ATE283719T1 - Vorrichtung zur elektroporation durch gewebemikroporen - Google Patents

Vorrichtung zur elektroporation durch gewebemikroporen

Info

Publication number
ATE283719T1
ATE283719T1 AT99911185T AT99911185T ATE283719T1 AT E283719 T1 ATE283719 T1 AT E283719T1 AT 99911185 T AT99911185 T AT 99911185T AT 99911185 T AT99911185 T AT 99911185T AT E283719 T1 ATE283719 T1 AT E283719T1
Authority
AT
Austria
Prior art keywords
tissue
electroporation
micropore
micropores
microporating
Prior art date
Application number
AT99911185T
Other languages
English (en)
Inventor
Jonathan A Eppstein
Michael R Hatch
Original Assignee
Spectrx Inc
Altea Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx Inc, Altea Therapeutics Corp filed Critical Spectrx Inc
Application granted granted Critical
Publication of ATE283719T1 publication Critical patent/ATE283719T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A61N1/0416—Anode and cathode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0476—Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
AT99911185T 1998-03-06 1999-03-05 Vorrichtung zur elektroporation durch gewebemikroporen ATE283719T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/036,169 US6022316A (en) 1998-03-06 1998-03-06 Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
PCT/US1999/004984 WO1999044678A1 (en) 1998-03-06 1999-03-05 Apparatus for electroporation through microporated tissue

Publications (1)

Publication Number Publication Date
ATE283719T1 true ATE283719T1 (de) 2004-12-15

Family

ID=21887040

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99911185T ATE283719T1 (de) 1998-03-06 1999-03-05 Vorrichtung zur elektroporation durch gewebemikroporen

Country Status (9)

Country Link
US (1) US6022316A (de)
EP (1) EP1059960B1 (de)
JP (1) JP3619453B2 (de)
AT (1) ATE283719T1 (de)
AU (1) AU748376B2 (de)
CA (1) CA2329169C (de)
DE (1) DE69922353T2 (de)
ES (1) ES2237091T3 (de)
WO (1) WO1999044678A1 (de)

Families Citing this family (199)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090143775A1 (en) * 1995-08-31 2009-06-04 Rizoiu Ioana M Medical laser having controlled-temperature and sterilized fluid output
US20060240381A1 (en) * 1995-08-31 2006-10-26 Biolase Technology, Inc. Fluid conditioning system
CA2253549C (en) * 1996-06-18 2005-10-25 Alza Corporation Device for enhancing transdermal agent delivery or sampling
ATE241405T1 (de) * 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) * 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US20060002959A1 (en) * 1996-11-14 2006-01-05 Government Of The United States Skin-sctive adjuvants for transcutaneous immuization
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US7204832B2 (en) 1996-12-02 2007-04-17 Pálomar Medical Technologies, Inc. Cooling system for a photo cosmetic device
US20060149343A1 (en) * 1996-12-02 2006-07-06 Palomar Medical Technologies, Inc. Cooling system for a photocosmetic device
US8182473B2 (en) * 1999-01-08 2012-05-22 Palomar Medical Technologies Cooling system for a photocosmetic device
US6517532B1 (en) * 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
DE69825447T2 (de) * 1997-05-15 2005-09-15 Palomar Medical Technologies, Inc., Burlington Gerät zur dermatologischen behandlung
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US20050003008A1 (en) * 1997-09-23 2005-01-06 Natalya Rapoport Method of in vivo drug targeting to solid tumors via acoustically triggered drug delivery in polymeric micelles
US20040258703A1 (en) * 1997-11-14 2004-12-23 The Government Of The Us, As Represented By The Secretary Of The Army Skin-active adjuvants for transcutaneous immunization
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
ES2245506T3 (es) 1998-03-12 2006-01-01 Palomar Medical Technologies, Inc. Sistema de aplicacion de radiacion electromagnetica sobre la piel.
JP2002520101A (ja) 1998-07-13 2002-07-09 ジェネトロニクス、インコーポレーテッド 電気的に補助される化粧用薬剤の局部送達法および装置
US6678556B1 (en) 1998-07-13 2004-01-13 Genetronics, Inc. Electrical field therapy with reduced histopathological change in muscle
US6697669B2 (en) 1998-07-13 2004-02-24 Genetronics, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
DE69939906D1 (de) 1998-07-14 2008-12-24 Altea Therapeutics Corp Transdermale transportvorrichtung zum kontrollierten entfernen von biologischen membranen durch pyrotechnische ladung
JP2002524120A (ja) 1998-09-04 2002-08-06 パウダージェクト リサーチ リミテッド 粒子送達法を使用するモニタリング方法
US6602678B2 (en) 1998-09-04 2003-08-05 Powderject Research Limited Non- or minimally invasive monitoring methods
US6059820A (en) 1998-10-16 2000-05-09 Paradigm Medical Corporation Tissue cooling rod for laser surgery
US6148232A (en) * 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
JP2003524462A (ja) 1999-04-01 2003-08-19 スペクトルクス，インコーポレイティド ２機能分析デバイス
DK1189660T3 (da) * 1999-06-08 2006-08-21 Altea Therapeutics Corp Apparat til mikroperforering af biologiske membraner ved hjælp af tyndfilms-vævsgrænseflade-anordninger samt fremgangsmåde til fremstilling deraf
US6951411B1 (en) 1999-06-18 2005-10-04 Spectrx, Inc. Light beam generation, and focusing and redirecting device
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US20020091377A1 (en) * 2000-01-25 2002-07-11 Anderson R. Rox Method and apparatus for medical treatment utilizing long duration electromagnetic radiation
IT1320520B1 (it) * 2000-04-21 2003-12-10 Igea Srl Dispositivo e metodo di elettro-porazione in cui la misura delleproprieta' elettriche dei campioni svolta dopo l'emissione degli
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US20050277887A1 (en) * 2000-05-08 2005-12-15 Joel Douglas Micro infusion drug delivery device
US6659982B2 (en) 2000-05-08 2003-12-09 Sterling Medivations, Inc. Micro infusion drug delivery device
US6706032B2 (en) 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
US7597692B2 (en) * 2000-06-08 2009-10-06 Massachusetts Institute Of Technology Microscission processes and procedures
US7141034B2 (en) * 2000-06-08 2006-11-28 Altea Therapeutics Corporation Transdermal drug delivery device, method of making same and method of using same
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
TW495353B (en) 2000-09-01 2002-07-21 Bayer Ag Adjustable endcap for lancing device
JP5507030B2 (ja) 2000-09-08 2014-05-28 アルザ・コーポレーシヨン 経路閉鎖を阻害することによる経皮的薬物流動の減少の抑制方法
IT1315449B1 (it) * 2000-09-22 2003-02-11 Elisabetta Rossi Dispositivo e metodo per il trasporto molecolare transdermico
US20070281037A9 (en) * 2000-09-28 2007-12-06 Nanocyte Inc. Sterile preparations and compositions including stinging capsules and methods of producing and using same
US7632522B2 (en) 2000-09-28 2009-12-15 Nanocyte Inc. Use of stinging cells/capsules for the delivery of active agents to keratinous substances
EP1379127B1 (de) * 2000-09-28 2013-04-17 Nanocyte Inc. Methoden, zusammensetzungen und vorrichtungen unter verwendung von stechzellen/kapseln zur abgabe eines therapeutischen mittels oder eines kosmetischen mittels in ein gewebe
AU2002227447B2 (en) * 2000-12-28 2007-05-10 Palomar Medical Technologies, Inc. Method and apparatus for therapeutic EMR treatment of the skin
US20080183162A1 (en) * 2000-12-28 2008-07-31 Palomar Medical Technologies, Inc. Methods And Devices For Fractional Ablation Of Tissue
DE10102817B4 (de) * 2001-01-23 2006-01-12 Lts Lohmann Therapie-Systeme Ag Vorrichtung und Verfahren zur Hitzepulsgestützten transdermalen Applikation von Wirkstoffen
DK1372708T3 (da) 2001-02-13 2008-10-20 Us Gov Sec Army Vaccine til transkutan immunisering mod rejsediarre
US6888319B2 (en) * 2001-03-01 2005-05-03 Palomar Medical Technologies, Inc. Flashlamp drive circuit
CN1872363A (zh) * 2001-03-02 2006-12-06 帕洛玛医疗技术公司 用于光照美容和光照皮肤病治疗的设备和方法
WO2002070040A1 (en) * 2001-03-05 2002-09-12 Klaus Hoyer Skin cleaning apparatus for the removal of puss or tallow by suction
US6687537B2 (en) * 2001-04-06 2004-02-03 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and cellulite reduction
US7083580B2 (en) 2001-04-06 2006-08-01 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US6980854B2 (en) 2001-04-06 2005-12-27 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery of lidocaine and/or other drugs
US7496401B2 (en) 2001-04-06 2009-02-24 Mattioli Engineering Ltd Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7520875B2 (en) 2001-04-06 2009-04-21 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
US7010343B2 (en) 2001-04-06 2006-03-07 Mattioli Engineering Ltd. Method and apparatus for skin absorption enhancement and transdermal drug delivery
ES2331302T3 (es) 2001-05-01 2009-12-29 A.V. Topchiev Institute Of Petrochemical Synthesis Composiciones de hidrogel.
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US8541021B2 (en) 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US6855117B2 (en) 2001-08-01 2005-02-15 Johnson & Johnson Consumer Companies, Inc. Method of treating the skin of a subject
US6790179B2 (en) 2001-08-01 2004-09-14 Johnson & Johnson Consumer Companies, Inc. Method of examining and diagnosing skin health
US6840910B2 (en) 2001-08-01 2005-01-11 Johnson & Johnson Consumer Companies, Inc. Method of distributing skin care products
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
EP1450876B1 (de) 2001-11-07 2016-08-17 Syneron Medical Ltd. Integriertes transdermales arzneimittelabgabesystem
US20040147984A1 (en) * 2001-11-29 2004-07-29 Palomar Medical Technologies, Inc. Methods and apparatus for delivering low power optical treatments
US20030109860A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser treatment
US20030216719A1 (en) * 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US20030109787A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser diagnostics
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
US7540869B2 (en) * 2001-12-27 2009-06-02 Palomar Medical Technologies, Inc. Method and apparatus for improved vascular related treatment
US20040073175A1 (en) * 2002-01-07 2004-04-15 Jacobson James D. Infusion system
US9918665B2 (en) * 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
EP1519755B1 (de) * 2002-03-26 2008-05-07 Nanocyte Inc. Nesselzellen mit expression eines exogenen polynucleotids, das ein therapeutisches, diagnostisches oder kosmetisches mittel kodiert, und diese nesselzellen verwendende verfahren, zusammensetzungen und vorrichtungen oder daraus gewonnene kapseln zur abgabe des therapeutischen, diagnostischen oder kosmetischen mittels in ein gewebe
AU2003226605A1 (en) * 2002-04-19 2003-11-03 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
WO2004037287A2 (en) * 2002-05-23 2004-05-06 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
US20070239142A1 (en) * 2006-03-10 2007-10-11 Palomar Medical Technologies, Inc. Photocosmetic device
AU2003245573A1 (en) 2002-06-19 2004-01-06 Palomar Medical Technologies, Inc. Method and apparatus for treatment of cutaneous and subcutaneous conditions
WO2004000150A1 (en) * 2002-06-19 2003-12-31 Palomar Medical Technologies, Inc. Method and apparatus for photothermal treatment of tissue at depth
US20070219604A1 (en) * 2006-03-20 2007-09-20 Palomar Medical Technologies, Inc. Treatment of tissue with radiant energy
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
IL152573A (en) * 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152574A (en) 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
US8133505B2 (en) * 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152575A (en) 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
WO2004058352A2 (en) * 2002-12-20 2004-07-15 Palomar Medical Technologies, Inc. Apparatus for light treatment of acne and other disorders of follicles
US20060217695A1 (en) * 2003-12-31 2006-09-28 Debenedictis Leonard C Optically-induced treatment of internal tissue
US20070265606A1 (en) * 2003-02-14 2007-11-15 Reliant Technologies, Inc. Method and Apparatus for Fractional Light-based Treatment of Obstructive Sleep Apnea
EP1599147A2 (de) * 2003-02-19 2005-11-30 Palomar Medical Technologies, Inc. Verfahren und gerät zur behandlung von pseudofolliculitis barbae
EP1613202B1 (de) * 2003-03-27 2011-02-09 The General Hospital Corporation Gerät für die dermatologische behandlung und fraktionale oberflächenerneuerung der haut
EP1617888B1 (de) 2003-04-23 2019-06-12 Valeritas, Inc. Hydraulisch aktivierte pumpe für langzeitabgabe von medikamenten
US7258673B2 (en) * 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US20040249254A1 (en) * 2003-06-06 2004-12-09 Joel Racchini Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US20040253736A1 (en) * 2003-06-06 2004-12-16 Phil Stout Analytical device with prediction module and related methods
EP1720605A4 (de) * 2003-06-23 2007-10-24 Transpharma Medical Ltd Transdermales abgabesystem für kosmetische mittel
EP1653876A1 (de) * 2003-07-11 2006-05-10 Reliant Technologies, Inc. Verfahren und vorrichtung zur fraktionellen phototherapie von haut
US7189341B2 (en) * 2003-08-15 2007-03-13 Animas Technologies, Llc Electrochemical sensor ink compositions, electrodes, and uses thereof
DE202004021824U1 (de) 2003-08-15 2011-04-28 Animas Technologies Llc Mikroprozessoren und Vorrichtungen zur Überwachung von physiologischen Analyten
US8016811B2 (en) * 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
US7309335B2 (en) * 2003-12-31 2007-12-18 Palomar Medical Technologies, Inc. Dermatological treatment with visualization
US20100151406A1 (en) * 2004-01-08 2010-06-17 Dmitri Boutoussov Fluid conditioning system
RU2380092C2 (ru) 2004-01-30 2010-01-27 Кориум Интернэшнл, Инк. Быстро растворяющаяся пленка для доставки активного агента
EP1727592B1 (de) * 2004-03-25 2017-04-19 University College Cork-National University of Ireland, Cork Gerät zur prophylaxe oder behandlung von gewebe
WO2005096979A1 (en) 2004-04-01 2005-10-20 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
CA2561344A1 (en) * 2004-04-09 2005-10-27 Palomar Medical Technologies, Inc. Methods and products for producing lattices of emr-treated islets in tissues, and uses therefor
US9011329B2 (en) * 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
US7857767B2 (en) * 2004-04-19 2010-12-28 Invention Science Fund I, Llc Lumen-traveling device
US9801527B2 (en) 2004-04-19 2017-10-31 Gearbox, Llc Lumen-traveling biological interface device
US8337482B2 (en) * 2004-04-19 2012-12-25 The Invention Science Fund I, Llc System for perfusion management
US20050234440A1 (en) * 2004-04-19 2005-10-20 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System with a sensor for perfusion management
US8353896B2 (en) 2004-04-19 2013-01-15 The Invention Science Fund I, Llc Controllable release nasal system
US7850676B2 (en) * 2004-04-19 2010-12-14 The Invention Science Fund I, Llc System with a reservoir for perfusion management
US7998060B2 (en) * 2004-04-19 2011-08-16 The Invention Science Fund I, Llc Lumen-traveling delivery device
US20070244520A1 (en) * 2004-04-19 2007-10-18 Searete Llc Lumen-traveling biological interface device and method of use
US8361013B2 (en) * 2004-04-19 2013-01-29 The Invention Science Fund I, Llc Telescoping perfusion management system
US8019413B2 (en) * 2007-03-19 2011-09-13 The Invention Science Fund I, Llc Lumen-traveling biological interface device and method of use
US20070010868A1 (en) * 2004-04-19 2007-01-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Lumenally-active device
US8092549B2 (en) 2004-09-24 2012-01-10 The Invention Science Fund I, Llc Ciliated stent-like-system
US7413572B2 (en) * 2004-06-14 2008-08-19 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
WO2006014425A1 (en) * 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
EP1791575B1 (de) 2004-08-05 2014-10-08 Corium International, Inc. Klebstoffzusammensetzung
BRPI0516978A (pt) * 2004-10-21 2008-09-30 Bayer Healthcare Llc método para determinação da concentração de um análito em um fluido corpóreo e sistema para o mesmo
US20060122584A1 (en) * 2004-10-27 2006-06-08 Bommannan D B Apparatus and method to treat heart disease using lasers to form microchannels
US7776373B2 (en) * 2004-11-19 2010-08-17 Eteka Llc Apparatus and method for the enhancement of food properties and food prepared therefrom
WO2006063063A2 (en) * 2004-12-09 2006-06-15 Flexible Medical Systems, Llc Apparatus and method for continuous real-time trace biomolecular sampling, analysis and delivery
CA2597719A1 (en) * 2005-02-18 2006-08-24 Palomar Medical Technologies, Inc. Dermatological treatment device
US20060253176A1 (en) * 2005-02-18 2006-11-09 Palomar Medical Technologies, Inc. Dermatological treatment device with deflector optic
US8834862B2 (en) * 2005-04-19 2014-09-16 Nanocyte Inc. Methods, compositions and devices utilizing stinging cells/capsules for conditioning a tissue prior to delivery of an active agent
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
CA2612866A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
RU2007144582A (ru) * 2005-06-03 2009-06-10 Байолейз Текнолоджи, Инк. (Us) Устройство и способ обработки ткани
US20080274166A1 (en) * 2005-06-10 2008-11-06 Transpharma Medical Ltd. Patch for Transdermal Drug Delivery
TWI419717B (zh) * 2005-06-17 2013-12-21 Altea Therapeutics Corp 滲透傳送系統及其使用方法
EP1913328A4 (de) * 2005-06-24 2014-12-24 Biolase Inc Geräte zur visuellen rückkopplung für vorrichtungen zur abgabe elektromagnetischer energie
US8346347B2 (en) 2005-09-15 2013-01-01 Palomar Medical Technologies, Inc. Skin optical characterization device
US8333874B2 (en) * 2005-12-09 2012-12-18 Flexible Medical Systems, Llc Flexible apparatus and method for monitoring and delivery
WO2007095183A2 (en) * 2006-02-13 2007-08-23 Reliant Technologies, Inc. Laser system for treatment of skin laxity
US20070194717A1 (en) * 2006-02-17 2007-08-23 Palomar Medical Technologies, Inc. Lamp for use in a tissue treatment device
US20070212335A1 (en) * 2006-03-07 2007-09-13 Hantash Basil M Treatment of alopecia by micropore delivery of stem cells
KR101361376B1 (ko) 2006-03-30 2014-02-10 발레리타스 인코포레이티드 복합-카트리지 유체 전달 장치
WO2007117580A2 (en) * 2006-04-06 2007-10-18 Palomar Medical Technologies, Inc. Apparatus and method for skin treatment with compression and decompression
US20080058788A1 (en) * 2006-04-12 2008-03-06 Searete Llc., A Limited Liability Corporation Of The State Of Delaware Autofluorescent imaging and target ablation
US9408530B2 (en) 2006-04-12 2016-08-09 Gearbox, Llc Parameter-based navigation by a lumen traveling device
US20080234626A1 (en) * 2006-04-26 2008-09-25 Chelak Todd M Multi-stage microporation device
US7586957B2 (en) 2006-08-02 2009-09-08 Cynosure, Inc Picosecond laser apparatus and methods for its operation and use
WO2008052198A2 (en) * 2006-10-26 2008-05-02 Reliant Technologies, Inc. Methods of increasing skin permeability by treatment with electromagnetic radiation
WO2008052189A2 (en) * 2006-10-26 2008-05-02 Reliant Technologies, Inc. Micropore delivery of active substances
WO2008062365A2 (en) * 2006-11-24 2008-05-29 Koninklijke Philips Electronics N.V. Iontophoretic device
AU2008208009B2 (en) 2007-01-22 2013-08-15 Passport Technologies, Inc. Transdermal porator and patch system and method for using same
US7815630B2 (en) * 2007-01-25 2010-10-19 Biolase Technology, Inc. Target-close electromagnetic energy emitting device
US9101377B2 (en) * 2007-01-25 2015-08-11 Biolase, Inc. Electromagnetic energy output system
US7695469B2 (en) * 2007-01-25 2010-04-13 Biolase Technology, Inc. Electromagnetic energy output system
US20080186591A1 (en) * 2007-02-01 2008-08-07 Palomar Medical Technologies, Inc. Dermatological device having a zoom lens system
EP2112943A1 (de) 2007-02-20 2009-11-04 Galderma Research & Development Verfahren zur verabreichung einer therapeutischen substanz in die haut
US20090225060A1 (en) * 2007-05-03 2009-09-10 Rizoiu Ioana M Wrist-mounted laser with animated, page-based graphical user-interface
US9037229B2 (en) * 2007-10-09 2015-05-19 Syneron Medical Ltd Magnetic patch coupling
US8281675B2 (en) * 2007-10-17 2012-10-09 Syneron Medical Ltd Dissolution rate verification
JP5508272B2 (ja) * 2007-10-29 2014-05-28 トランスファーマ メディカル リミテッド 垂直的なパッチ乾燥
KR101287351B1 (ko) 2007-12-05 2013-07-23 시네론 메디컬 리미티드 피부 치료장치용 캐리어
US20100004536A1 (en) * 2008-07-03 2010-01-07 Avner Rosenberg Method and apparatus for ultrasound tissue treatment
US20100017750A1 (en) * 2008-07-16 2010-01-21 Avner Rosenberg User interface
CA2771260C (en) * 2008-08-22 2017-04-25 Mark L. Faupel Method and apparatus for disease diagnosis and screening using extremely low frequency electromagnetic fields
WO2010083035A2 (en) 2009-01-14 2010-07-22 Corium International, Inc. Transdermal administration of tamsulosin
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
WO2010124346A1 (en) 2009-05-01 2010-11-04 Botanical Essentials Pty Ltd A method and system for delivering a treatment agent into the skin of a patient
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US20110245756A1 (en) 2009-12-03 2011-10-06 Rishi Arora Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
US9877673B2 (en) 2010-12-10 2018-01-30 Clinitech, Llc Transdermal sampling and analysis device
US9451913B2 (en) 2010-12-10 2016-09-27 Touchtek Labs, Llc Transdermal sampling and analysis device
US9968284B2 (en) 2011-12-02 2018-05-15 Clinitech, Llc Anti-interferent barrier layers for non-invasive transdermal sampling and analysis device
WO2013158299A1 (en) 2012-04-18 2013-10-24 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US20180099140A1 (en) * 2012-06-18 2018-04-12 Michael Tavger Method and system for triggering wound recovery by delivering solution into the pores of recipient
WO2013190537A1 (en) * 2012-06-18 2013-12-27 Michael Tavger Method and system for delivering solution into the pores of recipient human skin
US10898116B2 (en) 2013-03-15 2021-01-26 Cambridge Medical Technologies LLC Methods of manufacture to optimize performance of transdermal sampling and analysis device
EP2973894A2 (de) 2013-03-15 2016-01-20 Cynosure, Inc. Optische picosekunden-strahlungssysteme und verfahren zur verwendung
CN112042066A (zh) 2018-02-26 2020-12-04 赛诺秀股份有限公司 调q倾腔亚纳秒激光器
US12484952B2 (en) 2018-05-31 2025-12-02 North Carolina State University Electro-thermal therapy for the treatment of diseased or unwanted tissue
WO2019237107A1 (en) * 2018-06-08 2019-12-12 Mayo Foundation For Medical Education And Research Dermatological electroporation devices and methods
US11633129B2 (en) 2019-04-05 2023-04-25 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating redox cofactors
EP3975896A4 (de) * 2019-05-31 2023-06-28 North Carolina State University Verfahren und vorrichtung zur modifizierung oder abtötung von zellen durch manipulation der zellmembranladezeit
US11375931B2 (en) 2019-08-08 2022-07-05 Cambridge Medical Technologies LLC Non-invasive transdermal sampling and analysis device incorporating an electrochemical bioassay
WO2021077206A1 (en) * 2019-10-24 2021-04-29 Kiffik Inc. Artificial kidney system and devices
CN111107679B (zh) * 2019-12-02 2021-06-04 天津大学 一种用于反离子电渗抽取的柔性温控系统
MX2022011624A (es) * 2020-03-20 2022-10-13 Inovio Pharmaceuticals Inc Dispositivos de electroporacion asistidos por vacio y sistemas y metodos relacionados.
CN115666635A (zh) 2020-05-04 2023-01-31 新泽西州立罗格斯大学 使用抽吸来增强细胞的透化和转染的系统和方法
US20240042199A1 (en) * 2022-07-29 2024-02-08 Soovon Co. Ltd. Skin care method of skin beauty device

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4715388U (de) * 1971-03-20 1972-10-23
US5749847A (en) * 1988-01-21 1998-05-12 Massachusetts Institute Of Technology Delivery of nucleotides into organisms by electroporation
US5547467A (en) * 1988-01-21 1996-08-20 Massachusettes Institute Of Technology Method for rapid temporal control of molecular transport across tissue
DE68925030T2 (de) * 1988-01-21 1996-07-25 Massachusetts Inst Technology Molekültransport durch gewebe mit der verwendung von elektroporation.
US5362307A (en) * 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
WO1989006989A1 (en) * 1988-01-29 1989-08-10 The Regents Of The University Of California Iontophoretic non-invasive sampling or delivery device
JP2804968B2 (ja) * 1988-03-02 1998-09-30 新日本無線株式会社 試料採取用具
US5137817A (en) * 1990-10-05 1992-08-11 Amoco Corporation Apparatus and method for electroporation
US5215520A (en) * 1991-09-17 1993-06-01 Centre Internationale De Recherches Dermatologiques Galderma (C.I.R.D. Galderma) Method for delivering an active substance topically or percutaneously
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5464386A (en) * 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5462520A (en) * 1992-08-17 1995-10-31 Genetronics, Inc. Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
US5439440A (en) * 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US5445611A (en) * 1993-12-08 1995-08-29 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal delivery with ultrasound and chemical enhancers
US5458140A (en) * 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
DE69519023T2 (de) * 1994-06-24 2001-06-13 Cygnus, Inc. Einrichtung zur iontophoretischen probennahme
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy

Also Published As

Publication number Publication date
JP3619453B2 (ja) 2005-02-09
EP1059960B1 (de) 2004-12-01
AU2988999A (en) 1999-09-20
ES2237091T3 (es) 2005-07-16
DE69922353D1 (de) 2005-01-05
CA2329169C (en) 2014-11-25
US6022316A (en) 2000-02-08
JP2002505171A (ja) 2002-02-19
WO1999044678A1 (en) 1999-09-10
DE69922353T2 (de) 2005-12-22
EP1059960A1 (de) 2000-12-20
AU748376B2 (en) 2002-06-06
CA2329169A1 (en) 1999-09-10

Similar Documents

Publication Publication Date Title
DE69922353D1 (de) Vorrichtung zur elektroporation durch gewebemikroporen
ATE350514T1 (de) Vorrichtung und verfahren zur elektrolytischen behandlung von elektrisch isolierten strukturen
DE60215130D1 (de) Verfahren und vorrichtung zum dauerhaften verändern einer neuralen funktion eines patienten
DE60331351D1 (de) Verfahren zur feststellung von stimulationsparametern
DE60322523D1 (de) Ien mit übersetzenden elektrischen feldern und elektroden-polaritäts-umkehr
ATE329005T1 (de) Vorrichtung und verfahren zum elektrischen kontaktieren von in einer flüssigkeit in suspension befindlichen biologischen zellen
ATE395947T1 (de) Vorrichtung zur transkutanen stimulation eines nervs des menschlichen körpers
WO2002085451A3 (en) Handheld apparatus for transdermal drug delivery and analyte extraction
ATE437940T1 (de) Behältnis und vorrichtung zur erzeugung von elektrischen feldern in einzelnen reaktionsräumen
DE60007290D1 (de) Einbringen von makromolekülen in zellen
EP1785160A3 (de) Vorrichtung zur Nervenstimulation
TW368420B (en) Apparatus and method for transdermal molecular delivery by applying sufficient amplitude of electric field to induce migration of molecules through pores in the stratum corneum
ATE331557T1 (de) System zur veränderung von therapieparametern
WO2004030760A3 (en) Apparatus for treating a tumor by an electric field
ATE333843T1 (de) Vorrichtung zum mapping
DE69913153D1 (de) Gerät zum zusammendrücken einer gel/sensor-einheit
DE69104471D1 (de) Verfahren und Vorrichtung zur Behandlung eines Fluides unter Verwendung eines kapazitiven Effekts.
MXPA05012823A (es) Metodo y aparato para la mejora de absorcion cutanea y el suministro transdermico de droga de lidocaina y/u otras drogas.
DE60333457D1 (de) Elektrode für die behandlung von oberflächen mit elektrischen entladungen, verfahren zur behandlung von oberflächen mit elektrischen entladungen und vorrichtung zur behandlung von oberflächen mit elektrischen entladungen
DE602006008832D1 (de) Vorrichtung zur kontrollierten wärmeablation von tumoren durch elektromagnetische hochfrequenz-energie
EP3848090A3 (de) Vorrichtung zur stimulierung von akupunkturpunkten und verfahren zur stimulierung von akupunkturpunkten damit
ATE435279T1 (de) Kombiniertes elektroporations- und mikroinjektionsverfahren zur durchdringung von membranen mit lipid-doppelschichten
WO2007010441A3 (en) Apparatus and method for coupling implanted electrodes to nervous tissue
WO2009027596A3 (fr) Source micronique d'émission ionique
DE50214747D1 (de) Verfahren und Vorrichtung zur Bildung von Erdalkalicarbonat

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties