ATE286900T1 - (1,2,4)triazolo(1,5-c)pyrimidin-derivate - Google Patents

(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Info

Publication number: ATE286900T1
Authority: AT; Austria
Prior art keywords: represent; triazolo; aryl; pyrimidine derivatives; lower alkyl
Prior art date: 1998-09-22

Application number

AT99944771T

Other languages

English (en)

Inventor

Junichi Shimada

Hironori Imma

Naoto Osakada

Shizuo Shiozaki

Tomoyuki Kanda

Yoshihisa Kuwana

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-09-22

Filing date

1999-09-22

Publication date

2005-01-15

1999-09-22 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2005-01-15 Application granted granted Critical

2005-01-15 Publication of ATE286900T1 publication Critical patent/ATE286900T1/de

Links

QLOWGDIISXJREF-UHFFFAOYSA-N [1,2,4]triazolo[1,5-c]pyrimidine Chemical class C1=CN=CN2N=CN=C21 QLOWGDIISXJREF-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001721 carbon Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
102000007471 Adenosine A2A receptor Human genes 0.000 abstract 1
108010085277 Adenosine A2A receptor Proteins 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Psychiatry (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99944771T 1998-09-22 1999-09-22 (1,2,4)triazolo(1,5-c)pyrimidin-derivate ATE286900T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP26717898		1998-09-22
PCT/JP1999/005176 WO2000017201A1 (en)	1998-09-22	1999-09-22	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES

Publications (1)

Publication Number	Publication Date
ATE286900T1 true ATE286900T1 (de)	2005-01-15

Family

ID=17441200

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99944771T ATE286900T1 (de)	1998-09-22	1999-09-22	(1,2,4)triazolo(1,5-c)pyrimidin-derivate

Country Status (15)

Country	Link
US (1)	US6545000B1 (de)
EP (1)	EP1116722B1 (de)
KR (1)	KR20010087361A (de)
CN (1)	CN1328560A (de)
AT (1)	ATE286900T1 (de)
AU (1)	AU756144B2 (de)
BR (1)	BR9914040A (de)
CA (1)	CA2344828A1 (de)
DE (1)	DE69923197T2 (de)
EA (1)	EA200100265A1 (de)
HU (1)	HUP0103921A3 (de)
IL (1)	IL142128A0 (de)
NO (1)	NO20011417L (de)
NZ (1)	NZ510629A (de)
WO (1)	WO2000017201A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2002079204A1 (en) *	2001-03-28	2002-10-10	Kyowa Hakko Kogyo Co., Ltd.	8-thiazolyl[1,2,4]triazolo[1,5-c]pyrimidine derivative
JP5280597B2 (ja)	2001-03-30	2013-09-04	サンスター技研株式会社	一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材
WO2003022283A1 (en) *	2001-09-13	2003-03-20	Schering Corporation	Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic
ES2283625T3 (es)	2001-11-30	2007-11-01	Schering Corporation	Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos.
TW200300686A (en)	2001-11-30	2003-06-16	Schering Corp	Adenosine A2a receptor antagonists
US6734179B2 (en) *	2001-12-12	2004-05-11	Hoffmann-La Roche Inc.	Benzothiazoles
KR100581703B1 (ko) *	2001-12-12	2006-05-22	에프. 호프만-라 로슈 아게	아데노신 수용체 조절제로서의 벤조티오펜
ES2686123T3 (es)	2002-01-28	2018-10-16	Kyowa Hakko Kogyo Co., Ltd	Antagonistas del receptor A2A para su uso en el tratamiento de trastornos del movimiento
JPWO2003068776A1 (ja) *	2002-02-15	2005-06-02	協和醗酵工業株式会社	［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体
AU2003272886A1 (en) *	2002-09-24	2004-04-19	Kyowa Hakko Kogyo Co., Ltd.	(1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
US7285550B2 (en)	2003-04-09	2007-10-23	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines and methods of making and using the same
EP1618109A2 (de) *	2003-04-09	2006-01-25	Biogen Idec MA Inc.	Als a2a-adenosinrezeptorantagonisten geeignete triazolo[1,5-c]pyrimidine und pyrazolo[1,5-c]pyrimidine
DE602004018637D1 (de)	2003-04-09	2009-02-05	Biogen Idec Inc	A2a-adenosinrezeptorantagonisten
WO2004092177A1 (en) *	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
CN1787821A (zh) *	2003-06-10	2006-06-14	协和发酵工业株式会社	一种治疗焦虑症的方法
EP1902716A4 (de) *	2005-06-07	2009-05-13	Kyowa Hakko Kirin Co Ltd	Prophylaktisches und/oder therapeutisches mittel für motorische störungen
WO2008057855A2 (en)	2006-11-01	2008-05-15	Bristol-Myers Squibb Company	Heterocyclic compounds as modulators of glucocorticoid receptor, ap-i, and/or np-kappa-b activity
TWI473614B (zh) *	2008-05-29	2015-02-21	Kyowa Hakko Kirin Co Ltd	Anti-analgesic inhibitors
JP5599311B2 (ja) *	2008-07-23	2014-10-01	協和発酵キリン株式会社	片頭痛治療剤
EP2415767B1 (de) *	2009-03-27	2014-09-03	Takeda Pharmaceutical Company Limited	Poly(ADP-Ribose)Polymerase- (PARP-) Inhibitoren
WO2018166493A1 (zh) *	2017-03-16	2018-09-20	江苏恒瑞医药股份有限公司	杂芳基并[4，3-c]嘧啶-5-胺类衍生物、其制备方法及其在医药上的应用
BR122023024273A2 (pt)	2018-02-27	2024-02-20	Incyte Corporation	Compostos imidazopirimidinas e triazolopirimidinas, seus usos, método para inibir uma atividade de um receptor de adenosina e composição farmacêutica dos mesmos
EP3810610A1 (de)	2018-05-18	2021-04-28	Incyte Corporation	Kondensierte pyrimidinderivate als a2a/a2b-inhibitoren
AU2019297361B2 (en)	2018-07-05	2024-06-27	Incyte Corporation	Fused pyrazine derivatives as A2A / A2B inhibitors
CN110903291B (zh) *	2018-09-14	2021-09-03	江苏恒瑞医药股份有限公司	一种杂芳基并[4,3-c]嘧啶-5-胺类衍生物的盐、盐的晶型及制备方法
TWI829857B (zh)	2019-01-29	2024-01-21	美商英塞特公司	作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
KR20240161147A (ko)	2022-03-14	2024-11-12	슬랩 파마슈티컬스 엘엘씨	다중 사이클릭 화합물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4477450A (en)	1983-03-03	1984-10-16	Riker Laboratories, Inc.	Triazolo [4,3-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4572910A (en)	1983-03-03	1986-02-25	Riker Laboratories, Inc.	Triazolo[1,5-c]pyrimidines substituted by nitrogen-containing heterocyclic rings
US4483987A (en)	1983-06-20	1984-11-20	G. D. Searle & Co.	8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
NZ208996A (en)	1983-07-28	1989-08-29	American Cyanamid Co	5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions
GB2244487B (en) *	1990-05-29	1994-02-02	Ici Plc	Azole derivatives
US5356894A (en)	1990-05-29	1994-10-18	Rodney Peter W	Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
CA2148502A1 (en)	1993-09-06	1995-03-16	Fumio Suzuki	Antidepressants
CA2284737C (en)	1997-03-24	2007-03-13	Kyowa Hakko Kogyo Co., Ltd.	[1,2,4]triazolo[1,5-c]pyrimidine derivatives

1999
- 1999-09-22 WO PCT/JP1999/005176 patent/WO2000017201A1/ja not_active Ceased
- 1999-09-22 KR KR1020017003599A patent/KR20010087361A/ko not_active Withdrawn
- 1999-09-22 IL IL14212899A patent/IL142128A0/xx unknown
- 1999-09-22 NZ NZ510629A patent/NZ510629A/xx unknown
- 1999-09-22 HU HU0103921A patent/HUP0103921A3/hu unknown
- 1999-09-22 AU AU57579/99A patent/AU756144B2/en not_active Ceased
- 1999-09-22 EP EP99944771A patent/EP1116722B1/de not_active Expired - Lifetime
- 1999-09-22 CN CN99813569A patent/CN1328560A/zh active Pending
- 1999-09-22 BR BR9914040-3A patent/BR9914040A/pt not_active IP Right Cessation
- 1999-09-22 CA CA002344828A patent/CA2344828A1/en not_active Abandoned
- 1999-09-22 US US09/787,779 patent/US6545000B1/en not_active Expired - Fee Related
- 1999-09-22 DE DE69923197T patent/DE69923197T2/de not_active Expired - Fee Related
- 1999-09-22 AT AT99944771T patent/ATE286900T1/de not_active IP Right Cessation
- 1999-09-22 EA EA200100265A patent/EA200100265A1/ru unknown
2001
- 2001-03-20 NO NO20011417A patent/NO20011417L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN1328560A (zh)	2001-12-26
WO2000017201A1 (en)	2000-03-30
EP1116722A4 (de)	2002-05-29
BR9914040A (pt)	2002-01-15
HUP0103921A3 (en)	2002-12-28
DE69923197D1 (de)	2005-02-17
AU5757999A (en)	2000-04-10
NO20011417D0 (no)	2001-03-20
EP1116722B1 (de)	2005-01-12
NO20011417L (no)	2001-05-21
IL142128A0 (en)	2002-03-10
KR20010087361A (ko)	2001-09-15
CA2344828A1 (en)	2000-03-30
EA200100265A1 (ru)	2001-10-22
NZ510629A (en)	2003-04-29
EP1116722A1 (de)	2001-07-18
AU756144B2 (en)	2003-01-02
DE69923197T2 (de)	2005-12-29
HUP0103921A2 (hu)	2002-04-29
US6545000B1 (en)	2003-04-08

Legal Events

Date	Code	Title	Description
2005-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69923197D1 (de)	2005-02-17	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
DK254587D0 (da)	1987-05-19	Positionsspecifikke alkyleringsmidler
GB9910577D0 (en)	1999-07-07	Chemical compounds
ATE79380T1 (de)	1992-08-15	2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
DK724088A (da)	1989-06-29	Purinyl- pyrimidinylcyclobutaner
EA200600333A1 (ru)	2006-06-30	Производные индазола
ATE271045T1 (de)	2004-07-15	Sauerstoffhaltige heterocyclische verbindungen
DE69813605D1 (de)	2003-05-22	Benzofuranderivate
FI900461A0 (fi)	1990-01-30	Imidazopyridaziner, deras framstaellning och anvaendning.
ES2094772T3 (es)	1997-02-01	Derivados de imidazonaftiridinas.
WO2003068776A1 (en)	2003-08-21	[1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE DERIVATIVES
ES2065994T3 (es)	1995-03-01	Beta-dicetonas substituidas.
DE69910568D1 (de)	2003-09-25	Furopyridinderivate und ihre therapeutische verwendung
DK0601191T3 (da)	1999-04-26	Hidtil ukendt tetracyklisk forbindelse
ES2055211T3 (es)	1994-08-16	Purinil- y pirimidinil-tetrahidrofuranos.
MX9203996A (es)	1993-02-01	Preparacion de 2-(2-tienil)etilamina y sintesis de derivados de tieno (3-2-c) piridina a partir de la misma.
ES2109936T3 (es)	1998-02-01	Derivados de piperacina.
DK0497695T3 (da)	1995-05-15	N-2-chlorbenzyl-2-oxo- og N-2-chlorbenzyl-2,2-dioxo-1,2,3-oxathiazolidinderivater, deres fremstilling samt syntese af thieno/3,2-c/pyridinderivater
ES2015297B3 (es)	1990-08-16	Herbicidas de fenilurea.