ATE282621T1 - Indoloazepine als vasopressin rezeptor antagonisten - Google Patents

Indoloazepine als vasopressin rezeptor antagonisten

Info

Publication number
ATE282621T1
ATE282621T1 AT00941464T AT00941464T ATE282621T1 AT E282621 T1 ATE282621 T1 AT E282621T1 AT 00941464 T AT00941464 T AT 00941464T AT 00941464 T AT00941464 T AT 00941464T AT E282621 T1 ATE282621 T1 AT E282621T1
Authority
AT
Austria
Prior art keywords
receptor antagonists
vasopressin receptor
indoloazepines
ischemia
cardiac
Prior art date
Application number
AT00941464T
Other languages
English (en)
Inventor
William J Hoekstra
Michael N Greco
Leonard R Hecker
Bruce Maryanoff
Jay M Matthews
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Application granted granted Critical
Publication of ATE282621T1 publication Critical patent/ATE282621T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT00941464T 1999-06-17 2000-06-15 Indoloazepine als vasopressin rezeptor antagonisten ATE282621T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13962899P 1999-06-17 1999-06-17
US09/592,520 US6765004B1 (en) 1999-06-17 2000-06-12 Indoloazepines as vasopressin receptor antagonists
PCT/US2000/016549 WO2000078762A1 (en) 1999-06-17 2000-06-15 Indoloazepines as vasopressin receptor antagonists

Publications (1)

Publication Number Publication Date
ATE282621T1 true ATE282621T1 (de) 2004-12-15

Family

ID=26837417

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00941464T ATE282621T1 (de) 1999-06-17 2000-06-15 Indoloazepine als vasopressin rezeptor antagonisten

Country Status (20)

Country Link
US (1) US6765004B1 (de)
EP (1) EP1214323B1 (de)
JP (1) JP2003502426A (de)
CN (1) CN1399638A (de)
AT (1) ATE282621T1 (de)
AU (1) AU774768B2 (de)
BR (1) BR0012294A (de)
CA (1) CA2375268A1 (de)
DE (1) DE60015997T2 (de)
DK (1) DK1214323T3 (de)
ES (1) ES2233402T3 (de)
HU (1) HUP0201725A3 (de)
IL (1) IL147130A0 (de)
MX (1) MXPA01013286A (de)
NO (1) NO20016155L (de)
NZ (1) NZ516209A (de)
PL (1) PL352998A1 (de)
PT (1) PT1214323E (de)
TR (1) TR200200560T2 (de)
WO (1) WO2000078762A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0324269D0 (en) * 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
US8567448B2 (en) * 2007-12-26 2013-10-29 Smart Pipe Company, Inc. Methods and systems for in situ pipe lining
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用
CN113501825A (zh) * 2021-07-13 2021-10-15 青岛农业大学 一种具有生物活性的3,4-位稠杂七元杂环的氧化吲哚烯结构及其合成方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3314942A (en) * 1964-08-06 1967-04-18 Upjohn Co 3, 4, 5, 6-tetrahydro-1h-azepino(4, 3, 2-cd) indoles
US3249623A (en) * 1964-09-24 1966-05-03 Upjohn Co Derivatives of 3, 4, 5, 6-tetrahydro-1h-azepino [4, 3, 2-cd] indoles
BE795451A (fr) * 1972-02-23 1973-08-16 Pfizer Agents hypoglycemiants aza indoliques tricycliques
DE3525564A1 (de) 1985-07-15 1987-02-05 Schering Ag Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
JPS6434988A (en) * 1987-07-30 1989-02-06 Kissei Pharmaceutical Azepinoindole derivative
GB9307527D0 (en) * 1993-04-13 1993-06-02 Fujisawa Pharmaceutical Co New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
UA64690C2 (en) * 1993-07-21 2004-03-15 Yamanouty Farmaceutical Co Ltd A condensed benzadepine derivative, an intermediate compound for preparing thereof and a pharmaceutical composition
DE4438178A1 (de) * 1994-10-26 1996-05-02 Bayer Ag N-Methyl-N-isopropyl-heteroaryloxyacetamide

Also Published As

Publication number Publication date
HUP0201725A2 (en) 2002-10-28
NZ516209A (en) 2004-01-30
DK1214323T3 (da) 2005-01-10
DE60015997T2 (de) 2005-12-01
AU774768B2 (en) 2004-07-08
NO20016155D0 (no) 2001-12-17
PT1214323E (pt) 2005-02-28
WO2000078762A1 (en) 2000-12-28
NO20016155L (no) 2002-02-15
EP1214323B1 (de) 2004-11-17
EP1214323A1 (de) 2002-06-19
HUP0201725A3 (en) 2003-09-29
CA2375268A1 (en) 2000-12-28
CN1399638A (zh) 2003-02-26
US6765004B1 (en) 2004-07-20
AU5617000A (en) 2001-01-09
JP2003502426A (ja) 2003-01-21
IL147130A0 (en) 2002-08-14
DE60015997D1 (de) 2004-12-23
BR0012294A (pt) 2002-07-02
TR200200560T2 (tr) 2003-01-21
ES2233402T3 (es) 2005-06-16
MXPA01013286A (es) 2003-08-20
PL352998A1 (en) 2003-09-22

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