ATE282589T1 - Verfahren zur herstellung eines chiralen-beta- aminosäureesters - Google Patents

Verfahren zur herstellung eines chiralen-beta- aminosäureesters

Info

Publication number
ATE282589T1
ATE282589T1 AT00910040T AT00910040T ATE282589T1 AT E282589 T1 ATE282589 T1 AT E282589T1 AT 00910040 T AT00910040 T AT 00910040T AT 00910040 T AT00910040 T AT 00910040T AT E282589 T1 ATE282589 T1 AT E282589T1
Authority
AT
Austria
Prior art keywords
producing
amino acid
acid ester
beta amino
chiral beta
Prior art date
Application number
AT00910040T
Other languages
English (en)
Inventor
James W Malecha
Thomas P Fraher
Original Assignee
Searle Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle Llc filed Critical Searle Llc
Application granted granted Critical
Publication of ATE282589T1 publication Critical patent/ATE282589T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/08—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT00910040T 1999-03-03 2000-02-28 Verfahren zur herstellung eines chiralen-beta- aminosäureesters ATE282589T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/261,647 US6172256B1 (en) 1998-03-04 1999-03-03 Chiral-β-amino acid compounds and derivatives thereof
PCT/US2000/002525 WO2000051968A1 (en) 1999-03-03 2000-02-28 Method for the preparation of a chiral-beta-amino ester

Publications (1)

Publication Number Publication Date
ATE282589T1 true ATE282589T1 (de) 2004-12-15

Family

ID=22994225

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00910040T ATE282589T1 (de) 1999-03-03 2000-02-28 Verfahren zur herstellung eines chiralen-beta- aminosäureesters

Country Status (9)

Country Link
US (1) US6172256B1 (de)
EP (1) EP1156999B1 (de)
JP (1) JP2002538131A (de)
AT (1) ATE282589T1 (de)
AU (1) AU3219700A (de)
DE (1) DE60015931T2 (de)
ES (1) ES2233340T3 (de)
PT (1) PT1156999E (de)
WO (1) WO2000051968A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040058229A (ko) 2001-10-22 2004-07-03 더 스크립스 리서치 인스티튜트 항체 표적화 화합물
EP1572210A1 (de) * 2002-12-20 2005-09-14 Pharmacia Corporation Das r-isomer von beta-aminosäureverbindungen als integrinrezeptorantagonisten-derivate
WO2007048127A2 (en) * 2005-10-20 2007-04-26 The Scripps Research Institute Fc labeling for immunostaining and immunotargeting
JP2012517447A (ja) 2009-02-10 2012-08-02 ザ スクリプス リサーチ インスティチュート 化学的にプログラムされたワクチン接種法
WO2011119457A1 (en) * 2010-03-26 2011-09-29 Schering Corporation Process for synthesizing 6-bromo-3-(1-methyl-1h-pyrazol-4-yl)-5-(3(r)-piperidinyl)pyrazolo[1,5-a]pyrimidin-7-amine
HK1244806A1 (zh) 2015-12-30 2018-08-17 Saint Louis University 作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US6013651A (en) * 1995-08-30 2000-01-11 G. D. Searle & Co. Meta-azacyclic amino benzoic acid compounds and derivatives thereof
MX9801716A (es) 1995-08-30 1998-05-31 Searle & Co Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.
KR20010042614A (ko) * 1998-04-10 2001-05-25 윌리암스 로저 에이 비트로넥틴 길항제로서 복소환식 글리실 베타-알라닌 유도체

Also Published As

Publication number Publication date
US6172256B1 (en) 2001-01-09
EP1156999B1 (de) 2004-11-17
DE60015931T2 (de) 2006-03-02
WO2000051968A8 (en) 2000-11-09
DE60015931D1 (de) 2004-12-23
PT1156999E (pt) 2005-03-31
AU3219700A (en) 2000-09-21
JP2002538131A (ja) 2002-11-12
EP1156999A1 (de) 2001-11-28
ES2233340T3 (es) 2005-06-16
WO2000051968A1 (en) 2000-09-08

Similar Documents

Publication Publication Date Title
DE69530242D1 (de) Verfahren zur Herstellung von Glutaminsäure durch Fermentation
DE50003359D1 (de) Verfahren zur herstellung von acrylsäure
DE50000852D1 (de) Verfahren zur Herstellung von Aminen
DE69910562D1 (de) Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure
DE69903698D1 (de) Verfahren zur Herstellung von Acrylsäure
DE60040720D1 (de) Verfahren zur Herstellung von Nitrilverbindungen
DE69820831D1 (de) Verfahren zur Herstellung von Alkylnitrit
DE60015931D1 (de) Verfahren zur herstellung eines chiralen-beta-aminosäureesters
DE60043261D1 (de) Verfahren zur herstellung von phenylessigsäure derivaten
ATA218299A (de) Verfahren zur herstellung von oxindolen
ATE281434T1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
DE50204441D1 (de) Verfahren zur Herstellung von Salzen der Methallylsulfonsäure
DE60034843D1 (de) Verfahren zur Herstellung von L-arginin
DE60012337D1 (de) Verfahren zur herstellung von fluorcarbonsäureanyhydriden
DE59704450D1 (de) Verfahren zur herstellung von 2-(2-methylphenyl)-3-methoxyacrylsäure-methylester
ATE303356T1 (de) Verfahren zur herstellung von alkylendiamintriessigsäure
DE60107292D1 (de) Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin
ATE390400T1 (de) Verfahren zur herstellung von alpha'-chlorketonen
DE60012802D1 (de) Verfahren zur Herstellung von optisch aktiven Cyanhydrinen
ATE258161T1 (de) Verfahren zur herstellung von chiralen aminosäuren
DE69927315D1 (de) Verfahren zur Herstellung von L-Asparaginsäure
DE69707639D1 (de) Verfahren zur herstellung einer aktivierten aminosäure
DE69807527D1 (de) Verfahren zur herstellung von hochreinem tetranatriumsalz der ethylendiamintetraessigsäure
DE60019075D1 (de) Verfahren zur Herstellung von den Sulfonylaminocarbonyl-Triazolinonsalzen
DE59808082D1 (de) Verfahren zur herstellung von langkettigen glycin-n,n-diessigsäure-derivaten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1156999

Country of ref document: EP

REN Ceased due to non-payment of the annual fee