ATE283044T1 - Compactin zur behandlung von entzündungen - Google Patents

Compactin zur behandlung von entzündungen

Info

Publication number: ATE283044T1
Authority: AT; Austria
Prior art keywords: inhibitors; compactin; inflammation; treatment; disclosed
Prior art date: 1992-01-31

Application number

AT93904788T

Other languages

English (en)

Inventor

Gary M Bokoch

Original Assignee

Scripps Research Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-31

Filing date

1993-01-21

Publication date

2004-12-15

1993-01-21 Application filed by Scripps Research Inst filed Critical Scripps Research Inst

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE283044T1 publication Critical patent/ATE283044T1/de

Links

VGMFHMLQOYWYHN-UHFFFAOYSA-N Compactin Natural products OCC1OC(OC2C(O)C(O)C(CO)OC2Oc3cc(O)c4C(=O)C(=COc4c3)c5ccc(O)c(O)c5)C(O)C(O)C1O VGMFHMLQOYWYHN-UHFFFAOYSA-N 0.000 title 1
206010061218 Inflammation Diseases 0.000 title 1
AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 title 1
230000004054 inflammatory process Effects 0.000 title 1
AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 title 1
BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 3
102000004722 NADPH Oxidases Human genes 0.000 abstract 1
108010002998 NADPH Oxidases Proteins 0.000 abstract 1
230000004913 activation Effects 0.000 abstract 1
230000006122 isoprenylation Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
210000001539 phagocyte Anatomy 0.000 abstract 1
230000004481 post-translational protein modification Effects 0.000 abstract 1
230000019254 respiratory burst Effects 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Ignition Installations For Internal Combustion Engines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT93904788T 1992-01-31 1993-01-21 Compactin zur behandlung von entzündungen ATE283044T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/829,766 US5244916A (en)	1992-01-31	1992-01-31	Inhibition of respiratory burst using posttranslational modification inhibitors
PCT/US1993/000871 WO1993014749A1 (en)	1992-01-31	1993-01-21	Inhibition of respiratory burst using posttranslational modification inhibitors

Publications (1)

Publication Number	Publication Date
ATE283044T1 true ATE283044T1 (de)	2004-12-15

Family

ID=25255499

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93904788T ATE283044T1 (de)	1992-01-31	1993-01-21	Compactin zur behandlung von entzündungen

Country Status (6)

Country	Link
US (1)	US5244916A (de)
EP (1)	EP0727987B1 (de)
AT (1)	ATE283044T1 (de)
CA (1)	CA2129235C (de)
DE (1)	DE69333711T2 (de)
WO (1)	WO1993014749A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5587402A (en) *	1992-04-09	1996-12-24	Wisconsin Alumni Research Foundation	Regression of mammalian leukemia cell tumors
US5470877A (en) *	1992-04-09	1995-11-28	Wisconsin Alumni Research Foundation	Uses of perillic acid methyl ester
US5726155A (en) *	1993-08-02	1998-03-10	The Scripps Research Institute	Regulation of oxidative burst using LMWG-derived peptides and analogs
US5668171A (en) *	1993-11-08	1997-09-16	Board Of Regents, The University Of Texas System	Halogenated mevalonate compositions and uses thereof in ras-dependent cell growth
GB2285047B (en) *	1993-12-21	1998-04-15	Yamanouchi U K Ltd	Polypeptides which inhibit the NADPH oxidase complex
US5763496A (en) *	1995-11-27	1998-06-09	The Research Foundation Of State University Of New York	Prevention of atherosclerosis using NADPH oxidase inhibitors
WO1999026657A1 (en)	1997-11-25	1999-06-03	Musc Foundation For Research Development	Inhibitors of nitric oxide synthase
US5916595A (en) *	1997-12-12	1999-06-29	Andrx Pharmaceutials, Inc.	HMG co-reductase inhibitor
US20040029962A1 (en) *	1997-12-12	2004-02-12	Chih-Ming Chen	HMG-COA reductase inhibitor extended release formulation
US20060141036A1 (en) *	1997-12-12	2006-06-29	Andrx Labs Llc	HMG-CoA reductase inhibitor extended release formulation
US6242473B1 (en) *	1999-01-08	2001-06-05	Maxim Pharmaceuticals, Inc.	Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US20010006656A1 (en) *	1999-02-17	2001-07-05	University Of Washington	Methods and compositions for inhibiting inflammation associated with pulmonary disease
WO2001034123A1 (en) *	1999-11-08	2001-05-17	Andrx Corporation	Hmg-coa reductase inhibitor extended release formulation
US20020010128A1 (en) *	2000-04-13	2002-01-24	Parks Thomas P.	Treatment of hyperproliferative, inflammatory and related mucocutaneous disorders using inhibitors of mevalonate synthesis and metabolism
US20030195167A1 (en) *	2002-04-15	2003-10-16	Kowa Co., Ltd.	PTX3-gene expression inhibitor
WO2014030132A2 (en)	2012-08-22	2014-02-27	Universidad De Los Andes	Use of statins for periodontal disease and bone regeneration
FR3030248B1 (fr)	2014-12-22	2018-03-23	L'oreal	Association derive d'acide pyridine-dicarboxylique/agent anti-oxydant particulier

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2111384A (en) *	1981-08-03	1983-07-06	Wynne David	Improvement in preventative and curative medicine
US5593966A (en) *	1989-03-31	1997-01-14	The United States Of America As Represented By The Department Of Health And Human Services	Peptide derivatives of cytochrome b558 and their use as medicaments
FI915643A7 (fi) *	1990-03-30	1991-11-29	Amgen Inc	Hengityspurkausta vaimentava tekijä
ES2170068T3 (es) *	1992-06-16	2002-08-01	Icn Pharmaceuticals	Composicion para el tratamiento de la piel.
JP2004351839A (ja) *	2003-05-30	2004-12-16	Brother Ind Ltd	接合構造及び接合構造の製造方法

1992
- 1992-01-31 US US07/829,766 patent/US5244916A/en not_active Expired - Lifetime
1993
- 1993-01-21 EP EP93904788A patent/EP0727987B1/de not_active Expired - Lifetime
- 1993-01-21 DE DE69333711T patent/DE69333711T2/de not_active Expired - Fee Related
- 1993-01-21 WO PCT/US1993/000871 patent/WO1993014749A1/en not_active Ceased
- 1993-01-21 AT AT93904788T patent/ATE283044T1/de not_active IP Right Cessation
- 1993-01-21 CA CA002129235A patent/CA2129235C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2129235A1 (en)	1993-08-05
WO1993014749A1 (en)	1993-08-05
CA2129235C (en)	2004-04-06
AU670259B2 (en)	1996-07-11
AU3602793A (en)	1993-09-01
EP0727987A1 (de)	1996-08-28
EP0727987B1 (de)	2004-11-24
US5244916A (en)	1993-09-14
DE69333711T2 (de)	2005-12-15
EP0727987A4 (de)	1998-03-11
DE69333711D1 (de)	2004-12-30

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Legal Events

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2005-11-15

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Publication of translation of european patent specification

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2008-10-15

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