ATE283267T1 - O2-arylate oder o2 glycosyiate 1-substituierte diazen-1-ium-1,2 diolate und o2-substituierte 1 (2-carboxylate) pyrolidin-1-yl diazen-1-ium-1,2- diolate - Google Patents

O2-arylate oder o2 glycosyiate 1-substituierte diazen-1-ium-1,2 diolate und o2-substituierte 1 (2-carboxylate) pyrolidin-1-yl diazen-1-ium-1,2- diolate

Info

Publication number: ATE283267T1
Authority: AT; Austria
Prior art keywords: diolate; ium; substituted; diazene; glycosyiate
Prior art date: 1996-09-27

Application number

AT97944471T

Other languages

English (en)

Inventor

Joseph E Saavedra

Larry K Keefer

Aloka Srinivasan

Christian Freidrich Bogdan

William G Rice

Xinhua Ji

Original Assignee

Us Gov Health & Human Serv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-27

Filing date

1997-09-26

Publication date

2004-12-15

1997-09-26 Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE283267T1 publication Critical patent/ATE283267T1/de

Links

125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
208000007788 Acute Liver Failure Diseases 0.000 abstract 1
208000019838 Blood disease Diseases 0.000 abstract 1
208000024172 Cardiovascular disease Diseases 0.000 abstract 1
150000004008 N-nitroso compounds Chemical class 0.000 abstract 1
GZPJILHEBJUXSO-UHFFFAOYSA-N [O-][N+](N1C(C(O)=O)=CCC1)=NO Chemical compound [O-][N+](N1C(C(O)=O)=CCC1)=NO GZPJILHEBJUXSO-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
238000003776 cleavage reaction Methods 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000002255 enzymatic effect Effects 0.000 abstract 1
208000014951 hematologic disease Diseases 0.000 abstract 1
201000001881 impotence Diseases 0.000 abstract 1
201000004792 malaria Diseases 0.000 abstract 1
231100001223 noncarcinogenic Toxicity 0.000 abstract 1
230000000241 respiratory effect Effects 0.000 abstract 1
230000007017 scission Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/08—Azoxy compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/30—Nitrogen atoms non-acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT97944471T 1996-09-27 1997-09-26 O2-arylate oder o2 glycosyiate 1-substituierte diazen-1-ium-1,2 diolate und o2-substituierte 1 (2-carboxylate) pyrolidin-1-yl diazen-1-ium-1,2- diolate ATE283267T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US2681696P	1996-09-27	1996-09-27
US4591797P	1997-05-07	1997-05-07
US5169697P	1997-07-03	1997-07-03
PCT/US1997/017267 WO1998013358A1 (en)	1996-09-27	1997-09-26	O2-arylated or o2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and o2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates

Publications (1)

Publication Number	Publication Date
ATE283267T1 true ATE283267T1 (de)	2004-12-15

Family

ID=27362853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97944471T ATE283267T1 (de)	1996-09-27	1997-09-26	O2-arylate oder o2 glycosyiate 1-substituierte diazen-1-ium-1,2 diolate und o2-substituierte 1 (2-carboxylate) pyrolidin-1-yl diazen-1-ium-1,2- diolate

Country Status (7)

Country	Link
US (3)	US6610660B1 (de)
EP (2)	EP0929538B1 (de)
AT (1)	ATE283267T1 (de)
AU (1)	AU733590B2 (de)
CA (2)	CA2266908C (de)
DE (1)	DE69731758T2 (de)
WO (1)	WO1998013358A1 (de)

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1997
- 1997-09-26 CA CA2266908A patent/CA2266908C/en not_active Expired - Lifetime
- 1997-09-26 AT AT97944471T patent/ATE283267T1/de not_active IP Right Cessation
- 1997-09-26 CA CA2705474A patent/CA2705474C/en not_active Expired - Lifetime
- 1997-09-26 US US09/254,301 patent/US6610660B1/en not_active Expired - Lifetime
- 1997-09-26 DE DE69731758T patent/DE69731758T2/de not_active Expired - Lifetime
- 1997-09-26 EP EP97944471A patent/EP0929538B1/de not_active Expired - Lifetime
- 1997-09-26 EP EP10010885.1A patent/EP2292630B1/de not_active Expired - Lifetime
- 1997-09-26 WO PCT/US1997/017267 patent/WO1998013358A1/en not_active Ceased
- 1997-09-26 AU AU45957/97A patent/AU733590B2/en not_active Expired
2003
- 2003-01-07 US US10/337,495 patent/US6911433B2/en not_active Expired - Lifetime
2005
- 2005-04-12 US US11/104,232 patent/US7081524B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6610660B1 (en)	2003-08-26
AU733590B2 (en)	2001-05-17
WO1998013358A1 (en)	1998-04-02
US7081524B2 (en)	2006-07-25
DE69731758T2 (de)	2005-12-15
US6911433B2 (en)	2005-06-28
EP2292630B1 (de)	2015-11-25
DE69731758D1 (de)	2004-12-30
EP2292630A1 (de)	2011-03-09
CA2705474A1 (en)	1998-04-02
CA2705474C (en)	2013-07-16
US20050214249A1 (en)	2005-09-29
US20030147845A1 (en)	2003-08-07
EP0929538B1 (de)	2004-11-24
EP0929538A1 (de)	1999-07-21
CA2266908A1 (en)	1998-04-02
CA2266908C (en)	2010-07-20
AU4595797A (en)	1998-04-17

Legal Events

Date	Code	Title	Description
2005-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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