ATE286900T1 - (1,2,4)triazolo(1,5-c)pyrimidin-derivate - Google Patents

(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Info

Publication number: ATE286900T1
Authority: AT; Austria
Prior art keywords: represent; triazolo; aryl; pyrimidine derivatives; lower alkyl
Prior art date: 1998-09-22

Application number

AT99944771T

Other languages

English (en)

Inventor

Junichi Shimada

Hironori Imma

Naoto Osakada

Shizuo Shiozaki

Tomoyuki Kanda

Yoshihisa Kuwana

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-22

Filing date

1999-09-22

Publication date

2005-01-15

1999-09-22 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE286900T1 publication Critical patent/ATE286900T1/de

Links

QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001721 carbon Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Psychiatry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99944771T 1998-09-22 1999-09-22 (1,2,4)triazolo(1,5-c)pyrimidin-derivate ATE286900T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP26717898		1998-09-22
PCT/JP1999/005176 WO2000017201A1 (en)	1998-09-22	1999-09-22	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
ATE286900T1 true ATE286900T1 (de)	2005-01-15

Family

ID=17441200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99944771T ATE286900T1 (de)	1998-09-22	1999-09-22	(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Country Status (15)

Country	Link
US (1)	US6545000B1 (de)
EP (1)	EP1116722B1 (de)
KR (1)	KR20010087361A (de)
CN (1)	CN1328560A (de)
AT (1)	ATE286900T1 (de)
AU (1)	AU756144B2 (de)
BR (1)	BR9914040A (de)
CA (1)	CA2344828A1 (de)
DE (1)	DE69923197T2 (de)
EA (1)	EA200100265A1 (de)
HU (1)	HUP0103921A3 (de)
IL (1)	IL142128A0 (de)
NO (1)	NO20011417L (de)
NZ (1)	NZ510629A (de)
WO (1)	WO2000017201A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002079204A1 (en) *	2001-03-28	2002-10-10	Kyowa Hakko Kogyo Co., Ltd.	8-thiazolyl[1,2,4]triazolo[1,5-c]pyrimidine derivative
JP5280597B2 (ja)	2001-03-30	2013-09-04	サンスター技研株式会社	一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材
EP1425017A1 (de) *	2001-09-13	2004-06-09	Schering Corporation	Kombination eines adenosin-a2a-rezeptor-antagonisten mit einem antidepressivum oder anxiolytikum
TW200300686A (en) *	2001-11-30	2003-06-16	Schering Corp	Adenosine A2a receptor antagonists
CA2468658C (en) *	2001-11-30	2009-04-14	Schering Corporation	[1,2,4]-triazole bicyclic adenosine a2a receptor antagonists
EP1456196B1 (de) *	2001-12-12	2009-01-07	F. Hoffmann-La Roche Ag	Benzothiophene als adenosinrezeptormodulatoren
US6734179B2 (en)	2001-12-12	2004-05-11	Hoffmann-La Roche Inc.	Benzothiazoles
ES2716404T3 (es)	2002-01-28	2019-06-12	Kyowa Hakko Kogyo Kk	Antagonistas de receptores A2A para su uso en el tratamiento de trastornos del movimiento
JPWO2003068776A1 (ja) *	2002-02-15	2005-06-02	協和醗酵工業株式会社	［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
AU2003272886A1 (en) *	2002-09-24	2004-04-19	Kyowa Hakko Kogyo Co., Ltd.	(1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
EP1615931A1 (de) *	2003-04-09	2006-01-18	Biogen Idec MA Inc.	Triazolopyrazine und verfahren zu deren herstellung und anwendung
EP1618109A2 (de) *	2003-04-09	2006-01-25	Biogen Idec MA Inc.	Als a2a-adenosinrezeptorantagonisten geeignete triazolo[1,5-c]pyrimidine und pyrazolo[1,5-c]pyrimidine
EP1633756B1 (de)	2003-04-09	2008-12-24	Biogen Idec MA Inc.	A2a-adenosinrezeptorantagonisten
WO2004092170A2 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
EA200501924A1 (ru)	2003-06-10	2006-06-30	Киова Хакко Когио Ко., Лтд.	Способ лечения тревожного расстройства
JPWO2006132275A1 (ja) *	2005-06-07	2009-01-08	協和醗酵工業株式会社	運動障害の予防および／または治療剤
US7994190B2 (en)	2006-11-01	2011-08-09	Bristol-Myers Squibb Company	Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
TWI473614B (zh) *	2008-05-29	2015-02-21	Kyowa Hakko Kirin Co Ltd	Anti-analgesic inhibitors
NZ590793A (en) *	2008-07-23	2012-07-27	Kyowa Hakko Kirin Co Ltd	Therapeutic agent for migraine
EP2415767B1 (de) *	2009-03-27	2014-09-03	Takeda Pharmaceutical Company Limited	Poly(ADP-Ribose)Polymerase- (PARP-) Inhibitoren
KR20190129851A (ko) *	2017-03-16	2019-11-20	지앙수 헨그루이 메디슨 컴퍼니 리미티드	헤테로아릴[4,3-c]피리미딘-5-아민 유도체, 이의 제조 방법 및 이의 의학적 용도
AU2019227607C1 (en)	2018-02-27	2023-07-20	Incyte Corporation	Imidazopyrimidines and triazolopyrimidines as A2A / A2B inhibitors
EP3810610A1 (de)	2018-05-18	2021-04-28	Incyte Corporation	Kondensierte pyrimidinderivate als a2a/a2b-inhibitoren
CN117304191A (zh)	2018-07-05	2023-12-29	因赛特公司	作为a2a/a2b抑制剂的稠合吡嗪衍生物
CN110903291B (zh) *	2018-09-14	2021-09-03	江苏恒瑞医药股份有限公司	一种杂芳基并[4,3-c]嘧啶-5-胺类衍生物的盐、盐的晶型及制备方法
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
US20250214980A1 (en)	2022-03-14	2025-07-03	Slap Pharmaceuticals Llc	Multicyclic compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4572910A (en)	1983-03-03	1986-02-25	Riker Laboratories, Inc.	Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4477450A (en)	1983-03-03	1984-10-16	Riker Laboratories, Inc.	Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4483987A (en)	1983-06-20	1984-11-20	G. D. Searle & Co.	8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
NZ208996A (en)	1983-07-28	1989-08-29	American Cyanamid Co	5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions
US5356894A (en)	1990-05-29	1994-10-18	Rodney Peter W	Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
EP0459702A1 (de) *	1990-05-29	1991-12-04	Zeneca Limited	Azolderivate
AU7546794A (en)	1993-09-06	1995-03-27	Kyowa Hakko Kogyo Co. Ltd.	Depression remedy
WO1998042711A1 (en)	1997-03-24	1998-10-01	Kyowa Hakko Kogyo Co., Ltd.	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES

1999
- 1999-09-22 KR KR1020017003599A patent/KR20010087361A/ko not_active Withdrawn
- 1999-09-22 AT AT99944771T patent/ATE286900T1/de not_active IP Right Cessation
- 1999-09-22 BR BR9914040-3A patent/BR9914040A/pt not_active IP Right Cessation
- 1999-09-22 US US09/787,779 patent/US6545000B1/en not_active Expired - Fee Related
- 1999-09-22 AU AU57579/99A patent/AU756144B2/en not_active Ceased
- 1999-09-22 EA EA200100265A patent/EA200100265A1/ru unknown
- 1999-09-22 NZ NZ510629A patent/NZ510629A/xx unknown
- 1999-09-22 CN CN99813569A patent/CN1328560A/zh active Pending
- 1999-09-22 HU HU0103921A patent/HUP0103921A3/hu unknown
- 1999-09-22 CA CA002344828A patent/CA2344828A1/en not_active Abandoned
- 1999-09-22 IL IL14212899A patent/IL142128A0/xx unknown
- 1999-09-22 WO PCT/JP1999/005176 patent/WO2000017201A1/ja not_active Ceased
- 1999-09-22 EP EP99944771A patent/EP1116722B1/de not_active Expired - Lifetime
- 1999-09-22 DE DE69923197T patent/DE69923197T2/de not_active Expired - Fee Related
2001
- 2001-03-20 NO NO20011417A patent/NO20011417L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0103921A3 (en)	2002-12-28
EP1116722A4 (de)	2002-05-29
NO20011417D0 (no)	2001-03-20
CA2344828A1 (en)	2000-03-30
NO20011417L (no)	2001-05-21
HUP0103921A2 (hu)	2002-04-29
WO2000017201A1 (en)	2000-03-30
KR20010087361A (ko)	2001-09-15
AU756144B2 (en)	2003-01-02
AU5757999A (en)	2000-04-10
EP1116722A1 (de)	2001-07-18
EP1116722B1 (de)	2005-01-12
BR9914040A (pt)	2002-01-15
US6545000B1 (en)	2003-04-08
DE69923197D1 (de)	2005-02-17
NZ510629A (en)	2003-04-29
EA200100265A1 (ru)	2001-10-22
DE69923197T2 (de)	2005-12-29
IL142128A0 (en)	2002-03-10
CN1328560A (zh)	2001-12-26

Legal Events

Date	Code	Title	Description
2005-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69923197D1 (de)	2005-02-17	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
DK254587D0 (da)	1987-05-19	Positionsspecifikke alkyleringsmidler
GB9910577D0 (en)	1999-07-07	Chemical compounds
ATE79380T1 (de)	1992-08-15	2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
DK724088A (da)	1989-06-29	Purinyl- pyrimidinylcyclobutaner
EA200600333A1 (ru)	2006-06-30	Производные индазола
ATE271045T1 (de)	2004-07-15	Sauerstoffhaltige heterocyclische verbindungen
DE69813605D1 (de)	2003-05-22	Benzofuranderivate
FI900461A0 (fi)	1990-01-30	Imidazopyridaziner, deras framstaellning och anvaendning.
ES2094772T3 (es)	1997-02-01	Derivados de imidazonaftiridinas.
WO2003068776A1 (en)	2003-08-21	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
DE69910568D1 (de)	2003-09-25	Furopyridinderivate und ihre therapeutische verwendung
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
ES2055211T3 (es)	1994-08-16	Purinil- y pirimidinil-tetrahidrofuranos.
MX9203996A (es)	1993-02-01	Preparacion de 2-(2-tienil)etilamina y sintesis de derivados de tieno (3-2-c) piridina a partir de la misma.
ES2109936T3 (es)	1998-02-01	Derivados de piperacina.
DK0497695T3 (da)	1995-05-15	N-2-chlorbenzyl-2-oxo- og N-2-chlorbenzyl-2,2-dioxo-1,2,3-oxathiazolidinderivater, deres fremstilling samt syntese af thieno/3,2-c/pyridinderivater
ES2015297B3 (es)	1990-08-16	Herbicidas de fenilurea.