ATE283852T1 - Naphthostyril derivate und deren verwendung als inhibitoren von cyclin-abhängigen kinasen - Google Patents

Naphthostyril derivate und deren verwendung als inhibitoren von cyclin-abhängigen kinasen

Info

Publication number
ATE283852T1
ATE283852T1 AT02706711T AT02706711T ATE283852T1 AT E283852 T1 ATE283852 T1 AT E283852T1 AT 02706711 T AT02706711 T AT 02706711T AT 02706711 T AT02706711 T AT 02706711T AT E283852 T1 ATE283852 T1 AT E283852T1
Authority
AT
Austria
Prior art keywords
naphthostyril
cyclin
inhibitors
derivatives
dependent kinases
Prior art date
Application number
AT02706711T
Other languages
English (en)
Inventor
Yi Chen
Apostolos Dermatakis
Frederick Martin Konzelmann
Jin-Jun Liu
Kin-Chun Luk
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE283852T1 publication Critical patent/ATE283852T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT02706711T 2001-01-23 2002-01-16 Naphthostyril derivate und deren verwendung als inhibitoren von cyclin-abhängigen kinasen ATE283852T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26365801P 2001-01-23 2001-01-23
PCT/EP2002/000366 WO2002059109A2 (en) 2001-01-23 2002-01-16 Naphthostyril derivatives and their use as inhibitors of cyclin- dependent kinases

Publications (1)

Publication Number Publication Date
ATE283852T1 true ATE283852T1 (de) 2004-12-15

Family

ID=23002712

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02706711T ATE283852T1 (de) 2001-01-23 2002-01-16 Naphthostyril derivate und deren verwendung als inhibitoren von cyclin-abhängigen kinasen

Country Status (17)

Country Link
US (2) US6504034B2 (de)
EP (1) EP1358180B1 (de)
JP (1) JP4091434B2 (de)
KR (1) KR100563429B1 (de)
CN (1) CN1231479C (de)
AR (1) AR035738A1 (de)
AT (1) ATE283852T1 (de)
AU (1) AU2002240905B2 (de)
BR (1) BR0206621A (de)
CA (1) CA2434381C (de)
DE (1) DE60202131T2 (de)
ES (1) ES2232736T3 (de)
MX (1) MXPA03006423A (de)
PE (1) PE20020916A1 (de)
UY (1) UY27132A1 (de)
WO (1) WO2002059109A2 (de)
ZA (1) ZA200305383B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011525915A (ja) * 2008-06-26 2011-09-29 アムジエン・インコーポレーテツド キナーゼ阻害薬としてのアルキニルアルコール類
CN109665987B (zh) * 2018-12-28 2022-02-18 河南大学 萘内酰亚胺-多胺缀合物及其制备方法和用途
WO2020210630A1 (en) 2019-04-12 2020-10-15 C4 Therapeutics, Inc. Tricyclic degraders of ikaros and aiolos
MX2023004374A (es) * 2020-10-14 2023-07-06 C4 Therapeutics Inc Ligandos tricíclicos para la degradación de la familia ikaros 2 o la familia ikaros 4.
KR20240020735A (ko) 2021-05-07 2024-02-15 카이메라 쎄라퓨틱스 인코포레이티드 Cdk2 분해제 및 그 용도
JP2025505687A (ja) * 2022-02-09 2025-02-28 シーフォー セラピューティクス， インコーポレイテッド Ｃｆｔ７４５５のモルフィック形態及びその製造方法
WO2026024674A1 (en) 2024-07-22 2026-01-29 Genesis Therapeutics, Inc. Methods of treating skp2-associated cancers

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5081131A (en) * 1986-01-13 1992-01-14 American Cyanamid Company Omega-((hetero)alkyl)benz(cd)-indol-2-amines
KR930011300B1 (ko) 1989-07-25 1993-11-29 다이호오 야꾸힌 고오교오 가부시끼가이샤 옥시인돌유도체
WO1992007830A2 (en) 1990-10-29 1992-05-14 Pfizer Inc. Oxindole peptide antagonists
FR2694004B1 (fr) 1992-07-21 1994-08-26 Adir Nouvelles 3-(Hydroxybenzylidényl)-indoline-2-ones et 3-(hydroxybenzylidényl)-indoline-2-thiones, leurs procédés de préparation, et les compositions pharmaceutiques qui les contiennent.
GB9313638D0 (en) 1993-07-01 1993-08-18 Erba Carlo Spa Arylidene and heteroarylidene oxindole derivatives and process for their preparation
GB9423997D0 (en) 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation
GB9501567D0 (en) 1995-01-26 1995-03-15 Pharmacia Spa Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
GB9507298D0 (en) 1995-04-07 1995-05-31 Pharmacia Spa Substituted indolylmethylene-oxindale analogues as tyrosine kinase inhibitors
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DE29513441U1 (de) 1995-08-22 1995-10-19 Engelhardt, Rolf, 45883 Gelsenkirchen Aschenbecher zum Mitführen
DE69734521T9 (de) 1996-08-23 2006-12-07 Sugen, Inc., South San Francisco Kombinatorische indolinonbibliotheken und verwandte produkte und verfahren zur behandlung von erkrankungen
US5750556A (en) * 1996-10-30 1998-05-12 American Home Products Corporation 2-(aminomethyl)-3,4,7,9-tetrahydro-2H-pyrano- 2,3-E!indol-8-ones and derivatives
JP2002511852A (ja) 1997-05-07 2002-04-16 スージェン・インコーポレーテッド 蛋白質キナーゼ活性の調節剤としての２−インドリノン誘導体
BR9916327A (pt) 1998-12-17 2001-09-18 Hoffmann La Roche Oxindóis de 4-alquenila (e alquinila) como inibidores de cinases dependentes de ciclina, em particular, cdk2

Also Published As

Publication number Publication date
EP1358180B1 (de) 2004-12-01
AU2002240905B2 (en) 2007-03-01
DE60202131D1 (de) 2005-01-05
ZA200305383B (en) 2004-10-11
DE60202131T2 (de) 2005-12-01
CA2434381A1 (en) 2002-08-01
BR0206621A (pt) 2004-02-25
PE20020916A1 (es) 2002-10-21
UY27132A1 (es) 2002-07-31
KR20030069223A (ko) 2003-08-25
US6504034B2 (en) 2003-01-07
MXPA03006423A (es) 2003-10-15
CA2434381C (en) 2009-11-24
WO2002059109A3 (en) 2002-09-19
EP1358180A2 (de) 2003-11-05
US20020147343A1 (en) 2002-10-10
ES2232736T3 (es) 2005-06-01
WO2002059109A2 (en) 2002-08-01
CN1231479C (zh) 2005-12-14
US6531598B1 (en) 2003-03-11
JP4091434B2 (ja) 2008-05-28
AR035738A1 (es) 2004-07-07
KR100563429B1 (ko) 2006-03-22
JP2004517150A (ja) 2004-06-10
CN1487931A (zh) 2004-04-07

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