ATE282623T1 - Verfahren und verbindungen für die hemmung von mrp1 - Google Patents

Verfahren und verbindungen für die hemmung von mrp1

Info

Publication number
ATE282623T1
ATE282623T1 AT00986242T AT00986242T ATE282623T1 AT E282623 T1 ATE282623 T1 AT E282623T1 AT 00986242 T AT00986242 T AT 00986242T AT 00986242 T AT00986242 T AT 00986242T AT E282623 T1 ATE282623 T1 AT E282623T1
Authority
AT
Austria
Prior art keywords
mrp1
inhibition
compounds
methods
mammal
Prior art date
Application number
AT00986242T
Other languages
English (en)
Inventor
Rosanne Bonjouklian
Jeffrey Daniel Cohen
Joseph Michael Gruber
Douglas Webb Johnson
Louis Nickolaus Jungheim
Julian Stanley Kroin
Peter Ambrose Lander
Ho-Shen Lin
Mark Christopher Lohman
Brian Stephen Muehl
Bryan Hurst Norman
Vinod Francis Patel
Michael Enrico Richett
Kenneth Jeff Thrasher
Sreenivasarao Vepachedu
Wesley Todd White
Yongping Xie
Jeremy Schulenburg York
Brandon Lee Parkhurst
Quiping Wang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE282623T1 publication Critical patent/ATE282623T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT00986242T 1999-12-22 2000-12-11 Verfahren und verbindungen für die hemmung von mrp1 ATE282623T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17137399P 1999-12-22 1999-12-22
US22607600P 2000-08-17 2000-08-17
US23453900P 2000-09-22 2000-09-22
PCT/US2000/032443 WO2001046199A1 (en) 1999-12-22 2000-12-11 Methods and compounds for inhibiting mrp1

Publications (1)

Publication Number Publication Date
ATE282623T1 true ATE282623T1 (de) 2004-12-15

Family

ID=27389968

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00986242T ATE282623T1 (de) 1999-12-22 2000-12-11 Verfahren und verbindungen für die hemmung von mrp1

Country Status (12)

Country Link
EP (1) EP1250340B1 (de)
JP (1) JP2003518125A (de)
AT (1) ATE282623T1 (de)
AU (1) AU2251901A (de)
CA (1) CA2395513A1 (de)
CO (1) CO5261493A1 (de)
DE (1) DE60016039T2 (de)
ES (1) ES2233487T3 (de)
PE (1) PE20011085A1 (de)
PT (1) PT1250340E (de)
SV (1) SV2002000244A (de)
WO (1) WO2001046199A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096346A1 (en) * 2000-06-14 2001-12-20 Eli Lilly And Company Tricyclic compounds as mrp1-inhibitors
AU2001268040A1 (en) 2000-06-23 2002-01-08 Eli Lilly And Company Methods and compounds for inhibiting mrp1
WO2004016741A2 (en) * 2002-08-14 2004-02-26 Ppd Discovery, Inc. Prenylation inhibitors containing dimethyl-cyclobutane and methods of their synthesis and use
ZA200602755B (en) * 2003-09-06 2007-06-27 Vertex Pharma Modulators of ATP-binding cassette transporters
ITMI20032121A1 (it) * 2003-11-04 2005-05-05 Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm Procedimento per la preparazione di imiquimod e suoi intermedi
US7230002B2 (en) 2004-02-03 2007-06-12 Glenmark Pharmaceuticals Ltd. Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
WO2005075426A1 (en) * 2004-02-03 2005-08-18 Glenmark Pharmaceuticals Ltd. Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof
US20060035920A1 (en) * 2004-05-28 2006-02-16 Millennium Pharmaceuticals, Inc. Chk-1 inhibitors
WO2006011035A1 (en) * 2004-07-23 2006-02-02 Glenmark Pharmaceuticals Ltd. Novel dipeptidyl peptidase iv inhibitors; process for their preparation and compositions containing them
EP1799639B1 (de) * 2004-10-12 2013-09-04 Glenmark Pharmaceuticals S.A. Neue dipeptidylpeptidase-iv-inhibitoren, pharmazeutische zusammensetzungen, die diese enthalten, und verfahren zu deren herstellung
JP4845372B2 (ja) * 2004-11-30 2011-12-28 広栄化学工業株式会社 光学活性２−ヒドロキシエステル化合物の製造方法
JP2011504471A (ja) * 2007-11-23 2011-02-10 レオ ファーマ アクティーゼルスカブ 疾病処置用の新規環式炭化水素
WO2009146034A2 (en) * 2008-03-31 2009-12-03 Takeda Pharmaceutical Company Limited Mapk/erk kinase inhibitors and methods of use thereof
WO2012000498A1 (en) * 2010-06-30 2012-01-05 Leo Pharma A/S New polymorphic form of a calcimimetic compound
JP5968881B2 (ja) * 2010-06-30 2016-08-10 レオ ファーマ アクティーゼルスカブ カルシウム模倣化合物の新規多形
TW201534586A (zh) 2013-06-11 2015-09-16 Orion Corp 新穎ｃｙｐ１７抑制劑／抗雄激素劑
CN104230744B (zh) * 2014-09-01 2016-06-08 湖南尔康制药股份有限公司 一种替加环素原料药的生产方法
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
BR112017008809A2 (pt) 2014-11-05 2017-12-19 Flexus Biosciences Inc agentes imunorreguladores
CN112409207B (zh) * 2019-08-22 2022-11-22 新发药业有限公司 一种醚菌胺的制备方法
CN114890940A (zh) * 2022-04-21 2022-08-12 嘉兴瑞驰生物科技有限公司 一种6-甲氧基-2-吡啶甲酸的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980608A (en) * 1998-01-07 1999-11-09 Advanced Technology Materials, Inc. Throughflow gas storage and dispensing system
PL343313A1 (en) * 1998-04-08 2001-08-13 Lilly Co Eli Methods for inhibiting mrp1
CN1296410A (zh) * 1998-04-08 2001-05-23 伊莱利利公司 抑制mrp1的方法
CN1296408A (zh) * 1998-04-08 2001-05-23 伊莱利利公司 抑制mrp1的方法

Also Published As

Publication number Publication date
PE20011085A1 (es) 2001-10-24
AU2251901A (en) 2001-07-03
DE60016039D1 (de) 2004-12-23
CO5261493A1 (es) 2003-03-31
SV2002000244A (es) 2002-07-16
WO2001046199A1 (en) 2001-06-28
EP1250340A1 (de) 2002-10-23
CA2395513A1 (en) 2001-06-28
PT1250340E (pt) 2005-04-29
ES2233487T3 (es) 2005-06-16
EP1250340B1 (de) 2004-11-17
JP2003518125A (ja) 2003-06-03
DE60016039T2 (de) 2005-08-11

Similar Documents

Publication Publication Date Title
ATE282623T1 (de) Verfahren und verbindungen für die hemmung von mrp1
TR200200082T2 (tr) MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.
NO990855D0 (no) Substituerte sykliske amin-metallprotease-inhibitorer
NO20003018L (no) Triazinangiogenese-inhibitorer
BR9104181A (pt) Composto
BG103415A (en) Heteroaryl succinamides and their application as inhibitors of metalloproteinase
ATE482200T1 (de) Als kinaseinhibitoren geeignete arylsubstituierte pyrazolamidverbindungen
DK1140918T3 (da) Thrombininhibitorer
BG100692A (en) New heterocyclic compounds
TW200510317A (en) Caspase inhibitors and uses thereof
ATE293691T1 (de) Myostatin genpromoter und inhibierung dessen aktivierung
ATE443044T1 (de) Tace inhibitoren
WO2004033423A3 (en) Anticancer compounds
EA200000948A1 (ru) Новые полициклические азаиндолы, способ их получения и фармацевтические композиции, содержащие их
TR200102514T2 (tr) COPD tedavisi için metod
DK1347965T3 (da) Hidtil ukendte desloratidinsalte, fremgangsmåde til syntese deraf samt farmaceutiske præparater deraf
ATE277018T1 (de) 3,4-dihydrochinolin-derivative als stickstoffmonoxid-synthase (nos) inhibitoren
NO20032411D0 (no) Anvendelse av substituerte 6-dimetylaminometyl-1-fenyl- cykloheksan-forbindelser for behandling av urininkontinens
PT1276722E (pt) Inibidores de naftamidina-uroquinase
ATE488489T1 (de) Verfahren zur reduktiven deshalogenierung
EA199800931A1 (ru) Способ получения ингибиторов фосфодиэстеразы iv
ATE344666T1 (de) Pyridin-2-yl-methylamin-derivate zur behandlung von opiatsucht
ECSP003854A (es) Procedimientos y compuestos para la inhibicion de la mrp 1
DE60128336D1 (de) Eine zwischenverbindung und verfahren zu deren herstellung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1250340

Country of ref document: EP

REN Ceased due to non-payment of the annual fee