ATE288478T1 - Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen - Google Patents

Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen

Info

Publication number
ATE288478T1
ATE288478T1 AT00930192T AT00930192T ATE288478T1 AT E288478 T1 ATE288478 T1 AT E288478T1 AT 00930192 T AT00930192 T AT 00930192T AT 00930192 T AT00930192 T AT 00930192T AT E288478 T1 ATE288478 T1 AT E288478T1
Authority
AT
Austria
Prior art keywords
tissue
mold
dimensional
etched
living
Prior art date
Application number
AT00930192T
Other languages
English (en)
Inventor
Joseph P Vacanti
Jeffrey T Borenstein
Homer Dr Pien
Brian T Cunnungham
Original Assignee
Massachusetts Gen Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Gen Hospital filed Critical Massachusetts Gen Hospital
Application granted granted Critical
Publication of ATE288478T1 publication Critical patent/ATE288478T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3895—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0671—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography
    • C12N2535/10—Patterned coating

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Manufacturing & Machinery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Prostheses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Laser Surgery Devices (AREA)
  • Materials For Medical Uses (AREA)
AT00930192T 1999-04-30 2000-04-28 Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen ATE288478T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13193099P 1999-04-30 1999-04-30
US16532999P 1999-11-12 1999-11-12
PCT/US2000/011407 WO2000066036A2 (en) 1999-04-30 2000-04-28 Fabrication of vascularized tissue using microfabricated two-dimensional molds

Publications (1)

Publication Number Publication Date
ATE288478T1 true ATE288478T1 (de) 2005-02-15

Family

ID=26829934

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00930192T ATE288478T1 (de) 1999-04-30 2000-04-28 Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen

Country Status (8)

Country Link
US (3) US6455311B1 (de)
EP (1) EP1187909B1 (de)
JP (1) JP2002542883A (de)
AT (1) ATE288478T1 (de)
AU (1) AU772484B2 (de)
CA (1) CA2370781A1 (de)
DE (1) DE60017900T2 (de)
WO (1) WO2000066036A2 (de)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759113B2 (en) 1999-04-30 2010-07-20 The General Hospital Corporation Fabrication of tissue lamina using microfabricated two-dimensional molds
ATE288478T1 (de) * 1999-04-30 2005-02-15 Massachusetts Gen Hospital Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
US6793677B2 (en) * 1999-08-13 2004-09-21 Bret A. Ferree Method of providing cells and other biologic materials for transplantation
US6503273B1 (en) * 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US20040043006A1 (en) * 2002-08-27 2004-03-04 Badylak Stephen F. Tissue regenerative composition
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
AU2002239810A1 (en) * 2001-01-02 2002-07-16 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology
US7029838B2 (en) * 2001-03-30 2006-04-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized contructs for implantation to provide blood perfusion
GB0114399D0 (en) * 2001-06-13 2001-08-08 Univ Liverpool Substrates, biomaterials and methods
WO2003004254A1 (en) * 2001-07-03 2003-01-16 The Regents Of The University Of California Microfabricated biopolymer scaffolds and method of making same
DE10146903C1 (de) * 2001-09-24 2002-11-14 Cytonet Gmbh & Co Kg Verfahren zur Herstellung von in vitro-Hohlorganen
EP2292278B1 (de) 2001-11-16 2013-04-24 Children's Medical Center Corporation Verbesserung der Funktion von Organen
US7048963B2 (en) * 2001-11-30 2006-05-23 Cambridge Polymers Group, Inc. Layered aligned polymer structures and methods of making same
US20050019488A1 (en) * 2001-11-30 2005-01-27 Cambridge Polymer Group, Inc., Boston, Ma Layered aligned polymer structures and methods of making same
EP1451299A4 (de) * 2001-12-11 2008-03-05 Cytograft Tissue Engineering I Durch tissue-engineering gebildete zellagen, verfahren zur herstellung und verwendung davon
WO2003072748A2 (en) * 2002-02-22 2003-09-04 University Of Washington Bioengineered tissue substitutes
AU2003222697A1 (en) * 2002-04-24 2003-11-10 Biogentis Inc. Method for preparing tissue constructs
CA2389394A1 (en) * 2002-06-05 2003-12-05 Michael V. Sefton Modular assembly of tissue engineered constructs
GB2422843B (en) * 2002-08-12 2007-03-14 Pentax Corp Cell culture base
WO2004065616A2 (en) 2003-01-16 2004-08-05 The General Hospital Corporation Use of three-dimensional microfabricated tissue engineered systems for pharmacologic applications
US8828226B2 (en) 2003-03-01 2014-09-09 The Trustees Of Boston University System for assessing the efficacy of stored red blood cells using microvascular networks
US7517453B2 (en) 2003-03-01 2009-04-14 The Trustees Of Boston University Microvascular network device
US20040176855A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
US20040175366A1 (en) * 2003-03-07 2004-09-09 Acell, Inc. Scaffold for cell growth and differentiation
JP4247737B2 (ja) * 2003-03-11 2009-04-02 ウシオ電機株式会社 細胞固定用基板の製造方法および細胞固定用基板
GB2401612A (en) * 2003-05-13 2004-11-17 Univ Manchester Method and device for culturing tissue
WO2005034624A2 (en) 2003-05-21 2005-04-21 The General Hospital Corporation Microfabricated compositions and processes for engineering tissues containing multiple cell types
US7051654B2 (en) * 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
CA2530490A1 (en) 2003-06-25 2005-01-13 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
US20050014364A1 (en) * 2003-07-18 2005-01-20 Infineon Technologies North America Corp. Method of suppressing the effect of shining spots present at the edge of a wafer
WO2005060396A2 (en) 2003-08-18 2005-07-07 The General Hospital Corporation Nanotopographic compositions and methods for cellular organization in tissue engineered structures
US8043614B2 (en) * 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
KR100832286B1 (ko) * 2003-10-17 2008-05-26 다이니폰 인사츠 가부시키가이샤 인공 세포 조직의 작성 방법 및 그를 위한 기재
US7919305B2 (en) 2004-02-19 2011-04-05 Dai Nippon Printing Co., Ltd. Method for manufacturing cell culture substrate
JP4456393B2 (ja) 2004-03-26 2010-04-28 大日本印刷株式会社 細胞培養基板の製造方法および細胞培養基板製造装置
JP4585790B2 (ja) * 2004-03-27 2010-11-24 独立行政法人科学技術振興機構 細胞培養足場および細胞培養方法
JP4422719B2 (ja) * 2004-04-12 2010-02-24 大日本印刷株式会社 人工組織およびその製造方法
JP4303643B2 (ja) * 2004-06-01 2009-07-29 育男 森田 人工組織体およびその製造方法
WO2006028274A1 (ja) * 2004-09-08 2006-03-16 National University Corporation Nagoya University 細胞培養物の生産と該生産に用いる材料
US9427496B2 (en) 2005-02-18 2016-08-30 Drexel University Method for creating an internal transport system within tissue scaffolds using computer-aided tissue engineering
US9249386B2 (en) 2005-06-06 2016-02-02 Dai Nippon Printing Co., Ltd. Substrate for cell transfer
US7790028B1 (en) * 2005-09-28 2010-09-07 The Charles Stark Draper Laboratory, Inc. Systems, methods, and devices relating to a cellularized nephron unit
EP1948259B1 (de) 2005-10-26 2017-03-22 Genesis Technologies Limited Durch inkubation von azellulären blutprodukten hergestellte azelluläre bioresorbierbare geweberegenerationsmatrizen
US20080159604A1 (en) * 2005-12-30 2008-07-03 Allan Wang Method and system for imaging to identify vascularization
DK1980613T3 (en) * 2006-01-12 2016-02-08 Univ Tokyo Womens Medical PROCEDURE FOR KEEPING THE FUNCTION OF Liver Tissue Cells Over a Long Time
US20100273667A1 (en) * 2006-02-10 2010-10-28 The Regents Of The University Of Michigan Cell culture well-plates having inverted colloidal crystal scaffolds
US20090041825A1 (en) * 2006-02-10 2009-02-12 Kotov Nicholas A Cell culture well-plates having inverted colloidal crystal scaffolds
US7854505B2 (en) * 2006-03-15 2010-12-21 The Board Of Trustees Of The University Of Illinois Passive and active photonic crystal structures and devices
LT1998690T (lt) * 2006-03-29 2019-11-11 Swenora Biotech Ab Būdas nervo regeneravimo prietaisui sukurti
US20090239303A1 (en) * 2006-04-24 2009-09-24 Rhoades Lawrence J Ultrasonic Machining Fabrication of Guided Tissue Generation Surfaces and Tissue Scaffolds
JP4821466B2 (ja) * 2006-07-03 2011-11-24 富士ゼロックス株式会社 液滴吐出ヘッド
JP4934360B2 (ja) * 2006-07-05 2012-05-16 学校法人東京女子医科大学 細胞培養支持体
EP2097513A4 (de) * 2006-11-17 2012-11-28 Cytograft Tissue Engineering Inc Herstellung und verwendung von aus zellen synthetisierten fäden
DE102007014158A1 (de) * 2007-03-21 2008-09-25 Matthias Schreiber Verfahren zur Herstellung einer 3D Gefäßmatrix und Zellträgermatrix und In-vitro-Verfahren und Vorrichtung zur Inkubaktion
ES2859575T3 (es) * 2007-04-12 2021-10-04 Massachusetts Gen Hospital Red vascular biomimética
US9580688B2 (en) 2007-06-08 2017-02-28 Wake Forest University Health Sciences Kidney structures and methods of forming the same
EP2162529B1 (de) 2007-06-08 2019-03-27 Wake Forest University Health Sciences Selektive zelltherapie zur behandlung von nierenversagen
EP2200931B1 (de) 2007-09-19 2017-06-07 The Charles Stark Draper Laboratory, Inc. Mikrofluidstrukturen mit kreisförmigem querschnitt
WO2009042671A1 (en) * 2007-09-24 2009-04-02 The Board Of Trustees Of The University Of Illinois Three-dimensional microfabricated bioreactors with embedded capillary network
US20090234332A1 (en) * 2008-03-17 2009-09-17 The Charles Stark Draper Laboratory, Inc Artificial microvascular device and methods for manufacturing and using the same
US20110091926A1 (en) * 2008-03-25 2011-04-21 Novatissue Gmbh Perfusable bioreactor for the production of human or animal tissues
DE102008015633B4 (de) * 2008-03-25 2010-07-01 Nova Tissue Gmbh Perfundierbarer Bioreaktor zur Herstellung und/oder Kultivierung eines menschlichen oder tierischen Blutgefäßes und/oder eines menschlichen oder tierischen Gewebes
WO2010005753A1 (en) * 2008-06-16 2010-01-14 Cytograft Tissue Engineering, Inc. Arterial implants
WO2010009320A1 (en) 2008-07-18 2010-01-21 Cornell University Fabrication of a vascular system using sacrificial structures
WO2010057013A1 (en) 2008-11-14 2010-05-20 Wake Forest University Health Sciences Selective cell therapy for the treatment of renal failure
US20120058328A1 (en) * 2009-05-26 2012-03-08 Arnaud Tourvieille Controlling the porosity in an anisotropic coating
US20130323708A1 (en) 2009-07-01 2013-12-05 Massachusetts Institute Of Technology Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US8652500B2 (en) 2009-07-22 2014-02-18 Acell, Inc. Particulate tissue graft with components of differing density and methods of making and using the same
US8298586B2 (en) 2009-07-22 2012-10-30 Acell Inc Variable density tissue graft composition
US20110186165A1 (en) * 2009-10-05 2011-08-04 Borenstein Jeffrey T Three-dimensional microfluidic platforms and methods of use and manufacture thereof
US20110082563A1 (en) * 2009-10-05 2011-04-07 The Charles Stark Draper Laboratory, Inc. Microscale multiple-fluid-stream bioreactor for cell culture
CA2781866C (en) 2009-10-12 2019-12-03 New Health Sciences, Inc. Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
CN102905522A (zh) 2009-10-12 2013-01-30 新健康科学股份有限公司 用于从红细胞中除去氧的氧消耗装置和方法
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US12089589B2 (en) 2009-10-12 2024-09-17 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
ES2628782T3 (es) * 2009-10-29 2017-08-03 The Charles Stark Draper Laboratory, Inc Dispositivo microfluídico para la diálisis de sangre
AU2011247984B2 (en) * 2010-05-07 2015-04-30 University Of North Carolina At Chapel Hill Method of engrafting cells from solid tissues
CA2807438C (en) 2010-08-06 2020-09-01 Technische Universitaet Berlin Self-contained circulation system and method of use thereof
US9339025B2 (en) 2010-08-25 2016-05-17 New Health Sciences, Inc. Method for enhancing red blood cell quality and survival during storage
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
PT2635114T (pt) 2010-11-05 2020-06-16 New Health Sciences Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
EP2720731B1 (de) 2011-06-15 2020-11-18 The Charles Stark Draper Laboratory, Inc. Systeme, verfahren und vorrichtung in zusammenhang mit einer biomimetischen zell-nephroneinheit
ES2685638T3 (es) 2011-07-26 2018-10-10 The Curators Of The University Of Missouri Carne comestible producida artificialmente
ES2984863T3 (es) 2011-08-10 2024-10-31 Hemanext Inc Dispositivo integrado de filtrado de leucocitos, oxígeno y/o agotamiento de CO2, y separación de plasma
US8414654B1 (en) * 2011-11-23 2013-04-09 Amendia, Inc. Bone implants and method of manufacture
US20140308688A1 (en) 2011-12-08 2014-10-16 Research Triangle Institute Human emulated response with microfluidic enhanced systems
US8912006B2 (en) 2012-02-03 2014-12-16 The Charles Stark Draper Laboratory, Inc. Microfluidic device for generating neural cells to simulate post-stroke conditions
WO2013177339A1 (en) 2012-05-22 2013-11-28 New Health Sciences, Inc. Capillary network devices and methods of use
EP2903561B1 (de) * 2012-10-05 2020-03-18 Materialise N.V. Verfahren zur herstellung einer patientenspezifischen aortenstentvorrichtung
ES2900298T3 (es) 2013-02-28 2022-03-16 Hemanext Inc Dispositivo de agotamiento de gas para productos sanguíneos
US20160032239A1 (en) * 2013-03-12 2016-02-04 Northeastern University Deterministic Manufacturing Process For Creating 3D Living Tissues Based on 2D Directed Assembly And Origami Techniques
DE102013108616A1 (de) * 2013-08-09 2015-02-12 Karlsruher Institut für Technologie Bioreaktor, Verfahren und seine Verwendung zur Gewinnung von Zellmetaboliten
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
CN103767804A (zh) * 2014-01-20 2014-05-07 清华大学 一种具有微流体通道的血管化组织结构及其制备方法
JP2017505138A (ja) 2014-02-05 2017-02-16 モダン メドー インコーポレイテッド 培養筋細胞から形成される乾燥食品
TWI568849B (zh) * 2014-08-15 2017-02-01 國防醫學院 一種製造用於重建神經血管組織之細胞層片結構物的方法
PT3970731T (pt) 2015-03-10 2026-02-24 Hemanext Inc Kits descartáveis de redução de oxigénio, dispositivos e métodos de utilização dos mesmos
WO2016172645A1 (en) 2015-04-23 2016-10-27 New Health Sciences, Inc. Anaerobic blood storage containers
WO2016179242A1 (en) * 2015-05-05 2016-11-10 President And Fellows Of Harvard College Tubular tissue construct and a method of printing
CA2985799A1 (en) 2015-05-18 2016-11-24 New Health Sciences, Inc. Methods for the storage of whole blood, and compositions thereof
EP3334821A4 (de) 2015-08-14 2019-07-17 The General Hospital Corporation Systeme und verfahren zur verwendung biomimetischer strukturen für kommunikation in lebendem gewebe
CN114540192A (zh) 2015-08-26 2022-05-27 仿真股份有限公司 灌注歧管组件
EP3349816B1 (de) * 2015-09-17 2023-12-20 Bonus Therapeutics Ltd. Mikrokapillares netzwerkbasiertes gerüst
EP3337923B2 (de) 2015-09-21 2023-01-04 Modern Meadow, Inc. Faserverstärkte gewebeverbundwerkstoffe
JP7109882B2 (ja) 2016-02-15 2022-08-01 モダン メドウ，インコーポレイテッド コラーゲンフィブリルを含むバイオファブリケーテッド材料を作製するための方法
KR20240132129A (ko) 2016-05-27 2024-09-02 헤마넥스트 인코포레이티드 혐기성 혈액 저장 및 병원체 불활성화 방법
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
US10398795B2 (en) * 2017-12-29 2019-09-03 Tomi Environmental Solutions, Inc. Decontamination device and method using ultrasonic cavitation
US10073440B1 (en) * 2018-02-13 2018-09-11 University Of Central Florida Research Foundation, Inc. Method for the design and manufacture of composites having tunable physical properties
US20190358367A1 (en) * 2018-05-25 2019-11-28 The General Hospital Corporation Additive manufacture of complex implantable living devices
CN110607271B (zh) * 2018-06-14 2023-01-20 中国科学院大连化学物理研究所 一种基于微加工技术的体外血管化3d组织的制备方法
AU2020209847B2 (en) 2019-01-17 2024-10-17 Modern Meadow, Inc. Layered collagen materials and methods of making the same
US12448595B2 (en) 2019-10-16 2025-10-21 Wisconsin Alumni Research Foundation Mechanically stable and high cell density honeycomb retinal scaffold design for transplantation therapy of photoreceptor cells and retinal pigment epithelium
EP4143258A4 (de) 2020-05-01 2024-05-22 Modern Meadow, Inc. Proteinpolyurethanlegierungen und schichtmaterialien damit
CN111921016B (zh) * 2020-07-20 2022-04-26 中国医科大学 一种人工器官制造模具及人工器官制造方法
CN113081397A (zh) * 2021-03-10 2021-07-09 浙江工业大学 具有血管微循环通道和引导骨生长的下颌骨植入体制作方法及植入体
US11819415B2 (en) 2021-04-02 2023-11-21 Arthrex, Inc. Orthopaedic implant systems including internal networks and methods of repair
CN113229993A (zh) * 2021-05-10 2021-08-10 中国医科大学 可拆卸式组合模具及其制备带多分支通道复杂器官的方法
CN115503268A (zh) * 2022-09-05 2022-12-23 重庆三大伟业制药有限公司 一种用于血液循环的集装盒的制作方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4996154A (en) * 1989-05-04 1991-02-26 Millipore Corporation Method for growing cellular tissue
US5204055A (en) 1989-12-08 1993-04-20 Massachusetts Institute Of Technology Three-dimensional printing techniques
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
JP2609556B2 (ja) * 1990-06-08 1997-05-14 株式会社バイオマテリアル研究所 神経細胞の培養に用いる基質
US5486359A (en) * 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5549674A (en) 1992-03-02 1996-08-27 The Regents Of The University Of Michigan Methods and compositions of a bioartificial kidney suitable for use in vivo or ex vivo
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
CA2119064A1 (en) * 1993-03-17 1994-09-18 Richard A. Berg Dermal-epidermal in vitro test system
US6200802B1 (en) * 1993-10-08 2001-03-13 Arch Development Corporation Human peroxisome proliferator activated receptor gamma: compositions and methods
US6176874B1 (en) 1993-10-18 2001-01-23 Masschusetts Institute Of Technology Vascularized tissue regeneration matrices formed by solid free form fabrication techniques
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
JP2570621B2 (ja) * 1994-06-27 1997-01-08 日本電気株式会社 細胞培養用基板とその作製方法および細胞配列形成方法
AT405288B (de) 1994-09-21 1999-06-25 Chemie Linz Gmbh Flammfeste, glasfaserverstärkte polyamidharzmasse mit melamin- oder melem-phosphorsäure-umsetzungsprodukten als flammhemmer
JP2609073B2 (ja) * 1994-10-26 1997-05-14 鐘淵化学工業株式会社 細胞の配列制御用具および細胞の配列制御法
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5869243A (en) * 1996-03-05 1999-02-09 Rhode Island Hospital Immortalized hepatocytes
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
US6331406B1 (en) * 1997-03-31 2001-12-18 The John Hopkins University School Of Medicine Human enbryonic germ cell and methods of use
DE69903800T2 (de) * 1998-03-18 2003-10-02 Massachusetts Institute Of Technology, Cambridge Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane
US6143293A (en) * 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
WO1999052356A1 (en) * 1998-04-09 1999-10-21 Charlotte-Mecklenberg Hospital Authority Creation of three-dimensional tissues
ATE288478T1 (de) * 1999-04-30 2005-02-15 Massachusetts Gen Hospital Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
AU2002239810A1 (en) * 2001-01-02 2002-07-16 The Charles Stark Draper Laboratory, Inc. Tissue engineering of three-dimensional vascularized using microfabricated polymer assembly technology

Also Published As

Publication number Publication date
JP2002542883A (ja) 2002-12-17
EP1187909A2 (de) 2002-03-20
DE60017900T2 (de) 2006-04-06
EP1187909B1 (de) 2005-02-02
AU772484B2 (en) 2004-04-29
US6455311B1 (en) 2002-09-24
US20070148139A1 (en) 2007-06-28
WO2000066036A3 (en) 2001-02-08
AU4805500A (en) 2000-11-17
CA2370781A1 (en) 2000-11-09
US20030003575A1 (en) 2003-01-02
WO2000066036A2 (en) 2000-11-09
DE60017900D1 (de) 2005-03-10

Similar Documents

Publication Publication Date Title
ATE288478T1 (de) Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
Zhao et al. Review on the vascularization of organoids and organoids-on-a-C hip
Sutterby et al. Microfluidic skin‐on‐a‐chip models: Toward biomimetic artificial skin
CN112143642B (zh) 用于体外培养的血管化肿瘤微流控器官芯片及其制备方法
CN107312713A (zh) 一种微流控芯片及其应用
EP3383997A1 (de) Oben offene mikrofluidische vorrichtung mit strukturellem anker
AVCI et al. Recent advances in organ-on-a-chip technologies and future challenges: a review
US12029832B2 (en) Three-dimensional bioprinting of cardiac patch with anisotropic and perfusable architecture
CN114854588A (zh) 一种屏障-干细胞归巢仿生微流控芯片及其应用
Kashte et al. Bioinspired engineering for liver tissue regeneration and development of bioartificial liver: a review
Khanna et al. Cardiovascular human organ‐on‐a‐chip platform for disease modeling, drug development, and personalized therapy
Tien et al. Microstructured extracellular matrices in tissue engineering and development: an update
Sree et al. Nature-inspired vascularised materials and devices for biomedical engineering
Fan et al. Advancements in Microfluidic Organ-on-a-chip for Oral Medicine
Okhovatian et al. Biofabrication strategies for cardiac tissue engineering
Visconti et al. Cardiovascular tissue engineering I. Perfusion bioreactors: a review
Yadav et al. Three-dimensional models of human skin for biomedical applications
Bhumiratana et al. Principles of bioreactor design for tissue engineering
EP3138904A1 (de) Vorrichtung und verfahren für gewebekultur mit hermetisch verschlossener blutzirkulation
CN118956728A (zh) 一种皮肤芯片及其制备方法与应用
JP2002542817A (ja) 三次元的な細胞増殖のためのモジュール状の細胞キャリヤー系
KR20240014423A (ko) 역-미세둑 구조가 포함된 장기모사칩 및 이의 용도
CN108407156A (zh) 组织工程人工肝样组织构建模具和制造该模具的注塑模具的方法
CN114196615B (zh) 一种基于血管化心肌的冠心病体外模型及其构建方法和应用
KR102526678B1 (ko) 세포 배양 시 인체 환경적 모사가 가능한 세포 배양 칩

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties