ATE289305T1 - Benzothiophenderivate, benzofuranderivate und indolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen - Google Patents

Benzothiophenderivate, benzofuranderivate und indolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen

Info

Publication number: ATE289305T1
Authority: AT; Austria
Prior art keywords: alkyl; aryl; optionally substituted; derivatives; heteroaryl
Prior art date: 1999-10-15

Application number

AT00402831T

Other languages

English (en)

Inventor

Nanteuil Guillaume De

Christine Lila

Tony Verbeuren

Alain Rupin

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-15

Filing date

2000-10-13

Publication date

2005-03-15

2000-10-13 Application filed by Servier Lab filed Critical Servier Lab

2005-03-15 Application granted granted Critical

2005-03-15 Publication of ATE289305T1 publication Critical patent/ATE289305T1/de

Links

IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical class C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title abstract 5
FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title abstract 5
229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 3
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000003118 aryl group Chemical group 0.000 abstract 9
229910052760 oxygen Inorganic materials 0.000 abstract 6
-1 aralkylene Chemical group 0.000 abstract 5
125000002947 alkylene group Chemical group 0.000 abstract 4
229910052757 nitrogen Inorganic materials 0.000 abstract 4
229910052717 sulfur Inorganic materials 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000000732 arylene group Chemical group 0.000 abstract 3
125000001072 heteroaryl group Chemical group 0.000 abstract 3
125000005549 heteroarylene group Chemical group 0.000 abstract 3
125000006588 heterocycloalkylene group Chemical group 0.000 abstract 3
125000002252 acyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000004104 aryloxy group Chemical group 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002993 cycloalkylene group Chemical group 0.000 abstract 2
125000005553 heteroaryloxy group Chemical group 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
125000000592 heterocycloalkyl group Chemical group 0.000 abstract 2
150000002475 indoles Chemical class 0.000 abstract 2
JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical compound C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
SNUSZUYTMHKCPM-UHFFFAOYSA-N 1-hydroxypyridin-2-one Chemical compound ON1C=CC=CC1=O SNUSZUYTMHKCPM-UHFFFAOYSA-N 0.000 abstract 1
TZOYXRMEFDYWDQ-UHFFFAOYSA-N 3,4-dihydro-1h-quinolin-2-one Chemical compound C1=CC=C2NC(=O)CCC2=C1 TZOYXRMEFDYWDQ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000007513 acids Chemical class 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000005114 heteroarylalkoxy group Chemical group 0.000 abstract 1
125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000005885 heterocycloalkylalkyl group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
RAHZWNYVWXNFOC-UHFFFAOYSA-N sulfur dioxide Inorganic materials O=S=O RAHZWNYVWXNFOC-UHFFFAOYSA-N 0.000 abstract 1
125000004385 trihaloalkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)

AT00402831T 1999-10-15 2000-10-13 Benzothiophenderivate, benzofuranderivate und indolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen ATE289305T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9912899A FR2799756B1 (fr)	1999-10-15	1999-10-15	Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE289305T1 true ATE289305T1 (de)	2005-03-15

Family

ID=9550989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00402831T ATE289305T1 (de)	1999-10-15	2000-10-13	Benzothiophenderivate, benzofuranderivate und indolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen

Country Status (22)

Country	Link
US (1)	US6302837B1 (de)
EP (1)	EP1092716B1 (de)
JP (1)	JP3488683B2 (de)
KR (1)	KR100474753B1 (de)
CN (1)	CN1136213C (de)
AT (1)	ATE289305T1 (de)
AU (1)	AU774527B2 (de)
BR (1)	BR0005171A (de)
CA (1)	CA2323707C (de)
DE (1)	DE60018135T2 (de)
DK (1)	DK1092716T3 (de)
EA (1)	EA004147B1 (de)
ES (1)	ES2238261T3 (de)
FR (1)	FR2799756B1 (de)
HU (1)	HUP0004006A2 (de)
MX (1)	MXPA00010096A (de)
NO (1)	NO320693B1 (de)
NZ (1)	NZ507524A (de)
PL (1)	PL198579B1 (de)
PT (1)	PT1092716E (de)
SI (1)	SI1092716T1 (de)
ZA (1)	ZA200005668B (de)

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EP1129068A1 (de) *	1998-11-12	2001-09-05	Ariad Pharmaceuticals, Inc.	Bizyclische inhibitoren von signal-transduktion, sie enthaltende zusammensetzungen und ihre verwendungen
JP2001261674A (ja) *	2000-03-22	2001-09-26	Mitsui Chemicals Inc	ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
WO2002000641A2 (en) *	2000-06-28	2002-01-03	Eli Lilly And Company	Spla2 inhibitors
US6969730B2 (en) *	2001-03-16	2005-11-29	Abbott Laboratories	Amines as histamine-3 receptor ligands and their therapeutic applications
TWI224101B (en) *	2001-06-20	2004-11-21	Wyeth Corp	Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7074817B2 (en)	2001-06-20	2006-07-11	Wyeth	Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
EP1844771A3 (de)	2001-06-20	2007-11-07	Wyeth	Substituierte Indolsäurederivate als Inhibitoren von Plasminogen-Aktivator-Inhibitor-1 (PAI-1)
EP1569899B1 (de)	2002-12-10	2006-06-28	Wyeth	Substituierte 3-alkyl- und 3-arylalkyl-1h-indol-1-yl-essigsäure-derivate als plasminogen aktivator inhibitor-1 (pai-1) inhibitoren
WO2004052854A2 (en) *	2002-12-10	2004-06-24	Wyeth	Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
UA80453C2 (en)	2002-12-10	2007-09-25		Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
WO2004052856A1 (en) *	2002-12-10	2004-06-24	Wyeth	Substituted indole oxo-acetyl amino acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
US7078429B2 (en)	2002-12-10	2006-07-18	Wyeth	Substituted 3-carbonyl-1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1)
US7268159B2 (en)	2003-09-25	2007-09-11	Wyeth	Substituted indoles
US7411083B2 (en)	2003-09-25	2008-08-12	Wyeth	Substituted acetic acid derivatives
US7420083B2 (en)	2003-09-25	2008-09-02	Wyeth	Substituted aryloximes
US7442805B2 (en) *	2003-09-25	2008-10-28	Wyeth	Substituted sulfonamide-indoles
US7534894B2 (en)	2003-09-25	2009-05-19	Wyeth	Biphenyloxy-acids
US7265148B2 (en)	2003-09-25	2007-09-04	Wyeth	Substituted pyrrole-indoles
US7351726B2 (en) *	2003-09-25	2008-04-01	Wyeth	Substituted oxadiazolidinediones
US7163954B2 (en)	2003-09-25	2007-01-16	Wyeth	Substituted naphthyl benzothiophene acids
US7582773B2 (en)	2003-09-25	2009-09-01	Wyeth	Substituted phenyl indoles
US7446201B2 (en) *	2003-09-25	2008-11-04	Wyeth	Substituted heteroaryl benzofuran acids
US7342039B2 (en)	2003-09-25	2008-03-11	Wyeth	Substituted indole oximes
US7332521B2 (en)	2003-09-25	2008-02-19	Wyeth	Substituted indoles
US7141592B2 (en) *	2003-09-25	2006-11-28	Wyeth	Substituted oxadiazolidinediones
WO2006023864A1 (en)	2004-08-23	2006-03-02	Wyeth	Pyrrolo-naphthyl acids as pai-1 inhibitors
WO2006023866A2 (en)	2004-08-23	2006-03-02	Wyeth	Thiazolo-naphthyl acids as inhibitors of plasminogen activator inhibitor-1
MX2007002178A (es)	2004-08-23	2007-04-02	Wyeth Corp	Acidos de oxazolo-naftilo como moduladores del inhibidor del activador de plasminogeno tipo 1 (pai-1) util en el tratamiento de trombosis y enfermedades cardiovasculares.
US7674822B2 (en)	2004-11-24	2010-03-09	Wyeth	PTP1b inhibitors
US7683091B2 (en)	2005-08-17	2010-03-23	Wyeth	Substituted indoles and methods of their use
WO2008024724A1 (en) *	2006-08-21	2008-02-28	Genentech, Inc.	Aza-benzothiophenyl compounds and methods of use
CA2660546A1 (en) *	2006-08-21	2008-02-28	Genentech, Inc.	Aza-benzofuranyl compounds and methods of use
MX2009002921A (es) *	2006-09-15	2009-04-01	Schering Corp	Derivados de azetidinona para el tratamiento de trastornos del metabolismo lipidico.
WO2008033431A1 (en) *	2006-09-15	2008-03-20	Schering Corporation	Spirocyclic azetidinone derivatives for the treatment of disorders of lipid metabolism, pain, diabetes and other disorders
MX2009002918A (es) *	2006-09-15	2009-03-31	Schering Corp	Derivados azetidinona y sus metodos de uso.
JP2012513464A (ja)	2008-12-23	2012-06-14	ザトラスティーズオブコロンビアユニヴァーシティインザシティオブニューヨーク	ホスホジエステラーゼ阻害剤及びその使用

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US6048877A (en) *	1997-02-21	2000-04-11	Bristol-Myers Squibb Company	Tetralone derivatives as antiarrhythmic agents
FR2777886B1 (fr) *	1998-04-27	2002-05-31	Adir	Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

1999
- 1999-10-15 FR FR9912899A patent/FR2799756B1/fr not_active Expired - Fee Related
2000
- 2000-10-12 PL PL343147A patent/PL198579B1/pl unknown
- 2000-10-13 NO NO20005166A patent/NO320693B1/no unknown
- 2000-10-13 KR KR10-2000-0060286A patent/KR100474753B1/ko not_active Expired - Fee Related
- 2000-10-13 NZ NZ507524A patent/NZ507524A/en unknown
- 2000-10-13 PT PT00402831T patent/PT1092716E/pt unknown
- 2000-10-13 AU AU66503/00A patent/AU774527B2/en not_active Ceased
- 2000-10-13 ES ES00402831T patent/ES2238261T3/es not_active Expired - Lifetime
- 2000-10-13 CN CNB001304577A patent/CN1136213C/zh not_active Expired - Fee Related
- 2000-10-13 HU HU0004006A patent/HUP0004006A2/hu unknown
- 2000-10-13 DE DE60018135T patent/DE60018135T2/de not_active Expired - Fee Related
- 2000-10-13 CA CA002323707A patent/CA2323707C/fr not_active Expired - Fee Related
- 2000-10-13 AT AT00402831T patent/ATE289305T1/de not_active IP Right Cessation
- 2000-10-13 ZA ZA200005668A patent/ZA200005668B/xx unknown
- 2000-10-13 US US09/687,308 patent/US6302837B1/en not_active Expired - Fee Related
- 2000-10-13 DK DK00402831T patent/DK1092716T3/da active
- 2000-10-13 EA EA200000947A patent/EA004147B1/ru unknown
- 2000-10-13 EP EP00402831A patent/EP1092716B1/de not_active Expired - Lifetime
- 2000-10-13 SI SI200030642T patent/SI1092716T1/xx unknown
- 2000-10-13 JP JP2000313668A patent/JP3488683B2/ja not_active Expired - Fee Related
- 2000-10-16 MX MXPA00010096A patent/MXPA00010096A/es active IP Right Grant
- 2000-10-16 BR BR0005171-3A patent/BR0005171A/pt not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2323707C (fr)	2005-08-16
HU0004006D0 (en)	2000-12-28
HK1036447A1 (en)	2002-01-04
KR100474753B1 (ko)	2005-03-08
CN1136213C (zh)	2004-01-28
AU774527B2 (en)	2004-07-01
HUP0004006A2 (hu)	2002-04-29
SI1092716T1 (en)	2005-06-30
JP3488683B2 (ja)	2004-01-19
FR2799756B1 (fr)	2001-12-14
KR20010051018A (ko)	2001-06-25
PL343147A1 (en)	2001-04-23
AU6650300A (en)	2001-04-26
EP1092716A2 (de)	2001-04-18
CA2323707A1 (fr)	2001-04-15
NO320693B1 (no)	2006-01-16
DK1092716T3 (da)	2005-05-17
CN1293192A (zh)	2001-05-02
PL198579B1 (pl)	2008-06-30
JP2001122876A (ja)	2001-05-08
NZ507524A (en)	2002-03-01
BR0005171A (pt)	2001-05-29
EA200000947A1 (ru)	2001-04-23
NO20005166D0 (no)	2000-10-13
MXPA00010096A (es)	2002-08-06
FR2799756A1 (fr)	2001-04-20
ZA200005668B (en)	2001-05-15
EA004147B1 (ru)	2004-02-26
US6302837B1 (en)	2001-10-16
EP1092716A3 (de)	2001-08-08
PT1092716E (pt)	2005-05-31
DE60018135T2 (de)	2005-12-29
NO20005166L (no)	2001-04-17
DE60018135D1 (de)	2005-03-24
ES2238261T3 (es)	2005-09-01
EP1092716B1 (de)	2005-02-16

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2005-11-15

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Publication	Publication Date	Title
DE60018135D1 (de)	2005-03-24	Benzothiophenderivate, Benzofuranderivate und Indolderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
RU2225389C2 (ru)	2004-03-10	Производные аминометилкарбоновой кислоты и фармацевтическая композиция на их основе
BR9908764A (pt)	2000-11-14	Composto e seus sais farmaceuticamente aceitáveis ou ésteres hidrolisáveis in vivo, uso destes, processo para prepará-los, e, composição farmacêutica
FR2655988B1 (fr)	1994-05-20	Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK163120C (da)	1992-06-15	Analogifremgangsmaade til fremstilling af substituerede acylderivater af 1,2,3,4-tetrahydroisoquinolin-3-carboxylsyre (s,s,s) eller et farmaceutisk acceptabelt salt deraf
AR046193A2 (es)	2005-11-30	Derivados de piperidil o piperazinil 1,2,3,4-tetrahidronaftaleno sustituido, formulacion farmaceutica, usos en la manufactura de medicamentos, y proceso para su preparacion
FR2777886B1 (fr)	2002-05-31	Nouveaux derives benzothiopheniques, benzofuraniques et indoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK162992C (da)	1992-06-01	Analogifremgangsmaade til fremstilling af 1-piperazinyl-3-phenyl-indanderivater eller syreadditionssalte deraf
IL57577A0 (en)	1979-10-31	1,2-dihydroquinolin-2-one derivatives,process for their preparation and pharmaceutical compositions containing the same
AR019167A1 (es)	2001-12-26	Derivados heteroaromaticos de piperazinas di-n-sustituidas y piperidinas 1,4-disustituidas, composiciones farmaceuticas y el uso de los mismos para lapreparacion de medicamentos
KR910007928A (ko)	1991-05-30	신규 벤조[1,8] 나프티리딘 유도체, 그의 제조 및 그를 함유하는 조성물
BR0215200A (pt)	2004-10-13	Pirrolidina-2-onas como inibidores de fator xa
KR890001957A (ko)	1989-04-06	N-아미노부틸-n-페닐아릴아미드 유도체, 그의 제법 및 치료에의 응용
AR005233A1 (es)	1999-04-28	Derivados de 1,2,3,4-tetrahidroquinolina, procesos para su preparacion, una composicion farmaceutica y el uso en la elaboracion de un medicamento
MX9400681A (es)	1994-08-31	Nuevos derivados de piridinio, procedimiento para su preparacion y composiciones farmaceuticas que los incluyen.
KR880003611A (ko)	1988-05-28	니코틴 에스테르와 피리미딘 유도체에 기초하여 모발의 성장을 유발하고 촉진하며, 탈모를 지연시키기 위한 조성물
BR0010134A (pt)	2002-01-15	Uso de derivados de ácido 2,4-diamino-3-hidroxicarboxìlico como inibidores de proteassoma
FR2793245B1 (fr)	2002-10-11	Nouveaux composes pyridiniques ou piperidiniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK0462933T3 (da)	1994-08-15	Hidtil ukendte N-benzyl-N1-phenyl og -phenylalkyl-thiourinstoffer
FR2804958B1 (fr)	2005-07-08	Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant
ATE215080T1 (de)	2002-04-15	1,2-dithiolan derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
HUP0201797A2 (hu)	2002-12-28	3-Amino-2-benzil-1-fenil-propán-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
FR2793246B1 (fr)	2001-06-29	Nouveaux derives de 1-aza-2-alkyl-6-aryl-cycloalcanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE3674117D1 (de)	1990-10-18	Verfahren zur herstellung von 1,4-dihydropyridinderivaten ueber neue zwischenprodukte.
DK417380A (da)	1981-04-04	Analogifremgangsmaade til fremstilling af nitrosourinstofderivater eller syreadditionssalte deraf