ATE284676T1 - Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen - Google Patents
Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungenInfo
- Publication number
- ATE284676T1 ATE284676T1 AT01989339T AT01989339T ATE284676T1 AT E284676 T1 ATE284676 T1 AT E284676T1 AT 01989339 T AT01989339 T AT 01989339T AT 01989339 T AT01989339 T AT 01989339T AT E284676 T1 ATE284676 T1 AT E284676T1
- Authority
- AT
- Austria
- Prior art keywords
- drug
- precipitation
- evaporation
- production
- aqueous solutions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24547900P | 2000-11-03 | 2000-11-03 | |
| US09/808,332 US6756062B2 (en) | 2000-11-03 | 2001-03-14 | Preparation of drug particles using evaporation precipitation into aqueous solutions |
| PCT/US2001/051337 WO2002047659A2 (en) | 2000-11-03 | 2001-10-22 | Preparation of drug particles using evaporation precipitation into aqueous solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE284676T1 true ATE284676T1 (de) | 2005-01-15 |
Family
ID=26937266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01989339T ATE284676T1 (de) | 2000-11-03 | 2001-10-22 | Herstellung von wirkstoffpartikeln durch evaporation-präzipitation in wässrige lösungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6756062B2 (de) |
| EP (1) | EP1335705B1 (de) |
| JP (1) | JP2004515525A (de) |
| AT (1) | ATE284676T1 (de) |
| AU (1) | AU2002243441A1 (de) |
| CA (1) | CA2427625A1 (de) |
| DE (1) | DE60107872T2 (de) |
| WO (1) | WO2002047659A2 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7425543B2 (en) * | 1992-11-16 | 2008-09-16 | The Corporation Of Mercer University | Microencapsulated materials and method of making same |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US8551526B2 (en) * | 2000-11-03 | 2013-10-08 | Board Of Regents, The University Of Texas System | Preparation of drug particles using evaporation precipitation into aqueous solutions |
| KR20030074693A (ko) * | 2000-12-28 | 2003-09-19 | 알투스 바이올로직스 인코포레이티드 | 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법 |
| NZ530700A (en) * | 2001-06-21 | 2009-02-28 | Altus Pharmaceuticals Inc | Spherical protein particles and methods of making and using them |
| CA2450748A1 (en) * | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions containing polymer and drug assemblies |
| WO2003032951A1 (en) * | 2001-08-29 | 2003-04-24 | Dow Global Technologies Inc. | A process for preparing crystalline drug particles by means of precipitation |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| CA2526454C (en) | 2003-05-22 | 2013-08-13 | Applied Nanosystems B.V. | Gel-assisted production of small particles |
| US20050175683A1 (en) * | 2003-10-24 | 2005-08-11 | Yuanpeng Zhang | Preparation of lipid particles |
| US7754243B2 (en) * | 2004-08-03 | 2010-07-13 | Clemson University Research Foundation | Aqueous suspension of nanoscale drug particles from supercritical fluid processing |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| WO2006026502A1 (en) * | 2004-08-27 | 2006-03-09 | The Dow Chemical Company | Enhanced delivery of drug compositions to treat life threatening infections |
| EP1885335A1 (de) * | 2005-04-27 | 2008-02-13 | BAXTER INTERNATIONAL INC. (a Delaware corporation) | Oberflächenmodifizierte mikroteilchen und verfahren zu ihrer bildung und verwendung |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| IN2015DN00888A (de) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| GB0613925D0 (en) * | 2006-07-13 | 2006-08-23 | Unilever Plc | Improvements relating to nanodispersions |
| WO2008060786A2 (en) * | 2006-10-06 | 2008-05-22 | Baxter International Inc. | Microencapsules containing surface-modified microparticles and methods of forming and using the same |
| WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
| WO2008125940A2 (en) * | 2007-04-17 | 2008-10-23 | Pfizer Products Inc. | Nanoparticles comprising non-crystalline drug |
| CN101292958B (zh) * | 2007-04-27 | 2011-04-27 | 北京化工大学 | 一种超细达那唑粉体的制备方法 |
| WO2008135852A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Pharmaceutical compositions comprising nanoparticles and casein |
| US8309129B2 (en) * | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| US8703204B2 (en) | 2007-05-03 | 2014-04-22 | Bend Research, Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer |
| WO2008149230A2 (en) | 2007-06-04 | 2008-12-11 | Pfizer Products Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate |
| EP2162120B1 (de) | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer |
| US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
| EP2231169B1 (de) | 2007-12-06 | 2016-05-04 | Bend Research, Inc. | Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial |
| WO2009073216A1 (en) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an amine-functionalized methacrylate copolymer |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| US20100151037A1 (en) * | 2008-08-07 | 2010-06-17 | Yivan Jiang | Method for the preparation of nanoparticles containing a poorly water-soluble pharmaceutically active compound |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| CN104721825B (zh) | 2009-06-12 | 2019-04-12 | 曼金德公司 | 具有确定比表面积的二酮哌嗪颗粒 |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| SG10202010355PA (en) | 2010-03-12 | 2020-11-27 | Berg Llc | Intravenous formulations of coenzyme q10 (coq10) and methods of use thereof |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| EP2608772A2 (de) * | 2010-08-23 | 2013-07-03 | President and Fellows of Harvard College | Partikel für wirkstofffreisetzung und andere anwendung |
| AU2012236150B2 (en) | 2011-04-01 | 2016-03-31 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| EP2720680B1 (de) | 2011-06-17 | 2020-02-12 | Berg LLC | Inhalbierbare pharmazeutische zusammensetzungen |
| WO2012178082A1 (en) * | 2011-06-24 | 2012-12-27 | The Trustees Of Columbia University In The City Of New York | Improved methods, devices and systems to process x-ray diffraction data |
| BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| MX375448B (es) | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| KR102047025B1 (ko) * | 2019-05-07 | 2019-12-02 | 엔젯 주식회사 | 반도체 패키지의 언더필 방법 및 장치 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5766635A (en) * | 1991-06-28 | 1998-06-16 | Rhone-Poulenc Rorer S.A. | Process for preparing nanoparticles |
| GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9313650D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| ATE386506T1 (de) * | 1995-10-17 | 2008-03-15 | Jagotec Ag | Verabreichung unlöslicher arzneistoffe |
| AU5719798A (en) | 1996-12-31 | 1998-07-31 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
-
2001
- 2001-03-14 US US09/808,332 patent/US6756062B2/en not_active Expired - Fee Related
- 2001-10-22 JP JP2002549233A patent/JP2004515525A/ja not_active Withdrawn
- 2001-10-22 DE DE60107872T patent/DE60107872T2/de not_active Expired - Lifetime
- 2001-10-22 CA CA002427625A patent/CA2427625A1/en not_active Abandoned
- 2001-10-22 WO PCT/US2001/051337 patent/WO2002047659A2/en not_active Ceased
- 2001-10-22 AT AT01989339T patent/ATE284676T1/de not_active IP Right Cessation
- 2001-10-22 EP EP01989339A patent/EP1335705B1/de not_active Expired - Lifetime
- 2001-10-22 AU AU2002243441A patent/AU2002243441A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002047659A3 (en) | 2002-09-06 |
| US6756062B2 (en) | 2004-06-29 |
| AU2002243441A1 (en) | 2002-06-24 |
| US20020081334A1 (en) | 2002-06-27 |
| DE60107872D1 (de) | 2005-01-20 |
| CA2427625A1 (en) | 2002-06-20 |
| EP1335705A2 (de) | 2003-08-20 |
| WO2002047659A2 (en) | 2002-06-20 |
| JP2004515525A (ja) | 2004-05-27 |
| DE60107872T2 (de) | 2005-05-19 |
| EP1335705B1 (de) | 2004-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |