ATE289205T1 - Verfahren zur herstellung biologisch-abbaubarer polyester - Google Patents

Verfahren zur herstellung biologisch-abbaubarer polyester

Info

Publication number
ATE289205T1
ATE289205T1 AT99961296T AT99961296T ATE289205T1 AT E289205 T1 ATE289205 T1 AT E289205T1 AT 99961296 T AT99961296 T AT 99961296T AT 99961296 T AT99961296 T AT 99961296T AT E289205 T1 ATE289205 T1 AT E289205T1
Authority
AT
Austria
Prior art keywords
carboxyl
polymer
omega
protected carboxyl
acid derivative
Prior art date
Application number
AT99961296T
Other languages
English (en)
Inventor
Yoshio Hata
Yasutaka Igari
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Application granted granted Critical
Publication of ATE289205T1 publication Critical patent/ATE289205T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113Multiple emulsions, e.g. oil-in-water-in-oil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08Lactones or lactides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
AT99961296T 1998-12-15 1999-12-14 Verfahren zur herstellung biologisch-abbaubarer polyester ATE289205T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP35649798 1998-12-15
PCT/JP1999/007013 WO2000035990A1 (fr) 1998-12-15 1999-12-14 Procede de production d'un polymere

Publications (1)

Publication Number Publication Date
ATE289205T1 true ATE289205T1 (de) 2005-03-15

Family

ID=18449318

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99961296T ATE289205T1 (de) 1998-12-15 1999-12-14 Verfahren zur herstellung biologisch-abbaubarer polyester

Country Status (11)

Country Link
US (1) US6756472B1 (de)
EP (1) EP1158014B1 (de)
KR (1) KR100584634B1 (de)
CN (1) CN1134479C (de)
AT (1) ATE289205T1 (de)
AU (1) AU1797800A (de)
CA (1) CA2355186C (de)
DE (1) DE69923795T2 (de)
ES (1) ES2234325T3 (de)
PT (1) PT1158014E (de)
WO (1) WO2000035990A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL352499A1 (en) 1999-07-15 2003-08-25 Takeda Chemical Industries Ltd Compositions of prolonged active substance release, method of obtaining them and their applications
EP1291023A1 (de) * 2000-06-14 2003-03-12 Takeda Chemical Industries, Ltd. Formulierungen mit verzögerter wirkstofffreisetzung
CN1269870C (zh) 2000-08-07 2006-08-16 和光纯药工业株式会社 乳酸聚合物及其制备方法
FR2821360B1 (fr) 2001-02-27 2003-05-30 Sod Conseils Rech Applic Procede de preparation de polyesters avec des fonctions acides libres intracatenaires
TWI225416B (en) * 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
TWI332407B (en) * 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
CN100406567C (zh) * 2002-01-22 2008-07-30 生物材料公司 生物可降解聚合物的干燥方法
EP1923075B1 (de) * 2004-08-13 2015-11-11 Rutgers, The State University Röntgendichte Polymerstents
MX2009006653A (es) 2006-12-18 2009-07-02 Takeda Pharmaceutical Composicion de liberacion prolongada y metodo para producirla.
WO2008130158A1 (en) * 2007-04-19 2008-10-30 Dong-A Pharmaceutical. Co., Ltd A biodegradable microsphere composition suitable for the controlled release of glucose controlling peptide and formulation thereof
CN102686551B (zh) * 2009-12-01 2014-11-12 住友化学株式会社 环烷二羧酸单酯的制造方法
CN103275312B (zh) * 2013-05-16 2015-01-21 湘潭大学 含侧羟基或侧羧基官能团的聚丙交酯及其制备方法
US20160106804A1 (en) 2014-10-15 2016-04-21 Yuhua Li Pharmaceutical composition with improved stability

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
CA2167920A1 (en) 1993-07-23 1995-02-02 Abraham J. Domb Nonoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
EP0668073B1 (de) 1994-02-21 1999-04-14 Takeda Chemical Industries, Ltd. Polyester Matrix für eine pharmazeutische Zusammensetzung mit verzögerter Freigabe
PT839525E (pt) 1996-10-31 2004-10-29 Takeda Chemical Industries Ltd Preparacao de libertacao prolongada
TR200002059T2 (tr) 1998-01-16 2001-01-22 Takeda Chemical Industries, Ltd. Devamlı salınan bileşim, üretim yöntemi ve kullanımı.
PL352499A1 (en) * 1999-07-15 2003-08-25 Takeda Chemical Industries Ltd Compositions of prolonged active substance release, method of obtaining them and their applications

Also Published As

Publication number Publication date
DE69923795D1 (de) 2005-03-24
AU1797800A (en) 2000-07-03
WO2000035990A1 (fr) 2000-06-22
US6756472B1 (en) 2004-06-29
ES2234325T3 (es) 2005-06-16
KR20010082348A (ko) 2001-08-29
KR100584634B1 (ko) 2006-05-30
CA2355186C (en) 2008-03-18
EP1158014B1 (de) 2005-02-16
PT1158014E (pt) 2005-04-29
CN1134479C (zh) 2004-01-14
DE69923795T2 (de) 2006-03-16
CN1334834A (zh) 2002-02-06
EP1158014A1 (de) 2001-11-28
EP1158014A4 (de) 2003-01-22
CA2355186A1 (en) 2000-06-22

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