ATE284376T1 - Verfahren zur herstellung von verbindungen der valproinsäure - Google Patents
Verfahren zur herstellung von verbindungen der valproinsäureInfo
- Publication number
- ATE284376T1 ATE284376T1 AT00969152T AT00969152T ATE284376T1 AT E284376 T1 ATE284376 T1 AT E284376T1 AT 00969152 T AT00969152 T AT 00969152T AT 00969152 T AT00969152 T AT 00969152T AT E284376 T1 ATE284376 T1 AT E284376T1
- Authority
- AT
- Austria
- Prior art keywords
- valproic acid
- acid compounds
- molecule
- producing
- earth
- Prior art date
Links
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical class CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical class [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 abstract 5
- 239000003513 alkali Substances 0.000 abstract 3
- 229960000604 valproic acid Drugs 0.000 abstract 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH199799 | 1999-11-02 | ||
| PCT/CH2000/000578 WO2001032595A1 (de) | 1999-11-02 | 2000-10-31 | Verfahren zur herstellung von verbindungen der valproinsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE284376T1 true ATE284376T1 (de) | 2004-12-15 |
Family
ID=4223488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00969152T ATE284376T1 (de) | 1999-11-02 | 2000-10-31 | Verfahren zur herstellung von verbindungen der valproinsäure |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6753349B1 (de) |
| EP (1) | EP1230205B1 (de) |
| AT (1) | ATE284376T1 (de) |
| AU (1) | AU7897400A (de) |
| CA (1) | CA2387958C (de) |
| DE (1) | DE50008920D1 (de) |
| WO (1) | WO2001032595A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007004238A2 (en) * | 2005-07-06 | 2007-01-11 | Morepen Laboratories Limited | A process for the manufacture of divalproex sodium |
| US7482486B2 (en) * | 2005-10-07 | 2009-01-27 | Biolink Life Sciences, Inc. | Methods for the preparation and formulation of magnesium valproate hydrate |
| US20110015267A1 (en) * | 2009-07-20 | 2011-01-20 | Deanna Jean Nelson | Methods for the preparation and use of aqueous solutions of magnesium valproate hydrate and l-carnitine |
| US8729300B2 (en) * | 2009-08-11 | 2014-05-20 | Sci Pharmtech, Inc. | Method for preparing metal salt of valproic acid |
| CN111349003B (zh) * | 2018-12-20 | 2023-10-03 | 四川科瑞德制药股份有限公司 | 一种丙戊酸钠的制备方法 |
| CN114853595B (zh) * | 2022-06-01 | 2024-04-26 | 广州茂丰药业有限公司 | 一种丙戊酸钠、丙戊酸共晶的制备方法及其产品 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE215533C (de) | ||||
| DE3063328D1 (en) * | 1979-08-20 | 1983-07-07 | Abbott Lab | Mixed salt of valproic acid |
| DD215533A1 (de) * | 1983-05-24 | 1984-11-14 | Dresden Arzneimittel | Verfahren zur herstellung neuer alkali- und erdalkalisalze der di-n-propylessigsaeure |
| IL72381A (en) * | 1983-07-20 | 1988-03-31 | Sanofi Sa | Pharmaceutical composition based on valproic acid |
| DE3709230A1 (de) | 1987-03-20 | 1988-10-06 | Desitin Arzneimittel Gmbh | Neues calciumsalz der valproinsaeure |
| US5795615A (en) * | 1994-09-30 | 1998-08-18 | Kemin Industries, Inc. | Process for producing metal carboxylates for use as animal feed supplements |
| NZ270438A (en) * | 1995-02-02 | 1996-03-26 | Bernard Charles Sherman | Solid (granular) mixture of valproic acid (di-n-propyl acetic acid) and its sodium salt; pharmaceutical compositions |
-
2000
- 2000-10-31 AU AU78974/00A patent/AU7897400A/en not_active Abandoned
- 2000-10-31 EP EP00969152A patent/EP1230205B1/de not_active Expired - Lifetime
- 2000-10-31 DE DE2000508920 patent/DE50008920D1/de not_active Expired - Fee Related
- 2000-10-31 US US10/129,023 patent/US6753349B1/en not_active Expired - Fee Related
- 2000-10-31 AT AT00969152T patent/ATE284376T1/de not_active IP Right Cessation
- 2000-10-31 WO PCT/CH2000/000578 patent/WO2001032595A1/de not_active Ceased
- 2000-10-31 CA CA002387958A patent/CA2387958C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE50008920D1 (de) | 2005-01-13 |
| CA2387958A1 (en) | 2001-05-10 |
| EP1230205A1 (de) | 2002-08-14 |
| AU7897400A (en) | 2001-05-14 |
| CA2387958C (en) | 2010-02-02 |
| WO2001032595A1 (de) | 2001-05-10 |
| EP1230205B1 (de) | 2004-12-08 |
| US6753349B1 (en) | 2004-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |