ATE283857T1 - Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren - Google Patents

Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren

Info

Publication number: ATE283857T1
Authority: AT; Austria
Prior art keywords: döbenz; aöpyrimido; gaba; imidazo; receptor modulators
Prior art date: 2001-05-18

Application number

AT02771640T

Other languages

English (en)

Inventor

Raffaello Masciadri

Andrew William Thomas

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-08

Publication date

2004-12-15

2002-05-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE283857T1 publication Critical patent/ATE283857T1/de

Links

102000004300 GABA-A Receptors Human genes 0.000 title 1
108090000839 GABA-A Receptors Proteins 0.000 title 1
150000001538 azepines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT02771640T 2001-05-18 2002-05-08 Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren ATE283857T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01112222		2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en)	2001-05-18	2002-05-08	Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number	Publication Date
ATE283857T1 true ATE283857T1 (de)	2004-12-15

Family

ID=8177471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02771640T ATE283857T1 (de)	2001-05-18	2002-05-08	Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren

Country Status (37)

Country	Link
US (1)	US6686352B2 (de)
EP (1)	EP1399448B1 (de)
JP (1)	JP4068466B2 (de)
KR (1)	KR100533406B1 (de)
CN (1)	CN1230436C (de)
AR (1)	AR033753A1 (de)
AT (1)	ATE283857T1 (de)
AU (1)	AU2002338898B2 (de)
BG (1)	BG108369A (de)
BR (1)	BR0209859A (de)
CA (1)	CA2446903C (de)
CZ (1)	CZ20033355A3 (de)
DE (1)	DE60202147T2 (de)
DK (1)	DK1399448T3 (de)
EC (1)	ECSP034851A (de)
ES (1)	ES2232778T3 (de)
GT (1)	GT200200087A (de)
HR (1)	HRP20030890A2 (de)
HU (1)	HUP0400743A3 (de)
IL (2)	IL158572A0 (de)
JO (1)	JO2297B1 (de)
MA (1)	MA27024A1 (de)
MX (1)	MXPA03010529A (de)
MY (1)	MY127570A (de)
NO (1)	NO20035104L (de)
NZ (1)	NZ529097A (de)
PA (1)	PA8545201A1 (de)
PE (1)	PE20030041A1 (de)
PL (1)	PL366846A1 (de)
PT (1)	PT1399448E (de)
RU (1)	RU2287531C2 (de)
SI (1)	SI1399448T1 (de)
SK (1)	SK15252003A3 (de)
TW (1)	TWI251489B (de)
WO (1)	WO2002094834A1 (de)
YU (1)	YU90003A (de)
ZA (1)	ZA200308544B (de)

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KR101792651B1 (ko)	2004-05-14	2017-11-20	밀레니엄 파머슈티컬스 인코퍼레이티드	아우로라 키나아제의 억제에 의해 유사분열 진행을 억제하기 위한 화합물 및 그 화합물을 포함하는 약학적 조성물
EP1799684B1 (de) *	2004-10-04	2014-12-03	Millennium Pharmaceuticals, Inc.	Als proteinkinaseinhibotren geeignete lactamverbindungen
RU2007114763A (ru) *	2004-10-20	2008-11-27	Ф.Хоффманн-Ля Рош Аг (Ch)	Галогенозамещенные производные бензодиазепинов
NZ554439A (en) *	2004-10-20	2009-09-25	Hoffmann La Roche	Imidazo-benzodiazepine derivatives
JP4885967B2 (ja)	2005-10-11	2012-02-29	エフ．ホフマン−ラロシュアーゲー	イミダゾベンゾジアゼピン誘導体
PE20080145A1 (es)	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es)	2006-11-16	2008-04-04	Millennium Pharm Inc	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
JP5562865B2 (ja)	2007-12-17	2014-07-30	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｔｒｐｖ１のイミダゾロ−、オキサゾロ−、及びチアゾロピリミジン・モジュレーター
CN101735211B (zh) *	2008-11-04	2012-11-14	复旦大学	2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
US7998952B2 (en)	2008-12-05	2011-08-16	Millennium Pharmaceuticals, Inc.	Thiolactams and uses thereof
CN102264368B (zh)	2008-12-22	2014-09-10	米伦纽姆医药公司	极光激酶抑制剂与抗cd20抗体的组合
JO3635B1 (ar)	2009-05-18	2020-08-27	Millennium Pharm Inc	مركبات صيدلانية صلبة وطرق لانتاجها
WO2011103089A1 (en)	2010-02-19	2011-08-25	Millennium Pharmaceuticals, Inc.	Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6--methoxyphenyl)-5h -pyrimido[5,4-d][2]benzazepin-2yl]amino}-2-methoxybenzoate
CN101891706B (zh) *	2010-04-09	2013-05-29	复旦大学	3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) *	2011-10-31	2012-04-25	江苏阿尔法药业有限公司	一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
US20130303519A1 (en)	2012-03-20	2013-11-14	Millennium Pharmaceuticals, Inc.	Methods of treating cancer using aurora kinase inhibitors
EP2976086B1 (de)	2013-03-22	2020-10-14	Millennium Pharmaceuticals, Inc.	Kombination aus katalytischen mtorc 1/2-inhibitoren und selektiven inhibitoren der aurora-a-kinase
EP4032889B1 (de) *	2013-12-20	2026-05-06	Agenebio, Inc.	Benzodiazepinderivate, zusammensetzungen und verfahren zur behandlung von kognitiven störungen
EP3310785B1 (de)	2015-06-19	2024-11-20	Agenebio, Inc.	Benzodiazepinderivate, zusammensetzungen und verfahren zur behandlung kognitiver beeinträchtigung
EP3324976A4 (de)	2015-07-21	2019-03-27	Millennium Pharmaceuticals, Inc.	Verabreichung eines aurora-kinase-inhibitors und chemotherapeutika
US20180170941A1 (en)	2016-12-19	2018-06-21	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
AU2019288382B2 (en)	2018-06-19	2024-07-25	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110452172B (zh) *	2019-08-21	2021-03-26	爱斯特（成都）生物制药股份有限公司	一种苯并己内酰胺的合成方法
CN112159411A (zh) *	2020-10-15	2021-01-01	南京工业大学	一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

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RU2119496C1 (ru) *	1992-04-14	1998-09-27	Научно-исследовательский институт фармакологии Российской академии медицинских наук	Производные n-ацилпролилдипептидов
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2002
- 2002-04-09 US US10/118,584 patent/US6686352B2/en not_active Expired - Fee Related
- 2002-05-08 EP EP02771640A patent/EP1399448B1/de not_active Expired - Lifetime
- 2002-05-08 RU RU2003136078/04A patent/RU2287531C2/ru not_active IP Right Cessation
- 2002-05-08 MX MXPA03010529A patent/MXPA03010529A/es active IP Right Grant
- 2002-05-08 CA CA002446903A patent/CA2446903C/en not_active Expired - Fee Related
- 2002-05-08 DE DE60202147T patent/DE60202147T2/de not_active Expired - Lifetime
- 2002-05-08 HR HR20030890A patent/HRP20030890A2/xx not_active Application Discontinuation
- 2002-05-08 CN CNB028101774A patent/CN1230436C/zh not_active Expired - Fee Related
- 2002-05-08 SI SI200230055T patent/SI1399448T1/xx unknown
- 2002-05-08 AT AT02771640T patent/ATE283857T1/de not_active IP Right Cessation
- 2002-05-08 JP JP2002591507A patent/JP4068466B2/ja not_active Expired - Fee Related
- 2002-05-08 HU HU0400743A patent/HUP0400743A3/hu unknown
- 2002-05-08 PL PL02366846A patent/PL366846A1/xx not_active Application Discontinuation
- 2002-05-08 ES ES02771640T patent/ES2232778T3/es not_active Expired - Lifetime
- 2002-05-08 AU AU2002338898A patent/AU2002338898B2/en not_active Ceased
- 2002-05-08 KR KR10-2003-7015036A patent/KR100533406B1/ko not_active Expired - Fee Related
- 2002-05-08 DK DK02771640T patent/DK1399448T3/da active
- 2002-05-08 PT PT02771640T patent/PT1399448E/pt unknown
- 2002-05-08 BR BR0209859-8A patent/BR0209859A/pt not_active IP Right Cessation
- 2002-05-08 IL IL15857202A patent/IL158572A0/xx unknown
- 2002-05-08 YU YU90003A patent/YU90003A/sh unknown
- 2002-05-08 CZ CZ20033355A patent/CZ20033355A3/cs unknown
- 2002-05-08 WO PCT/EP2002/005121 patent/WO2002094834A1/en not_active Ceased
- 2002-05-08 SK SK1525-2003A patent/SK15252003A3/sk unknown
- 2002-05-08 NZ NZ529097A patent/NZ529097A/en unknown
- 2002-05-14 JO JO200243A patent/JO2297B1/en active
- 2002-05-15 PA PA20028545201A patent/PA8545201A1/es unknown
- 2002-05-15 TW TW091110162A patent/TWI251489B/zh not_active IP Right Cessation
- 2002-05-16 AR ARP020101805A patent/AR033753A1/es not_active Application Discontinuation
- 2002-05-16 PE PE2002000413A patent/PE20030041A1/es not_active Application Discontinuation
- 2002-05-16 GT GT200200087A patent/GT200200087A/es unknown
- 2002-05-17 MY MYPI20021808A patent/MY127570A/en unknown
2003
- 2003-10-23 IL IL158572A patent/IL158572A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308544A patent/ZA200308544B/en unknown
- 2003-11-14 MA MA27398A patent/MA27024A1/fr unknown
- 2003-11-17 NO NO20035104A patent/NO20035104L/no not_active Application Discontinuation
- 2003-11-17 EC EC2003004851A patent/ECSP034851A/es unknown
- 2003-11-18 BG BG108369A patent/BG108369A/bg unknown

Also Published As

Publication number	Publication date
GT200200087A (es)	2003-06-19
SI1399448T1 (en)	2005-02-28
RU2003136078A (ru)	2005-05-27
HUP0400743A3 (en)	2007-09-28
CZ20033355A3 (en)	2004-07-14
ECSP034851A (es)	2003-12-24
JP2004531563A (ja)	2004-10-14
CA2446903C (en)	2008-12-30
EP1399448B1 (de)	2004-12-01
HUP0400743A2 (hu)	2004-07-28
ES2232778T3 (es)	2005-06-01
NO20035104D0 (no)	2003-11-17
ZA200308544B (en)	2005-01-31
KR20040002975A (ko)	2004-01-07
PA8545201A1 (es)	2003-02-28
PE20030041A1 (es)	2003-02-07
DE60202147T2 (de)	2005-12-01
SK15252003A3 (sk)	2004-08-03
MXPA03010529A (es)	2004-03-02
NZ529097A (en)	2005-04-29
CN1230436C (zh)	2005-12-07
CA2446903A1 (en)	2002-11-28
MA27024A1 (fr)	2004-12-20
BR0209859A (pt)	2004-06-15
DE60202147D1 (de)	2005-01-05
HRP20030890A2 (en)	2005-08-31
DK1399448T3 (da)	2005-04-11
AU2002338898B8 (en)	2002-12-03
JP4068466B2 (ja)	2008-03-26
NO20035104L (no)	2003-11-17
US6686352B2 (en)	2004-02-03
PT1399448E (pt)	2005-03-31
HK1066544A1 (en)	2005-03-24
KR100533406B1 (ko)	2005-12-02
YU90003A (sh)	2006-08-17
MY127570A (en)	2006-12-29
JO2297B1 (en)	2005-09-12
US20030055042A1 (en)	2003-03-20
IL158572A (en)	2010-02-17
AU2002338898B2 (en)	2007-03-15
RU2287531C2 (ru)	2006-11-20
WO2002094834A1 (en)	2002-11-28
EP1399448A1 (de)	2004-03-24
AR033753A1 (es)	2004-01-07
TWI251489B (en)	2006-03-21
IL158572A0 (en)	2004-05-12
BG108369A (bg)	2005-01-31
CN1509289A (zh)	2004-06-30
PL366846A1 (en)	2005-02-07

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2005-08-15

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DE60103776D1 (de)	2004-07-15	Benzodiazepinderivate als gaba-a-rezeptormodulatoren
PT1444215E (pt)	2006-10-31	Derivados de 1,2,4-triadiazolio como moduladores do receptor de melanocortina
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