股份有限公司 | 心肌损伤评估方法、装置、样本分析系统及其用途 |
| WO2025035370A1 (zh) * | 2023-08-14 | 2025-02-20 | 深圳迈瑞生物医疗电子股份有限公司 | 检测总cTnITC的组合物、试剂盒和方法、及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4632901A (en) | 1984-05-11 | 1986-12-30 | Hybritech Incorporated | Method and apparatus for immunoassays |
| CA2006408A1 (en) * | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Bispecific monoclonal antibody, its production and use |
| DE3922873A1 (de) | 1989-04-25 | 1990-10-31 | Boehringer Mannheim Gmbh | Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen |
| JPH05504841A (ja) * | 1990-09-14 | 1993-07-22 | バイオサイト・ダイアグノスティックス・インコーポレイテッド | リガンドレセプター及びリガンドのコンプレックスに対する抗体及びリガンド―レセプターアッセーでのそれらの用途 |
| CA2027434C (en) | 1990-10-12 | 1999-01-05 | George Jackowski | Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof |
| US5604105B1 (en) * | 1990-10-12 | 1999-08-24 | Spectral Diagnostics Inc | Method and device for diagnosingand distinguishing chest pain in early onset thereof |
| US5458852A (en) | 1992-05-21 | 1995-10-17 | Biosite Diagnostics, Inc. | Diagnostic devices for the controlled movement of reagents without membranes |
| WO1994013774A1 (en) | 1992-12-09 | 1994-06-23 | Allergan, Inc. | Cleaning compositions and method for hydrophilic contact lenses |
| FR2701954B1 (fr) | 1993-02-23 | 1995-07-07 | Pasteur Sanofi Diagnostics | Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais. |
| DE69420556T2 (de) * | 1993-05-17 | 2000-03-23 | Fortron Bioscience, Inc. | Assay für troponin i aus dem herzmuskel |
| US5574779A (en) | 1995-05-01 | 1996-11-12 | Bell Communications Research, Inc. | Method and apparatus for provisioning network services |
-
1996
- 1996-04-18 US US08/633,248 patent/US6174686B1/en not_active Expired - Lifetime
- 1996-04-18 DE DE69633780T patent/DE69633780T3/de not_active Expired - Lifetime
- 1996-04-18 AT AT96913812T patent/ATE281648T1/de not_active IP Right Cessation
-
1999
- 1999-07-07 US US09/349,194 patent/US6939678B1/en not_active Expired - Fee Related
- 1999-10-21 US US09/425,318 patent/US6579687B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6174686B1 (en) | 2001-01-16 |
| US6939678B1 (en) | 2005-09-06 |
| US6579687B1 (en) | 2003-06-17 |
| DE69633780T2 (de) | 2005-11-03 |
| DE69633780T3 (de) | 2011-05-05 |
| DE69633780D1 (de) | 2004-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |