ATE283372T1 - Genvarianten des angiotensinogens und veranlagung zum bluthochdruck - Google Patents
Genvarianten des angiotensinogens und veranlagung zum bluthochdruckInfo
- Publication number
- ATE283372T1 ATE283372T1 AT94903230T AT94903230T ATE283372T1 AT E283372 T1 ATE283372 T1 AT E283372T1 AT 94903230 T AT94903230 T AT 94903230T AT 94903230 T AT94903230 T AT 94903230T AT E283372 T1 ATE283372 T1 AT E283372T1
- Authority
- AT
- Austria
- Prior art keywords
- angiotensinogen
- hypertension
- presidention
- genetic variants
- association
- Prior art date
Links
- 206010020772 Hypertension Diseases 0.000 title abstract 3
- 108090001067 Angiotensinogen Proteins 0.000 title abstract 2
- 102000004881 Angiotensinogen Human genes 0.000 title 1
- 230000002068 genetic effect Effects 0.000 title 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/952,442 US5374525A (en) | 1992-09-30 | 1992-09-30 | Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension |
| PCT/US1993/009136 WO1994008048A1 (en) | 1992-09-30 | 1993-09-29 | Angiotensinogen gene variants and predisposition to hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283372T1 true ATE283372T1 (de) | 2004-12-15 |
Family
ID=25492918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94903230T ATE283372T1 (de) | 1992-09-30 | 1993-09-29 | Genvarianten des angiotensinogens und veranlagung zum bluthochdruck |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US5374525A (de) |
| EP (1) | EP0665898B1 (de) |
| JP (1) | JP3159708B2 (de) |
| KR (1) | KR950704507A (de) |
| AT (1) | ATE283372T1 (de) |
| AU (1) | AU670990B2 (de) |
| CA (1) | CA2145415A1 (de) |
| DE (1) | DE69333710D1 (de) |
| NZ (1) | NZ259092A (de) |
| WO (1) | WO1994008048A1 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153386A (en) * | 1992-09-30 | 2000-11-28 | University Of Utah Research Foundation | Method to determine predisposition to hypertension |
| US5374525A (en) * | 1992-09-30 | 1994-12-20 | University Of Utah Research Foundation | Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension |
| US5750345A (en) * | 1995-10-31 | 1998-05-12 | Evanston Hospital Corporation | Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders |
| DE19613606C1 (de) | 1996-04-04 | 1997-04-30 | Progen Biotechnik Gmbh | Gen für Hypertonie |
| US6114118A (en) * | 1996-09-20 | 2000-09-05 | Texas A&M University System | Method of identification of animals resistant or susceptible to disease such as ruminant brucellosis, tuberculosis, paratuberculosis and salmonellosis |
| US6197505B1 (en) * | 1997-04-04 | 2001-03-06 | Pyrosequencing Ab | Methods for assessing cardiovascular status and compositions for use thereof |
| US20020123467A1 (en) * | 1999-09-02 | 2002-09-05 | Institut Pasteur | Therapeutic composition comprising the KAL protein and use of the KAL protein for the treatment of retinal, renal, neuronal and neural injury |
| US6194556B1 (en) * | 1997-12-11 | 2001-02-27 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therfor |
| US6610497B1 (en) * | 1997-12-11 | 2003-08-26 | Millennium Pharmaceuticals, Inc. | Angiotensin converting enzyme homolog and therapeutic and diagnostic uses therefor |
| US6893877B2 (en) | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
| WO1999034920A1 (en) * | 1998-01-12 | 1999-07-15 | Massachusetts Institute Of Technology | Method and apparatus for performing microassays |
| US6525185B1 (en) | 1998-05-07 | 2003-02-25 | Affymetrix, Inc. | Polymorphisms associated with hypertension |
| US6495338B1 (en) | 1998-09-04 | 2002-12-17 | University Of Utah Research Foundation | Drug screening and diagnosis based on paracrine tubular renin-angiotensin system |
| DE69920032T2 (de) * | 1998-11-10 | 2005-09-15 | Genset | Methoden, software und apparate zur identifizierung genomischer bereiche, die ein gen umfassen, das mit einem nachweisbaren merkmal assoziiert ist |
| US6306578B1 (en) * | 1999-03-19 | 2001-10-23 | Genencor International, Inc. | Multi-through hole testing plate for high throughput screening |
| US6902888B1 (en) * | 1999-05-21 | 2005-06-07 | Myriad Genetics, Inc. | Diabetes gene |
| AU5016200A (en) * | 1999-05-21 | 2000-12-12 | Myriad Genetics, Inc. | Diabetes gene |
| US20020119448A1 (en) * | 1999-06-23 | 2002-08-29 | Joseph A. Sorge | Methods of enriching for and identifying polymorphisms |
| US6177252B1 (en) * | 1999-08-27 | 2001-01-23 | University Of Utah Research Foundation | Method to determine predisposition to hypertension |
| US7076437B1 (en) | 1999-10-29 | 2006-07-11 | Victor Levy | Process for consumer-directed diagnostic and health care information |
| US20020151040A1 (en) | 2000-02-18 | 2002-10-17 | Matthew O' Keefe | Apparatus and methods for parallel processing of microvolume liquid reactions |
| US7332271B2 (en) * | 2000-02-18 | 2008-02-19 | Board Of Trustees Of The Leland Stanford Junior University | Apparatus and methods for parallel processing of micro-volume liquid reactions |
| AU2001264950A1 (en) * | 2000-05-26 | 2001-12-11 | Duke University | Methods of screening for parkinson's disease |
| AU2001273661A1 (en) * | 2000-06-30 | 2002-01-14 | Duke University | Methods of screening for alzheimer's disease |
| US20050239125A1 (en) * | 2000-09-06 | 2005-10-27 | Hodge Timothy A | Methods for genotype screening |
| US20030219776A1 (en) * | 2001-12-18 | 2003-11-27 | Jean-Marc Lalouel | Molecular variants, haplotypes and linkage disequilibrium within the human angiotensinogen gene |
| JP2006510341A (ja) * | 2002-02-27 | 2006-03-30 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 有害薬剤反応および薬剤効力を予測する単一ヌクレオチド多型 |
| US20040014109A1 (en) * | 2002-05-23 | 2004-01-22 | Pericak-Vance Margaret A. | Methods and genes associated with screening assays for age at onset and common neurodegenerative diseases |
| US20060183117A1 (en) * | 2002-07-08 | 2006-08-17 | Pericak-Vance Margaret A | Screening for alzheimer's disease |
| US8277753B2 (en) | 2002-08-23 | 2012-10-02 | Life Technologies Corporation | Microfluidic transfer pin |
| EP1608952B1 (de) | 2002-12-20 | 2016-08-10 | Life Technologies Corporation | Assay vorrichtung und verfahren unter verwendung von mikrofluiden matrixstrukturen |
| US20060246437A1 (en) * | 2003-07-11 | 2006-11-02 | Pericak-Vance Margaret A | Genetic susceptibility genes for asthma and atopy and asthma-related and atopic-related phenotypes |
| US20060068428A1 (en) * | 2003-11-03 | 2006-03-30 | Duke University | Identification of genetic markers associated with parkinson disease |
| US20050191652A1 (en) * | 2003-11-03 | 2005-09-01 | Vance Jeffery M. | Identification of genetic forms of a gene that leads to high risk for parkinson disease |
| WO2005089945A1 (en) | 2004-03-12 | 2005-09-29 | Biotrove, Inc. | Nanoliter array loading |
| US20060105453A1 (en) | 2004-09-09 | 2006-05-18 | Brenan Colin J | Coating process for microfluidic sample arrays |
| US12070731B2 (en) | 2004-08-04 | 2024-08-27 | Life Technologies Corporation | Methods and systems for aligning dispensing arrays with microfluidic sample arrays |
| US7807465B2 (en) * | 2004-10-27 | 2010-10-05 | Duke University | Methods for identifying an individual at increased risk of developing coronary artery disease |
| US7790390B2 (en) * | 2004-10-27 | 2010-09-07 | Duke University | Methods for identifying an individual at increased risk of developing coronary artery disease |
| WO2006069592A2 (en) * | 2004-12-31 | 2006-07-06 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg | Method for diagnosing an/or predicting preeclampsia and/or related disorders |
| US20070148661A1 (en) * | 2005-07-19 | 2007-06-28 | Duke University | LSAMP Gene Associated With Cardiovascular Disease |
| JP2007075015A (ja) * | 2005-09-14 | 2007-03-29 | Tokai Univ | 高血圧症の検査用マーカー遺伝子 |
| US20110044963A1 (en) * | 2009-03-09 | 2011-02-24 | Puschett Jules B | Method of Testing a Patient for Hypertension and Related Method of Treatment and Test Kit |
| SG11201609376SA (en) | 2014-05-22 | 2016-12-29 | Alnylam Pharmaceuticals Inc | Angiotensinogen (agt) irna compositions and methods of use thereof |
| CN108588211B (zh) * | 2018-05-02 | 2020-05-19 | 青岛泱深生物医药有限公司 | 一种子痫前期的生物标志物及其应用 |
| TWI851574B (zh) | 2018-05-14 | 2024-08-11 | 美商阿尼拉製藥公司 | 血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法 |
| IL292865A (en) | 2019-11-13 | 2022-07-01 | Alnylam Pharmaceuticals Inc | Methods and preparations for the treatment of angiotensinogen-related disorder - (agt) |
| IL309296A (en) | 2021-06-30 | 2024-02-01 | Alnylam Pharmaceuticals Inc | Methods and compositions for the treatment of angiotensinogen-related disorder (AGT-) |
| CA3228255A1 (en) | 2021-08-04 | 2023-02-09 | Alnylam Pharmaceuticals, Inc. | Irna compositions and methods for silencing angiotensinogen (agt) |
| WO2025128614A1 (en) | 2023-12-12 | 2025-06-19 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating an angiotensinogen- (agt-) associated disorder |
| WO2026133251A1 (en) | 2024-12-20 | 2026-06-25 | Novartis Ag | Combinations of antisense agents, pharmaceutical compositions and methods of use |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5374525A (en) * | 1992-09-30 | 1994-12-20 | University Of Utah Research Foundation | Methods to determine predisposition to hypertension and association of variant angiotensinogen gene and hypertension |
| US6153386A (en) * | 1992-09-30 | 2000-11-28 | University Of Utah Research Foundation | Method to determine predisposition to hypertension |
-
1992
- 1992-09-30 US US07/952,442 patent/US5374525A/en not_active Expired - Lifetime
-
1993
- 1993-09-29 DE DE69333710T patent/DE69333710D1/de not_active Expired - Lifetime
- 1993-09-29 EP EP94903230A patent/EP0665898B1/de not_active Expired - Lifetime
- 1993-09-29 AU AU57250/94A patent/AU670990B2/en not_active Ceased
- 1993-09-29 NZ NZ259092A patent/NZ259092A/en unknown
- 1993-09-29 CA CA002145415A patent/CA2145415A1/en not_active Abandoned
- 1993-09-29 WO PCT/US1993/009136 patent/WO1994008048A1/en not_active Ceased
- 1993-09-29 JP JP50921194A patent/JP3159708B2/ja not_active Expired - Fee Related
- 1993-09-29 KR KR1019950701223A patent/KR950704507A/ko not_active Ceased
- 1993-09-29 AT AT94903230T patent/ATE283372T1/de not_active IP Right Cessation
-
1994
- 1994-07-01 US US08/269,766 patent/US5589584A/en not_active Expired - Lifetime
- 1994-10-07 US US08/319,545 patent/US5763168A/en not_active Expired - Lifetime
-
1998
- 1998-06-08 US US09/092,988 patent/US5998145A/en not_active Expired - Lifetime
-
1999
- 1999-10-29 US US09/429,034 patent/US6165727A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5589584A (en) | 1996-12-31 |
| US5374525A (en) | 1994-12-20 |
| AU670990B2 (en) | 1996-08-08 |
| AU5725094A (en) | 1994-04-26 |
| US5998145A (en) | 1999-12-07 |
| CA2145415A1 (en) | 1994-04-14 |
| US6165727A (en) | 2000-12-26 |
| EP0665898A4 (de) | 1998-08-05 |
| NZ259092A (en) | 1996-05-28 |
| JPH08505043A (ja) | 1996-06-04 |
| EP0665898A1 (de) | 1995-08-09 |
| KR950704507A (ko) | 1995-11-20 |
| US5763168A (en) | 1998-06-09 |
| WO1994008048A1 (en) | 1994-04-14 |
| JP3159708B2 (ja) | 2001-04-23 |
| EP0665898B1 (de) | 2004-11-24 |
| DE69333710D1 (de) | 2004-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |