ATE283857T1 - Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren - Google Patents

Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren

Info

Publication number: ATE283857T1
Authority: AT; Austria
Prior art keywords: döbenz; aöpyrimido; gaba; imidazo; receptor modulators
Prior art date: 2001-05-18

Application number

AT02771640T

Other languages

English (en)

Inventor

Raffaello Masciadri

Andrew William Thomas

Juergen Wichmann

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-18

Filing date

2002-05-08

Publication date

2004-12-15

2002-05-08 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-15 Application granted granted Critical

2004-12-15 Publication of ATE283857T1 publication Critical patent/ATE283857T1/de

Links

102000004300 GABA-A Receptors Human genes 0.000 title 1
108090000839 GABA-A Receptors Proteins 0.000 title 1
150000001538 azepines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT02771640T 2001-05-18 2002-05-08 Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren ATE283857T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01112222		2001-05-18
PCT/EP2002/005121 WO2002094834A1 (en)	2001-05-18	2002-05-08	Imidazo [1,5-a] pyrimido [5,4-d] benzazepine derivatives as gaba a receptor modulators

Publications (1)

Publication Number	Publication Date
ATE283857T1 true ATE283857T1 (de)	2004-12-15

Family

ID=8177471

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02771640T ATE283857T1 (de)	2001-05-18	2002-05-08	Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren

Country Status (37)

Country	Link
US (1)	US6686352B2 (de)
EP (1)	EP1399448B1 (de)
JP (1)	JP4068466B2 (de)
KR (1)	KR100533406B1 (de)
CN (1)	CN1230436C (de)
AR (1)	AR033753A1 (de)
AT (1)	ATE283857T1 (de)
AU (1)	AU2002338898B2 (de)
BG (1)	BG108369A (de)
BR (1)	BR0209859A (de)
CA (1)	CA2446903C (de)
CZ (1)	CZ20033355A3 (de)
DE (1)	DE60202147T2 (de)
DK (1)	DK1399448T3 (de)
EC (1)	ECSP034851A (de)
ES (1)	ES2232778T3 (de)
GT (1)	GT200200087A (de)
HR (1)	HRP20030890A2 (de)
HU (1)	HUP0400743A3 (de)
IL (2)	IL158572A0 (de)
JO (1)	JO2297B1 (de)
MA (1)	MA27024A1 (de)
MX (1)	MXPA03010529A (de)
MY (1)	MY127570A (de)
NO (1)	NO20035104L (de)
NZ (1)	NZ529097A (de)
PA (1)	PA8545201A1 (de)
PE (1)	PE20030041A1 (de)
PL (1)	PL366846A1 (de)
PT (1)	PT1399448E (de)
RU (1)	RU2287531C2 (de)
SI (1)	SI1399448T1 (de)
SK (1)	SK15252003A3 (de)
TW (1)	TWI251489B (de)
WO (1)	WO2002094834A1 (de)
YU (1)	YU90003A (de)
ZA (1)	ZA200308544B (de)

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ES2540987T3 (es)	2004-05-14	2015-07-15	Millennium Pharmaceuticals, Inc.	Métodos para preparar inhibidores de la aurora cinasa
AU2005294575B2 (en) *	2004-10-04	2011-11-24	Millennium Pharmaceuticals, Inc.	Lactam compounds useful as protein kinase inhibitors
ES2399439T3 (es) *	2004-10-20	2013-04-01	F. Hoffmann-La Roche Ag	Derivados de imidazo-benzodiazepina
AU2005299031B2 (en) *	2004-10-20	2011-11-10	F. Hoffmann-La Roche Ag	Halogen substituted benzodiazepine derivatives
KR101009860B1 (ko) *	2005-10-11	2011-01-19	에프. 호프만-라 로슈 아게	이미다조 벤조다이아제핀 유도체
PE20080145A1 (es) *	2006-03-21	2008-02-11	Janssen Pharmaceutica Nv	Tetrahidro-pirimidoazepinas como moduladores de trpv1
CL2007003244A1 (es)	2006-11-16	2008-04-04	Millennium Pharm Inc	Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
WO2009078999A1 (en)	2007-12-17	2009-06-25	Janssen Pharmaceutica N.V.	Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
CN101735211B (zh) *	2008-11-04	2012-11-14	复旦大学	2,3-二氢[1,5]苯并噻氮杂*类化合物或其盐在制备GSK-3β抑制剂中的用途
US7998952B2 (en)	2008-12-05	2011-08-16	Millennium Pharmaceuticals, Inc.	Thiolactams and uses thereof
RU2535032C2 (ru)	2008-12-22	2014-12-10	Милленниум Фармасьютикалз, Инк.	Сочетание ингибиторов аврора киназы и анти-cd 20 антител
JO3635B1 (ar)	2009-05-18	2020-08-27	Millennium Pharm Inc	مركبات صيدلانية صلبة وطرق لانتاجها
CA2788774A1 (en)	2010-02-19	2011-08-25	Millennium Pharmaceuticals, Inc.	Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5h-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoate
CN101891706B (zh) *	2010-04-09	2013-05-29	复旦大学	3,4-二氢苯并[f][1,4]噻氮杂*类化合物或其盐及其药物用途
CN102424670A (zh) *	2011-10-31	2012-04-25	江苏阿尔法药业有限公司	一种合成3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2h-3-苯并氮杂卓-2-酮的方法
US20150374705A1 (en)	2012-02-14	2015-12-31	Shanghai Institues for Biological Sciences	Substances for treatment or relief of pain
US20130303519A1 (en)	2012-03-20	2013-11-14	Millennium Pharmaceuticals, Inc.	Methods of treating cancer using aurora kinase inhibitors
WO2014153509A1 (en)	2013-03-22	2014-09-25	Millennium Pharmaceuticals, Inc.	Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
EP3083569B1 (de)	2013-12-20	2022-01-26	Agenebio, Inc.	Benzodiazepinderivate, zusammensetzungen und verfahren zur behandlung von kognitiven störungen
JP6987384B2 (ja)	2015-06-19	2021-12-22	エージンバイオ，インコーポレイテッド	ベンゾジアゼピン誘導体、組成物、および認知障害を処置するための方法
JP2018524292A (ja)	2015-07-21	2018-08-30	ミレニアムファーマシューティカルズ，インコーポレイテッドＭｉｌｌｅｎｎｉｕｍＰｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ．	オーロラキナーゼインヒビターと化学療法剤の投与
US20180170941A1 (en)	2016-12-19	2018-06-21	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11505555B2 (en)	2016-12-19	2022-11-22	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
US11414425B2 (en)	2018-06-19	2022-08-16	Agenebio, Inc.	Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
CN110452172B (zh) *	2019-08-21	2021-03-26	爱斯特（成都）生物制药股份有限公司	一种苯并己内酰胺的合成方法
CN112159411A (zh) *	2020-10-15	2021-01-01	南京工业大学	一种三氟甲基取代嘧啶并[1,3]二氮杂*化合物及其制备方法

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RU2119496C1 (ru) *	1992-04-14	1998-09-27	Научно-исследовательский институт фармакологии Российской академии медицинских наук	Производные n-ацилпролилдипептидов
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FR2783828B1 (fr)	1998-09-29	2000-11-10	Synthelabo	Derives d'acide 5,6-dihydro-4h-imidazo[1,2-a][1] benzazepine -1-acetique, leur preparation et leur application en therapeutique
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TWI239333B (en)	2000-11-16	2005-09-11	Hoffmann La Roche	Benzodiazepine derivatives as GABA A receptor modulators

2002
- 2002-04-09 US US10/118,584 patent/US6686352B2/en not_active Expired - Fee Related
- 2002-05-08 YU YU90003A patent/YU90003A/sh unknown
- 2002-05-08 DE DE60202147T patent/DE60202147T2/de not_active Expired - Lifetime
- 2002-05-08 PL PL02366846A patent/PL366846A1/xx not_active Application Discontinuation
- 2002-05-08 PT PT02771640T patent/PT1399448E/pt unknown
- 2002-05-08 WO PCT/EP2002/005121 patent/WO2002094834A1/en not_active Ceased
- 2002-05-08 DK DK02771640T patent/DK1399448T3/da active
- 2002-05-08 CN CNB028101774A patent/CN1230436C/zh not_active Expired - Fee Related
- 2002-05-08 SI SI200230055T patent/SI1399448T1/xx unknown
- 2002-05-08 EP EP02771640A patent/EP1399448B1/de not_active Expired - Lifetime
- 2002-05-08 RU RU2003136078/04A patent/RU2287531C2/ru not_active IP Right Cessation
- 2002-05-08 HR HR20030890A patent/HRP20030890A2/xx not_active Application Discontinuation
- 2002-05-08 AT AT02771640T patent/ATE283857T1/de not_active IP Right Cessation
- 2002-05-08 CA CA002446903A patent/CA2446903C/en not_active Expired - Fee Related
- 2002-05-08 IL IL15857202A patent/IL158572A0/xx unknown
- 2002-05-08 AU AU2002338898A patent/AU2002338898B2/en not_active Ceased
- 2002-05-08 JP JP2002591507A patent/JP4068466B2/ja not_active Expired - Fee Related
- 2002-05-08 SK SK1525-2003A patent/SK15252003A3/sk unknown
- 2002-05-08 CZ CZ20033355A patent/CZ20033355A3/cs unknown
- 2002-05-08 ES ES02771640T patent/ES2232778T3/es not_active Expired - Lifetime
- 2002-05-08 MX MXPA03010529A patent/MXPA03010529A/es active IP Right Grant
- 2002-05-08 BR BR0209859-8A patent/BR0209859A/pt not_active IP Right Cessation
- 2002-05-08 NZ NZ529097A patent/NZ529097A/en unknown
- 2002-05-08 KR KR10-2003-7015036A patent/KR100533406B1/ko not_active Expired - Fee Related
- 2002-05-08 HU HU0400743A patent/HUP0400743A3/hu unknown
- 2002-05-14 JO JO200243A patent/JO2297B1/en active
- 2002-05-15 TW TW091110162A patent/TWI251489B/zh not_active IP Right Cessation
- 2002-05-15 PA PA20028545201A patent/PA8545201A1/es unknown
- 2002-05-16 GT GT200200087A patent/GT200200087A/es unknown
- 2002-05-16 PE PE2002000413A patent/PE20030041A1/es not_active Application Discontinuation
- 2002-05-16 AR ARP020101805A patent/AR033753A1/es not_active Application Discontinuation
- 2002-05-17 MY MYPI20021808A patent/MY127570A/en unknown
2003
- 2003-10-23 IL IL158572A patent/IL158572A/en not_active IP Right Cessation
- 2003-10-31 ZA ZA200308544A patent/ZA200308544B/en unknown
- 2003-11-14 MA MA27398A patent/MA27024A1/fr unknown
- 2003-11-17 EC EC2003004851A patent/ECSP034851A/es unknown
- 2003-11-17 NO NO20035104A patent/NO20035104L/no not_active Application Discontinuation
- 2003-11-18 BG BG108369A patent/BG108369A/bg unknown

Also Published As

Publication number	Publication date
KR100533406B1 (ko)	2005-12-02
PE20030041A1 (es)	2003-02-07
WO2002094834A1 (en)	2002-11-28
ZA200308544B (en)	2005-01-31
EP1399448A1 (de)	2004-03-24
YU90003A (sh)	2006-08-17
HRP20030890A2 (en)	2005-08-31
IL158572A (en)	2010-02-17
AU2002338898B8 (en)	2002-12-03
NO20035104D0 (no)	2003-11-17
SK15252003A3 (sk)	2004-08-03
JO2297B1 (en)	2005-09-12
US20030055042A1 (en)	2003-03-20
IL158572A0 (en)	2004-05-12
DE60202147D1 (de)	2005-01-05
MY127570A (en)	2006-12-29
JP2004531563A (ja)	2004-10-14
AU2002338898B2 (en)	2007-03-15
ECSP034851A (es)	2003-12-24
SI1399448T1 (en)	2005-02-28
HUP0400743A3 (en)	2007-09-28
CA2446903A1 (en)	2002-11-28
BG108369A (bg)	2005-01-31
PA8545201A1 (es)	2003-02-28
CN1230436C (zh)	2005-12-07
US6686352B2 (en)	2004-02-03
MA27024A1 (fr)	2004-12-20
PT1399448E (pt)	2005-03-31
MXPA03010529A (es)	2004-03-02
NZ529097A (en)	2005-04-29
TWI251489B (en)	2006-03-21
HUP0400743A2 (hu)	2004-07-28
CN1509289A (zh)	2004-06-30
RU2287531C2 (ru)	2006-11-20
GT200200087A (es)	2003-06-19
ES2232778T3 (es)	2005-06-01
DK1399448T3 (da)	2005-04-11
JP4068466B2 (ja)	2008-03-26
DE60202147T2 (de)	2005-12-01
CA2446903C (en)	2008-12-30
EP1399448B1 (de)	2004-12-01
NO20035104L (no)	2003-11-17
KR20040002975A (ko)	2004-01-07
AR033753A1 (es)	2004-01-07
RU2003136078A (ru)	2005-05-27
BR0209859A (pt)	2004-06-15
CZ20033355A3 (en)	2004-07-14
HK1066544A1 (en)	2005-03-24
PL366846A1 (en)	2005-02-07

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2005-08-15

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Publication	Publication Date	Title
ATE283857T1 (de)	2004-12-15	Imidazo(1,5-aöpyrimido)5,4-döbenz azepinderivate als gaba-a-rezeptormodulatoren
DE60103776D1 (de)	2004-07-15	Benzodiazepinderivate als gaba-a-rezeptormodulatoren
PT1444215E (pt)	2006-10-31	Derivados de 1,2,4-triadiazolio como moduladores do receptor de melanocortina
PT1218378E (pt)	2003-09-30	Derivados de terc-butil-(7-metil-imidazo-¬1,2-a\|-piridin-3-il)-amina
DE60202200D1 (de)	2005-01-13	Imidazo[1,2-a]-pyridinderivate als mglur5 antagonisten
NO20022738L (no)	2002-06-07	Pyrrolo(2,3-d)pyrimidinforbindelser
NO20043064L (no)	2004-09-17	1-alkyl-1-azoniabisyklo [2.2.2] oktankarbamatderivater og anvendelse av disse som muskarine reseptorantagonister
NO20013671D0 (no)	2001-07-26	Substituerte bicycliske derivater nyttige som anticancer midler
NO20023032L (no)	2002-06-21	Azaindoler
ATE253067T1 (de)	2003-11-15	Diazabicyloderivate als nikotin-acetylcholin- rezeptorliganden
DE60214428D1 (de)	2006-10-12	1, 4-dihydro-1, 4-diphenylpyridin-derivate
NO20032453D0 (no)	2003-05-28	Substituerte imidazopyridiner
ATE309245T1 (de)	2005-11-15	5-amino-5-phenyl-7-cyclobutyl-pyrrolo(2,3- d)pyrimidin-derivate
IT1308096B1 (it)	2001-11-29	Convertiplano
DE60110391D1 (de)	2005-06-02	Adenosin-rezeptor modulatoren
DE50202178D1 (de)	2005-03-10	Neue sulfonat-substituierte pyrazolopyridinderivate
DK1218382T3 (da)	2004-03-22	Bicykliske imidazo-3-ylaminderivater
DE60022893D1 (de)	2006-02-09	Naphthyridinverbindungen
NO20013456D0 (no)	2001-07-12	Funksjonaliserte heterocykler som chemokin-reseptor- modulatorer
DE50015443D1 (de)	2008-12-18	Bicyclische imidazo-5-yl-aminderivate
NO20013997D0 (no)	2001-08-16	Reseptoranalyse
DK1210349T3 (da)	2003-05-19	Pyrazolo[4,3-d]pyrimidiner
DE60214408D1 (de)	2006-10-12	5-METHOXY-8-ARYL-i1,2,4öTRIAZOLOi1,5-AöPYRIDINE DERIVATIVE ALS ADENOSIN-REZEPTOR ANTAGONISTEN
NO20021295L (no)	2002-05-14	Nikotinsyreacetylcholin-reseptor
DE50014162D1 (de)	2007-04-26	Tricyclische benzoylpyrazol-derivate als herbizide