ATE282627T1 - Pyrimidinnukleotid-vorläufer zur behandlung entzündlicher hepatitis - Google Patents

Pyrimidinnukleotid-vorläufer zur behandlung entzündlicher hepatitis

Info

Publication number: ATE282627T1
Authority: AT; Austria
Prior art keywords: treatment; pyrimidine nucleotide; nucleotide precursors; inflammatory hepatitis; hepatitis
Prior art date: 1992-12-08

Application number

AT94903322T

Other languages

English (en)

Inventor

Borstel Reid Warren Von

Michael Kevin Bamat

Bradley M Hiltbrand

Original Assignee

Wellstat Therapeutics Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-08

Filing date

1993-12-01

Publication date

2004-12-15

1993-12-01 Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE282627T1 publication Critical patent/ATE282627T1/de

Links

239000002243 precursor Substances 0.000 title abstract 2
239000002719 pyrimidine nucleotide Substances 0.000 title abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
208000006454 hepatitis Diseases 0.000 title 1
231100000283 hepatitis Toxicity 0.000 title 1
230000002757 inflammatory effect Effects 0.000 title 1
DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 abstract 2
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 abstract 1
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
206010040047 Sepsis Diseases 0.000 abstract 1
102000006405 Uridine phosphorylase Human genes 0.000 abstract 1
108010019092 Uridine phosphorylase Proteins 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
230000009885 systemic effect Effects 0.000 abstract 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 abstract 1
229940045145 uridine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Transplantation (AREA)
Gastroenterology & Hepatology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT94903322T 1992-12-08 1993-12-01 Pyrimidinnukleotid-vorläufer zur behandlung entzündlicher hepatitis ATE282627T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US98773092A	1992-12-08	1992-12-08
PCT/US1993/011531 WO1994013687A1 (en)	1992-12-08	1993-12-01	Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis

Publications (1)

Publication Number	Publication Date
ATE282627T1 true ATE282627T1 (de)	2004-12-15

Family

ID=25533509

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94903322T ATE282627T1 (de)	1992-12-08	1993-12-01	Pyrimidinnukleotid-vorläufer zur behandlung entzündlicher hepatitis

Country Status (14)

Country	Link
EP (2)	EP0679160B1 (de)
JP (3)	JPH08503699A (de)
KR (1)	KR100315890B1 (de)
CN (2)	CN1089239C (de)
AT (1)	ATE282627T1 (de)
AU (2)	AU5730594A (de)
CA (2)	CA2150940C (de)
DE (1)	DE69333699T2 (de)
ES (1)	ES2229212T3 (de)
IL (1)	IL107900A (de)
MX (1)	MX9307765A (de)
PT (1)	PT679160E (de)
WO (1)	WO1994013687A1 (de)
ZA (1)	ZA939208B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6329350B1 (en)	1987-10-28	2001-12-11	Pro-Neuron, Inc.	Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
US5691320A (en)	1987-10-28	1997-11-25	Pro-Neuron, Inc.	Acylated pyrimidine nucleosides for treatment of systemic inflammation and inflammatory hepatitis
JP4408450B2 (ja) *	1994-07-01	2010-02-03	ウェルスタットセラピューティクスコーポレイション	全身性炎症および炎症性肝炎の処置のためのピリミジンヌクレオチド前駆体
SE9701219D0 (sv) *	1997-04-04	1997-04-04	Astra Pharma Prod	New compounds
US20020006913A1 (en) *	1997-11-04	2002-01-17	Von Borstel Reid W.	Antimutagenic compositions for treatment and prevention of photodamage to skin
SE521031C2 (sv)	1999-05-05	2003-09-23	Srinivas Uppugunduri	Nya specifika inhibitorer av akut och kronisk inflammation
EP1402892A4 (de) *	2001-06-11	2006-11-08	Kyowa Hakko Kogyo Kk	Entzündungshemmende und hustenstillende zusammensetzungen
EP3002010A1 (de) *	2014-09-30	2016-04-06	Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.	Nahrungsaufnahme, Körpergewicht und Glucosemetabolismus durch Modulation der P2Y6-Rezeptorsignalisierung
WO2016008603A1 (en) *	2014-07-16	2016-01-21	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Food intake, body weight and glucose metabolism regulation by modulation of p2y6 receptor signaling
WO2018038599A1 (en) *	2016-08-23	2018-03-01	N.V. Nutricia	Product and method for increasing uridine concentration in blood plasma
EP4414001A4 (de)	2021-10-07	2025-12-03	Yamasa Corp	Hautpflegezusammensetzung und verwendung davon sowie hautpflegezusammensetzungs-quellmaterial
CN114469981A (zh) *	2021-12-16	2022-05-13	中国科学院动物研究所	尿苷在促进组织器官再生或治疗和/或预防和/或缓解和/或改善组织器官损伤中的应用

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GB1297398A (de) *	1969-08-06	1972-11-22
US3868451A (en) *	1971-03-30	1975-02-25	Abbott Lab	Adenosine-5{40 -esters in treating angina pectoris
JPS6037182B2 (ja) *	1977-03-24	1985-08-24	日本冶金工業株式会社	耐食性にすぐれた高強度オ−ステナイトステンレス鋼
JPS6037183B2 (ja) *	1977-03-24	1985-08-24	日本冶金工業株式会社	耐食性にすぐれた高力オ−ステナイトステンレス鋼
JPS5585659A (en) *	1978-12-25	1980-06-27	Daido Steel Co Ltd	Free-cutting nonmagnetic high-manganese steel
JPS58126956A (ja) *	1982-01-22	1983-07-28	Nippon Steel Corp	プレス加工性の優れた高強度薄鋼板
JPS6054374B2 (ja) *	1982-04-21	1985-11-29	新日本製鐵株式会社	オ−ステナイト鋼板および鋼帯の製造方法
DE3481191D1 (de) *	1983-07-20	1990-03-08	Teijin Ltd	Antineoplastisches mittel.
JPS60174797A (ja) *	1984-02-21	1985-09-09	Funai Corp	Ν−アロイルチミジン誘導体ならびに抗腫瘍活性物質の毒性低下剤
KR890002033B1 (ko) *	1985-08-31	1989-06-08	한국과학기술원	최저온용 합금 및 그 제조방법
EP0712629B1 (de) *	1987-10-28	2003-06-18	Wellstat Therapeutics Corporation	Acyldeoxyribonukleosid-Derivate und Verwendungen davon
CA1321994C (en) *	1987-10-28	1993-09-07	Reid Von Borstel	Acylated uridine and cytidine and uses thereof
US4874602A (en) *	1988-02-22	1989-10-17	Paul Calabresi	Reduction of the severity 3'-azido-3'-deoxythymidine-induced anemia using benzylacyclouridine
US5077280A (en) *	1988-04-12	1991-12-31	Brown University Research Foundation	Treatment of viral infections
JP2529605B2 (ja) *	1989-10-23	1996-08-28	株式会社大塚製薬工場	免疫賦活剤
JPH03169815A (ja) *	1989-11-29	1991-07-23	Nippon Mining Co Ltd	肝臓障害予防及び治療剤
US5141943A (en) *	1990-04-12	1992-08-25	Brown University Research Foundation	5-benzyl barbiturate derivatives

1993
- 1993-12-01 CA CA002150940A patent/CA2150940C/en not_active Expired - Fee Related
- 1993-12-01 JP JP6510442A patent/JPH08503699A/ja not_active Withdrawn
- 1993-12-01 ES ES94903322T patent/ES2229212T3/es not_active Expired - Lifetime
- 1993-12-01 AT AT94903322T patent/ATE282627T1/de not_active IP Right Cessation
- 1993-12-01 CA CA002588495A patent/CA2588495C/en not_active Expired - Fee Related
- 1993-12-01 PT PT94903322T patent/PT679160E/pt unknown
- 1993-12-01 WO PCT/US1993/011531 patent/WO1994013687A1/en not_active Ceased
- 1993-12-01 EP EP94903322A patent/EP0679160B1/de not_active Expired - Lifetime
- 1993-12-01 EP EP04020415A patent/EP1486210A1/de not_active Withdrawn
- 1993-12-01 AU AU57305/94A patent/AU5730594A/en not_active Abandoned
- 1993-12-01 DE DE69333699T patent/DE69333699T2/de not_active Expired - Fee Related
- 1993-12-01 KR KR1019950702327A patent/KR100315890B1/ko not_active Expired - Fee Related
- 1993-12-06 IL IL10790093A patent/IL107900A/en not_active IP Right Cessation
- 1993-12-07 CN CN93121700A patent/CN1089239C/zh not_active Expired - Fee Related
- 1993-12-08 MX MX9307765A patent/MX9307765A/es unknown
- 1993-12-08 ZA ZA939208A patent/ZA939208B/xx unknown
1998
- 1998-08-05 AU AU78813/98A patent/AU732120B2/en not_active Ceased
2000
- 2000-11-29 CN CNB001344811A patent/CN1211089C/zh not_active Expired - Fee Related
2004
- 2004-12-01 JP JP2004348587A patent/JP2005162757A/ja not_active Withdrawn
2007
- 2007-07-05 JP JP2007177101A patent/JP2007332144A/ja active Pending

Also Published As

Publication number	Publication date
JPH08503699A (ja)	1996-04-23
PT679160E (pt)	2005-02-28
CN1089239C (zh)	2002-08-21
HK1004484A1 (en)	1998-11-27
EP0679160A4 (de)	1997-06-11
WO1994013687A1 (en)	1994-06-23
CA2588495C (en)	2009-11-17
IL107900A (en)	1999-12-22
KR100315890B1 (ko)	2002-06-27
JP2005162757A (ja)	2005-06-23
KR950704342A (ko)	1995-11-20
AU732120B2 (en)	2001-04-12
CN1095268A (zh)	1994-11-23
CA2588495A1 (en)	1994-06-23
JP2007332144A (ja)	2007-12-27
AU7881398A (en)	1998-10-08
ZA939208B (en)	1994-08-08
ES2229212T3 (es)	2005-04-16
EP0679160B1 (de)	2004-11-17
CA2150940C (en)	2007-08-21
AU5730594A (en)	1994-07-04
EP0679160A1 (de)	1995-11-02
IL107900A0 (en)	1994-05-30
EP1486210A1 (de)	2004-12-15
MX9307765A (es)	1994-06-30
CA2150940A1 (en)	1994-06-23
DE69333699D1 (de)	2004-12-23
CN1211089C (zh)	2005-07-20
DE69333699T2 (de)	2006-07-27
CN1309970A (zh)	2001-08-29

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