ATE284864T1 - Verfahren zur alkylierung von gehinderten sulfonamiden, die zur herstellung von metallproteinasehemmer geeignet sind - Google Patents

Verfahren zur alkylierung von gehinderten sulfonamiden, die zur herstellung von metallproteinasehemmer geeignet sind

Info

Publication number: ATE284864T1
Authority: AT; Austria
Prior art keywords: metalproteinase; inhibitors; producing; alkylating; hindered sulfonamides
Prior art date: 1998-04-10

Application number

AT99917394T

Other languages

English (en)

Inventor

Brian Michael Andresen

Philip Dietrich Hammen

Joel Michael Hawkins

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-10

Filing date

1999-04-09

Publication date

2005-01-15

1999-04-09 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE284864T1 publication Critical patent/ATE284864T1/de

Links

230000002152 alkylating effect Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Psychology (AREA)
Psychiatry (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Pulmonology (AREA)
Tropical Medicine & Parasitology (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)

AT99917394T 1998-04-10 1999-04-09 Verfahren zur alkylierung von gehinderten sulfonamiden, die zur herstellung von metallproteinasehemmer geeignet sind ATE284864T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8131098P	1998-04-10	1998-04-10
PCT/US1999/007858 WO1999052862A1 (en)	1998-04-10	1999-04-09	Process for alkylating hindered sulfonamides useful in the production of matrix metalloproteinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE284864T1 true ATE284864T1 (de)	2005-01-15

Family

ID=22163376

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99302287T ATE206392T1 (de)	1998-04-10	1999-03-25	Verfahren zur alkylierug von gehinderten sulfonamiden
AT99917394T ATE284864T1 (de)	1998-04-10	1999-04-09	Verfahren zur alkylierung von gehinderten sulfonamiden, die zur herstellung von metallproteinasehemmer geeignet sind

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT99302287T ATE206392T1 (de)	1998-04-10	1999-03-25	Verfahren zur alkylierug von gehinderten sulfonamiden

Country Status (47)

Country	Link
US (2)	US6114568A (de)
EP (2)	EP0949245B1 (de)
JP (2)	JP3479511B2 (de)
KR (2)	KR100357660B1 (de)
CN (3)	CN1296474A (de)
AP (1)	AP1095A (de)
AR (1)	AR017731A1 (de)
AT (2)	ATE206392T1 (de)
AU (2)	AU760213B2 (de)
BG (1)	BG63665B1 (de)
BR (2)	BR9910110A (de)
CA (2)	CA2268684C (de)
CO (1)	CO4810299A1 (de)
DE (2)	DE69900321T2 (de)
DK (1)	DK0949245T3 (de)
DZ (1)	DZ2754A1 (de)
EA (1)	EA002277B1 (de)
EG (1)	EG21985A (de)
ES (2)	ES2163316T3 (de)
GT (1)	GT199900047A (de)
HN (1)	HN1999000043A (de)
HR (1)	HRP990106B1 (de)
HU (2)	HUP9901043A1 (de)
ID (2)	ID23244A (de)
IL (2)	IL129168A (de)
IN (1)	IN192485B (de)
IS (1)	IS5018A (de)
MA (1)	MA24833A1 (de)
NO (1)	NO991675L (de)
NZ (1)	NZ335105A (de)
OA (1)	OA11030A (de)
PA (1)	PA8469601A1 (de)
PE (1)	PE20000417A1 (de)
PL (2)	PL332451A1 (de)
PT (1)	PT949245E (de)
RU (1)	RU2197479C2 (de)
SA (1)	SA99200089A (de)
SG (1)	SG75167A1 (de)
SK (1)	SK45399A3 (de)
TN (1)	TNSN99054A1 (de)
TR (2)	TR199900756A2 (de)
TW (1)	TW520354B (de)
UA (1)	UA57039C2 (de)
UY (1)	UY25469A1 (de)
WO (1)	WO1999052862A1 (de)
YU (1)	YU18399A (de)
ZA (2)	ZA992627B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458822B2 (en)	2000-03-13	2002-10-01	Pfizer Inc.	2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
EP1134207A1 (de) *	2000-03-15	2001-09-19	Pfizer Products Inc.	Verfahren zur Herstellung von Resorcinolderivaten
US6548667B2 (en)	2000-04-07	2003-04-15	Samsung Electronics Co. Ltd.	Sulfonamide derivative as a matrix metalloproteinase inhibitor
US20020073441A1 (en)	2000-12-13	2002-06-13	Ross Brian D.	Compositions and methods for detecting proteolytic activity
US6844373B2 (en) *	2002-05-28	2005-01-18	Alcatel	Composition comprising fluorinated, radiation-curable dyes for surface energy control
WO2004060346A2 (en)	2002-12-30	2004-07-22	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
ITFI20040174A1 (it) *	2004-08-03	2004-11-03	Protera S R L	Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
ITBO20050005U1 (it) *	2005-01-31	2006-08-01	Ali Spa	Distributore di bevande ghiacciate e simili

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU523636A3 (ru) *	1973-06-18	1976-07-30	Стауффер Кемикал Компани (Фирма)	Способ получени сульфоксидных или сульфоновых производных тиокарбаматов
ZA794723B (en)	1978-09-11	1980-08-27	Univ Miami	Anti-hypertensive agents
GB9000725D0 (en)	1990-01-12	1990-03-14	Pfizer Ltd	Therapeutic agents
US5506242A (en)	1993-01-06	1996-04-09	Ciba-Geigy Corporation	Arylsufonamido-substituted hydroxamic acids
US5863949A (en) *	1995-03-08	1999-01-26	Pfizer Inc	Arylsulfonylamino hydroxamic acid derivatives
EP0922030A1 (de) *	1996-08-23	1999-06-16	Pfizer Inc.	Arylsulphonylamino-hydroxamsäure-derivate
HUP0000852A2 (hu)	1997-02-03	2001-05-28	Pfizer Products Inc.	Aril-szulfonil-amino-hidroxámsav-származékok, valamint e vegyületeket tartalmazó gyógyászati készítmények
TR200000368T2 (tr)	1997-08-08	2000-07-21	Pfizer Products Inc.	Ariloksiariarilsülfonilamino hidroksamik asit türevleri.
DE69805473T2 (de)	1997-08-08	2003-01-16	Pfizer Products Inc., Groton	Arylsulfonylaminohydroxamsäurederivate
PA8469401A1 (es)	1998-04-10	2000-05-24	Pfizer Prod Inc	Derivados biciclicos del acido hidroxamico

1999
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- 1999-04-08 YU YU18399A patent/YU18399A/sh unknown
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- 1999-04-09 AU AU23691/99A patent/AU755004B2/en not_active Ceased
- 1999-04-09 AT AT99917394T patent/ATE284864T1/de not_active IP Right Cessation
- 1999-04-09 CN CN99804961A patent/CN1296474A/zh active Pending
- 1999-04-09 CA CA002327498A patent/CA2327498C/en not_active Expired - Fee Related
- 1999-04-09 EA EA199900277A patent/EA002277B1/ru not_active IP Right Cessation
- 1999-04-09 HU HU9901043A patent/HUP9901043A1/hu unknown
- 1999-04-09 US US09/290,022 patent/US6229025B1/en not_active Expired - Fee Related
- 1999-04-09 BR BR9910110-6A patent/BR9910110A/pt not_active IP Right Cessation
- 1999-04-09 HU HU0101465A patent/HUP0101465A3/hu unknown
- 1999-04-09 BR BR9902219-2A patent/BR9902219A/pt not_active IP Right Cessation
- 1999-04-09 UA UA99042034A patent/UA57039C2/uk unknown
- 1999-04-09 RU RU2000125555/04A patent/RU2197479C2/ru not_active IP Right Cessation
- 1999-04-09 EP EP99917394A patent/EP1068180B1/de not_active Expired - Lifetime
- 1999-04-09 PL PL99332451A patent/PL332451A1/xx unknown
- 1999-04-09 WO PCT/US1999/007858 patent/WO1999052862A1/en not_active Ceased
- 1999-04-09 ID IDW20002031A patent/ID27208A/id unknown
- 1999-04-09 ES ES99917394T patent/ES2234253T3/es not_active Expired - Lifetime
- 1999-04-09 DE DE69922638T patent/DE69922638T2/de not_active Expired - Fee Related
- 1999-04-09 BG BG103320A patent/BG63665B1/bg unknown
- 1999-04-09 CN CN99104932A patent/CN1234396A/zh active Pending
- 1999-04-09 ZA ZA9902627A patent/ZA992627B/xx unknown
- 1999-04-09 HN HN1999000043A patent/HN1999000043A/es unknown
- 1999-04-09 HR HR990106A patent/HRP990106B1/xx not_active IP Right Cessation
- 1999-04-09 JP JP2000543425A patent/JP3479511B2/ja not_active Expired - Fee Related
- 1999-04-09 NZ NZ335105A patent/NZ335105A/xx unknown
- 1999-04-09 PL PL99343530A patent/PL343530A1/xx unknown
- 1999-04-12 CO CO99021411A patent/CO4810299A1/es unknown
- 1999-04-12 UY UY25469A patent/UY25469A1/es unknown
- 1999-04-12 JP JP10387399A patent/JP3540959B2/ja not_active Expired - Fee Related
- 1999-05-05 SA SA99200089A patent/SA99200089A/ar unknown
2000
- 2000-08-25 CN CN00126476A patent/CN1288885A/zh active Pending
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Publication number	Publication date
JP2000026400A (ja)	2000-01-25
BG63665B1 (bg)	2002-08-30
AU760213B2 (en)	2003-05-08
DE69922638D1 (de)	2005-01-20
TR200002950T2 (tr)	2000-12-21
SK45399A3 (en)	2000-08-14
HN1999000043A (es)	1999-11-03
UY25469A1 (es)	1999-11-17
ATE206392T1 (de)	2001-10-15
HUP0101465A3 (en)	2002-11-28
AU2369199A (en)	1999-10-21
KR100357660B1 (ko)	2002-10-25
TR199900756A2 (xx)	1999-11-22
AU3552799A (en)	1999-11-01
JP3540959B2 (ja)	2004-07-07
HUP0101465A2 (hu)	2002-03-28
UA57039C2 (uk)	2003-06-16
IL138778A0 (en)	2001-10-31
PT949245E (pt)	2002-02-28
EA002277B1 (ru)	2002-02-28
NO991675L (no)	1999-10-11
EG21985A (en)	2002-05-31
NO991675D0 (no)	1999-04-09
KR19990082986A (ko)	1999-11-25
EP0949245B1 (de)	2001-10-04
NZ335105A (en)	2000-03-27
YU18399A (sh)	2002-11-15
AR017731A1 (es)	2001-09-12
CA2268684C (en)	2004-07-13
US6114568A (en)	2000-09-05
DZ2754A1 (fr)	2003-09-15
DK0949245T3 (da)	2002-01-28
MA24833A1 (fr)	1999-12-31
EA199900277A3 (ru)	2000-04-24
EP1068180B1 (de)	2004-12-15
AP1095A (en)	2002-08-26
BG103320A (en)	2001-08-31
BR9902219A (pt)	2000-04-11
CA2327498C (en)	2006-01-31
IL129168A0 (en)	2000-02-17
DE69922638T2 (de)	2005-05-19
ID27208A (id)	2001-03-08
GT199900047A (es)	2000-09-15
EA199900277A2 (ru)	1999-10-28
DE69900321T2 (de)	2002-07-11
CN1288885A (zh)	2001-03-28
CN1296474A (zh)	2001-05-23
IN192485B (de)	2004-04-24
HRP990106B1 (en)	2003-08-31
JP2002511447A (ja)	2002-04-16
BR9910110A (pt)	2001-10-09
PE20000417A1 (es)	2000-05-24
PA8469601A1 (es)	2000-09-29
TNSN99054A1 (fr)	2005-11-10
SA99200089A (ar)	2005-12-03
PL332451A1 (en)	1999-10-11
AP9901506A0 (en)	1999-06-30
KR100377718B1 (ko)	2003-03-26
RU2197479C2 (ru)	2003-01-27
CA2327498A1 (en)	1999-10-21
CA2268684A1 (en)	1999-10-10
ZA200005370B (en)	2002-01-03
CO4810299A1 (es)	1999-06-30
SG75167A1 (en)	2000-09-19
HUP9901043A1 (hu)	2000-08-28
EP1068180A1 (de)	2001-01-17
CN1234396A (zh)	1999-11-10
ID23244A (id)	2000-03-30
EP0949245A1 (de)	1999-10-13
DE69900321D1 (de)	2001-11-08
IS5018A (is)	1999-10-11
PL343530A1 (en)	2001-08-27
OA11030A (en)	2002-02-07
US6229025B1 (en)	2001-05-08
JP3479511B2 (ja)	2003-12-15
KR20010042567A (ko)	2001-05-25
IL129168A (en)	2003-07-06
AU755004B2 (en)	2002-11-28
ES2163316T3 (es)	2002-01-16
HRP990106A2 (en)	1999-12-31
WO1999052862A1 (en)	1999-10-21
TW520354B (en)	2003-02-11
ES2234253T3 (es)	2005-06-16
HU9901043D0 (en)	1999-06-28
ZA992627B (en)	2000-10-09

Legal Events

Date	Code	Title	Description
2005-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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