ATE286038T1 - Verbindungen mit sulfonsäure-amidgruppe - Google Patents
Verbindungen mit sulfonsäure-amidgruppeInfo
- Publication number
- ATE286038T1 ATE286038T1 AT97905332T AT97905332T ATE286038T1 AT E286038 T1 ATE286038 T1 AT E286038T1 AT 97905332 T AT97905332 T AT 97905332T AT 97905332 T AT97905332 T AT 97905332T AT E286038 T1 ATE286038 T1 AT E286038T1
- Authority
- AT
- Austria
- Prior art keywords
- ring structure
- pct
- compounds
- sulfonic acid
- acid amide
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 title 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 abstract 1
- 102000014654 Aromatase Human genes 0.000 abstract 1
- 108010078554 Aromatase Proteins 0.000 abstract 1
- 229960003399 estrone Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
- -1 sulphamate compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
- C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9604709.7A GB9604709D0 (en) | 1996-03-05 | 1996-03-05 | A compound |
| GBGB9605725.2A GB9605725D0 (en) | 1996-03-05 | 1996-03-19 | A compound |
| PCT/GB1997/000600 WO1997032872A1 (en) | 1996-03-05 | 1997-03-04 | Compounds with a sulfamate group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE286038T1 true ATE286038T1 (de) | 2005-01-15 |
Family
ID=26308868
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97905332T ATE286038T1 (de) | 1996-03-05 | 1997-03-04 | Verbindungen mit sulfonsäure-amidgruppe |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6083978A (de) |
| EP (1) | EP0885211B1 (de) |
| JP (1) | JP2000506161A (de) |
| AT (1) | ATE286038T1 (de) |
| AU (1) | AU2225597A (de) |
| DE (1) | DE69732098T2 (de) |
| ES (1) | ES2233998T3 (de) |
| WO (1) | WO1997032872A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9603325D0 (en) | 1996-02-16 | 1996-04-17 | Imperial College | A compound |
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| US6903084B2 (en) | 1991-08-28 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
| US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
| US6921776B1 (en) | 1996-02-16 | 2005-07-26 | Sterix Limited | Compound |
| US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
| GB2331987B (en) * | 1997-12-04 | 2002-11-27 | Imperial College | Polycyclic sulphamate inhibitors of oestrone sulphatase |
| GB2331988B (en) | 1997-12-04 | 2003-04-16 | Imperial College | Polycyclic sulphamate inhibitors or oestrone sulphatase |
| ATE282032T1 (de) * | 1998-01-12 | 2004-11-15 | Nichimo Kabushiki Kaisha | Verfahren zur herstellung von isoflavonverbindungen |
| GB9807779D0 (en) * | 1998-04-09 | 1998-06-10 | Ciba Geigy Ag | Organic compounds |
| JP2000309599A (ja) | 1999-04-13 | 2000-11-07 | Kyowa Hakko Kogyo Co Ltd | エストラ−１，３，５（１０），１６−テトラエン誘導体 |
| US7078395B1 (en) | 1999-06-16 | 2006-07-18 | Sterix Limited | Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling |
| JP5042411B2 (ja) | 1999-04-30 | 2012-10-03 | ステリックス リミテッド | 抗腫瘍剤としてのエストロン誘導体の使用 |
| JP4320089B2 (ja) | 1999-07-06 | 2009-08-26 | あすか製薬株式会社 | フェニルスルファメート誘導体 |
| GB9915995D0 (en) * | 1999-07-09 | 1999-09-08 | Ahmed S | Non-steroidal sulphamate compounds for use as oestrone sulphatase inhibitors |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| PL205635B1 (pl) * | 2001-04-09 | 2010-05-31 | Inst Farmaceutyczny | Nowe pochodne genisteiny i zawierające je środki farmaceutyczne |
| CN1668287B (zh) * | 2001-09-06 | 2012-03-28 | 赛诺克思公司 | 3-脱氧类黄酮在制备抑制t淋巴细胞活性的药物中的用途 |
| GB0127923D0 (en) | 2001-11-21 | 2002-01-16 | Sterix Ltd | Compound |
| KR100841901B1 (ko) * | 2002-03-18 | 2008-06-27 | 동화약품공업주식회사 | 플라보노이드 계열 화합물 또는 이를 포함하는 강진향추출물을 함유한 매트릭스 메탈로프로테이나제 활성저해제 및 기능성 식품 |
| US7638554B2 (en) * | 2002-04-18 | 2009-12-29 | Sri International | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents |
| US20030229136A1 (en) * | 2002-04-18 | 2003-12-11 | Nurulain Zaveri | Novel flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents |
| GB0511190D0 (en) * | 2005-06-01 | 2005-07-06 | Sterix Ltd | Use |
| GB0624105D0 (en) * | 2006-12-01 | 2007-01-10 | Sterix Ltd | Use |
| SI2533638T1 (sl) * | 2010-02-12 | 2016-05-31 | Nivalis Therapeutics, Inc. | Novi inhibitorji S-nitrozoglutation reduktaze |
| WO2011099978A1 (en) | 2010-02-12 | 2011-08-18 | N30 Pharmaceuticals, Llc | Chromone inhibitors of s-nitrosoglutathione reductase |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3243158A1 (de) * | 1982-11-23 | 1984-05-24 | Basf Ag, 6700 Ludwigshafen | Neue sulfonsaeureester von hydroxycumarinen, ihre herstellung und sie enthaltende arzneimittel |
| FR2543140B1 (fr) * | 1983-03-24 | 1985-06-21 | Cortial | Nouveaux acides flavone-carboxyliques-4', leur methode de preparation et leur application en therapeutique |
| US4829084A (en) * | 1983-09-29 | 1989-05-09 | Sterling Drug Inc. | Method for treating malignant conditions |
| PT94305B (pt) * | 1989-06-12 | 1997-02-28 | Robins Co Inc A H | Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos |
| WO1992021353A1 (en) * | 1991-05-31 | 1992-12-10 | Genta Incorporated | Compositions and delivery systems for transdermal administration of neutral oligomers |
| GB9603325D0 (en) * | 1996-02-16 | 1996-04-17 | Imperial College | A compound |
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| US6011024A (en) * | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
-
1997
- 1997-03-04 US US09/142,194 patent/US6083978A/en not_active Expired - Lifetime
- 1997-03-04 AT AT97905332T patent/ATE286038T1/de not_active IP Right Cessation
- 1997-03-04 WO PCT/GB1997/000600 patent/WO1997032872A1/en not_active Ceased
- 1997-03-04 JP JP9531567A patent/JP2000506161A/ja active Pending
- 1997-03-04 DE DE69732098T patent/DE69732098T2/de not_active Expired - Lifetime
- 1997-03-04 AU AU22255/97A patent/AU2225597A/en not_active Abandoned
- 1997-03-04 ES ES97905332T patent/ES2233998T3/es not_active Expired - Lifetime
- 1997-03-04 EP EP97905332A patent/EP0885211B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2233998T3 (es) | 2005-06-16 |
| DE69732098D1 (de) | 2005-02-03 |
| EP0885211A1 (de) | 1998-12-23 |
| EP0885211B1 (de) | 2004-12-29 |
| US6083978A (en) | 2000-07-04 |
| AU2225597A (en) | 1997-09-22 |
| JP2000506161A (ja) | 2000-05-23 |
| WO1997032872A1 (en) | 1997-09-12 |
| DE69732098T2 (de) | 2005-12-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |