ATE286900T1 - (1,2,4)triazolo(1,5-c)pyrimidin-derivate - Google Patents

(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Info

Publication number: ATE286900T1
Authority: AT; Austria
Prior art keywords: represent; triazolo; aryl; pyrimidine derivatives; lower alkyl
Prior art date: 1998-09-22

Application number

AT99944771T

Other languages

English (en)

Inventor

Junichi Shimada

Hironori Imma

Naoto Osakada

Shizuo Shiozaki

Tomoyuki Kanda

Yoshihisa Kuwana

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-22

Filing date

1999-09-22

Publication date

2005-01-15

1999-09-22 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE286900T1 publication Critical patent/ATE286900T1/de

Links

QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001721 carbon Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99944771T 1998-09-22 1999-09-22 (1,2,4)triazolo(1,5-c)pyrimidin-derivate ATE286900T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP26717898		1998-09-22
PCT/JP1999/005176 WO2000017201A1 (en)	1998-09-22	1999-09-22	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
ATE286900T1 true ATE286900T1 (de)	2005-01-15

Family

ID=17441200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99944771T ATE286900T1 (de)	1998-09-22	1999-09-22	(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Country Status (15)

Country	Link
US (1)	US6545000B1 (de)
EP (1)	EP1116722B1 (de)
KR (1)	KR20010087361A (de)
CN (1)	CN1328560A (de)
AT (1)	ATE286900T1 (de)
AU (1)	AU756144B2 (de)
BR (1)	BR9914040A (de)
CA (1)	CA2344828A1 (de)
DE (1)	DE69923197T2 (de)
EA (1)	EA200100265A1 (de)
HU (1)	HUP0103921A3 (de)
IL (1)	IL142128A0 (de)
NO (1)	NO20011417L (de)
NZ (1)	NZ510629A (de)
WO (1)	WO2000017201A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPWO2002079204A1 (ja) *	2001-03-28	2004-07-22	協和醗酵工業株式会社	８−チアゾリル［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
JP5280597B2 (ja) *	2001-03-30	2013-09-04	サンスター技研株式会社	一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材
CA2459304A1 (en) *	2001-09-13	2003-03-20	Schering Corporation	Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic
IL161573A0 (en) *	2001-11-30	2004-09-27	Schering Corp	[1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS
AR038366A1 (es) *	2001-11-30	2005-01-12	Schering Corp	Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion
AU2002358597C1 (en) *	2001-12-12	2008-09-18	F. Hoffmann-La Roche Ag	Benzothiophenes as adenosine receptor modulators
US6734179B2 (en)	2001-12-12	2004-05-11	Hoffmann-La Roche Inc.	Benzothiazoles
KR101098209B1 (ko)	2002-01-28	2011-12-23	교와 핫꼬 기린 가부시키가이샤	운동성 질환에 걸린 환자의 치료 방법
JPWO2003068776A1 (ja) *	2002-02-15	2005-06-02	協和醗酵工業株式会社	［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
WO2004029056A1 (ja) *	2002-09-24	2004-04-08	Kyowa Hakko Kogyo Co., Ltd.	[１，２，４]トリアゾロ[１，５−ｃ]ピリミジン誘導体
WO2004092173A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	A2a adenosine receptor antagonists
WO2004092170A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
WO2004092177A1 (en) *	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
WO2004092172A2 (en) *	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosin e receptor antagonists
KR20060037252A (ko) *	2003-06-10	2006-05-03	교와 핫꼬 고교 가부시끼가이샤	불안 장애의 치료 방법
EP2258372B8 (de) *	2005-06-07	2012-12-19	Kyowa Hakko Kirin Co., Ltd.	A2A Antagonisten zur Behandlung von motorischen Störungen
EP2089389A2 (de)	2006-11-01	2009-08-19	Bristol-Myers Squibb Company	Heterocyclische verbindungen als modulatoren der glucocorticoidrezeptor,- ap1- und/oder nf-kappa-b-aktivität
TWI473614B (zh)	2008-05-29	2015-02-21	Kyowa Hakko Kirin Co Ltd	Anti-analgesic inhibitors
KR20110040856A (ko) *	2008-07-23	2011-04-20	교와 핫꼬 기린 가부시키가이샤	편두통 치료제
WO2010111626A2 (en) *	2009-03-27	2010-09-30	Takeda Pharmaceutical Company Limited	Poly (adp-ribose) polymerase (parp) inhibitors
AU2018233367B2 (en) *	2017-03-16	2021-08-12	Jiangsu Hengrui Medicine Co., Ltd.	Heteroaryl[4,3-c]pyrimidine-5-amine derivative, preparation method therefor, and medical uses thereof
TWI877770B (zh)	2018-02-27	2025-03-21	美商英塞特公司	作為a2a / a2b抑制劑之咪唑并嘧啶及三唑并嘧啶
EP3810610A1 (de)	2018-05-18	2021-04-28	Incyte Corporation	Kondensierte pyrimidinderivate als a2a/a2b-inhibitoren
WO2020010197A1 (en)	2018-07-05	2020-01-09	Incyte Corporation	Fused pyrazine derivatives as a2a / a2b inhibitors
CN110903291B (zh) *	2018-09-14	2021-09-03	江苏恒瑞医药股份有限公司	一种杂芳基并[4,3-c]嘧啶-5-胺类衍生物的盐、盐的晶型及制备方法
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
AU2023235233A1 (en)	2022-03-14	2024-09-12	Slap Pharmaceuticals Llc	Multicyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4572910A (en)	1983-03-03	1986-02-25	Riker Laboratories, Inc.	Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4477450A (en)	1983-03-03	1984-10-16	Riker Laboratories, Inc.	Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4483987A (en)	1983-06-20	1984-11-20	G. D. Searle & Co.	8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
NZ208996A (en)	1983-07-28	1989-08-29	American Cyanamid Co	5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions
EP0459702A1 (de)	1990-05-29	1991-12-04	Zeneca Limited	Azolderivate
US5356894A (en)	1990-05-29	1994-10-18	Rodney Peter W	Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
CA2148502A1 (en)	1993-09-06	1995-03-16	Fumio Suzuki	Antidepressants
DE69820866T2 (de)	1997-03-24	2004-12-30	Kyowa Hakko Kogyo Co., Ltd.	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE

1999
- 1999-09-22 WO PCT/JP1999/005176 patent/WO2000017201A1/ja not_active Ceased
- 1999-09-22 KR KR1020017003599A patent/KR20010087361A/ko not_active Withdrawn
- 1999-09-22 IL IL14212899A patent/IL142128A0/xx unknown
- 1999-09-22 DE DE69923197T patent/DE69923197T2/de not_active Expired - Fee Related
- 1999-09-22 EP EP99944771A patent/EP1116722B1/de not_active Expired - Lifetime
- 1999-09-22 BR BR9914040-3A patent/BR9914040A/pt not_active IP Right Cessation
- 1999-09-22 EA EA200100265A patent/EA200100265A1/ru unknown
- 1999-09-22 US US09/787,779 patent/US6545000B1/en not_active Expired - Fee Related
- 1999-09-22 CA CA002344828A patent/CA2344828A1/en not_active Abandoned
- 1999-09-22 NZ NZ510629A patent/NZ510629A/xx unknown
- 1999-09-22 AU AU57579/99A patent/AU756144B2/en not_active Ceased
- 1999-09-22 AT AT99944771T patent/ATE286900T1/de not_active IP Right Cessation
- 1999-09-22 HU HU0103921A patent/HUP0103921A3/hu unknown
- 1999-09-22 CN CN99813569A patent/CN1328560A/zh active Pending
2001
- 2001-03-20 NO NO20011417A patent/NO20011417L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA200100265A1 (ru)	2001-10-22
NO20011417L (no)	2001-05-21
HUP0103921A3 (en)	2002-12-28
EP1116722A4 (de)	2002-05-29
DE69923197T2 (de)	2005-12-29
KR20010087361A (ko)	2001-09-15
IL142128A0 (en)	2002-03-10
AU756144B2 (en)	2003-01-02
US6545000B1 (en)	2003-04-08
EP1116722B1 (de)	2005-01-12
CN1328560A (zh)	2001-12-26
EP1116722A1 (de)	2001-07-18
WO2000017201A1 (en)	2000-03-30
NZ510629A (en)	2003-04-29
CA2344828A1 (en)	2000-03-30
DE69923197D1 (de)	2005-02-17
AU5757999A (en)	2000-04-10
BR9914040A (pt)	2002-01-15
NO20011417D0 (no)	2001-03-20
HUP0103921A2 (hu)	2002-04-29

Legal Events

Date	Code	Title	Description
2005-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE286900T1 (de)	2005-01-15	(1,2,4)triazolo(1,5-c)pyrimidin-derivate
DK254587D0 (da)	1987-05-19	Positionsspecifikke alkyleringsmidler
GB0009532D0 (en)	2000-06-07	Chemical compounds
ATE79380T1 (de)	1992-08-15	2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
DK724088A (da)	1989-06-29	Purinyl- pyrimidinylcyclobutaner
EA200600333A1 (ru)	2006-06-30	Производные индазола
ATE271045T1 (de)	2004-07-15	Sauerstoffhaltige heterocyclische verbindungen
FI900461A0 (fi)	1990-01-30	Imidazopyridaziner, deras framstaellning och anvaendning.
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
DE69910568D1 (de)	2003-09-25	Furopyridinderivate und ihre therapeutische verwendung
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
ES2055211T3 (es)	1994-08-16	Purinil- y pirimidinil-tetrahidrofuranos.
MX9203996A (es)	1993-02-01	Preparacion de 2-(2-tienil)etilamina y sintesis de derivados de tieno (3-2-c) piridina a partir de la misma.
ES2109936T3 (es)	1998-02-01	Derivados de piperacina.
ES2066564T3 (es)	1995-03-01	Derivados de n-2-clorobencil-2-oxo y n-2-clorobencil-2,2-dioxo-1,2,3-oxatiazolidina, su preparacion y sintesis de derivados de tieno(3,2-c)piridina de estos.
ES2015297B3 (es)	1990-08-16	Herbicidas de fenilurea.