ATE287705T1 - Wärmegellierende bioabbaubare wässrige polymerlösung - Google Patents

Wärmegellierende bioabbaubare wässrige polymerlösung

Info

Publication number
ATE287705T1
ATE287705T1 AT01975509T AT01975509T ATE287705T1 AT E287705 T1 ATE287705 T1 AT E287705T1 AT 01975509 T AT01975509 T AT 01975509T AT 01975509 T AT01975509 T AT 01975509T AT E287705 T1 ATE287705 T1 AT E287705T1
Authority
AT
Austria
Prior art keywords
polymer solution
aqueous polymer
block
gelelling
biodegradable
Prior art date
Application number
AT01975509T
Other languages
English (en)
Inventor
Byeong Moon Jeong
Anna Gutowska
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Application granted granted Critical
Publication of ATE287705T1 publication Critical patent/ATE287705T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/10Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66Polyesters containing oxygen in the form of ether groups
    • C08G63/664Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polymers & Plastics (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Polymerisation Methods In General (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT01975509T 2000-09-28 2001-09-27 Wärmegellierende bioabbaubare wässrige polymerlösung ATE287705T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23692600P 2000-09-28 2000-09-28
US09/833,460 US6841617B2 (en) 2000-09-28 2001-04-11 Thermogelling biodegradable aqueous polymer solution
PCT/US2001/030322 WO2002026215A2 (en) 2000-09-28 2001-09-27 Thermogelling biodegradable aqueous polymer solution

Publications (1)

Publication Number Publication Date
ATE287705T1 true ATE287705T1 (de) 2005-02-15

Family

ID=26930226

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01975509T ATE287705T1 (de) 2000-09-28 2001-09-27 Wärmegellierende bioabbaubare wässrige polymerlösung

Country Status (8)

Country Link
US (1) US6841617B2 (de)
EP (1) EP1320359B1 (de)
JP (1) JP5031974B2 (de)
AT (1) ATE287705T1 (de)
AU (2) AU9482801A (de)
CA (1) CA2423488C (de)
DE (1) DE60108651T2 (de)
WO (1) WO2002026215A2 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7087244B2 (en) * 2000-09-28 2006-08-08 Battelle Memorial Institute Thermogelling oligopeptide polymers
US20040228794A1 (en) * 1998-04-10 2004-11-18 Battelle Memorial Institute Therapeutic agent carrier compositions
US6841617B2 (en) 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
TWI353854B (en) * 2002-06-25 2011-12-11 Alza Corp Short duration depot formulations
MXPA05002589A (es) * 2002-09-05 2005-09-20 Ambrose Catherine G Microesferas antibioticas para el tratamiento de infecciones y osteomelitis.
US8986737B2 (en) 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
TW200410717A (en) * 2002-12-31 2004-07-01 Ind Tech Res Inst Delivery system for control release of temperature sensitive bioactive material
GB0307011D0 (en) * 2003-03-27 2003-04-30 Regentec Ltd Porous matrix
AU2004201264B2 (en) * 2003-03-28 2009-12-24 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Adhesive Antineoplastic Compositions
US7051654B2 (en) 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
ES2379466T3 (es) 2003-06-26 2012-04-26 Psivida Us, Inc. Sistema de suministro de fármacos de liberación sostenida bioerosionables
JP5229768B2 (ja) * 2003-06-26 2013-07-03 シヴィダ・ユーエス・インコーポレイテッド In−Situゲル化薬物輸送システム
GB2408510B (en) * 2003-11-28 2008-05-14 Ind Tech Res Inst Thermosensitive biodegradable copolymer
US20060034889A1 (en) 2004-08-16 2006-02-16 Macromed, Inc. Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
US8128952B2 (en) * 2005-01-12 2012-03-06 Clemson University Research Foundation Ligand-mediated controlled drug delivery
US8663686B2 (en) * 2005-05-09 2014-03-04 University Of Washington Biodegradable chitosan-PEG compositions and methods of use
JP5178520B2 (ja) 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
EP1926780B1 (de) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-haltige poly(esteramid) und poly(esterurethan)-zusammensetzungen und verwendungsverfahren
US20070237803A1 (en) * 2006-04-11 2007-10-11 Medtronic Vascular, Inc. Biodegradable Biocompatible Amphiphilic Copolymers for Coating and Manufacturing Medical Devices
US8974542B2 (en) 2006-06-27 2015-03-10 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable elastomeric patch for treating cardiac or cardiovascular conditions
WO2008045904A2 (en) * 2006-10-10 2008-04-17 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Thermoresponsive, biodegradable, elastomeric material
US20080140106A1 (en) * 2006-12-12 2008-06-12 Kimberly-Clark Worldwide, Inc. Enhanced cuff sealing for endotracheal tubes
JP5264103B2 (ja) * 2007-05-09 2013-08-14 学校法人 関西大学 温度応答性を有する生分解性グラフト共重合体
US20090004243A1 (en) 2007-06-29 2009-01-01 Pacetti Stephen D Biodegradable triblock copolymers for implantable devices
JP5171146B2 (ja) * 2007-07-27 2013-03-27 学校法人 関西大学 温度応答性を有する生分解性ポリマー及びその製造方法
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
US20110027379A1 (en) * 2007-12-06 2011-02-03 Cornell University Oligo-Ethylene Glycol-Based Polymer Compositions and Methods of Use
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
TWI388591B (zh) * 2008-03-28 2013-03-11 Ind Tech Res Inst 溫度敏感性材料
US8916188B2 (en) * 2008-04-18 2014-12-23 Abbott Cardiovascular Systems Inc. Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block
JP5435534B2 (ja) * 2008-08-27 2014-03-05 多木化学株式会社 生体材料
US8821364B2 (en) 2008-09-02 2014-09-02 Battelle Memorial Institute Brachytherapy seed with fast dissolving matrix for optimal delivery of radionuclides to cancer tissue
TWI374903B (en) * 2008-12-31 2012-10-21 Ind Tech Res Inst Biodegradable copolymer hydrogel materials
BR112012002341A8 (pt) 2009-08-06 2017-10-10 Koninklijke Philips Electronics Nv Semente radioativa para uso na terapia oncológica e método de terapia oncológica
JP5653441B2 (ja) * 2009-09-18 2015-01-14 プロセリクス メディスンズ ディベロプメント リミテッド 再構成可能な逆熱ゲル化性ポリマー
KR101838304B1 (ko) * 2009-09-18 2018-03-13 비티지 인터내셔널 리미티드 향상된 방출 특성을 갖는 bab 트리블록 중합체
US8796234B2 (en) 2009-11-24 2014-08-05 Agency For Science, Technology And Research Crosslinking branched molecule through thiol-disulfide exchange to form hydrogel
WO2012024390A2 (en) 2010-08-17 2012-02-23 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Biohybrid composite scaffold
WO2012106317A1 (en) 2011-01-31 2012-08-09 Northwestern University Injectable thermoresponsive polyelectrolytes
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
EP4406558A3 (de) 2011-06-23 2024-10-23 DSM IP Assets B.V. Neue biologisch abbaubare polyesteramid-copolymere zur arzneimittelabgabe
AU2012286817A1 (en) 2011-07-26 2014-02-13 The Curators Of The University Of Missouri Engineered comestible meat
EP2596802A1 (de) * 2011-11-23 2013-05-29 PLS-Design GmbH Pharmazeutische Zusammensetzung zur Behandlung allergischer Reaktionen
WO2014179615A2 (en) * 2013-05-01 2014-11-06 Dae Won Park Biodegradable copolymers, systems including the copolymers, and methods of forming and using same
US10364451B2 (en) 2013-05-30 2019-07-30 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
US10392611B2 (en) 2013-05-30 2019-08-27 Duke University Polymer conjugates having reduced antigenicity and methods of using the same
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
CN106413417A (zh) 2014-02-05 2017-02-15 现代牧场有限公司 由培养的肌肉细胞制成的干燥的食物制品
KR20170094793A (ko) 2014-12-15 2017-08-21 더 존스 홉킨스 유니버시티 수니티닙 제제 및 녹내장의 치료에서의 그의 사용 방법
US10434071B2 (en) 2014-12-18 2019-10-08 Dsm Ip Assets, B.V. Drug delivery system for delivery of acid sensitivity drugs
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US10385115B2 (en) 2015-03-26 2019-08-20 Duke University Fibronectin type III domain-based fusion proteins
CA2994279A1 (en) 2015-08-04 2017-02-09 Duke University Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same
CN105062019B (zh) * 2015-08-18 2016-11-30 九江学院 一种具有快速凝胶能力的透明型温敏可逆可降解聚酯水凝胶及其制备方法
US11913166B2 (en) 2015-09-21 2024-02-27 Modern Meadow, Inc. Fiber reinforced tissue composites
MX2018005932A (es) 2015-11-12 2019-05-20 Graybug Vision Inc Microparticulas aglomerantes para terapia medica.
US20170136144A1 (en) 2015-11-12 2017-05-18 John C. Herr Compositions and methods for vas-occlusive contraception
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
KR20170096094A (ko) 2016-02-15 2017-08-23 브렌던 패트릭 퍼셀 복합체 물질을 생제작하는 방법
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
WO2018053201A1 (en) 2016-09-14 2018-03-22 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
JP2020500150A (ja) 2016-09-23 2020-01-09 デューク ユニバーシティ 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド
EP4400166A3 (de) 2017-01-05 2025-01-22 Contraline, Inc. Verfahren zum implantieren und umkehren von stimulierend wirkenden implantaten
US12383421B2 (en) 2017-01-05 2025-08-12 Contraline, Inc. Contraceptive devices
US11648200B2 (en) 2017-01-12 2023-05-16 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
EP3600324A4 (de) 2017-03-23 2020-12-09 Graybug Vision, Inc. Arzneimittel und zusammensetzungen zur behandlung von augenkrankheiten
US11911532B2 (en) 2017-03-29 2024-02-27 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
US11680083B2 (en) 2017-06-30 2023-06-20 Duke University Order and disorder as a design principle for stimuli-responsive biopolymer networks
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
AU2018384096B2 (en) * 2017-12-12 2021-04-15 Cardiol Therapeutics Inc. Amphiphilic block copolymers, micelles, and methods for treating or preventing heart failure
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
US12257308B2 (en) 2018-04-30 2025-03-25 Duke University Stimuli-responsive PEG-like polymer-based drug delivery platform
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
WO2020102234A1 (en) 2018-11-13 2020-05-22 Contraline, Inc. Systems and methods for delivering biomaterials
WO2020150443A1 (en) 2019-01-17 2020-07-23 Modern Meadow, Inc. Layered collagen materials and methods of making the same
US12521452B2 (en) 2019-07-01 2026-01-13 Vivos, Inc. Radiotherapy gel and method of preparing the same
US11478557B2 (en) 2019-07-01 2022-10-25 Vivos, Inc. Method of preparing a radioactive yttrium phosphate particle suspension
US12491269B2 (en) 2019-07-01 2025-12-09 Vivos, Inc. Radioactive yttrium phosphate suspension and method of preparing the same
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
WO2021094468A1 (en) 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures
WO2022209378A1 (ja) * 2021-03-30 2022-10-06 株式会社クレハ グリコール酸共重合体組成物、および固化押出成形物
CN113214462B (zh) * 2021-05-10 2022-06-10 复旦大学 含有烷基侧链的聚乙二醇/聚酯嵌段共聚物、包含其的热致水凝胶制剂及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE37983T1 (de) * 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4438253A (en) * 1982-11-12 1984-03-20 American Cyanamid Company Poly(glycolic acid)/poly(alkylene glycol) block copolymers and method of manufacturing the same
US4946686A (en) * 1987-09-24 1990-08-07 Merck & Co., Inc. Solubility modulated drug delivery system
US5843156A (en) * 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
EP0431046B1 (de) * 1988-08-24 1995-05-03 SLEPIAN, Marvin J. Endoluminale dichtung mit bisdegradierbaren polymeren
US5213580A (en) * 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5634946A (en) * 1988-08-24 1997-06-03 Focal, Inc. Polymeric endoluminal paving process
US5575815A (en) * 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
US5328471A (en) * 1990-02-26 1994-07-12 Endoluminal Therapeutics, Inc. Method and apparatus for treatment of focal disease in hollow tubular organs and other tissue lumens
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US6919067B2 (en) * 1991-09-13 2005-07-19 Syngenix Limited Compositions comprising a tissue glue and therapeutic agents
BR9306038A (pt) * 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US5573934A (en) * 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
AU7113594A (en) 1993-06-21 1995-01-17 Enzon, Inc. Site specific synthesis of conjugated peptides
US5646131A (en) * 1994-02-22 1997-07-08 The Arab Company For Drug Industries And Medical Applicances (Acdima) Method for solubilizing drugs using cyclodextrins and carboxylic acids
DE69531869T2 (de) 1994-07-21 2004-07-22 Sirus Pharmaceuticals Ltd. Zusammensetzung enthaltend einen gewebeklebstoff und ein immobilisiertes therapeutisches wirkstoffteilchen
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6413539B1 (en) * 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5702717A (en) * 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
AU712953B2 (en) * 1996-03-11 1999-11-18 Focal, Inc. Polymeric delivery of radionuclides and radiopharmaceuticals
ZA978537B (en) * 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
JP2001508802A (ja) 1997-06-06 2001-07-03 バッテル・メモリアル・インスティチュート 可逆的ゲル化コポリマーと製造方法
TR200001021T2 (tr) * 1997-07-18 2000-09-21 Infimed Inc. Aktif maddelerin kontrollü salınması için biyo aşındırılabilir makromerler.
WO1999007343A1 (en) 1997-08-08 1999-02-18 University Of Utah Research Foundation Injectable biodegradable block copolymer gels for use in drug delivery
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
ES2239408T3 (es) 1997-10-03 2005-09-16 Macromed Inc. Copolimeros tribloque de poli(lactido-co-glicolido) polietilenglicol de bajo peso molecular biodegradables con propiedades de gelificacion termica inversa.
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6686446B2 (en) 1998-03-19 2004-02-03 The Regents Of The University Of California Methods and compositions for controlled polypeptide synthesis
US6841617B2 (en) 2000-09-28 2005-01-11 Battelle Memorial Institute Thermogelling biodegradable aqueous polymer solution
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
WO2000056774A1 (en) 1999-03-19 2000-09-28 Duke University Methods of using bioelastomers
WO2001047501A1 (en) * 1999-12-29 2001-07-05 Nanodelivery, Inc. Drug delivery system exhibiting permeability control
US6444254B1 (en) 2000-03-03 2002-09-03 Duke University Microstamping activated polymer surfaces
US6852834B2 (en) * 2000-03-20 2005-02-08 Ashutosh Chilkoti Fusion peptides isolatable by phase transition

Also Published As

Publication number Publication date
JP5031974B2 (ja) 2012-09-26
CA2423488A1 (en) 2002-04-04
AU9482801A (en) 2002-04-08
US20020173586A1 (en) 2002-11-21
EP1320359B1 (de) 2005-01-26
WO2002026215A3 (en) 2003-01-30
US6841617B2 (en) 2005-01-11
DE60108651D1 (de) 2005-03-03
AU2001294828B2 (en) 2006-02-09
WO2002026215A2 (en) 2002-04-04
EP1320359A2 (de) 2003-06-25
CA2423488C (en) 2010-07-13
DE60108651T2 (de) 2006-03-30
JP2004525194A (ja) 2004-08-19

Similar Documents

Publication Publication Date Title
ATE287705T1 (de) Wärmegellierende bioabbaubare wässrige polymerlösung
ES2120042T3 (es) Polimero de varilla rigida a base de piridobisimidazol.
ATE244556T1 (de) Biologisch abbaubare ph/thermosensitive hydrogele zur verzörgerten freisetzung biologisch aktiver stoffe
BR0012588A (pt) Copolìmero em bloco, composição para suprimento de agente bioativo, e, formulação de medicamento para implantação subcutânea ou injeção intravenosa
NO995301D0 (no) Bionedbrytbare sammensetninger omfattende poly(cykloalifatisk fosfoester) forbindelser, artikler og fremgangsmÕte for anvendelse derav
NO994802D0 (no) Bionedbrytbare tereftalatpolyester-poly(fosfat)-polymerer, blandinger, gjenstander og fremgangsmÕte for fremstilling og anvendelse derav
DK1028753T3 (da) Indgivelse af poly(ethylenglycol)-konjugerede molekyler fra nedbrydellige hydrogeler
DE69837141D1 (de) Polyhydroxyalkanoate für in vivo anwendungen
TR200302105T4 (tr) Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları.
DE60224296D1 (de) Haarpflegezusammensetzungen
DE60138412D1 (de) Antimikrobielle medizinische artikel
GB0328168D0 (en) Biodegradable hyaluronic acid derivative and biodegradable polymeric micelle composition
DE69401204D1 (de) Gonadotropin enthaltende gefriergetrocknete troepfen
ATE375374T1 (de) Copolymere aus bioabbaubaren aliphatischen polyestern
ATE444324T1 (de) Verwendung von bioabbaubaren kunstoffgegenständen zum servieren von nahrungsmittel
DE60032255D1 (de) Polymer-stabilisierte neuropeptide
ATE254922T1 (de) Pharmazeutische zusammensetzungen mit antimikrobieller wirkung
WO2002043706A3 (en) Prolamin-based sustained-release compositions and delayed-onset compositions
ES2189472T3 (es) Agente para el tratamiento de agua.
DE69936635D1 (de) Verwendundung von Rhamnolipiden als Kosmetika
AR031056A1 (es) Composicion cosmetica que proporciona buenas propiedades de estabilidad y que incluye un copolimero de unidad acido
FR2803743B1 (fr) Compositions cosmetiques contenant des dispersions aqueuses de polymeres, filmogenes en l'absence de solvant organique
NO20021573L (no) Tverrbundne kopolymerer basert på ikke-tverrbundne polykarboksyl-kopolymerer
BR0212195A (pt) Composições contendo pectina e ácido ascórbico
TW200504123A (en) Biodegradable copolymer, and polymeric micelle composition containing the copolymer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties